GREMLIN Database
YMFH - Uncharacterized zinc protease YmfH
UniProt: O31766 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 428 (392)
Sequences: 14182 (10965)
Seq/√Len: 553.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_K189_Y4.3641.00
343_M346_R4.0521.00
353_A357_E4.0191.00
346_R349_E3.7031.00
130_E134_E3.4511.00
296_A355_K3.2471.00
402_T405_D3.1141.00
332_E335_Q3.0971.00
210_D213_A3.0121.00
300_S304_K2.9881.00
364_I399_E2.9051.00
279_H412_E2.8911.00
353_A403_L2.8691.00
345_L348_G2.8561.00
141_G181_S2.7811.00
113_E217_Q2.7651.00
405_D408_N2.7471.00
79_D125_D2.7271.00
27_V209_V2.6601.00
186_D190_E2.6561.00
159_V263_G2.5971.00
63_P187_L2.5221.00
287_L312_S2.5151.00
215_I219_R2.2771.00
205_I214_I2.2651.00
20_S219_R2.2631.00
190_E194_T2.2611.00
289_A351_I2.2461.00
121_D125_D2.1961.00
339_D342_S2.1901.00
286_L410_I2.1371.00
403_L407_Q2.1331.00
300_S343_M2.1321.00
352_T355_K2.1181.00
184_T187_L2.0851.00
18_K24_D2.0581.00
390_S393_D2.0161.00
17_E215_I2.0161.00
408_N412_E2.0131.00
42_T201_M1.9911.00
96_F103_A1.9411.00
134_E137_K1.9361.00
282_S409_V1.8951.00
108_S115_N1.8861.00
338_E342_S1.8841.00
158_G161_E1.8581.00
350_L407_Q1.8541.00
216_S220_E1.8281.00
40_F203_L1.8271.00
357_E360_R1.8151.00
177_V181_S1.8081.00
141_G177_V1.8051.00
279_H408_N1.8011.00
404_E408_N1.7941.00
357_E361_K1.7661.00
16_H24_D1.7431.00
407_Q411_Q1.7421.00
17_E25_V1.7261.00
85_D114_R1.7151.00
213_A216_S1.7051.00
278_K405_D1.6941.00
176_T179_S1.6821.00
129_T132_T1.6731.00
50_R62_V1.6721.00
356_I403_L1.6721.00
102_T196_Y1.6601.00
28_L377_I1.6431.00
133_V185_K1.6411.00
67_A191_C1.6411.00
124_Q224_K1.6331.00
396_T399_E1.6251.00
335_Q338_E1.6191.00
113_E220_E1.6101.00
334_D338_E1.6051.00
145_N177_V1.5941.00
27_V211_P1.5811.00
189_Y193_E1.5651.00
404_E407_Q1.5511.00
79_D127_Y1.5421.00
106_F115_N1.5381.00
282_S405_D1.4861.00
89_Q114_R1.4811.00
187_L190_E1.4711.00
62_V187_L1.4691.00
415_A418_R1.4641.00
50_R63_P1.4591.00
24_D202_L1.4391.00
70_L128_F1.4341.00
342_S346_R1.4271.00
31_K208_P1.4171.00
285_L401_I1.4051.00
66_I183_I1.3971.00
347_A351_I1.3861.00
117_E221_N1.3701.00
23_L201_M1.3691.00
23_L203_L1.3681.00
217_Q221_N1.3571.00
69_F133_V1.3541.00
26_Y202_L1.3541.00
41_T382_T1.3491.00
324_A330_T1.3411.00
16_H385_A1.3371.00
29_P210_D1.3271.00
17_E27_V1.3261.00
307_I310_T1.3181.00
50_R61_H1.3141.00
190_E193_E1.3101.00
46_S173_I1.3051.00
114_R117_E1.3001.00
109_T208_P1.2981.00
278_K397_V1.2921.00
100_T169_V1.2861.00
217_Q220_E1.2831.00
211_P215_I1.2761.00
282_S401_I1.2761.00
130_E185_K1.2721.00
213_A217_Q1.2661.00
43_K200_N1.2621.00
302_Y308_D1.2601.00
78_A121_D1.2591.00
209_V214_I1.2581.00
396_T400_Q1.2571.00
300_S339_D1.2511.00
120_I222_Q1.2461.00
38_A205_I1.2401.00
113_E221_N1.2391.00
296_A343_M1.2371.00
283_M409_V1.2321.00
29_P211_P1.2271.00
248_E251_I1.2271.00
203_L218_V1.2261.00
216_S219_R1.2251.00
81_D84_Q1.2141.00
327_G330_T1.2091.00
142_Q145_N1.2081.00
258_P333_P1.2071.00
86_F91_A1.1991.00
186_D189_Y1.1951.00
113_E213_A1.1891.00
326_I329_D1.1751.00
264_L341_S1.1751.00
24_D385_A1.1751.00
133_V188_L1.1751.00
47_I319_Y1.1741.00
301_L307_I1.1741.00
27_V214_I1.1641.00
61_H171_I1.1621.00
397_V400_Q1.1601.00
219_R223_G1.1591.00
247_K251_I1.1571.00
81_D85_D1.1491.00
68_H72_H1.1421.00
16_H26_Y1.1381.00
126_P192_Y1.1371.00
360_R398_L1.1361.00
116_L217_Q1.1331.00
111_N114_R1.1271.00
341_S345_L1.1211.00
199_S230_Q1.1171.00
120_I124_Q1.1131.00
286_L409_V1.1041.00
325_A328_G1.0981.00
198_P225_K1.0941.00
408_N411_Q1.0911.00
89_Q111_N1.0891.00
276_L279_H1.0861.00
37_Y107_S1.0831.00
299_E303_E1.0821.00
85_D88_K1.0791.00
202_L385_A1.0751.00
144_I174_A1.0751.00
36_T207_G1.0711.00
76_E136_E1.0701.00
86_F93_A1.0691.00
116_L218_V1.0681.00
206_V378_A1.0661.00
262_V341_S1.0631.00
44_Y191_C1.0591.00
69_F137_K1.0551.00
137_K141_G1.0531.00
63_P194_T1.0501.00
239_K242_E1.0431.00
73_K188_L1.0411.00
40_F201_M1.0401.00
26_Y385_A1.0381.00
288_E359_A1.0301.00
293_K298_Y1.0281.00
395_V399_E1.0271.00
301_L339_D1.0261.00
148_D177_V1.0261.00
281_L397_V1.0241.00
193_E228_T1.0121.00
356_I360_R1.0081.00
289_A359_A1.0081.00
266_S314_D1.0031.00
62_V179_S1.0011.00
144_I180_I1.0011.00
365_G369_K1.0001.00
99_F160_I0.9951.00
212_E215_I0.9941.00
42_T123_V0.9931.00
285_L356_I0.9881.00
279_H413_E0.9781.00
197_H200_N0.9721.00
40_F123_V0.9711.00
82_V86_F0.9691.00
199_S227_Y0.9691.00
205_I209_V0.9661.00
354_E358_L0.9571.00
36_T109_T0.9541.00
249_K252_K0.9511.00
68_H71_E0.9511.00
17_E211_P0.9501.00
394_V398_L0.9491.00
34_N208_P0.9481.00
339_D343_M0.9451.00
70_L188_L0.9451.00
132_T135_K0.9431.00
73_K133_V0.9421.00
165_K170_R0.9411.00
410_I414_I0.9361.00
28_L206_V0.9351.00
278_K282_S0.9331.00
137_K180_I0.9311.00
348_G411_Q0.9271.00
17_E219_R0.9241.00
136_E139_I0.9151.00
71_E97_T0.9141.00
281_L401_I0.9131.00
364_I395_V0.9131.00
25_V215_I0.9091.00
159_V261_L0.9041.00
255_V258_P0.9011.00
68_H143_E0.8981.00
324_A328_G0.8981.00
246_R251_I0.8971.00
373_S376_Y0.8941.00
85_D89_Q0.8911.00
199_S228_T0.8911.00
39_V103_A0.8901.00
30_K374_P0.8871.00
74_L126_P0.8861.00
113_E117_E0.8851.00
325_A330_T0.8851.00
104_Y196_Y0.8851.00
65_G175_G0.8831.00
342_S345_L0.8821.00
19_M25_V0.8821.00
325_A329_D0.8811.00
326_I330_T0.8811.00
64_D179_S0.8801.00
120_I221_N0.8771.00
141_G180_I0.8731.00
322_G326_I0.8731.00
141_G145_N0.8731.00
82_V122_F0.8691.00
360_R364_I0.8671.00
214_I218_V0.8611.00
80_G84_Q0.8591.00
291_F312_S0.8561.00
268_N276_L0.8561.00
140_I180_I0.8561.00
41_T103_A0.8551.00
283_M413_E0.8551.00
278_K400_Q0.8541.00
212_E216_S0.8521.00
257_G260_C0.8521.00
351_I356_I0.8521.00
150_N153_W0.8511.00
218_V221_N0.8501.00
179_S182_H0.8501.00
24_D43_K0.8501.00
158_G162_N0.8501.00
91_A108_S0.8491.00
23_L198_P0.8471.00
119_L122_F0.8451.00
343_M347_A0.8431.00
337_A341_S0.8431.00
38_A106_F0.8411.00
286_L406_V0.8401.00
66_I70_L0.8381.00
299_E304_K0.8371.00
134_E138_G0.8351.00
82_V118_T0.8341.00
109_T213_A0.8341.00
85_D118_T0.8311.00
96_F101_R0.8291.00
201_M225_K0.8291.00
306_Y332_E0.8281.00
112_V214_I0.8271.00
112_V217_Q0.8201.00
262_V421_V0.8181.00
74_L104_Y0.8151.00
40_F222_Q0.8111.00
258_P265_K0.8061.00
248_E337_A0.8051.00
324_A329_D0.8051.00
262_V337_A0.8041.00
360_R399_E0.8011.00
138_G141_G0.7981.00
185_K188_L0.7941.00
72_H136_E0.7931.00
136_E140_I0.7901.00
335_Q339_D0.7901.00
106_F119_L0.7891.00
240_E243_A0.7881.00
68_H97_T0.7881.00
267_K413_E0.7841.00
166_E170_R0.7821.00
48_D233_I0.7751.00
178_E182_H0.7701.00
364_I368_L0.7671.00
324_A327_G0.7651.00
301_L310_T0.7631.00
191_C195_F0.7631.00
397_V401_I0.7581.00
44_Y48_D0.7571.00
21_N223_G0.7571.00
197_H228_T0.7561.00
283_M286_L0.7561.00
44_Y195_F0.7511.00
351_I407_Q0.7491.00
354_E357_E0.7491.00
84_Q88_K0.7491.00
72_H97_T0.7431.00
63_P183_I0.7421.00
63_P66_I0.7411.00
247_K250_E0.7391.00
310_T340_I0.7381.00
116_L221_N0.7381.00
321_F324_A0.7371.00
284_N394_V0.7371.00
147_Y153_W0.7361.00
285_L359_A0.7361.00
140_I143_E0.7361.00
68_H140_I0.7351.00
156_Y160_I0.7341.00
334_D337_A0.7341.00
131_K135_K0.7331.00
72_H143_E0.7331.00
351_I403_L0.7321.00
69_F188_L0.7321.00
298_Y302_Y0.7281.00
157_F161_E0.7281.00
289_A355_K0.7251.00
74_L122_F0.7211.00
352_T403_L0.7201.00
155_L261_L0.7201.00
318_E321_F0.7191.00
260_C263_G0.7191.00
256_Q259_K0.7141.00
328_G336_L0.7131.00
359_A363_K0.7131.00
128_F133_V0.7121.00
288_E362_K0.7121.00
124_Q225_K0.7111.00
76_E132_T0.7091.00
99_F173_I0.7081.00
40_F119_L0.7061.00
69_F140_I0.7051.00
268_N277_L0.7021.00
163_M322_G0.7021.00
321_F326_I0.7011.00
247_K252_K0.7011.00
82_V85_D0.6981.00
167_H170_R0.6951.00
91_A115_N0.6941.00
204_F378_A0.6891.00
120_I224_K0.6881.00
258_P264_L0.6871.00
83_F86_F0.6871.00
64_D171_I0.6851.00
70_L191_C0.6841.00
286_L347_A0.6831.00
221_N224_K0.6811.00
341_S419_L0.6801.00
46_S99_F0.6801.00
186_D193_E0.6771.00
67_A70_L0.6771.00
258_P263_G0.6761.00
73_K76_E0.6751.00
297_Q310_T0.6751.00
288_E363_K0.6741.00
36_T205_I0.6731.00
375_E379_N0.6721.00
350_L403_L0.6721.00
282_S286_L0.6711.00
319_Y323_F0.6711.00
72_H140_I0.6701.00
72_H75_F0.6701.00
374_P377_I0.6691.00
204_F381_F0.6681.00
368_L395_V0.6671.00
195_F200_N0.6661.00
83_F93_A0.6641.00
246_R249_K0.6641.00
30_K377_I0.6641.00
380_Q384_Y0.6641.00
71_E102_T0.6631.00
326_I340_I0.6621.00
49_N65_G0.6611.00
78_A126_P0.6601.00
322_G330_T0.6601.00
204_F382_T0.6601.00
356_I401_I0.6581.00
246_R250_E0.6571.00
191_C196_Y0.6561.00
251_I254_N0.6551.00
43_K202_L0.6541.00
133_V183_I0.6541.00
162_N422_C0.6541.00
178_E181_S0.6531.00
72_H94_N0.6521.00
350_L410_I0.6521.00
321_F325_A0.6501.00
199_S229_D0.6501.00
154_R158_G0.6501.00
69_F73_K0.6471.00
324_A340_I0.6471.00
71_E75_F0.6441.00
289_A296_A0.6421.00
333_P337_A0.6411.00
128_F192_Y0.6411.00
362_K365_G0.6401.00
393_D396_T0.6401.00
78_A125_D0.6391.00
128_F185_K0.6381.00
97_T102_T0.6381.00
71_E143_E0.6371.00
195_F198_P0.6371.00
382_T386_F0.6371.00
46_S49_N0.6341.00
37_Y374_P0.6331.00
36_T112_V0.6321.00
306_Y335_Q0.6321.00
78_A127_Y0.6311.00
248_E252_K0.6311.00
50_R194_T0.6301.00
298_Y303_E0.6281.00
292_G298_Y0.6281.00
286_L414_I0.6271.00
319_Y322_G0.6271.00
27_V218_V0.6241.00
23_L225_K0.6221.00
43_K318_E0.6211.00
179_S183_I0.6201.00
205_I218_V0.6181.00
329_D332_E0.6181.00
346_R350_L0.6171.00
321_F329_D0.6151.00
295_S298_Y0.6141.00
41_T204_F0.6141.00
337_A421_V0.6121.00
71_E95_A0.6121.00
407_Q410_I0.6121.00
239_K243_A0.6111.00
25_V218_V0.6111.00
39_V378_A0.6111.00
258_P261_L0.6091.00
302_Y307_I0.6081.00
362_K366_T0.6071.00
340_I343_M0.6061.00
39_V105_L0.6061.00
95_A104_Y0.6041.00
409_V413_E0.6041.00
257_G263_G0.6031.00
347_A410_I0.6021.00
243_A246_R0.6011.00
377_I381_F0.6011.00
95_A143_E0.5981.00
238_V241_Q0.5981.00
44_Y102_T0.5971.00
300_S346_R0.5971.00
290_L344_L0.5961.00
246_R252_K0.5961.00
255_V259_K0.5951.00
367_F394_V0.5951.00
66_I187_L0.5941.00
220_E223_G0.5941.00
37_Y378_A0.5941.00
136_E175_G0.5891.00
285_L363_K0.5881.00
36_T209_V0.5881.00
257_G265_K0.5881.00
285_L406_V0.5871.00
350_L404_E0.5871.00
26_Y204_F0.5871.00
287_L291_F0.5861.00
38_A115_N0.5861.00
152_D259_K0.5851.00
244_V247_K0.5841.00
196_Y200_N0.5831.00
31_K34_N0.5831.00
30_K206_V0.5821.00
192_Y196_Y0.5811.00
26_Y381_F0.5801.00
285_L360_R0.5770.99
301_L306_Y0.5740.99
301_L340_I0.5730.99
147_Y174_A0.5730.99
254_N257_G0.5730.99
349_E407_Q0.5690.99
19_M219_R0.5680.99
146_M150_N0.5680.99
210_D214_I0.5680.99
296_A352_T0.5660.99
21_N198_P0.5650.99
72_H95_A0.5640.99
245_F248_E0.5620.99
296_A300_S0.5610.99
137_K181_S0.5610.99
345_L416_A0.5610.99
23_L222_Q0.5610.99
279_H282_S0.5610.99
188_L192_Y0.5580.99
68_H139_I0.5560.99
123_V192_Y0.5550.99
258_P266_S0.5540.99
406_V410_I0.5530.99
125_D224_K0.5520.99
376_Y380_Q0.5520.99
76_E135_K0.5500.99
211_P214_I0.5500.99
305_G308_D0.5490.99
142_Q146_M0.5480.99
322_G325_A0.5480.99
307_I328_G0.5460.99
381_F385_A0.5450.99
30_K33_F0.5430.99
157_F172_D0.5430.99
63_P67_A0.5420.99
260_C333_P0.5420.99
203_L222_Q0.5410.99
300_S342_S0.5390.99
202_L386_F0.5390.99
198_P226_P0.5380.99
277_L412_E0.5370.99
277_L280_E0.5370.99
415_A419_L0.5360.99
298_Y307_I0.5350.99
116_L214_I0.5350.99
148_D157_F0.5340.99
235_R238_V0.5330.99
96_F105_L0.5320.99
266_S269_P0.5310.99
31_K210_D0.5300.99
17_E218_V0.5290.99
133_V137_K0.5280.99
153_W157_F0.5280.99
49_N64_D0.5270.99
416_A419_L0.5270.99
384_Y389_M0.5250.99
280_E316_T0.5240.99
118_T121_D0.5240.99
389_M393_D0.5230.99
403_L406_V0.5230.99
128_F189_Y0.5230.99
238_V242_E0.5220.99
95_A122_F0.5220.99
71_E140_I0.5210.99
71_E196_Y0.5210.99
291_F295_S0.5210.99
355_K358_L0.5200.99
104_Y119_L0.5190.99
280_E284_N0.5170.99
27_V215_I0.5170.99
98_S101_R0.5160.99
376_Y379_N0.5150.99
279_H409_V0.5130.99
81_D86_F0.5130.99
28_L381_F0.5120.99
72_H139_I0.5120.99
49_N67_A0.5090.99
172_D176_T0.5090.99
97_T143_E0.5090.99
401_I405_D0.5080.99
347_A350_L0.5080.99
20_S223_G0.5080.99
76_E139_I0.5080.99
411_Q415_A0.5070.99
145_N148_D0.5060.99
155_L159_V0.5060.99
38_A112_V0.5050.99
333_P423_K0.5040.99
42_T102_T0.5040.99
83_F87_S0.5030.99
313_F324_A0.5020.99
114_R118_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xeaA 2 0.979 100 0.194 Contact Map
3eoqA 2 0.9182 100 0.217 Contact Map
1hr6B 1 0.9463 100 0.219 Contact Map
3amiA 2 0.9463 100 0.226 Contact Map
1pp9A 1 0.9579 100 0.229 Contact Map
4nnzA 2 0.8995 100 0.234 Contact Map
1q2lA 1 0.9626 100 0.235 Contact Map
3hdiA 2 0.9159 100 0.236 Contact Map
3amjB 1 0.9229 100 0.255 Contact Map
3cx5A 1 0.9159 100 0.256 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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