GREMLIN Database
YMFF - Probable inactive metalloprotease YmfF
UniProt: O31764 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (391)
Sequences: 15700 (12164)
Seq/√Len: 615.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
349_E353_A4.4421.00
187_A191_Y4.0781.00
338_Q341_A3.9521.00
291_K351_D3.6101.00
341_A345_G3.4491.00
132_S136_A3.3491.00
400_T403_D3.1601.00
212_D215_Q3.1221.00
403_D406_K3.1031.00
360_R397_E3.0371.00
327_N330_Q2.9591.00
18_I211_V2.9511.00
340_Q344_N2.8631.00
295_N299_K2.7821.00
161_L262_G2.7721.00
110_E219_A2.7571.00
281_N308_S2.7571.00
188_E192_E2.7241.00
349_E401_K2.7111.00
57_K122_S2.6191.00
273_D410_K2.6191.00
143_K183_D2.4871.00
61_K64_G2.3471.00
41_Q189_Q2.2921.00
11_H221_D2.2831.00
136_A139_K2.2611.00
348_S351_D2.2331.00
295_N300_A2.2261.00
207_V216_V2.1651.00
343_K409_E2.1621.00
118_E122_S2.1591.00
217_Q221_D2.1401.00
401_K405_I2.1181.00
283_L347_F2.1131.00
192_E196_S2.0761.00
280_F408_G2.0731.00
33_M203_L1.9991.00
295_N338_Q1.9881.00
31_F205_L1.9861.00
9_S15_T1.9411.00
333_S337_E1.9321.00
346_D405_I1.8821.00
58_S114_Q1.8821.00
406_K410_K1.8751.00
334_I337_E1.8741.00
300_A334_I1.8631.00
186_T189_Q1.8471.00
178_E181_D1.8341.00
96_I112_G1.8271.00
160_R163_Q1.8051.00
402_E406_K1.7931.00
273_D406_K1.7921.00
276_A407_A1.7781.00
340_Q343_K1.7481.00
300_A330_Q1.7371.00
58_S118_E1.7201.00
143_K179_I1.7191.00
329_E333_S1.7191.00
45_R193_T1.7081.00
391_D394_A1.7011.00
179_I183_D1.6961.00
394_A397_E1.6881.00
68_Y111_K1.6631.00
352_I401_K1.6541.00
319_V335_I1.6511.00
110_E222_K1.6351.00
215_Q218_S1.6301.00
218_S221_D1.6211.00
297_R304_Y1.6181.00
90_I198_I1.6131.00
8_K217_Q1.6071.00
405_I409_E1.6031.00
402_E405_I1.6001.00
19_V373_L1.5991.00
330_Q333_S1.5841.00
353_A357_A1.5821.00
69_L75_T1.5801.00
261_I336_A1.5521.00
15_T204_D1.5421.00
131_Q134_Y1.5401.00
8_K16_A1.5271.00
353_A356_K1.5221.00
279_V399_V1.5211.00
147_Q179_I1.5191.00
121_F226_T1.5021.00
18_I213_S1.4891.00
72_L111_K1.4851.00
189_Q192_E1.4821.00
56_T118_E1.4811.00
94_L112_G1.4721.00
218_S222_K1.4721.00
191_Y195_Q1.4661.00
47_L135_V1.4361.00
388_P391_D1.4351.00
46_A50_H1.4341.00
17_H204_D1.4231.00
14_L205_L1.4121.00
291_K338_Q1.4041.00
123_P130_F1.3911.00
22_E210_D1.3851.00
192_E195_Q1.3771.00
135_V187_A1.3711.00
57_K129_A1.3571.00
20_K212_D1.3471.00
276_A399_V1.3411.00
337_E341_A1.3401.00
342_M347_F1.3341.00
34_L202_Q1.3341.00
135_V190_L1.3261.00
117_A224_F1.3241.00
276_A403_D1.3201.00
391_D395_N1.3181.00
205_L220_I1.3161.00
394_A398_N1.3131.00
111_K114_Q1.3061.00
80_D91_T1.3031.00
272_Q403_D1.3021.00
110_E215_Q1.2991.00
309_R318_M1.2871.00
110_E223_Y1.2781.00
14_L203_L1.2761.00
272_Q395_N1.2651.00
219_A223_Y1.2631.00
215_Q219_A1.2511.00
263_Y336_A1.2481.00
58_S122_S1.2451.00
246_K250_D1.2401.00
31_F203_L1.2381.00
219_A222_K1.2341.00
208_V374_S1.2301.00
188_E191_Y1.2281.00
277_L407_A1.2191.00
20_K213_S1.2161.00
113_L219_A1.2151.00
321_S331_A1.2071.00
44_K185_I1.2011.00
32_K378_Y1.1931.00
29_L207_V1.1871.00
72_L108_L1.1821.00
273_D411_I1.1821.00
132_S187_A1.1781.00
200_K227_E1.1691.00
303_A306_A1.1691.00
37_L175_V1.1671.00
296_V303_A1.1601.00
123_P194_Y1.1591.00
54_R138_E1.1571.00
295_N334_I1.1561.00
406_K409_E1.1551.00
323_I331_A1.1481.00
213_S217_Q1.1451.00
8_K18_I1.1441.00
48_L130_F1.1431.00
139_K143_K1.1361.00
257_G328_F1.1351.00
139_K182_V1.1341.00
211_V216_V1.1331.00
280_F407_A1.1231.00
356_K396_I1.1211.00
35_A193_T1.1181.00
46_A49_P1.1121.00
69_L77_V1.1121.00
275_P395_N1.1101.00
68_Y71_E1.1071.00
347_F352_I1.1041.00
40_D189_Q1.1021.00
114_Q223_Y1.1011.00
144_Q147_Q1.0941.00
33_M120_V1.0931.00
108_L111_K1.0921.00
65_L119_L1.0901.00
146_I176_N1.0861.00
18_I216_V1.0851.00
281_N317_L1.0851.00
117_A121_F1.0791.00
268_T271_D1.0741.00
51_V190_L1.0741.00
395_N398_N1.0711.00
98_N210_D1.0711.00
288_S293_F1.0651.00
307_A320_M1.0571.00
369_T372_G1.0531.00
247_E332_V1.0521.00
15_T381_A1.0521.00
64_G68_Y1.0491.00
48_L190_L1.0461.00
113_L220_I1.0441.00
25_K210_D1.0421.00
221_D225_K1.0401.00
78_S81_L1.0391.00
47_L139_K1.0331.00
321_S335_I1.0231.00
116_L119_L1.0201.00
32_K91_T1.0141.00
214_N217_Q1.0121.00
265_T310_I1.0101.00
275_P399_V1.0081.00
360_R393_L1.0071.00
41_Q196_S1.0071.00
361_N365_E1.0031.00
280_F404_I1.0011.00
134_Y137_Q0.9991.00
27_V209_G0.9981.00
59_H118_E0.9961.00
50_H138_E0.9911.00
385_V388_P0.9901.00
240_D243_V0.9891.00
282_G355_T0.9811.00
28_S95_E0.9801.00
52_L123_P0.9791.00
17_H381_A0.9741.00
43_T177_G0.9711.00
270_T273_D0.9691.00
352_I356_K0.9681.00
283_L355_T0.9631.00
296_V334_I0.9571.00
207_V211_V0.9521.00
110_E114_Q0.9521.00
50_H145_R0.9511.00
303_A321_S0.9471.00
279_V352_I0.9451.00
294_I299_K0.9401.00
146_I182_V0.9391.00
68_Y72_L0.9381.00
109_L219_A0.9361.00
204_D381_A0.9341.00
46_A145_R0.9331.00
94_L116_L0.9331.00
136_A140_R0.9331.00
347_F401_K0.9321.00
261_I332_V0.9281.00
214_N218_S0.9241.00
332_V336_A0.9231.00
8_K213_S0.9231.00
51_V135_V0.9211.00
138_E141_T0.9171.00
364_L393_L0.9081.00
150_Y179_I0.9081.00
336_A340_Q0.9061.00
42_V181_D0.9021.00
294_I298_E0.9011.00
50_H53_L0.8981.00
161_L260_N0.8971.00
239_A243_V0.8971.00
306_A335_I0.8961.00
413_L416_T0.8951.00
203_L227_E0.8931.00
201_D230_T0.8931.00
44_K48_L0.8921.00
390_E394_A0.8891.00
30_I91_T0.8891.00
344_N409_E0.8891.00
123_P129_A0.8861.00
143_K147_Q0.8851.00
92_F198_I0.8781.00
56_T123_P0.8741.00
27_V98_N0.8741.00
143_K182_V0.8711.00
242_K245_P0.8691.00
277_L411_I0.8681.00
393_L397_E0.8671.00
117_A223_Y0.8641.00
84_K171_Y0.8611.00
408_G412_Q0.8591.00
14_L200_K0.8571.00
109_L216_V0.8531.00
167_K172_A0.8481.00
337_E340_Q0.8461.00
199_Q230_T0.8461.00
65_L115_L0.8461.00
201_D229_R0.8451.00
80_D85_G0.8411.00
142_L182_V0.8381.00
82_T85_G0.8221.00
291_K348_S0.8201.00
201_D232_G0.8181.00
283_L291_K0.8181.00
220_I223_Y0.8161.00
152_D155_R0.8141.00
259_L321_S0.8111.00
334_I338_Q0.8111.00
278_Q392_F0.8101.00
239_A242_K0.8091.00
356_K397_E0.8061.00
19_V208_V0.8031.00
338_Q342_M0.8001.00
15_T34_L0.7991.00
59_H68_Y0.7961.00
64_G67_S0.7921.00
52_L119_L0.7911.00
293_F298_E0.7911.00
140_R143_K0.7891.00
133_Q137_Q0.7871.00
130_F135_V0.7871.00
199_Q202_Q0.7851.00
280_F342_M0.7851.00
49_P53_L0.7841.00
350_Q354_Q0.7821.00
180_D184_D0.7811.00
16_A217_Q0.7811.00
350_Q353_A0.7801.00
356_K360_R0.7791.00
63_A67_S0.7781.00
113_L223_Y0.7751.00
206_Y377_L0.7731.00
165_M316_L0.7691.00
306_A319_V0.7691.00
296_V306_A0.7691.00
46_A142_L0.7681.00
392_F396_I0.7671.00
149_V155_R0.7621.00
50_H142_L0.7611.00
258_K322_G0.7611.00
193_T197_A0.7581.00
285_G308_S0.7551.00
54_R134_Y0.7551.00
348_S401_K0.7541.00
195_Q230_T0.7531.00
165_M262_G0.7531.00
47_L142_L0.7521.00
346_D401_K0.7521.00
187_A190_L0.7521.00
31_F120_V0.7521.00
292_L306_A0.7491.00
262_G318_M0.7481.00
302_L327_N0.7461.00
250_D253_D0.7441.00
10_K16_A0.7431.00
29_L94_L0.7401.00
18_I220_I0.7401.00
47_L190_L0.7391.00
330_Q334_I0.7381.00
168_N172_A0.7371.00
34_L204_D0.7351.00
75_T96_I0.7341.00
68_Y115_L0.7341.00
81_L85_G0.7331.00
271_D411_I0.7311.00
72_L75_T0.7311.00
27_V207_V0.7311.00
142_L145_R0.7281.00
78_S82_T0.7251.00
216_V220_I0.7241.00
341_A346_D0.7211.00
43_T46_A0.7171.00
121_F227_E0.7141.00
279_V359_I0.7121.00
52_L92_F0.7121.00
347_F405_I0.7101.00
41_Q185_I0.7101.00
324_E327_N0.7091.00
376_F380_Q0.7071.00
329_E332_V0.7071.00
181_D184_D0.7071.00
283_L351_D0.7051.00
30_I374_S0.7041.00
386_E391_D0.7021.00
21_T370_A0.7001.00
343_K346_D0.7001.00
49_P81_L0.6991.00
50_H141_T0.6991.00
181_D185_I0.6921.00
138_E142_L0.6911.00
49_P145_R0.6911.00
280_F284_F0.6901.00
83_K162_I0.6891.00
258_K320_M0.6871.00
272_Q276_A0.6871.00
12_G200_K0.6871.00
239_A245_P0.6871.00
35_A197_A0.6861.00
81_L84_K0.6861.00
272_Q398_N0.6841.00
355_T359_I0.6821.00
41_Q45_R0.6801.00
301_S304_Y0.6791.00
281_N285_G0.6781.00
360_R364_L0.6771.00
21_T208_V0.6751.00
390_E393_L0.6721.00
48_L52_L0.6701.00
160_R164_E0.6691.00
407_A411_I0.6691.00
166_C314_K0.6681.00
188_E195_Q0.6661.00
56_T129_A0.6651.00
358_V361_N0.6651.00
12_G225_K0.6641.00
276_A280_F0.6641.00
345_G405_I0.6631.00
279_V355_T0.6611.00
158_N162_I0.6611.00
46_A81_L0.6591.00
157_S260_N0.6581.00
212_D216_V0.6571.00
295_N337_E0.6561.00
18_I207_V0.6551.00
44_K189_Q0.6531.00
240_D245_P0.6521.00
42_V173_L0.6521.00
50_H81_L0.6501.00
141_T145_R0.6491.00
135_V185_I0.6471.00
206_Y378_Y0.6471.00
51_V54_R0.6461.00
41_Q44_K0.6461.00
160_R248_V0.6461.00
282_G359_I0.6451.00
165_M264_R0.6451.00
117_A226_T0.6441.00
59_H65_L0.6431.00
206_Y374_S0.6421.00
65_L69_L0.6391.00
14_L227_E0.6371.00
45_R48_L0.6361.00
164_E248_V0.6361.00
282_G358_V0.6361.00
67_S71_E0.6351.00
266_S411_I0.6341.00
8_K221_D0.6311.00
193_T198_I0.6311.00
115_L118_E0.6301.00
75_T112_G0.6291.00
174_H178_E0.6261.00
296_V335_I0.6261.00
79_A82_T0.6261.00
190_L194_Y0.6241.00
308_S317_L0.6231.00
56_T122_S0.6231.00
293_F297_R0.6221.00
284_F339_F0.6201.00
49_P90_I0.6191.00
27_V211_V0.6171.00
59_H114_Q0.6171.00
49_P141_T0.6151.00
378_Y382_A0.6151.00
31_F224_F0.6141.00
240_D244_Q0.6141.00
46_A53_L0.6121.00
346_D408_G0.6091.00
17_H206_Y0.6091.00
149_V176_N0.6081.00
130_F194_Y0.6061.00
49_P142_L0.6051.00
48_L193_T0.6041.00
46_A138_E0.6031.00
206_Y381_A0.6031.00
46_A141_T0.6011.00
409_E413_L0.5971.00
198_I202_Q0.5961.00
169_D172_A0.5961.00
59_H115_L0.5961.00
322_G325_V0.5941.00
335_I338_Q0.5931.00
296_V302_L0.5911.00
287_F290_S0.5911.00
353_A397_E0.5891.00
14_L224_F0.5891.00
237_N240_D0.5891.00
78_S85_G0.5881.00
285_G290_S0.5871.00
21_T25_K0.5861.00
116_L120_V0.5851.00
27_V109_L0.5831.00
279_V356_K0.5811.00
208_V370_A0.5801.00
22_E25_K0.5791.00
54_R137_Q0.5781.00
328_F332_V0.5781.00
97_P108_L0.5771.00
197_A200_K0.5761.00
295_N341_A0.5761.00
280_F412_Q0.5761.00
204_D382_A0.5751.00
130_F187_A0.5741.00
156_Y160_R0.5731.00
256_Q322_G0.5721.00
263_Y339_F0.5711.00
180_D183_D0.5701.00
28_S370_A0.5701.00
302_L330_Q0.5681.00
279_V404_I0.5681.00
62_T134_Y0.5671.00
408_G411_I0.5671.00
18_I212_D0.5671.00
98_N107_P0.5661.00
302_L331_A0.5651.00
112_G116_L0.5651.00
216_V219_A0.5641.00
58_S129_A0.5631.00
207_V220_I0.5631.00
241_E245_P0.5621.00
297_R303_A0.5621.00
138_E177_G0.5621.00
8_K220_I0.5611.00
261_I335_I0.5611.00
247_E250_D0.5611.00
75_T79_A0.5601.00
157_S161_L0.5601.00
254_V257_G0.5601.00
67_S70_D0.5591.00
138_E145_R0.5581.00
259_L328_F0.5571.00
159_L163_Q0.5561.00
134_Y141_T0.5541.00
147_Q150_Y0.5541.00
277_L280_F0.5541.00
207_V213_S0.5541.00
32_K206_Y0.5521.00
154_M258_K0.5521.00
50_H177_G0.5511.00
395_N399_V0.5511.00
35_A90_I0.5501.00
414_D417_Y0.5501.00
259_L332_V0.5480.99
191_Y194_Y0.5480.99
384_Q388_P0.5480.99
343_K405_I0.5480.99
29_L205_L0.5470.99
405_I408_G0.5450.99
271_D274_Y0.5450.99
97_P107_P0.5440.99
47_L182_V0.5420.99
265_T268_T0.5410.99
358_V362_Q0.5410.99
311_E318_M0.5400.99
43_T50_H0.5390.99
78_S93_R0.5390.99
331_A335_I0.5390.99
30_I93_R0.5380.99
50_H78_S0.5380.99
241_E244_Q0.5370.99
49_P198_I0.5370.99
352_I399_V0.5370.99
148_A152_D0.5370.99
282_G362_Q0.5350.99
341_A344_N0.5340.99
57_K118_E0.5330.99
36_P43_T0.5330.99
197_A202_Q0.5330.99
10_K221_D0.5320.99
166_C316_L0.5320.99
120_V194_Y0.5310.99
54_R141_T0.5290.99
200_K228_E0.5290.99
291_K295_N0.5250.99
211_V220_I0.5240.99
282_G286_G0.5240.99
66_R77_V0.5240.99
346_D402_E0.5230.99
275_P392_F0.5220.99
201_D231_L0.5220.99
256_Q304_Y0.5220.99
194_Y198_I0.5210.99
29_L116_L0.5210.99
114_Q118_E0.5210.99
46_A92_F0.5210.99
158_N260_N0.5200.99
314_K317_L0.5180.99
363_V392_F0.5180.99
283_L404_I0.5180.99
273_D276_A0.5170.99
21_T373_L0.5170.99
80_D375_E0.5170.99
17_H377_L0.5170.99
351_D354_Q0.5150.99
271_D410_K0.5140.99
259_L323_I0.5130.99
98_N108_L0.5130.99
72_L115_L0.5130.99
50_H92_F0.5120.99
31_F116_L0.5110.99
339_F343_K0.5090.99
223_Y226_T0.5080.99
342_M408_G0.5080.99
144_Q148_A0.5070.99
404_I408_G0.5060.99
274_Y278_Q0.5050.99
146_I178_E0.5050.99
298_E303_A0.5050.99
49_P138_E0.5050.99
287_F293_F0.5040.99
251_E254_V0.5030.99
260_N318_M0.5020.99
280_F317_L0.5020.99
339_F412_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eoqA 2 0.9343 100 0.149 Contact Map
1hr6B 1 0.9531 100 0.162 Contact Map
3hdiA 2 0.9343 100 0.165 Contact Map
3amiA 2 0.9554 100 0.171 Contact Map
4nnzA 2 0.8991 100 0.176 Contact Map
1q2lA 1 0.9531 100 0.188 Contact Map
3gwbA 2 0.939 100 0.191 Contact Map
3amjB 1 0.9437 100 0.191 Contact Map
1pp9A 1 0.946 100 0.192 Contact Map
1hr6A 1 0.946 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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