GREMLIN Database
RASP - Regulator of sigma-W protease RasP
UniProt: O31754 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (412)
Sequences: 454 (341)
Seq/√Len: 16.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_H159_Y6.3781.00
167_P170_Q6.3011.00
329_S333_G6.0941.00
33_I174_A4.2501.00
281_G284_G4.1661.00
278_K284_G4.0251.00
189_I350_F4.0161.00
256_V265_I4.0041.00
123_M156_I3.9311.00
16_L360_L3.5261.00
187_Y301_A3.4581.00
27_L180_I3.4260.99
402_V406_M3.2450.99
173_K180_I3.1640.99
172_I376_L3.1340.99
228_S231_G3.0380.99
277_K284_G2.9240.98
27_L173_K2.8210.98
278_K283_F2.7450.97
195_L296_A2.6950.97
175_I379_L2.6070.96
53_E161_R2.4670.95
143_E160_N2.4420.95
180_I184_I2.4370.95
172_I380_F2.4210.95
280_I283_F2.4100.94
229_I240_I2.3660.94
176_A180_I2.3540.94
255_A262_T2.3280.93
277_K283_F2.3060.93
168_V171_R2.2690.92
49_F52_N2.2680.92
276_N281_G2.2240.92
97_K153_E2.1970.91
247_N252_M2.1530.90
25_L35_C2.1330.90
112_I127_G2.0800.88
63_V406_M2.0470.88
276_N283_F2.0180.87
228_S255_A1.9950.86
279_T284_G1.9870.86
292_G295_S1.9760.86
22_L25_L1.9660.85
280_I284_G1.9590.85
33_I69_M1.9490.85
126_T138_S1.9340.84
396_F400_I1.8420.81
120_E159_Y1.8420.81
234_M240_I1.8300.81
18_F58_I1.8270.81
26_L181_M1.8250.81
277_K281_G1.7760.79
170_Q366_L1.7630.78
399_F403_A1.7630.78
141_V144_T1.7530.78
137_S140_T1.7470.78
51_K240_I1.7370.77
279_T283_F1.7360.77
90_N94_Q1.7320.77
390_N393_K1.7120.76
10_I356_L1.7070.76
192_M196_I1.7020.76
124_K138_S1.6980.76
257_K260_N1.6870.75
181_M184_I1.6790.75
25_L102_Q1.6790.75
375_R378_F1.6770.75
276_N284_G1.6730.74
191_V297_V1.6720.74
229_I254_V1.6720.74
220_L254_V1.6650.74
16_L320_T1.6230.72
206_L220_L1.6200.72
256_V263_L1.6140.72
56_Y67_V1.5870.70
116_T126_T1.5740.70
377_L381_I1.5520.69
169_W173_K1.5450.68
234_M280_I1.5420.68
336_D420_L1.5190.67
166_K375_R1.5110.66
25_L56_Y1.5040.66
297_V301_A1.4880.65
53_E155_Q1.4770.65
175_I375_R1.4580.64
12_I189_I1.4480.63
314_N363_V1.4460.63
278_K282_R1.4390.63
19_F52_N1.4380.63
226_I351_Q1.4270.62
406_M410_L1.4160.61
10_I14_G1.4050.61
7_I128_Y1.4040.61
247_N250_K1.3980.60
204_P234_M1.3980.60
211_D216_A1.3870.60
199_V244_V1.3830.59
123_M160_N1.3750.59
66_F174_A1.3690.59
168_V376_L1.3640.58
13_F17_V1.3630.58
224_D258_R1.3620.58
375_R379_L1.3620.58
5_T366_L1.3500.57
166_K175_I1.3420.57
98_V125_I1.3310.56
272_V282_R1.3290.56
119_L141_V1.3120.55
255_A259_D1.3030.55
210_T213_G1.2960.54
276_N280_I1.2830.54
31_A173_K1.2820.53
225_Y257_K1.2790.53
42_F53_E1.2780.53
256_V377_L1.2740.53
191_V320_T1.2740.53
209_L216_A1.2720.53
25_L52_N1.2670.53
22_L26_L1.2590.52
278_K281_G1.2520.52
25_L49_F1.2500.52
227_Q257_K1.2420.51
255_A264_H1.2410.51
344_T348_N1.2240.50
377_L397_V1.2170.50
290_E295_S1.2100.49
215_A220_L1.2060.49
206_L241_V1.1980.49
193_L197_Q1.1890.48
232_E259_D1.1890.48
156_I160_N1.1880.48
16_L186_A1.1750.47
234_M270_E1.1740.47
98_V419_R1.1640.46
256_V264_H1.1580.46
7_I410_L1.1560.46
383_A411_V1.1470.45
228_S340_Q1.1390.45
321_G356_L1.1280.44
236_S240_I1.1210.44
340_Q343_K1.1200.44
230_N243_A1.1190.44
6_V188_V1.1180.44
399_F402_V1.1170.44
70_A394_E1.1070.43
206_L209_L1.0890.42
159_Y368_I1.0860.42
346_I350_F1.0850.42
239_D343_K1.0830.42
100_I151_G1.0830.42
385_R390_N1.0790.42
228_S239_D1.0790.42
27_L40_I1.0780.41
18_F40_I1.0750.41
120_E162_Q1.0720.41
256_V297_V1.0710.41
403_A407_L1.0700.41
227_Q262_T1.0630.41
207_G400_I1.0600.40
43_G62_P1.0600.40
293_V387_K1.0580.40
213_G216_A1.0560.40
336_D340_Q1.0550.40
318_L327_M1.0520.40
200_P209_L1.0500.40
214_R267_V1.0450.40
271_A278_K1.0440.40
34_L392_E1.0420.39
391_R402_V1.0380.39
282_R342_A1.0320.39
189_I358_I1.0280.39
194_G334_I1.0280.39
319_V322_Q1.0270.39
243_A252_M1.0270.39
236_S239_D1.0230.38
166_K378_F1.0220.38
221_K258_R1.0210.38
175_I353_A1.0160.38
13_F183_F1.0130.38
216_A244_V1.0090.38
207_G222_E1.0080.37
18_F22_L1.0070.37
366_L406_M1.0070.37
39_A363_V0.9970.37
13_F45_K0.9930.37
42_F66_F0.9890.36
380_F384_I0.9830.36
230_N235_R0.9830.36
11_I350_F0.9830.36
73_D397_V0.9780.36
211_D266_S0.9780.36
326_D400_I0.9770.36
35_C110_L0.9770.36
386_G393_K0.9700.35
233_K264_H0.9680.35
183_F361_G0.9660.35
386_G390_N0.9650.35
187_Y302_T0.9650.35
51_K269_P0.9610.35
58_I134_D0.9590.35
69_M174_A0.9570.35
212_N216_A0.9530.34
237_W374_G0.9510.34
94_Q140_T0.9510.34
102_Q107_P0.9490.34
335_Y377_L0.9490.34
15_T19_F0.9480.34
53_E352_F0.9470.34
103_K150_D0.9470.34
254_V267_V0.9450.34
387_K390_N0.9450.34
92_E260_N0.9450.34
202_N207_G0.9440.34
13_F57_T0.9410.34
47_F104_E0.9380.34
299_Y338_T0.9380.34
366_L405_L0.9370.34
336_D339_D0.9360.34
129_E137_S0.9360.34
27_L181_M0.9300.33
378_F398_V0.9250.33
184_I265_I0.9250.33
15_T353_A0.9230.33
166_K398_V0.9140.32
187_Y272_V0.9050.32
99_I166_K0.9040.32
175_I378_F0.8990.32
92_E244_V0.8980.32
8_A11_I0.8980.32
260_N263_L0.8950.31
27_L30_R0.8930.31
51_K188_V0.8890.31
340_Q347_V0.8890.31
196_I209_L0.8850.31
240_I337_M0.8850.31
315_L362_I0.8850.31
73_D338_T0.8840.31
211_D238_T0.8840.31
277_K282_R0.8830.31
15_T310_A0.8830.31
26_L30_R0.8810.31
116_T124_K0.8750.30
309_K313_T0.8730.30
72_E398_V0.8710.30
11_I346_I0.8700.30
53_E99_I0.8700.30
390_N395_A0.8690.30
234_M255_A0.8680.30
46_I205_M0.8660.30
74_P375_R0.8660.30
206_L231_G0.8640.30
303_S351_Q0.8620.30
55_V319_V0.8610.30
217_E273_K0.8580.30
291_K296_A0.8580.30
342_A349_L0.8570.30
376_L406_M0.8570.30
99_I375_R0.8500.29
73_D376_L0.8490.29
142_S160_N0.8490.29
228_S233_K0.8490.29
72_E375_R0.8470.29
84_T341_V0.8460.29
209_L226_I0.8440.29
136_L292_G0.8400.29
80_K102_Q0.8350.28
256_V272_V0.8340.28
55_V326_D0.8320.28
80_K87_L0.8300.28
70_A330_G0.8290.28
329_S348_N0.8290.28
68_R415_N0.8270.28
58_I249_E0.8270.28
27_L31_A0.8270.28
265_I297_V0.8260.28
101_N161_R0.8250.28
221_K268_T0.8220.28
184_I199_V0.8190.28
140_T143_E0.8170.28
144_T148_I0.8160.28
210_T235_R0.8150.27
86_G109_A0.8130.27
258_R263_L0.8130.27
77_I229_I0.8110.27
121_H160_N0.8080.27
240_I244_V0.8080.27
11_I16_L0.8060.27
59_R67_V0.8030.27
206_L267_V0.8020.27
399_F406_M0.7990.27
76_M214_R0.7980.27
171_R403_A0.7960.27
162_Q407_L0.7960.27
316_S320_T0.7950.27
92_E211_D0.7920.26
7_I10_I0.7910.26
168_V173_K0.7890.26
357_S369_P0.7860.26
193_L355_F0.7850.26
291_K295_S0.7840.26
334_I337_M0.7820.26
44_P330_G0.7790.26
314_N318_L0.7790.26
293_V297_V0.7790.26
188_V253_D0.7770.26
248_P284_G0.7770.26
240_I273_K0.7770.26
167_P173_K0.7760.26
318_L322_Q0.7750.26
6_V174_A0.7720.25
252_M269_P0.7720.25
95_V407_L0.7710.25
231_G410_L0.7700.25
29_Q54_T0.7700.25
351_Q355_F0.7690.25
240_I254_V0.7670.25
395_A402_V0.7670.25
102_Q302_T0.7640.25
131_G134_D0.7630.25
93_D267_V0.7630.25
20_H24_H0.7620.25
21_E24_H0.7620.25
208_Q234_M0.7610.25
30_R163_F0.7590.25
248_P282_R0.7590.25
92_E184_I0.7570.25
6_V400_I0.7560.25
95_V234_M0.7560.25
59_R62_P0.7550.25
164_G380_F0.7530.25
248_P343_K0.7520.25
59_R331_P0.7510.25
358_I397_V0.7500.24
126_T318_L0.7480.24
168_V379_L0.7470.24
74_P181_M0.7440.24
74_P166_K0.7440.24
311_I358_I0.7410.24
5_T339_D0.7390.24
79_V113_E0.7390.24
123_M145_S0.7370.24
349_L411_V0.7360.24
59_R330_G0.7350.24
221_K228_S0.7340.24
19_F324_K0.7340.24
385_R393_K0.7320.24
145_S154_V0.7310.24
256_V259_D0.7280.24
154_V380_F0.7280.24
208_Q222_E0.7260.23
220_L267_V0.7240.23
241_V259_D0.7230.23
259_D262_T0.7210.23
148_I375_R0.7210.23
221_K261_K0.7200.23
92_E217_E0.7190.23
223_G264_H0.7180.23
89_F174_A0.7150.23
253_D302_T0.7140.23
308_T358_I0.7120.23
125_I417_I0.7120.23
195_L300_G0.7110.23
376_L380_F0.7090.23
196_I256_V0.7080.23
14_G356_L0.7080.23
10_I75_E0.7080.23
317_K322_Q0.7060.23
29_Q56_Y0.7060.23
215_A224_D0.7050.23
122_D273_K0.7020.22
42_F63_V0.7010.22
157_A412_V0.7010.22
375_R398_V0.7000.22
44_P62_P0.6980.22
14_G56_Y0.6980.22
47_F253_D0.6970.22
228_S234_M0.6960.22
55_V220_L0.6960.22
155_Q161_R0.6920.22
395_A404_F0.6910.22
194_G410_L0.6910.22
67_V421_F0.6890.22
226_I240_I0.6870.22
412_V415_N0.6840.22
380_F383_A0.6840.22
22_L181_M0.6840.22
59_R70_A0.6820.22
43_G59_R0.6820.22
89_F105_K0.6800.22
270_E273_K0.6800.22
35_C111_V0.6790.22
263_L266_S0.6780.21
91_K96_E0.6760.21
313_T377_L0.6750.21
116_T122_D0.6750.21
175_I399_F0.6740.21
192_M257_K0.6730.21
32_G182_N0.6720.21
173_K409_M0.6720.21
12_I67_V0.6710.21
47_F353_A0.6700.21
46_I97_K0.6690.21
44_P59_R0.6670.21
221_K256_V0.6670.21
212_N225_Y0.6640.21
14_G18_F0.6630.21
208_Q216_A0.6600.21
235_R253_D0.6580.21
212_N260_N0.6570.21
18_F213_G0.6550.21
246_E257_K0.6540.21
240_I243_A0.6540.21
370_A414_W0.6540.21
370_A394_E0.6510.20
272_V279_T0.6510.20
259_D268_T0.6510.20
74_P175_I0.6500.20
167_P203_E0.6500.20
257_K261_K0.6500.20
191_V304_T0.6490.20
188_V214_R0.6490.20
20_H23_G0.6480.20
227_Q256_V0.6480.20
94_Q259_D0.6440.20
39_A318_L0.6440.20
15_T106_Y0.6410.20
53_E375_R0.6410.20
16_L37_E0.6410.20
53_E101_N0.6400.20
188_V289_T0.6390.20
100_I403_A0.6370.20
166_K379_L0.6370.20
25_L172_I0.6370.20
231_G264_H0.6370.20
70_A401_G0.6370.20
318_L328_L0.6360.20
414_W418_Q0.6360.20
213_G262_T0.6360.20
249_E271_A0.6350.20
179_P361_G0.6350.20
22_L27_L0.6340.20
39_A93_D0.6340.20
273_K293_V0.6320.20
249_E270_E0.6300.20
385_R392_E0.6300.20
404_F411_V0.6300.20
15_T233_K0.6300.20
16_L321_G0.6280.20
145_S148_I0.6280.20
276_N389_I0.6250.19
186_A358_I0.6230.19
244_V272_V0.6230.19
205_M240_I0.6220.19
135_E205_M0.6210.19
333_G374_G0.6200.19
70_A331_P0.6200.19
153_E408_L0.6190.19
222_E241_V0.6190.19
175_I181_M0.6180.19
94_Q141_V0.6160.19
31_A196_I0.6150.19
279_T282_R0.6130.19
63_V402_V0.6130.19
368_I398_V0.6120.19
251_E266_S0.6100.19
314_N322_Q0.6080.19
82_G85_V0.6080.19
232_E246_E0.6070.19
238_T263_L0.6060.19
262_T266_S0.6050.19
202_N407_L0.6040.19
63_V78_E0.6040.19
5_T411_V0.6030.19
158_P412_V0.6030.19
171_R360_L0.6020.19
206_L248_P0.6010.19
48_S342_A0.6000.19
62_P382_E0.5990.18
337_M341_V0.5990.18
114_V138_S0.5960.18
175_I349_L0.5960.18
183_F419_R0.5960.18
19_F379_L0.5950.18
344_T351_Q0.5950.18
339_D393_K0.5950.18
129_E363_V0.5950.18
15_T18_F0.5930.18
124_K215_A0.5920.18
19_F204_P0.5910.18
42_F376_L0.5910.18
334_I374_G0.5900.18
196_I228_S0.5890.18
25_L339_D0.5860.18
209_L225_Y0.5860.18
238_T384_I0.5860.18
188_V247_N0.5860.18
233_K247_N0.5850.18
25_L105_K0.5850.18
148_I166_K0.5850.18
180_I298_A0.5840.18
188_V238_T0.5840.18
138_S141_V0.5830.18
19_F205_M0.5830.18
66_F410_L0.5830.18
345_G369_P0.5820.18
336_D348_N0.5790.18
195_L387_K0.5780.18
336_D419_R0.5780.18
262_T302_T0.5770.18
237_W393_K0.5750.18
311_I412_V0.5740.18
217_E229_I0.5740.18
170_Q189_I0.5730.18
173_K329_S0.5730.18
83_Y319_V0.5730.18
237_W333_G0.5710.17
206_L395_A0.5700.17
234_M397_V0.5700.17
161_R341_V0.5690.17
16_L420_L0.5690.17
230_N293_V0.5690.17
203_E350_F0.5660.17
47_F385_R0.5640.17
61_L206_L0.5630.17
62_P67_V0.5630.17
91_K265_I0.5610.17
230_N247_N0.5610.17
293_V296_A0.5600.17
189_I353_A0.5600.17
131_G381_I0.5600.17
195_L291_K0.5600.17
147_F175_I0.5580.17
19_F381_I0.5550.17
14_G374_G0.5540.17
227_Q319_V0.5520.17
259_D264_H0.5520.17
45_K57_T0.5520.17
16_L377_L0.5520.17
111_V181_M0.5520.17
187_Y387_K0.5510.17
51_K325_L0.5510.17
411_V420_L0.5510.17
12_I349_L0.5510.17
298_A302_T0.5500.17
134_D192_M0.5500.17
383_A403_A0.5490.17
19_F322_Q0.5490.17
36_R408_L0.5480.17
43_G382_E0.5470.17
39_A59_R0.5460.17
393_K418_Q0.5440.17
389_I397_V0.5430.17
209_L286_Y0.5420.17
167_P236_S0.5410.16
93_D261_K0.5410.16
181_M188_V0.5410.16
99_I106_Y0.5390.16
148_I378_F0.5390.16
192_M263_L0.5380.16
229_I347_V0.5380.16
51_K238_T0.5370.16
181_M375_R0.5360.16
207_G220_L0.5360.16
181_M333_G0.5350.16
30_R169_W0.5350.16
282_R287_A0.5330.16
37_E157_A0.5330.16
356_L406_M0.5330.16
210_T223_G0.5320.16
209_L213_G0.5310.16
211_D251_E0.5310.16
63_V404_F0.5310.16
253_D257_K0.5290.16
192_M209_L0.5290.16
124_K217_E0.5270.16
142_S180_I0.5270.16
191_V195_L0.5270.16
250_K270_E0.5270.16
116_T241_V0.5270.16
256_V346_I0.5270.16
271_A280_I0.5270.16
157_A415_N0.5270.16
11_I15_T0.5250.16
70_A158_P0.5230.16
35_C148_I0.5220.16
9_F379_L0.5220.16
146_F175_I0.5210.16
17_V37_E0.5200.16
59_R413_T0.5200.16
113_E171_R0.5200.16
103_K362_I0.5200.16
135_E259_D0.5200.16
196_I325_L0.5190.16
94_Q139_F0.5180.16
175_I398_V0.5180.16
158_P415_N0.5170.16
9_F113_E0.5170.16
72_E378_F0.5170.16
213_G221_K0.5160.16
307_V358_I0.5160.16
8_A18_F0.5160.16
7_I356_L0.5160.16
6_V252_M0.5150.16
14_G324_K0.5140.16
181_M378_F0.5110.16
396_F402_V0.5110.16
153_E173_K0.5100.15
230_N253_D0.5090.15
106_Y168_V0.5090.15
55_V66_F0.5090.15
230_N298_A0.5080.15
187_Y305_V0.5060.15
58_I396_F0.5060.15
45_K388_P0.5050.15
73_D334_I0.5040.15
173_K184_I0.5030.15
231_G236_S0.5010.15
12_I353_A0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.3697 99.8 0.878 Contact Map
2vz5A 1 0.2393 99.8 0.883 Contact Map
1v5lA 1 0.237 99.7 0.891 Contact Map
2zpmA 2 0.1872 99.6 0.896 Contact Map
3i18A 1 0.2227 99.6 0.899 Contact Map
1v5qA 1 0.2749 99.6 0.902 Contact Map
2kjpA 1 0.2109 99.5 0.905 Contact Map
3wkmA 1 0.4147 99.5 0.906 Contact Map
4c2eA 2 0.6019 99.5 0.906 Contact Map
3id1A 1 0.2038 99.5 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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