GREMLIN Database
DXR - 1-deoxy-D-xylulose 5-phosphate reductoisomerase
UniProt: O31753 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 383 (378)
Sequences: 3317 (2113)
Seq/√Len: 108.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_R48_V5.5981.00
9_A45_M3.8451.00
17_T96_V3.1741.00
3_N29_Q3.1331.00
181_K185_E3.0241.00
192_E338_G3.0211.00
167_E249_E3.0151.00
344_A347_D3.0081.00
287_E290_E2.8801.00
186_L189_V2.8651.00
137_A144_L2.8481.00
18_L49_F2.8241.00
19_D265_R2.7311.00
211_A342_F2.7021.00
113_E136_H2.6871.00
180_D303_R2.6091.00
168_R235_D2.5951.00
4_I21_L2.4601.00
341_P344_A2.4561.00
241_E295_H2.3791.00
231_Y314_G2.3721.00
117_T143_P2.3011.00
42_A56_V2.2791.00
214_M324_L2.2771.00
22_R49_F2.2491.00
182_T185_E2.2321.00
168_R249_E2.2141.00
333_A337_A2.1731.00
110_K113_E2.1611.00
109_L136_H2.1391.00
43_V68_M2.1141.00
230_P233_Q2.1091.00
363_S366_D2.0911.00
232_E315_K2.0741.00
38_N41_K2.0391.00
320_M353_L2.0031.00
350_E354_T1.9811.00
352_A378_V1.9611.00
21_L30_L1.9441.00
332_V336_L1.9371.00
167_E285_R1.9281.00
135_E139_K1.9001.00
308_Q312_E1.9001.00
220_V311_F1.8971.00
284_K290_E1.8861.00
53_F77_G1.8791.00
180_D297_E1.8471.00
352_A374_T1.8341.00
319_T356_H1.7821.00
179_R297_E1.7461.00
46_I54_V1.7361.00
33_M45_M1.7351.00
181_K193_D1.7161.00
41_K44_P1.7081.00
154_I169_L1.6681.00
319_T370_V1.6531.00
301_F308_Q1.6231.00
371_D375_R1.6101.00
191_V338_G1.6001.00
5_C32_S1.6001.00
19_D23_A1.5901.00
330_V379_N1.5701.00
53_F86_A1.5671.00
214_M349_I1.5461.00
81_E85_E1.5431.00
181_K189_V1.5371.00
27_Q276_D1.5091.00
29_Q52_K1.5081.00
224_H234_I1.5011.00
184_E187_E1.4971.00
32_S86_A1.4951.00
301_F311_F1.4911.00
41_K45_M1.4871.00
30_L33_M1.4861.00
157_A256_I1.4841.00
224_H314_G1.4791.00
10_T35_F1.4731.00
247_M288_L1.4651.00
112_I142_V1.4601.00
313_S353_L1.4551.00
369_E372_K1.4531.00
131_H135_E1.4491.00
195_L207_T1.4491.00
220_V236_V1.4461.00
195_L208_I1.4451.00
136_H139_K1.4441.00
39_I56_V1.4441.00
54_V74_C1.4391.00
334_A339_K1.4341.00
348_C378_V1.4191.00
80_E106_I1.4161.00
217_G310_A1.4141.00
113_E140_Y1.4111.00
55_S86_A1.4101.00
31_V89_M1.4031.00
340_I344_A1.4021.00
214_M306_C1.3971.00
305_R350_E1.3971.00
108_T118_I1.3941.00
352_A377_Y1.3891.00
34_S83_L1.3861.00
36_G57_G1.3791.00
306_C349_I1.3681.00
2_K117_T1.3571.00
15_E45_M1.3531.00
177_S304_F1.3361.00
213_M301_F1.3351.00
235_D298_K1.3260.99
34_S86_A1.3230.99
306_C346_E1.3190.99
96_V147_V1.3140.99
299_A307_L1.3090.99
112_I118_I1.3070.99
37_R58_D1.3060.99
62_Y66_K1.2950.99
125_T133_V1.2860.99
161_E250_F1.2830.99
162_Q165_N1.2820.99
128_T367_I1.2760.99
376_G380_S1.2740.99
190_T193_D1.2670.99
372_K376_G1.2660.99
355_R377_Y1.2620.99
43_V65_L1.2450.99
15_E41_K1.2420.99
169_L229_I1.2420.99
224_H231_Y1.2400.99
224_H230_P1.2330.99
200_W242_S1.2320.99
186_L343_L1.2300.99
351_K354_T1.2290.99
52_K91_E1.2210.99
55_S77_G1.2110.99
131_H225_W1.2100.99
359_L362_P1.2090.99
44_P48_V1.2060.99
61_T64_K1.2030.99
96_V119_A1.2020.99
323_V356_H1.2010.99
179_R240_K1.1890.99
58_D61_T1.1740.99
31_V52_K1.1730.99
369_E373_D1.1700.99
377_Y380_S1.1650.99
35_F56_V1.1480.99
46_I51_P1.1450.98
39_I65_L1.1390.98
56_V61_T1.1350.98
290_E298_K1.1340.98
35_F42_A1.1340.98
53_F89_M1.1300.98
94_I272_L1.1290.98
191_V336_L1.1290.98
75_Q85_E1.1290.98
246_S258_Q1.1240.98
374_T378_V1.1230.98
4_I94_I1.1070.98
247_M255_V1.1070.98
84_I106_I1.1040.98
33_M42_A1.1030.98
330_V378_V1.0950.98
204_A337_A1.0940.98
208_I336_L1.0900.98
40_D44_P1.0860.98
224_H228_D1.0860.98
183_R343_L1.0830.98
46_I69_S1.0810.98
40_D68_M1.0780.98
152_S270_Y1.0770.98
289_W298_K1.0710.98
362_P366_D1.0670.98
308_Q350_E1.0660.98
170_I235_D1.0650.98
316_I320_M1.0650.98
106_I368_Q1.0640.98
161_E256_I1.0600.97
273_T278_L1.0530.97
331_A349_I1.0480.97
212_T345_I1.0450.97
205_K328_N1.0430.97
178_F194_A1.0360.97
3_N93_D1.0320.97
370_V374_T1.0310.97
24_H273_T1.0300.97
220_V234_I1.0270.97
312_E316_I1.0230.97
17_T272_L1.0220.97
3_N31_V1.0210.97
40_D64_K1.0160.97
55_S82_G1.0130.97
115_K140_Y1.0080.97
356_H373_D1.0080.97
9_A33_M1.0060.97
52_K75_Q1.0050.97
9_A41_K1.0020.96
312_E354_T0.9970.96
300_D303_R0.9950.96
94_I119_A0.9890.96
165_N251_H0.9880.96
182_T303_R0.9750.96
147_V271_A0.9720.96
113_E139_K0.9700.96
28_F278_L0.9680.96
102_S128_T0.9650.96
23_A282_D0.9640.96
56_V62_Y0.9620.96
47_E71_S0.9600.95
280_L283_A0.9590.95
119_A147_V0.9580.95
288_L291_I0.9570.95
5_C86_A0.9510.95
177_S180_D0.9510.95
199_N260_G0.9500.95
92_V95_V0.9470.95
30_L45_M0.9460.95
213_M303_R0.9450.95
152_S271_A0.9440.95
330_V371_D0.9410.95
37_R61_T0.9410.95
28_F273_T0.9370.95
109_L133_V0.9300.95
63_H66_K0.9240.94
47_E72_F0.9210.94
218_L328_N0.9180.94
31_V92_V0.9160.94
187_E347_D0.9150.94
95_V116_K0.9140.94
43_V47_E0.9120.94
195_L204_A0.9120.94
177_S238_L0.9110.94
229_I233_Q0.9110.94
373_D377_Y0.9070.94
182_T186_L0.9070.94
110_K114_Q0.9060.94
155_F274_Y0.9060.94
288_L292_G0.9060.94
63_H67_Q0.9050.94
136_H140_Y0.8990.94
21_L28_F0.8950.93
59_L63_H0.8940.93
312_E315_K0.8920.93
181_K303_R0.8900.93
94_I117_T0.8880.93
365_A369_E0.8870.93
97_N118_I0.8860.93
331_A348_C0.8850.93
188_S341_P0.8840.93
102_S371_D0.8830.93
64_K67_Q0.8800.93
260_G266_V0.8790.93
196_K207_T0.8770.93
32_S53_F0.8760.93
112_I136_H0.8730.93
351_K355_R0.8710.93
18_L22_R0.8700.92
112_I133_V0.8670.92
305_R347_D0.8660.92
346_E349_I0.8640.92
97_N125_T0.8630.92
155_F275_P0.8630.92
183_R187_E0.8620.92
250_F256_I0.8620.92
111_A118_I0.8590.92
191_V207_T0.8530.92
194_A208_I0.8490.92
64_K68_M0.8480.91
236_V299_A0.8470.91
180_D240_K0.8450.91
99_L103_V0.8450.91
185_E193_D0.8430.91
19_D22_R0.8430.91
134_K225_W0.8420.91
91_E116_K0.8410.91
236_V307_L0.8390.91
323_V352_A0.8380.91
348_C352_A0.8380.91
182_T187_E0.8350.91
339_K379_N0.8350.91
309_F350_E0.8340.91
154_I246_S0.8330.91
170_I249_E0.8290.91
165_N276_D0.8270.90
46_I74_C0.8240.90
183_R303_R0.8210.90
66_K70_F0.8180.90
24_H278_L0.8180.90
319_T358_L0.8180.90
77_G86_A0.8180.90
6_L30_L0.8160.90
16_Q19_D0.8160.90
186_L303_R0.8140.90
330_V333_A0.8140.90
69_S72_F0.8110.90
244_I247_M0.8100.90
269_Q273_T0.8100.90
173_A213_M0.8090.89
205_K209_D0.8090.89
59_L78_L0.8080.89
239_H294_L0.8060.89
373_D376_G0.8060.89
128_T322_T0.8050.89
340_I348_C0.8030.89
88_V110_K0.8010.89
157_A250_F0.7990.89
251_H279_P0.7970.89
330_V334_A0.7890.88
66_K75_Q0.7870.88
220_V231_Y0.7840.88
84_I88_V0.7840.88
244_I257_A0.7840.88
112_I137_A0.7810.88
97_N108_T0.7790.88
5_C87_A0.7780.88
183_R346_E0.7750.87
62_Y78_L0.7740.87
5_C92_V0.7730.87
31_V53_F0.7690.87
117_T142_V0.7650.87
356_H377_Y0.7640.87
160_G256_I0.7640.87
164_K251_H0.7640.87
39_I61_T0.7630.87
238_L304_F0.7620.86
166_I248_V0.7620.86
313_S321_P0.7590.86
183_R302_D0.7580.86
62_Y76_I0.7580.86
72_F76_I0.7570.86
170_I289_W0.7560.86
330_V375_R0.7550.86
134_K137_A0.7510.86
289_W292_G0.7480.85
322_T370_V0.7470.85
220_V314_G0.7440.85
80_E84_I0.7440.85
112_I140_Y0.7430.85
83_L99_L0.7430.85
325_N328_N0.7420.85
225_W228_D0.7410.85
376_G379_N0.7400.85
217_G321_P0.7390.85
323_V370_V0.7360.85
361_K366_D0.7350.84
309_F324_L0.7330.84
324_L353_L0.7330.84
244_I294_L0.7290.84
183_R213_M0.7290.84
96_V272_L0.7290.84
311_F315_K0.7260.84
297_E304_F0.7250.84
266_V283_A0.7210.83
16_Q97_N0.7200.83
59_L81_E0.7190.83
238_L303_R0.7190.83
16_Q265_R0.7170.83
42_A45_M0.7160.83
55_S83_L0.7150.83
311_F314_G0.7130.83
364_L368_Q0.7120.83
6_L17_T0.7120.83
212_T342_F0.7060.82
316_I358_L0.7060.82
126_L134_K0.7050.82
177_S297_E0.7030.82
84_I110_K0.7000.81
153_A246_S0.6990.81
305_R308_Q0.6970.81
39_I43_V0.6930.81
319_T361_K0.6930.81
161_E165_N0.6920.81
199_N242_S0.6900.81
243_I259_L0.6870.80
302_D308_Q0.6870.80
109_L364_L0.6860.80
79_G82_G0.6860.80
238_L297_E0.6860.80
9_A15_E0.6840.80
167_E251_H0.6800.80
137_A142_V0.6800.80
167_E253_K0.6800.80
238_L299_A0.6790.79
24_H27_Q0.6790.79
90_E116_K0.6760.79
191_V195_L0.6740.79
334_A378_V0.6740.79
181_K186_L0.6730.79
42_A61_T0.6730.79
235_D249_E0.6710.79
217_G306_C0.6700.79
187_E341_P0.6700.79
314_G321_P0.6690.78
156_Q277_R0.6670.78
159_Q256_I0.6660.78
235_D289_W0.6630.78
53_F75_Q0.6630.78
159_Q270_Y0.6590.77
261_T283_A0.6590.77
20_V269_Q0.6570.77
65_L76_I0.6560.77
103_V371_D0.6540.77
25_Q28_F0.6530.77
231_Y311_F0.6520.77
192_E204_A0.6520.77
259_L294_L0.6520.77
361_K367_I0.6510.77
244_I291_I0.6500.76
322_T367_I0.6490.76
166_I229_I0.6440.76
23_A279_P0.6430.76
27_Q273_T0.6430.76
187_E343_L0.6410.75
69_S76_I0.6410.75
5_C31_V0.6390.75
43_V71_S0.6370.75
247_M257_A0.6350.75
134_K228_D0.6350.75
3_N91_E0.6340.75
320_M358_L0.6320.74
77_G85_E0.6320.74
122_N125_T0.6280.74
36_G83_L0.6270.74
106_I110_K0.6260.74
244_I296_F0.6250.74
44_P47_E0.6250.74
82_G85_E0.6250.74
65_L69_S0.6240.74
102_S368_Q0.6220.73
81_E84_I0.6220.73
243_I291_I0.6200.73
193_D196_K0.6190.73
137_A140_Y0.6190.73
145_L152_S0.6180.73
288_L294_L0.6150.72
183_R347_D0.6140.72
208_I332_V0.6140.72
204_A336_L0.6130.72
77_G82_G0.6120.72
334_A348_C0.6080.72
5_C53_F0.6080.72
237_V289_W0.6080.72
255_V286_L0.6070.71
125_T129_A0.6040.71
347_D351_K0.6020.71
23_A265_R0.6020.71
195_L336_L0.6020.71
313_S320_M0.5990.70
5_C89_M0.5990.70
2_K94_I0.5980.70
50_Q73_E0.5980.70
80_E103_V0.5970.70
183_R238_L0.5970.70
213_M304_F0.5950.70
60_D64_K0.5920.70
318_G322_T0.5910.69
46_I65_L0.5900.69
39_I42_A0.5890.69
119_A152_S0.5880.69
109_L113_E0.5860.69
104_G108_T0.5850.69
40_D43_V0.5840.69
188_S191_V0.5840.69
240_K253_K0.5840.69
250_F253_K0.5830.68
95_V111_A0.5830.68
118_I125_T0.5820.68
249_E285_R0.5820.68
170_I255_V0.5810.68
220_V224_H0.5790.68
177_S207_T0.5780.68
247_M289_W0.5770.68
191_V196_K0.5770.68
170_I247_M0.5770.68
177_S189_V0.5760.68
118_I133_V0.5750.67
318_G321_P0.5740.67
231_Y315_K0.5740.67
195_L332_V0.5740.67
46_I76_I0.5730.67
109_L132_I0.5730.67
240_K297_E0.5720.67
204_A208_I0.5700.67
158_L250_F0.5700.67
370_V373_D0.5700.67
12_S201_S0.5690.67
318_G370_V0.5670.66
12_S16_Q0.5670.66
349_I353_L0.5650.66
313_S324_L0.5640.66
34_S57_G0.5640.66
85_E88_V0.5640.66
362_P367_I0.5640.66
97_N144_L0.5620.66
53_F92_V0.5620.66
182_T189_V0.5610.65
128_T131_H0.5610.65
95_V114_Q0.5600.65
348_C351_K0.5590.65
314_G318_G0.5590.65
312_E350_E0.5570.65
269_Q278_L0.5570.65
221_I231_Y0.5500.64
108_T133_V0.5490.64
367_I370_V0.5480.64
9_A34_S0.5470.64
89_M92_V0.5450.63
189_V211_A0.5420.63
319_T366_D0.5410.63
185_E188_S0.5400.63
133_V136_H0.5390.62
344_A348_C0.5370.62
196_K208_I0.5360.62
112_I125_T0.5360.62
39_I64_K0.5350.62
43_V76_I0.5350.62
180_D238_L0.5350.62
155_F159_Q0.5340.62
55_S92_V0.5330.62
45_M51_P0.5310.61
19_D263_D0.5310.61
34_S55_S0.5310.61
319_T322_T0.5280.61
159_Q165_N0.5280.61
32_S55_S0.5270.61
52_K89_M0.5270.61
54_V65_L0.5270.61
154_I227_F0.5260.61
120_L144_L0.5250.60
253_K285_R0.5250.60
180_D213_M0.5250.60
57_G82_G0.5230.60
254_S258_Q0.5230.60
191_V204_A0.5220.60
59_L80_E0.5210.60
39_I68_M0.5210.60
87_A92_V0.5200.60
301_F307_L0.5200.60
145_L155_F0.5200.60
158_L166_I0.5190.60
199_N266_V0.5180.59
15_E19_D0.5180.59
295_H298_K0.5170.59
118_I142_V0.5170.59
323_V373_D0.5170.59
69_S74_C0.5170.59
243_I261_T0.5160.59
32_S92_V0.5160.59
159_Q250_F0.5150.59
320_M356_H0.5140.59
163_A233_Q0.5140.59
97_N129_A0.5130.59
217_G324_L0.5120.59
88_V113_E0.5120.59
54_V76_I0.5110.58
109_L367_I0.5110.58
179_R303_R0.5100.58
126_L133_V0.5090.58
43_V64_K0.5090.58
217_G307_L0.5090.58
21_L25_Q0.5090.58
286_L292_G0.5070.58
61_T78_L0.5050.57
105_L128_T0.5050.57
105_L133_V0.5040.57
57_G83_L0.5020.57
23_A280_L0.5010.57
255_V259_L0.5000.57
100_L103_V0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q0qA 2 0.9974 100 0.005 Contact Map
3au8A 2 0.9922 100 0.007 Contact Map
4zn6A 2 0.9817 100 0.008 Contact Map
4y67A 2 0.9974 100 0.013 Contact Map
3a06A 2 0.9556 100 0.033 Contact Map
2y1eA 2 0.9739 100 0.089 Contact Map
1r0kA 2 0.9896 100 0.121 Contact Map
3uplA 2 0.9269 100 0.836 Contact Map
3ingA 2 0.7232 99.9 0.851 Contact Map
3do5A 2 0.7337 99.9 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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