GREMLIN Database
CDSA - Phosphatidate cytidylyltransferase
UniProt: O31752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (260)
Sequences: 4743 (3677)
Seq/√Len: 228.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_T241_L6.0611.00
154_G186_I5.2391.00
165_R178_E4.3071.00
158_V182_G4.1751.00
180_F219_Q3.8561.00
225_E237_S3.3611.00
150_S190_L3.2971.00
44_L116_A3.0371.00
164_K178_E2.9651.00
160_K176_T2.8881.00
158_V186_I2.8771.00
145_C149_W2.6801.00
40_A247_I2.6431.00
158_V162_L2.6251.00
151_T219_Q2.3651.00
11_G16_I2.3621.00
144_A258_M2.1691.00
8_I157_F2.1551.00
167_L180_F2.0901.00
4_M8_I2.0761.00
47_M234_V2.0181.00
191_A211_T2.0151.00
47_M237_S2.0051.00
165_R177_V1.9911.00
244_H250_R1.9521.00
181_A185_V1.9441.00
143_Y211_T1.9281.00
151_T215_S1.9121.00
151_T218_G1.8951.00
21_L32_L1.8871.00
24_V28_P1.8701.00
177_V181_A1.8501.00
167_L177_V1.8491.00
39_V247_I1.8361.00
12_V16_I1.8241.00
157_F161_S1.8201.00
155_A183_G1.8111.00
11_G15_A1.7821.00
42_F46_R1.7531.00
4_M157_F1.7501.00
158_V161_S1.7241.00
36_M247_I1.6541.00
35_A39_V1.6421.00
148_I257_V1.5861.00
167_L223_L1.5851.00
217_F260_F1.5851.00
126_Y258_M1.5601.00
41_L45_L1.5421.00
210_I264_L1.5301.00
188_L208_L1.4991.00
207_L211_T1.4671.00
184_I212_L1.4651.00
5_K9_L1.4581.00
150_S186_I1.4391.00
42_F238_G1.4311.00
251_F254_F1.4211.00
206_Y264_L1.4161.00
89_F93_L1.3961.00
123_C126_Y1.3921.00
9_L13_L1.3891.00
146_V190_L1.3871.00
217_F257_V1.3791.00
147_V191_A1.3751.00
126_Y263_F1.3731.00
193_I197_V1.3731.00
166_K174_N1.3721.00
40_A248_L1.3511.00
158_V185_V1.3381.00
144_A261_L1.3361.00
187_A215_S1.3191.00
31_I35_A1.3131.00
166_K176_T1.3121.00
189_V193_I1.3121.00
111_G115_L1.3091.00
47_M232_Y1.2791.00
40_A251_F1.2541.00
126_Y262_Y1.2491.00
10_T242_P1.2481.00
184_I215_S1.2431.00
183_G215_S1.2381.00
224_V256_F1.2341.00
16_I20_F1.2301.00
148_I254_F1.2241.00
215_S219_Q1.2221.00
177_V180_F1.2141.00
154_G182_G1.2051.00
168_W171_I1.2041.00
25_G28_P1.2011.00
188_L212_L1.2011.00
10_T13_L1.1981.00
143_Y194_F1.1881.00
147_V187_A1.1881.00
19_L23_I1.1881.00
20_F24_V1.1851.00
163_G178_E1.1721.00
224_V228_L1.1621.00
98_T101_V1.1591.00
129_E262_Y1.1501.00
33_I128_I1.1501.00
192_T208_L1.1441.00
37_G124_F1.1371.00
218_G253_S1.1271.00
214_L261_L1.1271.00
28_P31_I1.1251.00
30_T128_I1.1151.00
193_I196_L1.1141.00
160_K174_N1.1041.00
4_M156_Y1.0971.00
148_I218_G1.0961.00
44_L48_K1.0921.00
180_F216_V1.0791.00
238_G241_L1.0711.00
123_C127_F1.0711.00
145_C254_F1.0701.00
103_N107_F1.0671.00
205_I209_L1.0651.00
115_L119_Y1.0631.00
187_A190_L1.0611.00
167_L181_A1.0481.00
120_I255_L1.0451.00
194_F198_A1.0371.00
214_L257_V1.0351.00
241_L247_I1.0301.00
14_A251_F1.0231.00
93_L96_T1.0211.00
126_Y129_E1.0201.00
10_T243_G1.0191.00
11_G157_F1.0161.00
167_L219_Q1.0161.00
95_L98_T1.0131.00
257_V261_L0.9951.00
89_F92_L0.9911.00
90_A93_L0.9901.00
64_L68_L0.9851.00
14_A241_L0.9841.00
16_I149_W0.9821.00
131_R137_G0.9811.00
192_T196_L0.9791.00
68_L72_Q0.9791.00
36_M251_F0.9781.00
91_V95_L0.9771.00
127_F141_I0.9761.00
143_Y261_L0.9701.00
68_L71_S0.9671.00
203_P206_Y0.9501.00
169_P180_F0.9401.00
90_A100_L0.9341.00
191_A207_L0.9301.00
147_V211_T0.9261.00
39_V42_F0.9241.00
55_L60_G0.9221.00
59_I63_L0.9171.00
38_S61_L0.9171.00
202_I206_Y0.9131.00
143_Y191_A0.9121.00
8_I153_S0.9050.99
162_L178_E0.9030.99
192_T204_Y0.9030.99
120_I248_L0.8940.99
154_G158_V0.8920.99
83_K86_I0.8880.99
8_I12_V0.8880.99
149_W244_H0.8870.99
81_I84_M0.8830.99
83_K87_A0.8810.99
166_K169_P0.8650.99
29_F141_I0.8610.99
28_P32_L0.8580.99
13_L16_I0.8490.99
15_A19_L0.8490.99
195_Q207_L0.8480.99
151_T183_G0.8460.99
131_R138_L0.8410.99
95_L99_V0.8410.99
6_Q10_T0.8390.99
45_L60_G0.8380.99
6_Q9_L0.8310.99
55_L62_L0.8250.99
225_E248_L0.8230.99
120_I123_C0.8180.99
119_Y225_E0.8180.99
5_K8_I0.8160.99
165_R181_A0.8140.99
41_L116_A0.8120.99
186_I190_L0.8120.99
92_L97_Y0.8110.99
93_L100_L0.8090.99
224_V227_A0.8010.99
119_Y123_C0.7890.99
11_G149_W0.7880.99
14_A17_V0.7850.98
149_W250_R0.7800.98
150_S154_G0.7780.98
163_G176_T0.7670.98
38_S42_F0.7660.98
88_L91_V0.7660.98
107_F111_G0.7660.98
41_L64_L0.7610.98
127_F258_M0.7580.98
151_T187_A0.7550.98
234_V237_S0.7540.98
97_Y101_V0.7490.98
21_L25_G0.7480.98
172_S175_K0.7470.98
154_G157_F0.7460.98
159_G235_K0.7450.98
40_A120_I0.7440.98
45_L113_I0.7400.98
206_Y209_L0.7350.98
64_L67_F0.7330.98
206_Y210_I0.7300.98
92_L96_T0.7290.98
154_G183_G0.7280.98
247_I251_F0.7270.98
92_L99_V0.7260.98
44_L248_L0.7260.98
23_I138_L0.7260.98
222_D235_K0.7250.97
93_L97_Y0.7240.97
84_M91_V0.7220.97
14_A149_W0.7200.97
213_F264_L0.7200.97
190_L194_F0.7190.97
22_V141_I0.7180.97
171_I227_A0.7130.97
104_T107_F0.7090.97
86_I89_F0.7080.97
57_G61_L0.7080.97
86_I93_L0.7030.97
82_S85_E0.7020.97
148_I253_S0.7010.97
56_P60_G0.7000.97
65_W69_L0.6920.97
148_I237_S0.6910.97
216_V219_Q0.6900.97
38_S65_W0.6870.97
47_M225_E0.6830.96
56_P63_L0.6820.96
172_S235_K0.6820.96
126_Y130_I0.6800.96
92_L98_T0.6790.96
18_F149_W0.6790.96
75_F78_A0.6710.96
91_V99_V0.6710.96
159_G172_S0.6700.96
148_I225_E0.6650.96
187_A194_F0.6640.96
108_D112_F0.6600.96
62_L69_L0.6590.96
22_V29_F0.6580.96
39_V238_G0.6540.95
174_N177_V0.6540.95
64_L71_S0.6540.95
47_M228_L0.6530.95
9_L16_I0.6530.95
225_E228_L0.6470.95
175_K235_K0.6460.95
164_K253_S0.6450.95
216_V220_L0.6430.95
10_T14_A0.6410.95
21_L28_P0.6410.95
79_D82_S0.6400.95
127_F254_F0.6400.95
188_L192_T0.6390.95
93_L99_V0.6370.95
60_G63_L0.6360.95
168_W223_L0.6360.95
102_K105_F0.6350.95
17_V20_F0.6320.95
8_I161_S0.6310.94
88_L92_L0.6290.94
18_F251_F0.6280.94
96_T100_L0.6280.94
106_T109_E0.6270.94
137_G140_Y0.6270.94
158_V176_T0.6250.94
147_V214_L0.6240.94
167_L176_T0.6220.94
26_K131_R0.6190.94
127_F131_R0.6180.94
37_G120_I0.6160.94
181_A184_I0.6150.94
196_L204_Y0.6110.93
79_D94_L0.6050.93
172_S245_G0.6050.93
246_G249_D0.6030.93
57_G60_G0.6030.93
27_L31_I0.6010.93
211_T215_S0.5990.93
127_F145_C0.5980.93
175_K179_G0.5970.93
90_A97_Y0.5940.92
130_I141_I0.5940.92
245_G249_D0.5930.92
238_G243_G0.5920.92
195_Q204_Y0.5920.92
235_K245_G0.5910.92
88_L99_V0.5900.92
116_A119_Y0.5890.92
42_F240_I0.5890.92
144_A148_I0.5880.92
204_Y208_L0.5880.92
149_W259_P0.5870.92
168_W174_N0.5860.92
142_F146_V0.5850.92
187_A211_T0.5830.92
180_F215_S0.5800.92
208_L212_L0.5800.92
119_Y127_F0.5790.92
149_W153_S0.5760.91
67_F70_P0.5750.91
159_G173_P0.5750.91
89_F96_T0.5750.91
90_A101_V0.5740.91
180_F184_I0.5690.91
119_Y255_L0.5680.91
88_L95_L0.5680.91
93_L98_T0.5680.91
29_F131_R0.5680.91
144_A254_F0.5680.91
96_T99_V0.5670.91
30_T34_Y0.5670.91
139_T198_A0.5660.91
32_L36_M0.5660.91
155_A186_I0.5640.90
232_Y237_S0.5640.90
7_R237_S0.5630.90
17_V21_L0.5630.90
154_G190_L0.5610.90
161_S176_T0.5610.90
240_I247_I0.5580.90
103_N106_T0.5570.90
49_K57_G0.5560.90
158_V178_E0.5550.90
151_T154_G0.5550.90
11_G244_H0.5550.90
159_G175_K0.5540.90
41_L44_L0.5530.90
254_F258_M0.5530.90
256_F259_P0.5530.90
25_G131_R0.5520.90
63_L66_M0.5510.89
122_M255_L0.5480.89
91_V94_L0.5480.89
128_I132_N0.5460.89
230_R235_K0.5460.89
89_F94_L0.5450.89
64_L121_G0.5450.89
36_M124_F0.5440.89
168_W227_A0.5430.89
95_L100_L0.5420.89
149_W155_A0.5410.89
71_S77_E0.5410.89
111_G125_H0.5400.88
201_P205_I0.5390.88
228_L237_S0.5360.88
226_S229_K0.5310.88
45_L116_A0.5310.88
65_W68_L0.5310.88
68_L128_I0.5300.88
146_V150_S0.5290.87
202_I205_I0.5290.87
29_F33_I0.5280.87
88_L93_L0.5280.87
42_F239_N0.5280.87
263_F266_A0.5260.87
89_F100_L0.5260.87
236_D244_H0.5230.87
82_S87_A0.5220.87
16_I19_L0.5210.87
23_I150_S0.5210.87
33_I260_F0.5190.86
92_L95_L0.5180.86
85_E93_L0.5170.86
226_S235_K0.5170.86
80_G84_M0.5150.86
149_W254_F0.5140.86
165_R170_E0.5120.86
168_W220_L0.5120.86
14_A18_F0.5120.86
167_L238_G0.5100.86
23_I142_F0.5080.85
228_L232_Y0.5070.85
110_V205_I0.5050.85
218_G257_V0.5040.85
12_V15_A0.5040.85
114_T118_I0.5040.85
91_V98_T0.5030.85
29_F128_I0.5020.85
96_T101_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.9517 100 0.135 Contact Map
3hd6A 3 0.9108 4.3 0.968 Contact Map
3rlfF 1 0.3086 3.2 0.97 Contact Map
4c48C 1 0.171 2.9 0.971 Contact Map
4qtnA 3 0.2007 2.2 0.972 Contact Map
3b9wA 3 0.8885 2 0.973 Contact Map
3mk7C 2 0.2454 1.7 0.974 Contact Map
2k1kA 2 0.1413 1.6 0.975 Contact Map
2nwlA 3 0.3197 1.3 0.976 Contact Map
4khaA 1 0.2119 1.3 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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