ISPT - BACSU - GREMLIN Contacts

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ISPT - Isoprenyl transferase

UniProt:	O31751	Sequences: MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYGGRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	260 (232)
Sequences:	5046 (3229)
Seq/√Len:	212.0

ECOLI - UPPS
BACSU - ISPT
HALSA - UPPS Q9HP67
SULSO - UPPS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_E	77_K	3.289	1.00
175_K	194_Y	3.149	1.00
175_K	180_S	2.801	1.00
233_V	242_H	2.729	1.00
64_V	81_L	2.684	1.00
118_N	150_G	2.678	1.00
143_Q	146_A	2.503	1.00
115_V	144_D	2.437	1.00
43_G	53_R	2.427	1.00
104_E	133_H	2.400	1.00
206_L	223_V	2.386	1.00
108_N	137_A	2.377	1.00
51_L	55_A	2.316	1.00
118_N	149_D	2.292	1.00
70_L	244_L	2.202	1.00
73_E	240_E	2.183	1.00
54_I	98_F	2.165	1.00
242_H	245_Q	2.122	1.00
63_V	66_R	2.020	1.00
203_P	226_S	2.020	1.00
115_V	148_N	2.018	1.00
93_K	97_D	1.998	1.00
167_S	196_M	1.989	1.00
166_V	191_F	1.955	1.00
127_E	139_E	1.944	1.00
126_D	167_S	1.943	1.00
239_K	242_H	1.937	1.00
65_K	110_Y	1.936	1.00
72_N	150_G	1.933	1.00
154_N	200_L	1.926	1.00
135_L	139_E	1.916	1.00
229_V	249_E	1.888	1.00
215_L	223_V	1.879	1.00
71_A	243_F	1.856	1.00
229_V	246_A	1.779	1.00
127_E	142_V	1.735	1.00
78_V	201_Q	1.725	1.00
78_V	200_L	1.723	1.00
123_I	138_I	1.713	1.00
162_R	202_D	1.705	1.00
163_T	167_S	1.703	1.00
31_I	76_V	1.671	1.00
90_K	259_G	1.671	1.00
182_N	185_D	1.665	1.00
129_A	158_N	1.643	1.00
78_V	154_N	1.638	1.00
74_L	244_L	1.611	1.00
48_K	234_L	1.606	1.00
206_L	226_S	1.587	1.00
171_S	194_Y	1.564	1.00
35_I	243_F	1.548	1.00
66_R	240_E	1.546	1.00
122_R	152_I	1.542	1.00
132_A	136_R	1.540	1.00
69_K	117_E	1.532	1.00
169_A	191_F	1.531	1.00
59_E	62_K	1.531	1.00
78_V	152_I	1.508	1.00
55_A	58_H	1.505	1.00
118_N	148_N	1.486	1.00
174_E	178_E	1.482	1.00
164_E	196_M	1.479	1.00
163_T	196_M	1.439	1.00
172_L	190_L	1.435	1.00
37_I	67_T	1.422	1.00
173_A	176_V	1.410	1.00
187_D	190_L	1.402	1.00
140_K	144_D	1.398	1.00
162_R	188_E	1.369	1.00
74_L	247_L	1.368	1.00
172_L	186_I	1.367	1.00
139_E	143_Q	1.360	1.00
127_E	135_L	1.352	1.00
80_T	156_A	1.337	1.00
172_L	194_Y	1.330	1.00
70_L	73_E	1.289	1.00
161_G	220_L	1.288	1.00
247_L	251_Q	1.278	1.00
69_K	113_E	1.269	1.00
37_I	79_L	1.259	1.00
126_D	163_T	1.244	1.00
130_L	157_L	1.241	1.00
192_S	202_D	1.221	1.00
136_R	140_K	1.211	1.00
191_F	194_Y	1.209	1.00
111_L	141_A	1.191	1.00
132_A	135_L	1.191	1.00
120_Q	152_I	1.171	1.00
38_I	206_L	1.164	1.00
177_K	183_I	1.157	1.00
249_E	252_Q	1.155	1.00
104_E	137_A	1.148	1.00
177_K	182_N	1.146	1.00
52_P	55_A	1.142	1.00
126_D	129_A	1.140	1.00
63_V	67_T	1.140	1.00
124_I	197_T	1.138	1.00
189_S	193_T	1.137	1.00
167_S	171_S	1.114	1.00
104_E	134_T	1.112	1.00
80_T	219_M	1.111	1.00
124_I	156_A	1.105	1.00
205_L	246_A	1.103	1.00
165_I	191_F	1.101	1.00
173_A	186_I	1.099	1.00
176_V	181_L	1.097	1.00
81_L	153_L	1.096	1.00
122_R	142_V	1.095	1.00
63_V	239_K	1.091	1.00
84_F	89_W	1.086	1.00
84_F	96_V	1.085	1.00
164_E	222_Q	1.079	1.00
181_L	190_L	1.074	1.00
61_M	106_F	1.062	1.00
103_P	157_L	1.053	1.00
124_I	154_N	1.051	1.00
164_E	167_S	1.048	1.00
223_V	226_S	1.046	1.00
213_I	230_F	1.045	1.00
137_A	140_K	1.045	1.00
35_I	247_L	1.042	1.00
111_L	144_D	1.039	1.00
58_H	105_E	1.036	1.00
119_V	151_M	1.028	1.00
248_G	251_Q	0.995	1.00
123_I	127_E	0.993	1.00
171_S	174_E	0.981	1.00
243_F	247_L	0.966	1.00
35_I	76_V	0.963	1.00
70_L	243_F	0.962	1.00
176_V	183_I	0.959	1.00
190_L	194_Y	0.952	1.00
165_I	169_A	0.951	1.00
174_E	177_K	0.951	1.00
172_L	181_L	0.942	0.99
112_P	144_D	0.940	0.99
81_L	155_F	0.928	0.99
58_H	62_K	0.923	0.99
121_V	141_A	0.921	0.99
68_T	153_L	0.918	0.99
223_V	228_F	0.912	0.99
72_N	151_M	0.910	0.99
35_I	71_A	0.910	0.99
112_P	116_E	0.910	0.99
39_M	83_A	0.908	0.99
134_T	137_A	0.908	0.99
36_A	203_P	0.902	0.99
108_N	140_K	0.896	0.99
86_T	160_G	0.891	0.99
176_V	179_G	0.887	0.99
139_E	142_V	0.879	0.99
122_R	154_N	0.872	0.99
170_K	184_E	0.868	0.99
36_A	206_L	0.864	0.99
67_T	70_L	0.864	0.99
215_L	220_L	0.861	0.99
31_I	251_Q	0.857	0.99
245_Q	249_E	0.852	0.99
79_L	151_M	0.846	0.99
174_E	184_E	0.841	0.99
169_A	173_A	0.840	0.99
68_T	119_V	0.838	0.99
131_P	134_T	0.838	0.99
166_V	186_I	0.837	0.99
96_V	100_M	0.821	0.99
240_E	244_L	0.821	0.99
229_V	242_H	0.821	0.99
76_V	247_L	0.815	0.99
72_N	117_E	0.809	0.98
244_L	248_G	0.806	0.98
173_A	177_K	0.798	0.98
172_L	191_F	0.794	0.98
122_R	199_S	0.788	0.98
166_V	169_A	0.786	0.98
170_K	173_A	0.785	0.98
70_L	240_E	0.778	0.98
128_T	135_L	0.776	0.98
66_R	239_K	0.776	0.98
100_M	130_L	0.775	0.98
210_S	256_R	0.775	0.98
231_T	246_A	0.773	0.98
94_M	97_D	0.772	0.98
57_H	95_E	0.770	0.98
123_I	142_V	0.766	0.98
167_S	170_K	0.766	0.98
74_L	243_F	0.762	0.98
49_R	237_D	0.761	0.98
161_G	164_E	0.761	0.98
241_D	244_L	0.760	0.98
166_V	170_K	0.760	0.98
122_R	200_L	0.758	0.98
55_A	59_E	0.755	0.98
203_P	223_V	0.750	0.97
67_T	240_E	0.748	0.97
175_K	193_T	0.747	0.97
209_T	231_T	0.742	0.97
160_G	217_N	0.741	0.97
158_N	259_G	0.740	0.97
87_E	160_G	0.737	0.97
174_E	183_I	0.734	0.97
190_L	193_T	0.733	0.97
78_V	203_P	0.732	0.97
203_P	206_L	0.732	0.97
89_W	158_N	0.725	0.97
210_S	213_I	0.725	0.97
45_W	237_D	0.723	0.97
105_E	109_T	0.719	0.97
126_D	158_N	0.715	0.97
65_K	113_E	0.715	0.97
213_I	249_E	0.712	0.96
70_L	74_L	0.709	0.96
185_D	190_L	0.704	0.96
220_L	224_A	0.704	0.96
169_A	172_L	0.703	0.96
37_I	207_I	0.703	0.96
191_F	195_L	0.694	0.96
43_G	92_P	0.694	0.96
234_L	237_D	0.693	0.96
103_P	106_F	0.691	0.96
123_I	155_F	0.691	0.96
72_N	119_V	0.690	0.96
192_S	195_L	0.689	0.96
31_I	247_L	0.687	0.96
103_P	134_T	0.686	0.96
66_R	69_K	0.679	0.95
175_K	178_E	0.677	0.95
170_K	183_I	0.677	0.95
173_A	181_L	0.677	0.95
87_E	217_N	0.673	0.95
101_K	133_H	0.673	0.95
68_T	151_M	0.673	0.95
31_I	75_G	0.672	0.95
183_I	187_D	0.672	0.95
77_K	152_I	0.668	0.95
186_I	190_L	0.666	0.95
161_G	218_F	0.662	0.95
181_L	186_I	0.660	0.95
32_P	35_I	0.659	0.95
233_V	237_D	0.657	0.95
193_T	199_S	0.654	0.94
110_Y	113_E	0.653	0.94
103_P	155_F	0.652	0.94
48_K	237_D	0.650	0.94
213_I	232_D	0.646	0.94
161_G	215_L	0.645	0.94
231_T	242_H	0.645	0.94
137_A	141_A	0.645	0.94
134_T	138_I	0.644	0.94
168_A	191_F	0.643	0.94
35_I	207_I	0.642	0.94
69_K	73_E	0.637	0.94
138_I	155_F	0.637	0.94
138_I	157_L	0.636	0.94
62_K	109_T	0.632	0.93
59_E	63_V	0.631	0.93
205_L	229_V	0.624	0.93
212_E	256_R	0.623	0.93
197_T	222_Q	0.622	0.93
30_E	251_Q	0.621	0.93
82_Y	217_N	0.620	0.93
127_E	138_I	0.618	0.93
192_S	199_S	0.616	0.92
71_A	79_L	0.615	0.92
97_D	101_K	0.613	0.92
36_A	218_F	0.610	0.92
180_S	194_Y	0.607	0.92
101_K	105_E	0.606	0.92
173_A	183_I	0.603	0.92
183_I	190_L	0.602	0.92
161_G	165_I	0.601	0.92
31_I	74_L	0.597	0.91
100_M	131_P	0.594	0.91
80_T	124_I	0.593	0.91
238_F	246_A	0.592	0.91
152_I	200_L	0.590	0.91
47_K	53_R	0.588	0.91
57_H	102_L	0.587	0.91
241_D	245_Q	0.584	0.90
107_L	111_L	0.583	0.90
188_E	192_S	0.581	0.90
207_I	246_A	0.579	0.90
215_L	228_F	0.578	0.90
59_E	66_R	0.578	0.90
66_R	70_L	0.577	0.90
136_R	139_E	0.575	0.90
209_T	230_F	0.574	0.90
108_N	112_P	0.573	0.89
103_P	107_L	0.572	0.89
67_T	243_F	0.569	0.89
229_V	245_Q	0.568	0.89
231_T	238_F	0.568	0.89
210_S	234_L	0.567	0.89
113_E	116_E	0.567	0.89
32_P	251_Q	0.566	0.89
181_L	185_D	0.565	0.89
248_G	252_Q	0.565	0.89
170_K	174_E	0.563	0.89
29_G	251_Q	0.562	0.89
104_E	108_N	0.561	0.88
49_R	52_P	0.560	0.88
124_I	219_M	0.559	0.88
183_I	186_I	0.559	0.88
70_L	239_K	0.559	0.88
63_V	70_L	0.558	0.88
49_R	53_R	0.554	0.88
235_W	238_F	0.554	0.88
82_Y	164_E	0.553	0.88
85_S	160_G	0.553	0.88
186_I	194_Y	0.551	0.88
121_V	155_F	0.551	0.88
68_T	79_L	0.550	0.88
225_Y	255_R	0.548	0.87
166_V	188_E	0.547	0.87
227_E	255_R	0.544	0.87
170_K	185_D	0.543	0.87
111_L	137_A	0.541	0.87
115_V	147_Q	0.541	0.87
69_K	72_N	0.541	0.87
253_R	256_R	0.540	0.87
111_L	115_V	0.535	0.86
239_K	245_Q	0.534	0.86
87_E	225_Y	0.532	0.86
114_L	153_L	0.531	0.86
204_E	257_F	0.531	0.86
207_I	238_F	0.529	0.85
192_S	221_W	0.528	0.85
83_A	155_F	0.527	0.85
114_L	119_V	0.525	0.85
244_L	251_Q	0.525	0.85
43_G	54_I	0.520	0.84
193_T	198_E	0.520	0.84
104_E	131_P	0.518	0.84
128_T	158_N	0.517	0.84
68_T	72_N	0.516	0.84
57_H	99_L	0.512	0.84
121_V	153_L	0.512	0.84
173_A	180_S	0.512	0.84
231_T	249_E	0.511	0.83
172_L	175_K	0.509	0.83
82_Y	215_L	0.509	0.83
101_K	104_E	0.507	0.83
89_W	100_M	0.507	0.83
148_N	151_M	0.506	0.83
173_A	179_G	0.505	0.83
227_E	253_R	0.503	0.83
107_L	141_A	0.502	0.82
86_T	217_N	0.500	0.82
176_V	186_I	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1f75A	2	0.8346	100	0.116	Contact Map
2vg3A	2	1	100	0.121	Contact Map
4q9mA	2	0.8692	100	0.125	Contact Map
4h8eA	2	0.9038	100	0.125	Contact Map
3sgvB	2	0.8769	100	0.126	Contact Map
2d2rA	2	0.8346	100	0.143	Contact Map
3ugsB	2	0.8	100	0.157	Contact Map
2vg0A	2	0.8538	100	0.163	Contact Map
3wqlA	2	0.9	97.7	0.913	Contact Map
2infA	2	0.4962	22.5	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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