GREMLIN Database
PYRH - Uridylate kinase
UniProt: O31749 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (220)
Sequences: 7850 (4396)
Seq/√Len: 296.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_A176_D4.7101.00
8_R47_E3.7701.00
226_R231_E3.4321.00
39_K43_E2.9681.00
49_A153_I2.6241.00
36_K95_L2.5631.00
97_I128_V2.5271.00
167_G181_K2.2331.00
39_K97_I2.1681.00
104_S107_M2.1331.00
170_N180_V2.0461.00
188_L207_M2.0301.00
160_M163_N2.0031.00
159_L216_F1.9601.00
15_G58_W1.9561.00
42_A126_K1.9341.00
170_N176_D1.9221.00
42_A97_I1.9201.00
40_E225_K1.8911.00
171_A178_S1.8661.00
151_A211_I1.8531.00
72_T75_Y1.8461.00
99_S102_Q1.7581.00
32_Q94_T1.7531.00
11_L38_V1.7511.00
42_A47_E1.7351.00
56_N60_G1.7031.00
17_A218_I1.6791.00
122_H127_R1.6581.00
35_A91_S1.6321.00
225_K229_I1.6311.00
32_Q95_L1.6161.00
110_V114_Y1.6021.00
98_Q127_R1.5991.00
42_A128_V1.5951.00
85_S132_A1.5861.00
56_N59_R1.5831.00
172_D175_K1.5811.00
164_N174_R1.5591.00
65_D68_M1.5441.00
147_A206_C1.5351.00
183_E232_S1.5311.00
157_V214_I1.5261.00
119_A131_F1.5241.00
190_V203_S1.5151.00
39_K95_L1.5011.00
33_S36_K1.4891.00
102_Q122_H1.4871.00
58_W61_K1.4871.00
111_A114_Y1.4731.00
118_K122_H1.4621.00
98_Q101_V1.4601.00
44_L229_I1.4591.00
173_P179_A1.4431.00
37_Q222_G1.4251.00
64_S68_M1.4201.00
189_D192_K1.4161.00
166_D169_Y1.4051.00
170_N182_Y1.3801.00
120_I124_E1.3521.00
55_G58_W1.3451.00
81_T98_Q1.3431.00
189_D193_D1.3361.00
166_D217_S1.3341.00
57_L137_N1.3231.00
220_E226_R1.3231.00
216_F227_A1.3221.00
55_G60_G1.3161.00
214_I227_A1.3021.00
40_E221_E1.2851.00
121_R124_E1.2751.00
121_R125_K1.2731.00
217_S220_E1.2671.00
181_K217_S1.2571.00
206_C213_L1.2571.00
104_S108_R1.2551.00
166_D220_E1.2411.00
58_W62_T1.2391.00
163_N215_V1.2371.00
216_F223_N1.2361.00
40_E43_E1.2341.00
224_I227_A1.2331.00
10_V155_A1.2241.00
122_H129_V1.2231.00
47_E124_E1.2231.00
57_L60_G1.2161.00
131_F149_R1.2161.00
116_R120_I1.2041.00
223_N226_R1.1961.00
33_S37_Q1.1821.00
131_F153_I1.1781.00
55_G59_R1.1541.00
133_A136_G1.1521.00
159_L224_I1.1491.00
32_Q91_S1.1411.00
9_I46_V1.1341.00
188_L192_K1.1311.00
37_Q221_E1.1261.00
109_Q113_P1.1241.00
38_V128_V1.1091.00
7_K156_D1.1041.00
168_V185_L1.1031.00
91_S95_L1.0881.00
39_K92_L1.0841.00
60_G63_G1.0811.00
47_E126_K1.0791.00
40_E44_L1.0691.00
116_R154_E1.0691.00
147_A158_I1.0681.00
79_L82_V1.0651.00
55_G61_K1.0611.00
49_A123_L1.0601.00
8_R120_I1.0591.00
109_Q112_E1.0551.00
38_V50_V1.0541.00
79_L83_M1.0521.00
42_A48_V1.0431.00
150_A158_I1.0391.00
49_A131_F1.0301.00
166_D181_K1.0291.00
171_A179_A1.0111.00
41_I228_V1.0091.00
41_I44_L1.0041.00
182_Y193_D0.9981.00
59_R62_T0.9871.00
192_K204_S0.9811.00
32_Q36_K0.9781.00
194_G207_M0.9781.00
41_I46_V0.9781.00
34_I88_L0.9771.00
85_S88_L0.9761.00
85_S101_V0.9711.00
144_T201_T0.9681.00
159_L214_I0.9561.00
161_A216_F0.9501.00
99_S103_T0.9471.00
91_S94_T0.9411.00
41_I48_V0.9401.00
56_N61_K0.9391.00
171_A177_E0.9391.00
77_G84_N0.9361.00
119_A129_V0.9361.00
36_K94_T0.9281.00
151_A209_N0.9251.00
43_E97_I0.9221.00
144_T205_L0.9211.00
187_Y203_S0.9191.00
64_S67_G0.9161.00
105_I108_R0.9141.00
101_V104_S0.9131.00
188_L191_L0.9111.00
58_W63_G0.9031.00
172_D179_A0.8871.00
102_Q106_E0.8871.00
81_T84_N0.8831.00
38_V48_V0.8821.00
146_A158_I0.8771.00
65_D69_D0.8691.00
109_Q114_Y0.8641.00
198_M215_V0.8571.00
39_K128_V0.8571.00
169_Y173_P0.8551.00
16_E19_A0.8541.00
76_M87_A0.8451.00
11_L41_I0.8451.00
30_V33_S0.8441.00
164_N219_M0.8431.00
31_I91_S0.8431.00
101_V107_M0.8421.00
13_L50_V0.8411.00
80_A84_N0.8391.00
36_K221_E0.8301.00
73_A77_G0.8251.00
122_H125_K0.8221.00
56_N62_T0.8151.00
150_A211_I0.8131.00
106_E112_E0.8091.00
20_G27_N0.8091.00
168_V182_Y0.8091.00
100_R122_H0.8051.00
75_Y121_R0.8051.00
201_T204_S0.8041.00
78_M81_T0.8031.00
71_A75_Y0.8001.00
108_R111_A0.7991.00
39_K42_A0.7950.99
92_L97_I0.7940.99
222_G225_K0.7880.99
59_R63_G0.7800.99
78_M134_G0.7790.99
52_V88_L0.7700.99
207_M213_L0.7650.99
181_K232_S0.7650.99
77_G80_A0.7640.99
7_K46_V0.7590.99
9_I228_V0.7580.99
182_Y185_L0.7570.99
175_K196_E0.7530.99
77_G83_M0.7520.99
100_R127_R0.7510.99
191_L200_S0.7500.99
134_G138_P0.7480.99
102_Q107_M0.7370.99
37_Q40_E0.7360.99
41_I159_L0.7350.99
77_G81_T0.7330.99
46_V156_D0.7270.99
201_T205_L0.7240.99
9_I157_V0.7210.99
36_K40_E0.7170.99
35_A92_L0.7170.99
205_L209_N0.7150.99
9_I48_V0.7110.99
149_R153_I0.7080.99
134_G137_N0.7070.99
80_A83_M0.6990.99
56_N63_G0.6980.99
160_M164_N0.6940.99
11_L48_V0.6940.99
108_R113_P0.6870.99
57_L80_A0.6860.98
92_L128_V0.6850.98
102_Q129_V0.6830.98
28_P32_Q0.6830.98
27_N30_V0.6780.98
57_L61_K0.6770.98
222_G226_R0.6740.98
11_L159_L0.6670.98
113_P116_R0.6650.98
106_E109_Q0.6640.98
168_V215_V0.6640.98
17_A164_N0.6610.98
79_L84_N0.6580.98
204_S208_D0.6580.98
120_I154_E0.6570.98
187_Y190_V0.6500.98
119_A123_L0.6460.98
36_K39_K0.6420.98
107_M110_V0.6400.98
157_V212_P0.6390.98
176_D179_A0.6380.98
169_Y181_K0.6360.98
89_Q99_S0.6310.97
206_C211_I0.6290.97
44_L225_K0.6250.97
61_K65_D0.6230.97
75_Y125_K0.6220.97
37_Q220_E0.6210.97
34_I38_V0.6190.97
11_L224_I0.6180.97
110_V113_P0.6180.97
82_V85_S0.6160.97
89_Q93_E0.6160.97
74_D80_A0.6160.97
33_S218_I0.6150.97
74_D77_G0.6150.97
40_E222_G0.6140.97
78_M83_M0.6130.97
101_V106_E0.6120.97
57_L83_M0.6110.97
99_S106_E0.6100.97
78_M84_N0.6070.97
170_N179_A0.6070.97
166_D222_G0.5980.96
198_M213_L0.5970.96
197_V201_T0.5970.96
76_M86_L0.5960.96
75_Y83_M0.5950.96
169_Y179_A0.5930.96
100_R107_M0.5920.96
55_G63_G0.5910.96
88_L130_I0.5890.96
198_M202_A0.5880.96
27_N219_M0.5830.96
75_Y79_L0.5830.96
191_L204_S0.5830.96
187_Y191_L0.5780.96
17_A30_V0.5780.96
129_V132_A0.5750.96
22_Q27_N0.5720.95
73_A78_M0.5710.95
56_N196_E0.5700.95
92_L95_L0.5700.95
8_R156_D0.5690.95
76_M83_M0.5680.95
13_L18_L0.5670.95
90_D93_E0.5660.95
85_S89_Q0.5640.95
30_V34_I0.5640.95
147_A205_L0.5610.95
29_T32_Q0.5590.95
105_I109_Q0.5580.95
63_G89_Q0.5580.95
33_S222_G0.5560.95
30_V218_I0.5550.95
43_E95_L0.5540.95
75_Y82_V0.5520.94
187_Y207_M0.5480.94
52_V130_I0.5460.94
105_I111_A0.5450.94
30_V219_M0.5380.94
102_Q118_K0.5360.94
20_G30_V0.5350.94
82_V86_L0.5300.93
9_I41_I0.5300.93
35_A95_L0.5270.93
68_M90_D0.5240.93
164_N173_P0.5210.93
7_K157_V0.5200.93
180_V184_S0.5190.92
151_A205_L0.5180.92
52_V85_S0.5180.92
54_G80_A0.5180.92
78_M82_V0.5170.92
186_S189_D0.5140.92
90_D94_T0.5140.92
103_T111_A0.5130.92
198_M203_S0.5130.92
172_D176_D0.5110.92
135_T138_P0.5100.92
64_S79_L0.5090.92
64_S69_D0.5080.92
8_R11_L0.5070.92
19_A58_W0.5040.91
106_E110_V0.5030.91
122_H126_K0.5030.91
37_Q223_N0.5020.91
55_G62_T0.5020.91
100_R103_T0.5000.91
78_M118_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q1tA 4 0.9333 100 0.254 Contact Map
2j5vA 2 0.8542 100 0.257 Contact Map
1z9dA 5 0.9708 100 0.265 Contact Map
3ek6A 5 0.9958 100 0.267 Contact Map
3nwyA 5 0.9708 100 0.271 Contact Map
2a1fA 5 0.9667 100 0.274 Contact Map
2va1A 5 0.9875 100 0.276 Contact Map
2jjxA 5 0.9833 100 0.283 Contact Map
1ybdA 5 0.9833 100 0.283 Contact Map
4a7wA 2 0.9333 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.