GREMLIN Database
RNH2 - Ribonuclease HII
UniProt: O31744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (197)
Sequences: 2023 (1389)
Seq/√Len: 99.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_A221_E5.7821.00
217_M238_Y3.9101.00
211_Y243_L3.2881.00
130_V199_I3.1481.00
124_M130_V2.5941.00
90_V134_I2.5721.00
166_Y181_A2.5371.00
91_A152_A2.4551.00
120_Y124_M2.4181.00
219_G230_E2.4161.00
168_L193_I2.3511.00
117_E206_R2.3381.00
146_Y172_M2.2161.00
106_T110_K2.1141.00
113_E209_S2.0591.00
115_K118_E2.0381.00
139_V151_M2.0361.00
131_G159_D1.9561.00
233_E237_A1.9031.00
71_F165_D1.8571.00
235_L240_P1.8551.00
135_V155_K1.7671.00
124_M199_I1.7581.00
143_I151_M1.7391.00
141_D247_T1.7211.00
105_L198_C1.7181.00
122_L126_E1.7091.00
222_K230_E1.7041.00
62_Y189_K1.6671.00
120_Y206_R1.6571.00
60_T191_V1.6541.00
67_R98_E1.6521.00
66_A166_Y1.6251.00
121_E206_R1.6171.00
73_L165_D1.6151.00
120_Y203_T1.5841.00
86_A220_F1.5841.00
212_A217_M1.5741.00
120_Y202_V1.5631.00
139_V155_K1.5561.00
229_K233_E1.5451.00
219_G234_A1.5431.00
93_A160_L1.5341.00
75_A93_A1.5191.00
106_T188_A1.4991.00
136_E139_V1.4901.00
129_A161_S1.4851.00
217_M234_A1.4601.00
123_I127_A1.4381.00
140_I145_I1.4341.00
134_I203_T1.4141.00
85_L232_L1.4091.00
147_E150_K1.3981.00
138_T246_K1.3620.99
210_A213_E1.3490.99
71_F166_Y1.3380.99
186_G193_I1.3380.99
219_G223_N1.3340.99
77_V167_L1.3150.99
134_I207_M1.2890.99
207_M211_Y1.2870.99
219_G222_K1.2700.99
77_V149_S1.2660.99
75_A95_I1.2610.99
80_V223_N1.2490.99
86_A208_M1.2450.99
59_M194_A1.2430.99
89_V145_I1.2140.99
113_E117_E1.2100.99
220_F223_N1.2050.99
249_A252_Q1.1960.98
139_V143_I1.1920.98
111_L198_C1.1900.98
160_L164_P1.1880.98
172_M182_S1.1860.98
183_I189_K1.1700.98
185_K188_A1.1440.98
132_I203_T1.1410.98
110_K188_A1.1280.98
223_N234_A1.1270.98
105_L191_V1.1260.98
235_L251_V1.1220.98
72_R165_D1.1020.97
151_M155_K1.0930.97
117_E202_V1.0930.97
233_E236_A1.0870.97
232_L236_A1.0860.97
154_V176_L1.0740.97
154_V158_Q1.0740.97
128_L162_D1.0630.97
80_V199_I1.0540.97
240_P246_K1.0420.96
90_V203_T1.0420.96
92_S132_I1.0420.96
144_N149_S1.0340.96
135_V151_M1.0330.96
209_S224_K1.0260.96
93_A156_A1.0250.96
166_Y179_A1.0240.96
185_K189_K1.0110.96
91_A149_S1.0090.96
105_L194_A1.0060.95
67_R74_I0.9990.95
105_L195_A0.9970.95
102_I105_L0.9750.95
144_N147_E0.9740.95
167_L178_T0.9650.94
100_C126_E0.9600.94
61_S65_L0.9580.94
139_V142_E0.9570.94
104_G115_K0.9410.94
137_A243_L0.9390.93
227_G232_L0.9260.93
119_Y198_C0.9230.93
183_I193_I0.9180.93
80_V120_Y0.9180.93
66_A181_A0.9170.93
62_Y183_I0.9140.93
72_R98_E0.9070.92
133_G152_A0.9030.92
97_P100_C0.8990.92
60_T64_R0.8950.92
114_K118_E0.8850.91
80_V224_K0.8780.91
135_V152_A0.8760.91
75_A164_P0.8760.91
112_S115_K0.8740.91
215_Y242_E0.8730.91
220_F243_L0.8720.91
121_E124_M0.8700.91
65_L181_A0.8680.90
135_V139_V0.8640.90
203_T207_M0.8640.90
150_K175_P0.8630.90
171_A182_S0.8610.90
167_L180_Q0.8610.90
129_A162_D0.8600.90
91_A135_V0.8580.90
157_I167_L0.8380.89
113_E224_K0.8330.89
150_K172_M0.8330.89
232_L250_P0.8270.88
118_E122_L0.8200.88
56_W59_M0.8180.88
96_L105_L0.8180.88
138_T142_E0.8170.88
77_V153_M0.8150.87
111_L119_Y0.8150.87
77_V169_V0.8150.87
223_N228_T0.8150.87
56_W191_V0.8070.87
167_L176_L0.8060.87
57_V64_R0.8030.87
85_L227_G0.8020.87
174_L180_Q0.7970.86
95_I160_L0.7970.86
91_A131_G0.7920.86
173_T180_Q0.7910.86
91_A133_G0.7890.86
215_Y243_L0.7870.86
86_A243_L0.7830.85
137_A141_D0.7780.85
86_A244_H0.7710.84
210_A214_T0.7670.84
202_V206_R0.7660.84
75_A160_L0.7600.84
94_V123_I0.7580.83
132_I199_I0.7580.83
143_I147_E0.7570.83
146_Y173_T0.7570.83
212_A224_K0.7550.83
133_G156_A0.7510.83
119_Y123_I0.7470.83
80_V202_V0.7450.82
222_K228_T0.7430.82
235_L241_T0.7410.82
89_V144_N0.7390.82
146_Y171_A0.7340.81
150_K171_A0.7320.81
157_I176_L0.7250.81
94_V130_V0.7250.81
151_M154_V0.7250.81
120_Y130_V0.7150.80
89_V149_S0.7150.80
183_I186_G0.7140.80
111_L115_K0.7090.79
64_R67_R0.7060.79
220_F241_T0.6990.78
223_N230_E0.6980.78
209_S213_E0.6980.78
80_V134_I0.6970.78
75_A157_I0.6960.78
121_E125_K0.6950.78
208_M220_F0.6940.78
80_V203_T0.6940.78
63_E70_G0.6870.77
190_S194_A0.6820.76
102_I119_Y0.6820.76
203_T206_R0.6800.76
230_E234_A0.6790.76
95_I164_P0.6770.76
58_N61_S0.6750.76
92_S130_V0.6720.75
171_A184_I0.6720.75
131_G160_L0.6660.75
184_I193_I0.6600.74
56_W60_T0.6590.74
229_K232_L0.6590.74
146_Y149_S0.6580.74
138_T242_E0.6580.74
215_Y241_T0.6570.74
94_V127_A0.6560.74
214_T243_L0.6460.72
124_M203_T0.6440.72
65_L69_K0.6440.72
150_K174_L0.6430.72
89_V146_Y0.6390.72
96_L127_A0.6360.71
217_M241_T0.6340.71
198_C243_L0.6310.71
117_E120_Y0.6310.71
80_V234_A0.6270.70
168_L186_G0.6240.70
169_V182_S0.6230.70
65_L68_N0.6190.69
137_A241_T0.6180.69
94_V199_I0.6140.69
122_L125_K0.6090.68
223_N241_T0.6040.67
84_P140_I0.6020.67
133_G155_K0.5990.67
73_L162_D0.5940.66
71_F74_I0.5930.66
110_K185_K0.5900.66
95_I129_A0.5890.65
93_A153_M0.5880.65
169_V181_A0.5820.65
80_V92_S0.5810.64
101_E191_V0.5800.64
223_N235_L0.5780.64
155_K159_D0.5780.64
247_T250_P0.5760.64
85_L250_P0.5750.64
155_K158_Q0.5670.63
230_E233_E0.5670.63
136_E142_E0.5660.62
102_I122_L0.5650.62
135_V143_I0.5650.62
224_K241_T0.5640.62
102_I126_E0.5620.62
169_V180_Q0.5610.62
97_P128_L0.5610.62
221_E224_K0.5610.62
131_G156_A0.5590.61
212_A238_Y0.5570.61
235_L250_P0.5560.61
127_A130_V0.5560.61
89_V156_A0.5540.61
214_T242_E0.5530.61
229_K236_A0.5520.60
146_Y150_K0.5520.60
89_V133_G0.5520.60
136_E243_L0.5500.60
96_L195_A0.5500.60
85_L145_I0.5480.60
63_E190_S0.5480.60
154_V169_V0.5460.60
158_Q177_D0.5450.60
154_V174_L0.5430.59
95_I128_L0.5410.59
123_I199_I0.5400.59
227_G244_H0.5400.59
152_A156_A0.5370.58
171_A183_I0.5330.58
73_L163_T0.5330.58
84_P146_Y0.5310.58
106_T119_Y0.5290.57
84_P144_N0.5240.57
231_H244_H0.5180.56
174_L182_S0.5180.56
214_T217_M0.5160.55
115_K119_Y0.5090.54
137_A223_N0.5080.54
146_Y248_F0.5070.54
59_M110_K0.5070.54
56_W103_L0.5060.54
167_L174_L0.5060.54
97_P101_E0.5050.54
246_K251_V0.5050.54
85_L140_I0.5040.54
124_M206_R0.5030.54
163_T178_T0.5010.53
60_T105_L0.5010.53
217_M221_E0.5010.53
205_D226_Y0.5010.53
223_N244_H0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2etjA 1 0.7137 100 0.248 Contact Map
1uaxA 1 0.7059 100 0.329 Contact Map
1i39A 1 0.6902 100 0.332 Contact Map
1io2A 1 0.7059 100 0.334 Contact Map
1ekeA 2 0.702 100 0.34 Contact Map
3kioA 1 0.8118 100 0.347 Contact Map
2d0bA 1 0.9647 100 0.373 Contact Map
3vn5A 1 0.9294 100 0.393 Contact Map
4py5A 1 0.9333 100 0.395 Contact Map
3gocA 2 0.7176 51.2 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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