GREMLIN Database
RBGA - Ribosome biogenesis GTPase A
UniProt: O31743 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (267)
Sequences: 3193 (2117)
Seq/√Len: 129.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_G254_I4.5221.00
67_V276_S4.2651.00
35_I192_T3.6671.00
225_Y266_D2.6901.00
149_G154_I2.6341.00
30_L136_L2.6131.00
11_A15_R2.6091.00
233_D236_E2.5621.00
74_H78_Q2.5341.00
40_R45_E2.4941.00
72_K82_S2.4661.00
37_M75_F2.4511.00
72_K84_S2.3011.00
147_K154_I2.2111.00
236_E240_A2.1801.00
141_A161_V2.1791.00
191_V209_G2.1671.00
56_L85_I2.1251.00
69_Q73_E2.0841.00
209_G267_I2.0601.00
63_A68_T2.0511.00
65_A274_R2.0471.00
72_K76_E2.0061.00
67_V70_Q1.9781.00
241_I259_T1.9541.00
43_M46_D1.9491.00
28_Y100_S1.8871.00
255_N258_K1.8811.00
68_T84_S1.8591.00
237_L241_I1.8571.00
247_C262_V1.8551.00
220_R223_E1.8531.00
54_I99_A1.8511.00
212_F216_H1.8401.00
219_E222_K1.8201.00
267_I277_F1.8001.00
14_R18_T1.7781.00
211_R214_E1.7551.00
35_I39_S1.7551.00
31_V55_M1.7491.00
86_N89_N1.7301.00
62_K270_E1.7101.00
245_R262_V1.7031.00
65_A69_Q1.6781.00
125_I136_L1.6691.00
238_F259_T1.6431.00
188_R278_E1.6381.00
99_A102_E1.6091.00
247_C258_K1.6021.00
222_K228_D1.5831.00
24_I124_L1.5731.00
257_D261_E1.5581.00
17_V124_L1.5481.00
243_E248_L1.5461.00
141_A145_I1.5341.00
66_A70_Q1.5291.00
265_R269_T1.5281.00
266_D271_K1.5281.00
96_I136_L1.5201.00
160_W170_L1.5141.00
249_M255_N1.5131.00
7_P10_M1.4931.00
210_L237_L1.4761.00
238_F263_I1.4761.00
28_Y56_L1.4711.00
221_L225_Y1.4591.00
235_A239_D1.4511.00
80_I84_S1.4471.00
243_E254_I1.4461.00
162_K168_E1.4401.00
219_E223_E1.4371.00
96_I100_S1.4361.00
31_V57_L1.4281.00
216_H279_Q1.4141.00
15_R19_E1.4081.00
150_D269_T1.4081.00
236_E239_D1.3921.00
184_L188_R1.3841.00
100_S103_I1.3791.00
206_A260_T1.3741.00
30_L58_N1.3731.00
73_E77_N1.3651.00
56_L83_L1.3591.00
101_K166_E1.3561.00
220_R272_F1.3541.00
16_E20_K1.3501.00
241_I263_I1.3441.00
73_E76_E1.3391.00
196_K199_I1.3381.00
58_N87_S1.3291.00
261_E265_R1.3241.00
56_L96_I1.3061.00
45_E53_R1.3001.00
222_K227_L1.2961.00
180_F186_G1.2871.00
20_K158_Q1.2801.00
16_E158_Q1.2791.00
16_E19_E1.2661.00
67_V279_Q1.2581.00
222_K229_E1.2581.00
249_M253_L1.2551.00
75_F78_Q1.2441.00
240_A243_E1.2351.00
26_I104_L1.2301.00
239_D243_E1.2291.00
29_E40_R1.2291.00
104_L108_F1.2231.00
81_R102_E1.2221.00
81_R99_A1.2211.00
86_N91_Q1.2171.00
235_A256_Y1.2171.00
207_V234_I1.2120.99
70_Q73_E1.2100.99
102_E105_Q1.2020.99
191_V267_I1.1990.99
136_L140_L1.1670.99
80_I85_I1.1630.99
29_E55_M1.1300.99
147_K159_Q1.1110.99
242_G259_T1.1040.99
81_R85_I1.1000.99
46_D50_N1.0980.99
182_D185_V1.0850.99
135_T148_T1.0820.99
248_L252_G1.0770.99
31_V40_R1.0750.99
76_E81_R1.0730.99
29_E53_R1.0710.99
17_V126_I1.0680.99
239_D256_Y1.0470.98
124_L172_T1.0410.98
188_R212_F1.0410.98
104_L107_K1.0260.98
262_V266_D1.0120.98
14_R43_M1.0110.98
247_C259_T1.0100.98
28_Y125_I1.0080.98
18_T43_M1.0070.98
28_Y123_A1.0070.98
256_Y259_T1.0050.98
27_V48_L1.0020.98
158_Q172_T1.0020.98
207_V211_R0.9970.98
31_V39_S0.9970.98
240_A244_K0.9940.98
100_S108_F0.9920.98
97_V101_K0.9910.98
46_D49_K0.9800.98
211_R215_E0.9790.98
71_W74_H0.9690.97
105_Q108_F0.9650.97
200_I205_V0.9540.97
8_G12_K0.9530.97
160_W168_E0.9520.97
26_I103_I0.9500.97
17_V175_I0.9480.97
68_T276_S0.9440.97
38_S188_R0.9390.97
92_G95_Q0.9360.97
64_D217_Y0.9360.97
189_L194_A0.9330.97
57_L71_W0.9320.97
199_I202_L0.9310.97
211_R234_I0.9270.97
197_D205_V0.9160.96
267_I270_E0.9150.96
28_Y54_I0.9140.96
197_D268_R0.9140.96
56_L136_L0.9140.96
95_Q98_P0.9100.96
82_S85_I0.9090.96
90_G139_R0.9070.96
92_G96_I0.8930.96
20_K23_L0.8900.96
203_Q256_Y0.8860.96
40_R55_M0.8800.96
211_R233_D0.8780.96
71_W75_F0.8780.96
128_I176_L0.8770.95
103_I106_E0.8740.95
122_R160_W0.8720.95
41_N172_T0.8630.95
254_I259_T0.8610.95
201_N205_V0.8570.95
48_L126_I0.8440.94
116_V119_R0.8430.94
187_L191_V0.8410.94
99_A103_I0.8390.94
187_L204_D0.8370.94
267_I275_L0.8340.94
95_Q99_A0.8210.94
96_I104_L0.8210.94
48_L53_R0.8200.94
83_L87_S0.8200.94
193_G196_K0.8190.94
259_T263_I0.8160.93
28_Y136_L0.8100.93
123_A167_L0.8100.93
9_H13_A0.8030.93
14_R17_V0.8000.93
85_I93_L0.7960.93
204_D209_G0.7910.92
70_Q74_H0.7810.92
207_V235_A0.7790.92
209_G277_F0.7750.92
26_I123_A0.7740.91
54_I103_I0.7710.91
234_I237_L0.7690.91
250_S253_L0.7650.91
58_N86_N0.7650.91
71_W278_E0.7570.91
210_L234_I0.7480.90
92_G99_A0.7400.90
224_R227_L0.7370.89
214_E234_I0.7360.89
209_G263_I0.7340.89
13_A17_V0.7340.89
268_R277_F0.7310.89
228_D232_E0.7300.89
122_R168_E0.7300.89
64_D67_V0.7300.89
207_V238_F0.7220.88
59_K62_K0.7200.88
222_K230_I0.7190.88
25_D51_K0.7180.88
209_G213_L0.7170.88
14_R46_D0.7150.88
104_L121_I0.7150.88
103_I107_K0.7140.88
118_P166_E0.7140.88
204_D208_F0.7140.88
216_H220_R0.7120.88
197_D200_I0.7110.88
82_S86_N0.7100.88
85_I96_I0.7090.87
80_I83_L0.7080.87
81_R84_S0.7070.87
201_N204_D0.7060.87
58_N163_V0.7060.87
218_P222_K0.7030.87
54_I96_I0.7000.87
60_A68_T0.6970.87
210_L263_I0.6970.87
201_N212_F0.6960.87
33_A57_L0.6880.86
237_L263_I0.6850.86
242_G245_R0.6840.86
11_A19_E0.6840.86
90_G93_L0.6820.85
180_F185_V0.6800.85
155_T171_D0.6790.85
120_A168_E0.6780.85
91_Q94_N0.6770.85
151_R156_T0.6770.85
7_P12_K0.6750.85
219_E225_Y0.6750.85
242_G252_G0.6720.85
191_V205_V0.6690.84
101_K105_Q0.6690.84
275_L278_E0.6670.84
100_S167_L0.6670.84
142_K157_S0.6660.84
273_G277_F0.6650.84
163_V169_L0.6650.84
197_D202_L0.6640.84
202_L261_E0.6620.84
49_K79_G0.6580.83
81_R86_N0.6570.83
87_S90_G0.6550.83
15_R160_W0.6540.83
58_N85_I0.6500.83
10_M41_N0.6500.83
37_M40_R0.6490.82
74_H279_Q0.6450.82
264_I267_I0.6440.82
191_V208_F0.6410.82
117_K167_L0.6380.81
206_A210_L0.6380.81
176_L193_G0.6370.81
140_L163_V0.6360.81
191_V194_A0.6350.81
56_L93_L0.6320.81
11_A18_T0.6320.81
12_K160_W0.6310.81
227_L230_I0.6300.81
10_M176_L0.6290.80
208_F211_R0.6290.80
26_I168_E0.6260.80
249_M252_G0.6250.80
63_A276_S0.6240.80
263_I267_I0.6210.80
16_E156_T0.6200.80
248_L254_I0.6190.79
33_A63_A0.6190.79
13_A158_Q0.6170.79
60_A87_S0.6130.79
98_P105_Q0.6120.79
191_V264_I0.6100.78
193_G197_D0.6080.78
221_L224_R0.6080.78
145_I161_V0.6050.78
139_R144_N0.6030.78
11_A16_E0.6020.78
205_V208_F0.6020.78
89_N92_G0.6020.78
132_G174_G0.6010.77
204_D207_V0.5990.77
25_D58_N0.5970.77
37_M74_H0.5960.77
217_Y220_R0.5950.77
132_G171_D0.5950.77
151_R154_I0.5920.76
31_V159_Q0.5920.76
129_P153_G0.5910.76
29_E41_N0.5900.76
225_Y241_I0.5900.76
229_E232_E0.5890.76
223_E228_D0.5880.76
219_E229_E0.5880.76
237_L242_G0.5870.76
246_G252_G0.5840.75
64_D68_T0.5840.75
188_R277_F0.5830.75
83_L90_G0.5790.75
26_I54_I0.5790.75
131_V169_L0.5780.75
108_F140_L0.5780.75
21_L220_R0.5760.74
125_I258_K0.5760.74
223_E226_G0.5740.74
192_T275_L0.5740.74
14_R175_I0.5740.74
18_T22_K0.5730.74
88_V92_G0.5730.74
89_N93_L0.5720.74
210_L214_E0.5710.74
93_L97_V0.5670.73
146_A172_T0.5660.73
167_L234_I0.5660.73
137_I275_L0.5660.73
182_D188_R0.5650.73
20_K124_L0.5630.73
38_S185_V0.5630.73
98_P101_K0.5620.73
39_S128_I0.5600.72
183_E186_G0.5580.72
104_L115_G0.5570.72
232_E236_E0.5540.72
90_G95_Q0.5520.71
171_D174_G0.5480.71
76_E82_S0.5480.71
232_E237_L0.5470.71
117_K120_A0.5460.70
90_G96_I0.5450.70
230_I237_L0.5450.70
69_Q72_K0.5440.70
242_G248_L0.5420.70
75_F79_G0.5420.70
189_L192_T0.5420.70
35_I194_A0.5420.70
243_E246_G0.5410.70
81_R103_I0.5400.70
11_A135_T0.5400.70
120_A123_A0.5350.69
190_A277_F0.5330.69
169_L258_K0.5320.68
202_L257_D0.5310.68
20_K265_R0.5300.68
11_A14_R0.5280.68
29_E190_A0.5260.68
69_Q84_S0.5260.68
70_Q102_E0.5240.67
44_I126_I0.5220.67
74_H77_N0.5200.67
255_N261_E0.5180.66
137_I161_V0.5170.66
203_Q207_V0.5160.66
182_D186_G0.5140.66
38_S195_I0.5140.66
45_E49_K0.5130.66
20_K24_I0.5090.65
10_M14_R0.5090.65
124_L197_D0.5090.65
96_I103_I0.5080.65
57_L84_S0.5080.65
239_D254_I0.5080.65
161_V169_L0.5070.65
10_M13_A0.5070.65
93_L108_F0.5070.65
40_R44_I0.5070.65
67_V278_E0.5050.64
84_S87_S0.5050.64
132_G155_T0.5040.64
176_L179_K0.5020.64
242_G247_C0.5020.64
207_V256_Y0.5020.64
222_K225_Y0.5020.64
30_L118_P0.5010.64
88_V97_V0.5010.64
27_V126_I0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pujA 1 0.9255 100 0.25 Contact Map
3cnlA 1 0.8227 100 0.444 Contact Map
3h2yA 1 0.8865 100 0.666 Contact Map
3ec1A 1 0.8972 99.9 0.676 Contact Map
2yv5A 1 0.7589 99.9 0.678 Contact Map
1mkyA 1 0.9326 99.9 0.684 Contact Map
1t9hA 1 0.7305 99.9 0.692 Contact Map
4dcuA 1 0.8972 99.9 0.692 Contact Map
3j8gX 1 0.9433 99.9 0.704 Contact Map
1u0lA 1 0.7411 99.9 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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