GREMLIN Database
RL19 - 50S ribosomal protein L19
UniProt: O31742 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 115 (111)
Sequences: 2147 (868)
Seq/√Len: 82.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_H83_K3.6451.00
50_R57_E3.3451.00
29_H42_I2.7731.00
27_R44_E2.7351.00
46_V100_L2.6801.00
3_K6_E2.6091.00
29_H40_I2.5521.00
26_L47_V2.2981.00
103_L107_A2.2291.00
90_G110_I2.1521.00
9_T56_S1.9791.00
29_H85_E1.9441.00
52_G57_E1.9421.00
20_F47_V1.8811.00
31_K38_E1.8111.00
13_L77_H1.7951.00
27_R87_V1.7821.00
31_K82_A1.7321.00
27_R85_E1.7031.00
53_G57_E1.6791.00
20_F59_F1.6451.00
27_R42_I1.6281.00
71_E101_R1.6261.00
49_K96_K1.6181.00
30_V72_R1.5961.00
6_E10_K1.5801.00
14_R77_H1.5681.00
88_R112_E1.5501.00
33_V38_E1.5160.99
21_R113_I1.4710.99
105_G108_A1.4610.99
33_V36_N1.4520.99
9_T55_I1.4050.99
7_D10_K1.3040.98
91_K113_I1.2790.98
25_T46_V1.2760.98
38_E80_K1.2710.98
33_V80_K1.2680.98
30_V74_F1.2470.98
8_I11_E1.2450.98
44_E87_V1.2450.98
50_R76_V1.2430.98
6_E9_T1.1920.97
49_K73_T1.1650.97
21_R89_Y1.1580.97
91_K111_K1.1490.96
48_I98_Y1.1110.96
89_Y113_I1.1090.96
60_T73_T1.0980.95
97_L100_L1.0950.95
49_K98_Y1.0900.95
16_D77_H1.0470.94
25_T90_G1.0410.94
44_E88_R1.0320.93
10_K13_L1.0300.93
28_V81_I1.0110.93
57_E76_V1.0050.93
5_I8_I0.9820.92
22_P95_A0.9390.90
26_L61_V0.9310.89
7_D11_E0.9200.89
99_Y110_I0.9130.88
51_R58_T0.9020.88
30_V80_K0.8880.87
4_L7_D0.8840.87
100_L105_G0.8680.86
75_P80_K0.8630.85
15_T77_H0.8630.85
63_K66_Y0.8610.85
46_V110_I0.8590.85
28_V59_F0.8440.84
58_T68_V0.8430.84
57_E77_H0.8370.84
47_V59_F0.8310.83
51_R56_S0.8250.83
5_I9_T0.8180.82
30_V81_I0.8110.82
22_P109_R0.8010.81
103_L108_A0.7990.81
14_R17_L0.7910.80
81_I84_I0.7890.80
8_I12_Q0.7840.79
59_F81_I0.7790.79
22_P63_K0.7700.78
3_K7_D0.7650.78
54_G57_E0.7590.77
92_V110_I0.7560.77
5_I11_E0.7420.76
94_R97_L0.7380.75
4_L8_I0.7330.75
51_R73_T0.7280.74
34_E37_R0.7270.74
22_P110_I0.7250.74
38_E82_A0.7250.74
58_T76_V0.7180.73
40_I82_A0.7150.73
86_V89_Y0.7130.73
5_I12_Q0.7060.72
17_L84_I0.7010.71
51_R98_Y0.6980.71
68_V73_T0.6920.70
40_I83_K0.6870.70
65_S108_A0.6830.69
10_K15_T0.6810.69
18_P86_V0.6800.69
20_F24_D0.6700.68
37_R66_Y0.6670.68
24_D89_Y0.6660.68
20_F50_R0.6640.67
60_T75_P0.6550.66
9_T12_Q0.6540.66
21_R97_L0.6470.65
43_F74_F0.6430.65
16_D111_K0.6260.63
42_I83_K0.6260.63
64_I109_R0.6240.62
104_R109_R0.6180.62
44_E85_E0.6140.61
99_Y106_K0.6090.61
43_F61_V0.6050.60
25_T87_V0.6030.60
56_S96_K0.6020.60
32_V37_R0.5980.59
61_V74_F0.5960.59
20_F86_V0.5960.59
48_I101_R0.5940.59
53_G68_V0.5910.58
89_Y110_I0.5900.58
58_T73_T0.5900.58
20_F112_E0.5890.58
59_F73_T0.5850.58
8_I53_G0.5850.58
22_P97_L0.5830.57
59_F76_V0.5820.57
49_K60_T0.5770.57
19_A89_Y0.5760.56
46_V88_R0.5740.56
62_R70_V0.5650.55
22_P66_Y0.5640.55
42_I87_V0.5480.53
72_R109_R0.5460.52
17_L76_V0.5450.52
22_P50_R0.5410.52
94_R99_Y0.5400.52
20_F28_V0.5380.51
75_P112_E0.5370.51
60_T101_R0.5360.51
31_K43_F0.5330.51
24_D90_G0.5330.51
46_V105_G0.5300.50
13_L52_G0.5280.50
19_A50_R0.5240.50
17_L77_H0.5220.49
36_N64_I0.5220.49
89_Y112_E0.5200.49
41_Q63_K0.5160.49
52_G56_S0.5160.49
4_L73_T0.5130.48
4_L11_E0.5090.48
21_R63_K0.5080.47
64_I67_G0.5040.47
55_I77_H0.5010.47
98_Y101_R0.5010.47
95_A98_Y0.5000.46
52_G88_R0.5000.46
42_I68_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6T 1 1 100 0.064 Contact Map
2zjrM 1 0.8783 100 0.067 Contact Map
4tp9P 1 0.9913 100 0.082 Contact Map
3j3wP 1 0.9739 100 0.082 Contact Map
3j7yQ 1 0.9217 100 0.174 Contact Map
3bboR 1 0.9565 100 0.183 Contact Map
1vw4M 1 0.9391 100 0.249 Contact Map
4hczA 1 0.4783 43.1 0.927 Contact Map
1pjrA 1 0.1391 41.8 0.927 Contact Map
4c2tA 1 0.113 25.6 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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