GREMLIN Database
SEPF - Cell division protein SepF
UniProt: O31728 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (138)
Sequences: 1486 (1164)
Seq/√Len: 99.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_D112_Y5.1141.00
79_A110_T3.3261.00
95_I103_I2.9991.00
115_G131_D2.8031.00
82_L114_I2.6871.00
51_N55_L2.2121.00
68_E122_G2.2081.00
65_V81_H2.2041.00
35_Q38_K2.1871.00
34_E37_E2.1381.00
52_V55_L2.1341.00
31_E35_Q2.1051.00
83_K115_G2.0721.00
37_E40_A2.0161.00
104_V108_S1.8971.00
20_Y23_I1.7321.00
4_K7_L1.6871.00
113_A128_C1.6851.00
46_P49_K1.6641.00
31_E34_E1.6121.00
21_E26_E1.5981.00
66_L87_A1.5801.00
102_R105_D1.5511.00
64_V127_L1.5511.00
31_E36_K1.5451.00
79_A112_Y1.5291.00
9_N14_E1.5251.00
70_R94_R1.4821.00
36_K39_P1.4681.00
89_V121_I1.4371.00
26_E31_E1.4341.00
54_S59_Q1.4041.00
53_V57_S1.3981.00
76_Q80_D1.3880.99
79_A108_S1.3780.99
34_E39_P1.3720.99
28_E31_E1.3660.99
33_H36_K1.3400.99
33_H37_E1.3300.99
67_S81_H1.3120.99
7_L11_F1.2960.99
32_E35_Q1.2780.99
53_V56_Q1.2640.99
21_E24_E1.2610.99
93_Q122_G1.2550.99
118_I128_C1.2470.99
64_V92_L1.2410.99
110_T113_A1.2240.99
81_H86_R1.2160.99
25_T28_E1.2040.99
122_G128_C1.1850.98
33_H39_P1.1700.98
22_Y25_T1.1570.98
5_N11_F1.1510.98
93_Q123_S1.1350.98
27_R34_E1.1310.98
62_S93_Q1.1190.98
79_A102_R1.1010.97
121_I127_L1.0900.97
95_I99_Q1.0850.97
79_A104_V1.0760.97
90_V107_L1.0580.97
72_Y97_H1.0480.96
65_V86_R1.0470.96
35_Q39_P1.0420.96
24_E28_E1.0380.96
120_R126_F1.0320.96
100_A104_V1.0270.96
11_F14_E1.0250.96
32_E39_P1.0130.96
8_K11_F1.0070.95
78_I90_V0.9870.95
114_I120_R0.9730.95
31_E39_P0.9670.94
104_V111_V0.9640.94
95_I125_I0.9520.94
30_H34_E0.9450.94
104_V127_L0.9450.94
5_N9_N0.9410.94
32_E36_K0.9370.93
7_L14_E0.9230.93
93_Q108_S0.9220.93
108_S115_G0.9190.93
33_H38_K0.9190.93
67_S88_V0.9100.92
31_E41_Y0.9060.92
38_K41_Y0.9020.92
32_E37_E0.8780.91
127_L135_V0.8740.91
64_V85_R0.8690.91
72_Y128_C0.8670.90
22_Y40_A0.8590.90
85_R131_D0.8540.90
5_N8_K0.8480.89
34_E38_K0.8470.89
17_E24_E0.8470.89
36_K40_A0.8440.89
107_L122_G0.8430.89
66_L93_Q0.8360.89
111_V128_C0.8310.88
64_V86_R0.8300.88
86_R96_Q0.8220.88
68_E94_R0.8110.87
30_H36_K0.8090.87
2_S5_N0.8060.87
137_G141_E0.8020.87
18_Y30_H0.8000.87
54_S57_S0.7990.86
29_S36_K0.7980.86
5_N13_M0.7930.86
64_V124_D0.7930.86
18_Y27_R0.7880.86
9_N12_S0.7860.86
76_Q102_R0.7830.85
118_I141_E0.7810.85
30_H33_H0.7790.85
10_F13_M0.7750.85
29_S34_E0.7660.84
23_I27_R0.7610.84
32_E38_K0.7560.83
97_H118_I0.7550.83
25_T33_H0.7530.83
23_I34_E0.7510.83
83_K114_I0.7510.83
29_S32_E0.7500.83
74_E92_L0.7390.82
107_L110_T0.7340.81
27_R33_H0.7260.81
16_E91_N0.7230.80
8_K14_E0.7230.80
60_K125_I0.7190.80
69_P78_I0.7130.80
19_E23_I0.7090.79
92_L122_G0.7060.79
120_R123_S0.7040.79
7_L10_F0.6850.77
87_A116_G0.6820.76
87_A125_I0.6790.76
111_V126_F0.6760.76
7_L82_L0.6740.76
102_R110_T0.6730.76
21_E25_T0.6730.76
104_V126_F0.6720.75
51_N54_S0.6690.75
23_I26_E0.6680.75
84_N117_D0.6660.75
24_E40_A0.6640.75
63_K92_L0.6620.74
92_L128_C0.6620.74
89_V125_I0.6600.74
20_Y25_T0.6570.74
82_L91_N0.6570.74
74_E77_E0.6550.74
90_V135_V0.6510.73
31_E40_A0.6500.73
36_K41_Y0.6460.73
68_E128_C0.6450.72
71_V74_E0.6360.71
52_V57_S0.6310.71
67_S95_I0.6290.71
110_T114_I0.6280.70
37_E47_A0.6280.70
83_K92_L0.6270.70
34_E49_K0.6260.70
23_I28_E0.6250.70
104_V118_I0.6240.70
74_E133_V0.6230.70
41_Y46_P0.6200.69
25_T31_E0.6180.69
102_R108_S0.6150.69
32_E40_A0.6100.68
37_E41_Y0.6090.68
29_S33_H0.6090.68
102_R138_T0.6070.68
74_E87_A0.6030.67
83_K125_I0.6000.67
26_E37_E0.5980.67
24_E35_Q0.5980.67
31_E38_K0.5950.66
22_Y39_P0.5940.66
75_A79_A0.5890.66
87_A133_V0.5880.65
8_K72_Y0.5810.64
94_R99_Q0.5780.64
68_E91_N0.5740.64
25_T30_H0.5720.63
64_V83_K0.5710.63
101_K126_F0.5650.62
41_Y47_A0.5650.62
93_Q99_Q0.5580.61
8_K12_S0.5440.59
72_Y95_I0.5420.59
90_V128_C0.5350.58
76_Q87_A0.5310.58
77_E81_H0.5280.57
35_Q48_G0.5270.57
62_S132_N0.5260.57
84_N107_L0.5240.57
134_D137_G0.5230.56
65_V88_V0.5220.56
36_K46_P0.5190.56
16_E23_I0.5170.56
4_K9_N0.5160.55
33_H40_A0.5130.55
90_V103_I0.5100.55
6_K13_M0.5060.54
66_L139_I0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zihA 2 0.5298 100 0.35 Contact Map
3p04A 2 0.5166 100 0.389 Contact Map
3zieA 2 0.5497 99.9 0.438 Contact Map
3zigA 2 0.5364 99.9 0.447 Contact Map
4gyiA 1 0.0993 22.6 0.932 Contact Map
2i3bA 1 0.6755 17.2 0.936 Contact Map
1jeyA 1 0.6887 13.6 0.939 Contact Map
1k0wA 3 0.3974 13.6 0.939 Contact Map
3f2gA 1 0.596 10.5 0.942 Contact Map
3tnpB 1 0.6424 9.6 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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