SEPF - BACSU - GREMLIN Contacts

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SEPF - Cell division protein SepF

UniProt:	O31728	Sequences: MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGNKPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKRIVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	151 (138)
Sequences:	1486 (1164)
Seq/√Len:	99.1

BACSU - SEPF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_D	112_Y	5.114	1.00
79_A	110_T	3.326	1.00
95_I	103_I	2.999	1.00
115_G	131_D	2.803	1.00
82_L	114_I	2.687	1.00
51_N	55_L	2.212	1.00
68_E	122_G	2.208	1.00
65_V	81_H	2.204	1.00
35_Q	38_K	2.187	1.00
34_E	37_E	2.138	1.00
52_V	55_L	2.134	1.00
31_E	35_Q	2.105	1.00
83_K	115_G	2.072	1.00
37_E	40_A	2.016	1.00
104_V	108_S	1.897	1.00
20_Y	23_I	1.732	1.00
4_K	7_L	1.687	1.00
113_A	128_C	1.685	1.00
46_P	49_K	1.664	1.00
31_E	34_E	1.612	1.00
21_E	26_E	1.598	1.00
66_L	87_A	1.580	1.00
102_R	105_D	1.551	1.00
64_V	127_L	1.551	1.00
31_E	36_K	1.545	1.00
79_A	112_Y	1.529	1.00
9_N	14_E	1.525	1.00
70_R	94_R	1.482	1.00
36_K	39_P	1.468	1.00
89_V	121_I	1.437	1.00
26_E	31_E	1.434	1.00
54_S	59_Q	1.404	1.00
53_V	57_S	1.398	1.00
76_Q	80_D	1.388	0.99
79_A	108_S	1.378	0.99
34_E	39_P	1.372	0.99
28_E	31_E	1.366	0.99
33_H	36_K	1.340	0.99
33_H	37_E	1.330	0.99
67_S	81_H	1.312	0.99
7_L	11_F	1.296	0.99
32_E	35_Q	1.278	0.99
53_V	56_Q	1.264	0.99
21_E	24_E	1.261	0.99
93_Q	122_G	1.255	0.99
118_I	128_C	1.247	0.99
64_V	92_L	1.241	0.99
110_T	113_A	1.224	0.99
81_H	86_R	1.216	0.99
25_T	28_E	1.204	0.99
122_G	128_C	1.185	0.98
33_H	39_P	1.170	0.98
22_Y	25_T	1.157	0.98
5_N	11_F	1.151	0.98
93_Q	123_S	1.135	0.98
27_R	34_E	1.131	0.98
62_S	93_Q	1.119	0.98
79_A	102_R	1.101	0.97
121_I	127_L	1.090	0.97
95_I	99_Q	1.085	0.97
79_A	104_V	1.076	0.97
90_V	107_L	1.058	0.97
72_Y	97_H	1.048	0.96
65_V	86_R	1.047	0.96
35_Q	39_P	1.042	0.96
24_E	28_E	1.038	0.96
120_R	126_F	1.032	0.96
100_A	104_V	1.027	0.96
11_F	14_E	1.025	0.96
32_E	39_P	1.013	0.96
8_K	11_F	1.007	0.95
78_I	90_V	0.987	0.95
114_I	120_R	0.973	0.95
31_E	39_P	0.967	0.94
104_V	111_V	0.964	0.94
95_I	125_I	0.952	0.94
30_H	34_E	0.945	0.94
104_V	127_L	0.945	0.94
5_N	9_N	0.941	0.94
32_E	36_K	0.937	0.93
7_L	14_E	0.923	0.93
93_Q	108_S	0.922	0.93
108_S	115_G	0.919	0.93
33_H	38_K	0.919	0.93
67_S	88_V	0.910	0.92
31_E	41_Y	0.906	0.92
38_K	41_Y	0.902	0.92
32_E	37_E	0.878	0.91
127_L	135_V	0.874	0.91
64_V	85_R	0.869	0.91
72_Y	128_C	0.867	0.90
22_Y	40_A	0.859	0.90
85_R	131_D	0.854	0.90
5_N	8_K	0.848	0.89
34_E	38_K	0.847	0.89
17_E	24_E	0.847	0.89
36_K	40_A	0.844	0.89
107_L	122_G	0.843	0.89
66_L	93_Q	0.836	0.89
111_V	128_C	0.831	0.88
64_V	86_R	0.830	0.88
86_R	96_Q	0.822	0.88
68_E	94_R	0.811	0.87
30_H	36_K	0.809	0.87
2_S	5_N	0.806	0.87
137_G	141_E	0.802	0.87
18_Y	30_H	0.800	0.87
54_S	57_S	0.799	0.86
29_S	36_K	0.798	0.86
5_N	13_M	0.793	0.86
64_V	124_D	0.793	0.86
18_Y	27_R	0.788	0.86
9_N	12_S	0.786	0.86
76_Q	102_R	0.783	0.85
118_I	141_E	0.781	0.85
30_H	33_H	0.779	0.85
10_F	13_M	0.775	0.85
29_S	34_E	0.766	0.84
23_I	27_R	0.761	0.84
32_E	38_K	0.756	0.83
97_H	118_I	0.755	0.83
25_T	33_H	0.753	0.83
23_I	34_E	0.751	0.83
83_K	114_I	0.751	0.83
29_S	32_E	0.750	0.83
74_E	92_L	0.739	0.82
107_L	110_T	0.734	0.81
27_R	33_H	0.726	0.81
16_E	91_N	0.723	0.80
8_K	14_E	0.723	0.80
60_K	125_I	0.719	0.80
69_P	78_I	0.713	0.80
19_E	23_I	0.709	0.79
92_L	122_G	0.706	0.79
120_R	123_S	0.704	0.79
7_L	10_F	0.685	0.77
87_A	116_G	0.682	0.76
87_A	125_I	0.679	0.76
111_V	126_F	0.676	0.76
7_L	82_L	0.674	0.76
102_R	110_T	0.673	0.76
21_E	25_T	0.673	0.76
104_V	126_F	0.672	0.75
51_N	54_S	0.669	0.75
23_I	26_E	0.668	0.75
84_N	117_D	0.666	0.75
24_E	40_A	0.664	0.75
63_K	92_L	0.662	0.74
92_L	128_C	0.662	0.74
89_V	125_I	0.660	0.74
20_Y	25_T	0.657	0.74
82_L	91_N	0.657	0.74
74_E	77_E	0.655	0.74
90_V	135_V	0.651	0.73
31_E	40_A	0.650	0.73
36_K	41_Y	0.646	0.73
68_E	128_C	0.645	0.72
71_V	74_E	0.636	0.71
52_V	57_S	0.631	0.71
67_S	95_I	0.629	0.71
110_T	114_I	0.628	0.70
37_E	47_A	0.628	0.70
83_K	92_L	0.627	0.70
34_E	49_K	0.626	0.70
23_I	28_E	0.625	0.70
104_V	118_I	0.624	0.70
74_E	133_V	0.623	0.70
41_Y	46_P	0.620	0.69
25_T	31_E	0.618	0.69
102_R	108_S	0.615	0.69
32_E	40_A	0.610	0.68
37_E	41_Y	0.609	0.68
29_S	33_H	0.609	0.68
102_R	138_T	0.607	0.68
74_E	87_A	0.603	0.67
83_K	125_I	0.600	0.67
26_E	37_E	0.598	0.67
24_E	35_Q	0.598	0.67
31_E	38_K	0.595	0.66
22_Y	39_P	0.594	0.66
75_A	79_A	0.589	0.66
87_A	133_V	0.588	0.65
8_K	72_Y	0.581	0.64
94_R	99_Q	0.578	0.64
68_E	91_N	0.574	0.64
25_T	30_H	0.572	0.63
64_V	83_K	0.571	0.63
101_K	126_F	0.565	0.62
41_Y	47_A	0.565	0.62
93_Q	99_Q	0.558	0.61
8_K	12_S	0.544	0.59
72_Y	95_I	0.542	0.59
90_V	128_C	0.535	0.58
76_Q	87_A	0.531	0.58
77_E	81_H	0.528	0.57
35_Q	48_G	0.527	0.57
62_S	132_N	0.526	0.57
84_N	107_L	0.524	0.57
134_D	137_G	0.523	0.56
65_V	88_V	0.522	0.56
36_K	46_P	0.519	0.56
16_E	23_I	0.517	0.56
4_K	9_N	0.516	0.55
33_H	40_A	0.513	0.55
90_V	103_I	0.510	0.55
6_K	13_M	0.506	0.54
66_L	139_I	0.500	0.53

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zihA	2	0.5298	100	0.35	Contact Map
3p04A	2	0.5166	100	0.389	Contact Map
3zieA	2	0.5497	99.9	0.438	Contact Map
3zigA	2	0.5364	99.9	0.447	Contact Map
4gyiA	1	0.0993	22.6	0.932	Contact Map
2i3bA	1	0.6755	17.2	0.936	Contact Map
1jeyA	1	0.6887	13.6	0.939	Contact Map
1k0wA	3	0.3974	13.6	0.939	Contact Map
3f2gA	1	0.596	10.5	0.942	Contact Map
3tnpB	1	0.6424	9.6	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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