GREMLIN Database
YLMD - Laccase domain protein YlmD
UniProt: O31726 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (237)
Sequences: 3216 (2409)
Seq/√Len: 156.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_V178_I3.2551.00
190_C248_C3.2461.00
190_C251_S3.0771.00
136_F147_V2.9061.00
64_K67_E2.7551.00
148_A163_M2.7071.00
252_E255_L2.5941.00
129_F271_S2.5351.00
137_F148_A2.5011.00
44_K47_E2.4371.00
195_D199_D2.4261.00
43_Q61_D2.4201.00
64_K68_Y2.3641.00
115_G163_M2.3011.00
135_L160_G2.2751.00
141_V177_D2.2171.00
161_R231_I2.1981.00
133_V185_S2.1921.00
189_A251_S2.1681.00
89_N162_E2.1411.00
226_E229_R2.1151.00
84_D112_A2.1091.00
35_T69_I2.0531.00
115_G148_A2.0391.00
185_S225_K1.9541.00
144_L167_W1.9321.00
49_L69_I1.9191.00
58_K61_D1.9121.00
191_Y222_L1.9091.00
137_F180_A1.9011.00
53_L63_V1.8581.00
187_S190_C1.7911.00
216_A219_Q1.7711.00
247_L252_E1.7651.00
137_F178_I1.7521.00
137_F163_M1.7241.00
187_S248_C1.7041.00
124_F274_G1.6001.00
229_R233_M1.5741.00
89_N157_K1.5701.00
133_V228_N1.5701.00
155_T228_N1.5671.00
162_E165_K1.5531.00
41_V64_K1.5481.00
173_S178_I1.5331.00
34_F271_S1.5261.00
186_I250_E1.5241.00
139_D143_S1.4871.00
247_L256_F1.4781.00
90_R112_A1.4671.00
41_V61_D1.4471.00
164_V235_S1.4411.00
247_L255_L1.4391.00
147_V273_I1.4371.00
158_Q161_R1.4311.00
140_P177_D1.4281.00
48_S257_Y1.4261.00
180_A232_L1.4131.00
30_V275_M1.4121.00
198_M202_R1.4091.00
225_K244_V1.3931.00
198_M212_A1.3791.00
145_V273_I1.3651.00
229_R244_V1.3641.00
198_M220_Y1.3591.00
59_D63_V1.3401.00
194_D197_V1.3391.00
46_F265_K1.3341.00
93_K119_N1.3171.00
41_V68_Y1.3141.00
92_Q113_T1.3041.00
116_I125_L1.2911.00
156_V201_V1.2911.00
117_Y146_G1.2811.00
150_A228_N1.2801.00
126_A270_M1.2791.00
148_A160_G1.2601.00
192_T219_Q1.2591.00
190_C250_E1.2581.00
96_Q120_E1.2581.00
140_P179_Y1.2561.00
136_F271_S1.2501.00
80_W126_A1.2461.00
86_T112_A1.2451.00
142_K173_S1.2431.00
136_F273_I1.2351.00
83_A116_I1.2231.00
144_L173_S1.1981.00
226_E230_L1.1961.00
160_G228_N1.1961.00
238_A241_Q1.1871.00
75_T124_F1.1871.00
69_I272_F1.1851.00
51_T69_I1.1781.00
93_K171_E1.1711.00
187_S251_S1.1711.00
34_F269_M1.1691.00
225_K245_S1.1681.00
91_V162_E1.1641.00
94_V116_I1.1611.00
125_L145_V1.1571.00
38_N255_L1.1481.00
199_D203_A1.1481.00
259_H266_T1.1441.00
140_P241_Q1.1381.00
83_A127_L1.1281.00
83_A113_T1.1251.00
51_T270_M1.1231.00
134_P183_G1.1221.00
82_F126_A1.1211.00
248_C251_S1.1201.00
117_Y167_W1.1081.00
168_T175_P1.1071.00
153_K157_K1.1010.99
180_A237_L1.0780.99
55_V266_T1.0720.99
35_T272_F1.0570.99
164_V237_L1.0470.99
118_T123_V1.0420.99
139_D275_M1.0370.99
127_L147_V1.0330.99
95_T98_D1.0280.99
139_D167_W1.0280.99
146_G163_M1.0240.99
138_Y179_Y1.0230.99
124_F272_F1.0220.99
188_G223_D1.0190.99
139_D144_L1.0120.99
173_S177_D1.0100.99
214_Q221_Q1.0090.99
115_G159_I1.0010.99
26_N179_Y0.9920.99
223_D226_E0.9840.99
54_H84_D0.9680.99
118_T125_L0.9660.99
76_D79_S0.9570.99
27_N30_V0.9540.99
79_S99_R0.9470.98
179_Y241_Q0.9440.98
211_A226_E0.9440.98
165_K169_E0.9390.98
39_G42_S0.9360.98
49_L68_Y0.9260.98
29_E275_M0.9250.98
27_N138_Y0.9240.98
133_V182_I0.9230.98
34_F181_V0.9210.98
166_Q169_E0.9100.98
211_A230_L0.9100.98
165_K235_S0.9100.98
165_K168_T0.9050.98
70_A80_W0.9040.98
250_E261_R0.9010.98
195_D220_Y0.8980.98
128_C270_M0.8970.98
93_K117_Y0.8910.98
29_E138_Y0.8900.98
262_D266_T0.8840.98
253_P261_R0.8800.98
81_V123_V0.8790.97
75_T274_G0.8730.97
156_V200_A0.8710.97
224_L250_E0.8690.97
135_L148_A0.8670.97
54_H128_C0.8600.97
94_V125_L0.8600.97
129_F147_V0.8570.97
208_A227_L0.8560.97
91_V163_M0.8520.97
55_V268_R0.8480.97
117_Y166_Q0.8480.97
137_F160_G0.8440.97
139_D173_S0.8430.97
158_Q231_I0.8310.96
117_Y144_L0.8210.96
201_V205_P0.8200.96
207_S230_L0.8170.96
153_K200_A0.8140.96
83_A128_C0.8140.96
95_T120_E0.8110.96
214_Q217_K0.8100.96
159_I162_E0.8070.96
174_N177_D0.8030.96
135_L180_A0.7930.95
180_A235_S0.7830.95
76_D80_W0.7830.95
82_F128_C0.7820.95
230_L234_D0.7780.95
90_R113_T0.7760.95
197_V200_A0.7760.95
74_N77_L0.7760.95
225_K247_L0.7750.95
142_K177_D0.7730.95
158_Q234_D0.7610.94
253_P262_D0.7600.94
81_V98_D0.7550.94
30_V138_Y0.7530.94
40_G57_D0.7510.94
33_G272_F0.7470.94
39_G48_S0.7440.94
155_T227_L0.7440.94
91_V117_Y0.7430.94
94_V123_V0.7430.94
67_E71_D0.7420.93
88_D157_K0.7410.93
119_N171_E0.7400.93
120_E123_V0.7380.93
233_M242_I0.7350.93
33_G73_F0.7350.93
55_V62_V0.7300.93
54_H66_R0.7290.93
143_S275_M0.7280.93
156_V197_V0.7280.93
158_Q204_L0.7280.93
117_Y163_M0.7270.93
52_G55_V0.7270.93
119_N144_L0.7260.93
93_K169_E0.7210.92
191_Y250_E0.7180.92
31_I274_G0.7170.92
93_K166_Q0.7160.92
213_N221_Q0.7160.92
259_H262_D0.7160.92
133_V224_L0.7120.92
150_A155_T0.7120.92
200_A203_A0.7090.92
144_L178_I0.7080.92
42_S65_N0.7070.92
125_L146_G0.7060.92
89_N159_I0.7020.91
188_G225_K0.7000.91
252_E256_F0.6930.91
57_D62_V0.6930.91
150_A154_G0.6870.91
34_F184_P0.6810.90
195_D198_M0.6800.90
75_T80_W0.6760.90
161_R165_K0.6720.90
231_I235_S0.6700.89
40_G65_N0.6700.89
181_V243_S0.6690.89
229_R242_I0.6650.89
138_Y143_S0.6640.89
95_T119_N0.6620.89
138_Y275_M0.6600.89
121_K143_S0.6590.89
167_W178_I0.6590.89
35_T51_T0.6570.89
61_D64_K0.6530.88
205_P230_L0.6510.88
139_D142_K0.6510.88
186_I191_Y0.6480.88
215_T219_Q0.6480.88
66_R268_R0.6460.88
152_W197_V0.6460.88
127_L271_S0.6450.88
53_L59_D0.6450.88
222_L227_L0.6440.88
182_I244_V0.6420.87
53_L66_R0.6410.87
53_L84_D0.6400.87
237_L242_I0.6380.87
187_S250_E0.6360.87
129_F269_M0.6330.87
38_N48_S0.6320.87
213_N216_A0.6310.86
45_P265_K0.6310.86
50_N57_D0.6280.86
84_D111_K0.6280.86
213_N217_K0.6280.86
45_P266_T0.6250.86
228_N231_I0.6240.86
32_A181_V0.6230.86
77_L80_W0.6220.86
188_G221_Q0.6220.86
133_V155_T0.6180.85
215_T221_Q0.6160.85
195_D218_A0.6150.85
244_V247_L0.6140.85
197_V201_V0.6130.85
208_A231_I0.6110.85
150_A159_I0.6050.84
81_V94_V0.6040.84
147_V271_S0.6040.84
214_Q219_Q0.6040.84
52_G268_R0.6010.84
205_P231_I0.6010.84
139_D177_D0.5990.84
150_A224_L0.5990.84
82_F270_M0.5960.83
129_F134_P0.5950.83
63_V67_E0.5950.83
191_Y219_Q0.5950.83
194_D219_Q0.5930.83
230_L233_M0.5920.83
76_D124_F0.5880.82
185_S244_V0.5840.82
39_G65_N0.5820.82
69_I270_M0.5800.82
90_R162_E0.5790.81
121_K275_M0.5770.81
157_K200_A0.5750.81
93_K144_L0.5730.81
144_L171_E0.5680.80
205_P234_D0.5640.80
91_V166_Q0.5620.80
68_Y71_D0.5610.79
192_T221_Q0.5610.79
91_V115_G0.5600.79
155_T160_G0.5600.79
35_T73_F0.5590.79
186_I193_V0.5590.79
81_V116_I0.5590.79
189_A221_Q0.5580.79
259_H265_K0.5580.79
186_I224_L0.5570.79
36_T256_F0.5570.79
75_T272_F0.5540.79
126_A272_F0.5510.78
210_L230_L0.5490.78
115_G129_F0.5480.78
110_L113_T0.5460.78
208_A230_L0.5450.77
88_D112_A0.5430.77
70_A79_S0.5370.76
75_T79_S0.5370.76
168_T174_N0.5310.76
88_D154_G0.5310.76
152_W221_Q0.5300.75
77_L124_F0.5270.75
191_Y221_Q0.5260.75
36_T252_E0.5260.75
27_N179_Y0.5250.75
43_Q58_K0.5250.75
42_S61_D0.5240.75
55_V66_R0.5230.75
193_V197_V0.5220.74
73_F272_F0.5190.74
60_A63_V0.5170.74
117_Y171_E0.5170.74
196_R200_A0.5150.73
207_S234_D0.5150.73
156_V204_L0.5150.73
136_F269_M0.5120.73
189_A250_E0.5120.73
195_D219_Q0.5120.73
202_R209_D0.5090.73
139_D179_Y0.5090.73
161_R235_S0.5080.72
195_D217_K0.5070.72
92_Q95_T0.5070.72
93_K120_E0.5070.72
248_C262_D0.5040.72
138_Y142_K0.5010.71
179_Y243_S0.5010.71
36_T269_M0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t8hA 1 0.9748 100 0.103 Contact Map
1xfjA 1 0.9029 100 0.142 Contact Map
1z9tA 1 0.8633 100 0.158 Contact Map
1rv9A 1 0.8705 100 0.16 Contact Map
2f9zC 1 0.4784 34.5 0.965 Contact Map
1np7A 1 0.5827 23.3 0.968 Contact Map
1owlA 1 0.5647 14.5 0.971 Contact Map
3ch0A 1 0.3777 11.1 0.972 Contact Map
4g55A 1 0.2122 9.6 0.973 Contact Map
4k0rA 1 0.5144 7.8 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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