GREMLIN Database
FAPD - N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase
UniProt: O31724 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (360)
Sequences: 29114 (20870)
Seq/√Len: 1099.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_K149_I3.3501.00
47_A51_N3.0201.00
25_T45_W2.8531.00
114_L399_K2.6881.00
214_I222_G2.6501.00
47_A59_K2.5631.00
355_K418_S2.5511.00
74_K147_D2.5251.00
299_E303_N2.4511.00
355_K414_D2.4371.00
83_S147_D2.4311.00
295_A299_E2.4261.00
351_A418_S2.3501.00
49_Y52_E2.3331.00
198_E276_E2.3091.00
53_L135_K2.2561.00
136_L413_L2.2411.00
50_L71_G2.2171.00
265_E278_R2.1971.00
229_M264_I2.1811.00
228_K317_P2.1751.00
229_M277_C2.1691.00
83_S149_I2.1361.00
45_W49_Y2.1271.00
72_K147_D2.1171.00
296_A300_D2.1031.00
229_M279_L2.0931.00
136_L140_A2.0701.00
85_I173_A2.0581.00
263_V280_W2.0161.00
29_Y45_W1.9801.00
16_K406_V1.9551.00
198_E278_R1.9521.00
350_T354_Q1.9441.00
40_E44_S1.9361.00
356_V414_D1.9131.00
18_E135_K1.9071.00
200_K276_E1.9031.00
231_K234_A1.8961.00
103_H111_K1.8791.00
230_A233_I1.8611.00
196_W278_R1.8071.00
349_L415_F1.7701.00
48_G52_E1.7611.00
41_G44_S1.7421.00
232_I302_V1.7401.00
49_Y53_L1.7201.00
44_S48_G1.7111.00
102_K397_N1.6871.00
200_K318_V1.6871.00
164_L168_K1.6801.00
22_L49_Y1.6571.00
303_N307_D1.6521.00
223_A228_K1.6491.00
55_F73_L1.6471.00
19_L409_T1.6421.00
45_W48_G1.6341.00
77_D145_P1.6331.00
414_D417_I1.6171.00
212_N223_A1.6111.00
24_K28_S1.6071.00
230_A234_A1.6041.00
354_Q360_C1.5991.00
225_A277_C1.5991.00
297_E300_D1.5921.00
292_D296_A1.5901.00
135_K139_E1.5831.00
266_G277_C1.5831.00
196_W280_W1.5801.00
25_T28_S1.5751.00
104_D107_H1.5741.00
21_Q25_T1.5721.00
231_K309_D1.5571.00
47_A69_V1.5481.00
44_S59_K1.5431.00
213_M275_D1.5311.00
43_Q90_V1.5291.00
227_E237_G1.5181.00
17_E21_Q1.5151.00
25_T41_G1.5041.00
290_T293_Q1.5031.00
56_S74_K1.4981.00
40_E67_P1.4961.00
46_I90_V1.4921.00
347_L350_T1.4911.00
129_C408_Y1.4841.00
235_G301_Y1.4661.00
199_I232_I1.4651.00
48_G51_N1.4571.00
25_T29_Y1.4471.00
85_I151_Q1.4451.00
198_E320_K1.4341.00
414_D418_S1.4241.00
51_N57_I1.4211.00
348_A418_S1.4111.00
352_S418_S1.4041.00
293_Q297_E1.4001.00
113_G403_E1.3971.00
235_G304_R1.3961.00
47_A57_I1.3961.00
82_Y174_D1.3911.00
85_I176_A1.3801.00
165_E168_K1.3791.00
49_Y135_K1.3771.00
19_L132_F1.3611.00
51_N59_K1.3611.00
380_I383_V1.3561.00
28_S110_E1.3451.00
218_G221_F1.3321.00
56_S72_K1.3211.00
296_A299_E1.3151.00
138_R141_S1.3121.00
165_E169_R1.3111.00
20_I24_K1.3091.00
407_E410_K1.3041.00
196_W322_G1.2971.00
257_N294_V1.2891.00
73_L138_R1.2881.00
21_Q24_K1.2781.00
295_A323_G1.2741.00
243_W297_E1.2711.00
406_V410_K1.2691.00
353_H411_I1.2671.00
231_K308_S1.2661.00
22_L132_F1.2651.00
300_D304_R1.2621.00
44_S47_A1.2541.00
125_G405_L1.2531.00
86_I130_V1.2511.00
31_T42_I1.2491.00
88_G123_M1.2421.00
22_L45_W1.2391.00
356_V410_K1.2271.00
226_I266_G1.2261.00
255_G287_P1.2261.00
110_E402_I1.2251.00
18_E21_Q1.2221.00
125_G400_V1.2201.00
352_S414_D1.2181.00
350_T363_I1.2161.00
403_E407_E1.2151.00
58_D72_K1.2121.00
348_A352_S1.2051.00
351_A355_K1.1941.00
140_A413_L1.1911.00
103_H109_I1.1801.00
352_S356_V1.1781.00
26_L42_I1.1741.00
22_L135_K1.1631.00
76_T145_P1.1621.00
226_I264_I1.1601.00
33_A158_V1.1521.00
86_I416_I1.1471.00
57_I60_W1.1431.00
134_V150_L1.1291.00
16_K403_E1.1241.00
83_S174_D1.1151.00
300_D303_N1.1151.00
293_Q296_A1.1121.00
27_I117_G1.1111.00
200_K320_K1.1071.00
24_K110_E1.1071.00
19_L128_A1.1031.00
347_L351_A1.0971.00
322_G331_G1.0961.00
27_I120_A1.0951.00
235_G238_E1.0911.00
43_Q69_V1.0871.00
25_T49_Y1.0841.00
287_P290_T1.0831.00
354_Q359_E1.0811.00
239_L297_E1.0741.00
401_S404_Q1.0701.00
16_K20_I1.0671.00
302_V319_F1.0631.00
28_S107_H1.0631.00
114_L401_S1.0601.00
301_Y305_L1.0601.00
303_N306_S1.0551.00
24_K108_P1.0541.00
41_G45_W1.0541.00
29_Y41_G1.0411.00
183_D393_A1.0401.00
297_E301_Y1.0391.00
77_D81_Y1.0391.00
140_A417_I1.0381.00
78_S81_Y1.0361.00
233_I279_L1.0351.00
179_A412_I1.0321.00
234_A238_E1.0291.00
82_Y146_G1.0281.00
55_F71_G1.0271.00
301_Y304_R1.0251.00
30_Q38_N1.0221.00
46_I127_M1.0161.00
24_K402_I1.0131.00
81_Y146_G1.0111.00
235_G305_L1.0091.00
351_A354_Q1.0091.00
343_H347_L1.0081.00
306_S319_F1.0051.00
261_P281_I1.0031.00
113_G401_S0.9921.00
269_H272_F0.9891.00
125_G181_T0.9861.00
18_E22_L0.9861.00
38_N41_G0.9771.00
376_Y381_P0.9751.00
96_K112_N0.9741.00
413_L417_I0.9721.00
73_L144_L0.9711.00
130_V150_L0.9681.00
132_F135_K0.9671.00
236_L298_I0.9611.00
68_N154_I0.9601.00
164_L374_W0.9601.00
231_K238_E0.9511.00
133_A413_L0.9501.00
227_E233_I0.9461.00
223_A317_P0.9451.00
400_V405_L0.9421.00
50_L131_L0.9381.00
352_S355_K0.9371.00
299_E321_W0.9361.00
19_L405_L0.9311.00
190_G195_G0.9291.00
90_V127_M0.9281.00
110_E113_G0.9281.00
90_V152_S0.9271.00
410_K414_D0.9261.00
57_I71_G0.9241.00
88_G127_M0.9211.00
75_G147_D0.9211.00
37_R155_G0.9201.00
231_K235_G0.9201.00
101_W104_D0.9171.00
136_L410_K0.9151.00
270_A280_W0.9141.00
386_G389_D0.9141.00
190_G193_I0.9051.00
233_I261_P0.9051.00
379_G382_C0.9021.00
43_Q47_A0.8991.00
100_E103_H0.8961.00
26_L45_W0.8941.00
304_R307_D0.8921.00
409_T413_L0.8921.00
295_A332_E0.8881.00
133_A412_I0.8881.00
348_A351_A0.8851.00
49_Y131_L0.8791.00
18_E49_Y0.8761.00
188_G365_V0.8761.00
175_F419_W0.8751.00
55_F134_V0.8741.00
304_R308_S0.8701.00
305_L308_S0.8701.00
105_P108_P0.8661.00
43_Q59_K0.8631.00
233_I264_I0.8621.00
175_F345_G0.8621.00
404_Q407_E0.8611.00
229_M233_I0.8601.00
195_G295_A0.8551.00
95_V106_F0.8521.00
264_I277_C0.8521.00
199_I229_M0.8501.00
161_A165_E0.8461.00
231_K237_G0.8431.00
344_P347_L0.8421.00
61_D65_G0.8401.00
111_K114_L0.8401.00
261_P279_L0.8381.00
70_V149_I0.8371.00
53_L138_R0.8371.00
342_G345_G0.8351.00
265_E268_R0.8331.00
349_L383_V0.8331.00
75_G78_S0.8321.00
227_E230_A0.8301.00
103_H107_H0.8271.00
99_E103_H0.8231.00
348_A415_F0.8221.00
197_I279_L0.8211.00
73_L134_V0.8201.00
226_I277_C0.8191.00
149_I173_A0.8181.00
392_N395_S0.8151.00
25_T48_G0.8131.00
102_K111_K0.8131.00
346_V350_T0.8101.00
103_H106_F0.8071.00
108_P111_K0.8051.00
285_F291_H0.8041.00
227_E238_E0.8021.00
403_E406_V0.7981.00
288_N292_D0.7941.00
76_T143_E0.7931.00
58_D170_G0.7931.00
192_V195_G0.7891.00
31_T124_K0.7861.00
18_E132_F0.7831.00
228_K309_D0.7821.00
86_I133_A0.7791.00
22_L25_T0.7761.00
134_V138_R0.7761.00
195_G281_I0.7751.00
103_H108_P0.7741.00
109_I112_N0.7731.00
405_L409_T0.7721.00
344_P348_A0.7701.00
111_K116_I0.7691.00
42_I90_V0.7671.00
193_I197_I0.7651.00
292_D295_A0.7651.00
129_C412_I0.7641.00
236_L259_I0.7631.00
55_F138_R0.7601.00
140_A143_E0.7571.00
129_C409_T0.7561.00
374_W377_D0.7521.00
136_L139_E0.7511.00
198_E322_G0.7511.00
349_L411_I0.7481.00
177_I415_F0.7461.00
149_I172_H0.7451.00
107_H118_R0.7411.00
52_E135_K0.7401.00
333_I336_A0.7391.00
53_L131_L0.7381.00
23_A115_L0.7371.00
108_P115_L0.7361.00
186_I190_G0.7361.00
234_A237_G0.7351.00
289_E293_Q0.7351.00
22_L128_A0.7301.00
136_L409_T0.7281.00
20_I110_E0.7261.00
292_D332_E0.7261.00
283_V294_V0.7241.00
214_I273_I0.7221.00
133_A409_T0.7211.00
384_I388_G0.7191.00
104_D108_P0.7171.00
194_T282_T0.7161.00
357_K360_C0.7131.00
32_P94_E0.7131.00
244_S257_N0.7131.00
58_D70_V0.7111.00
129_C133_A0.7071.00
212_N395_S0.7051.00
130_V179_A0.7041.00
291_H295_A0.7011.00
353_H356_V0.7001.00
46_I152_S0.7001.00
232_I279_L0.6981.00
92_V106_F0.6981.00
78_S147_D0.6981.00
32_P38_N0.6961.00
323_G332_E0.6911.00
132_F409_T0.6911.00
263_V278_R0.6901.00
374_W378_A0.6881.00
240_E259_I0.6871.00
372_G382_C0.6871.00
135_K138_R0.6831.00
37_R158_V0.6831.00
28_S108_P0.6831.00
73_L150_L0.6821.00
348_A419_W0.6811.00
300_D307_D0.6781.00
384_I387_P0.6781.00
352_S415_F0.6771.00
43_Q67_P0.6761.00
225_A274_A0.6731.00
223_A310_I0.6731.00
259_I283_V0.6731.00
158_V161_A0.6721.00
190_G199_I0.6711.00
84_L416_I0.6711.00
46_I131_L0.6701.00
127_M152_S0.6701.00
220_T245_I0.6691.00
186_I189_Q0.6681.00
100_E104_D0.6661.00
54_G57_I0.6661.00
231_K305_L0.6621.00
24_K27_I0.6621.00
57_I69_V0.6561.00
176_A380_I0.6561.00
188_G191_G0.6561.00
392_N397_N0.6551.00
387_P390_L0.6541.00
20_I402_I0.6501.00
190_G194_T0.6501.00
84_L175_F0.6501.00
224_S274_A0.6481.00
22_L26_L0.6471.00
386_G390_L0.6471.00
66_D165_E0.6461.00
32_P106_F0.6461.00
306_S317_P0.6451.00
46_I69_V0.6451.00
55_F150_L0.6411.00
137_I142_I0.6401.00
305_L309_D0.6401.00
342_G347_L0.6371.00
102_K105_P0.6341.00
335_P377_D0.6331.00
61_D67_P0.6321.00
265_E280_W0.6301.00
26_L127_M0.6301.00
69_V152_S0.6291.00
195_G198_E0.6281.00
334_F374_W0.6251.00
83_S146_G0.6251.00
123_M126_G0.6251.00
59_K67_P0.6241.00
388_G400_V0.6181.00
379_G383_V0.6181.00
151_Q166_C0.6171.00
410_K413_L0.6151.00
105_P111_K0.6151.00
24_K115_L0.6131.00
357_K411_I0.6111.00
411_I415_F0.6051.00
237_G309_D0.6041.00
242_H297_E0.6041.00
383_V386_G0.6021.00
129_C179_A0.6011.00
116_I399_K0.5971.00
167_C378_A0.5951.00
155_G158_V0.5941.00
26_L128_A0.5911.00
191_G194_T0.5901.00
22_L131_L0.5901.00
309_D317_P0.5891.00
197_I232_I0.5891.00
199_I279_L0.5881.00
265_E276_E0.5881.00
392_N399_K0.5881.00
227_E231_K0.5871.00
323_G333_I0.5871.00
20_I115_L0.5871.00
115_L402_I0.5871.00
58_D61_D0.5871.00
33_A159_G0.5831.00
188_G198_E0.5831.00
87_N151_Q0.5811.00
74_K77_D0.5801.00
88_G130_V0.5801.00
232_I301_Y0.5781.00
281_I298_I0.5751.00
228_K305_L0.5751.00
37_R41_G0.5731.00
38_N114_L0.5731.00
105_P109_I0.5731.00
40_E59_K0.5721.00
319_F323_G0.5721.00
41_G48_G0.5711.00
352_S411_I0.5711.00
29_Y42_I0.5711.00
189_Q195_G0.5701.00
357_K407_E0.5691.00
51_N56_S0.5681.00
350_T360_C0.5671.00
70_V151_Q0.5661.00
92_V118_R0.5651.00
163_T167_C0.5641.00
288_N377_D0.5581.00
336_A340_D0.5571.00
189_Q193_I0.5561.00
227_E234_A0.5561.00
83_S172_H0.5551.00
32_P114_L0.5541.00
76_T81_Y0.5541.00
20_I406_V0.5541.00
107_H110_E0.5531.00
195_G321_W0.5531.00
39_T155_G0.5521.00
23_A402_I0.5521.00
296_A303_N0.5511.00
187_Q363_I0.5501.00
176_A375_L0.5501.00
376_Y382_C0.5491.00
402_I406_V0.5491.00
74_K78_S0.5471.00
178_V372_G0.5441.00
84_L419_W0.5431.00
101_W105_P0.5421.00
168_K378_A0.5411.00
216_A262_A0.5411.00
104_D109_I0.5401.00
68_N166_C0.5401.00
102_K106_F0.5391.00
232_I305_L0.5371.00
232_I236_L0.5361.00
23_A128_A0.5361.00
95_V117_G0.5341.00
236_L261_P0.5341.00
26_L46_I0.5331.00
193_I196_W0.5331.00
151_Q375_L0.5331.00
77_D147_D0.5321.00
267_G276_E0.5311.00
216_A282_T0.5301.00
345_G348_A0.5301.00
22_L53_L0.5281.00
81_Y145_P0.5281.00
358_R361_P0.5251.00
340_D343_H0.5241.00
199_I228_K0.5241.00
180_D184_M0.5231.00
56_S59_K0.5221.00
356_V411_I0.5211.00
151_Q176_A0.5211.00
157_E394_H0.5211.00
228_K232_I0.5201.00
50_L55_F0.5191.00
295_A333_I0.5181.00
263_V268_R0.5171.00
175_F381_P0.5171.00
72_K83_S0.5171.00
353_H357_K0.5161.00
196_W331_G0.5161.00
29_Y111_K0.5151.00
60_W169_R0.5151.00
87_N153_V0.5141.00
216_A260_N0.5131.00
285_F294_V0.5121.00
19_L23_A0.5111.00
228_K231_K0.5101.00
33_A37_R0.5101.00
386_G391_H0.5061.00
193_I199_I0.5051.00
230_A237_G0.5041.00
82_Y175_F0.5041.00
225_A273_I0.5011.00
385_Y411_I0.5001.00
176_A382_C0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfoA 2 0.9413 100 0.244 Contact Map
4g1pA 2 0.9413 100 0.3 Contact Map
3iszA 2 0.8427 100 0.302 Contact Map
1cg2A 4 0.885 100 0.303 Contact Map
4mmoA 2 0.8803 100 0.303 Contact Map
4pqaA 2 0.8521 100 0.304 Contact Map
2pokA 2 0.9202 100 0.307 Contact Map
3pfeA 2 0.9178 100 0.311 Contact Map
3rzaA 2 0.8427 100 0.312 Contact Map
2zogA 2 0.9296 100 0.314 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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