GREMLIN Database
YKPB - Uncharacterized oxidoreductase YkpB
UniProt: O31717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (297)
Sequences: 5067 (3936)
Seq/√Len: 228.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_K261_E4.5611.00
280_K290_E4.5491.00
279_A286_A3.7771.00
229_E282_L3.4241.00
195_T254_S2.9611.00
2_K25_D2.8991.00
16_G28_F2.8861.00
4_L67_F2.8471.00
272_H289_L2.7561.00
225_V286_A2.7321.00
218_L292_V2.7211.00
36_E40_K2.5801.00
148_E154_T2.5191.00
276_I290_E2.4691.00
79_L100_L2.3701.00
278_K281_R2.3071.00
286_A290_E2.2961.00
199_Q261_E2.2751.00
269_D297_Q2.2471.00
69_V97_I2.2271.00
71_I97_I2.1921.00
148_E156_R2.1871.00
257_L261_E2.1571.00
253_K257_L2.1111.00
229_E278_K2.0361.00
46_H134_E2.0141.00
188_I192_A2.0091.00
3_F163_A1.9051.00
218_L288_V1.8641.00
6_V82_V1.8501.00
182_W226_L1.7921.00
21_E52_V1.7901.00
8_A28_F1.7901.00
18_R21_E1.7701.00
35_A39_K1.7551.00
80_G108_Q1.7471.00
33_K36_E1.7091.00
201_P204_P1.6971.00
44_V51_N1.6921.00
47_S137_H1.6621.00
186_L222_I1.6611.00
176_H179_K1.6551.00
69_V160_L1.6531.00
217_T288_V1.6451.00
276_I286_A1.6361.00
99_F121_G1.6161.00
199_Q257_L1.5961.00
37_Q41_T1.5851.00
147_G177_I1.5831.00
158_R162_E1.5821.00
60_S63_E1.5701.00
84_E112_A1.5631.00
87_K112_A1.5571.00
3_F69_V1.5421.00
216_Q239_E1.5401.00
278_K282_L1.5401.00
13_G135_I1.5391.00
189_A222_I1.5371.00
145_V174_S1.5281.00
114_S117_Q1.5231.00
119_L157_I1.5221.00
285_A290_E1.5121.00
143_R172_I1.5101.00
32_Q36_E1.5011.00
293_Y297_Q1.4971.00
79_L105_H1.4861.00
269_D293_Y1.4791.00
196_T260_M1.4771.00
130_D136_H1.4761.00
197_L295_N1.4611.00
46_H51_N1.4551.00
266_T296_L1.4471.00
91_H94_S1.4451.00
268_G296_L1.4421.00
174_S180_D1.4211.00
90_I94_S1.4211.00
24_N166_G1.4081.00
272_H293_Y1.3981.00
225_V275_L1.3931.00
44_V53_S1.3881.00
193_G256_M1.3791.00
161_E165_S1.3721.00
106_Y181_I1.3571.00
32_Q35_A1.3511.00
46_H136_H1.3511.00
228_K284_L1.3491.00
212_R216_Q1.3471.00
276_I293_Y1.3371.00
203_G250_Y1.3221.00
25_D57_E1.2991.00
15_I99_F1.2901.00
34_R38_L1.2901.00
98_P109_L1.2471.00
214_T291_T1.2461.00
269_D277_E1.2381.00
104_R107_E1.2351.00
260_M266_T1.2311.00
36_E39_K1.2291.00
14_Y127_S1.2281.00
84_E87_K1.2231.00
162_E165_S1.2181.00
199_Q299_Y1.2071.00
277_E281_R1.2021.00
44_V134_E1.1911.00
290_E294_A1.1881.00
4_L70_V1.1791.00
192_A256_M1.1761.00
11_V73_A1.1741.00
4_L29_L1.1681.00
291_T295_N1.1581.00
216_Q220_G1.1561.00
80_G84_E1.1411.00
80_G111_A1.1401.00
30_V38_L1.1371.00
212_R246_T1.1351.00
34_R132_K1.1321.00
162_E166_G1.1321.00
157_I173_I1.1261.00
96_I113_F1.1151.00
95_V156_R1.1141.00
218_L289_L1.1131.00
22_K167_V1.1121.00
122_L181_I1.1111.00
193_G272_H1.1091.00
76_A270_H1.1081.00
95_V119_L1.1051.00
27_T67_F1.0911.00
131_N134_E1.0861.00
5_V71_I1.0841.00
228_K282_L1.0831.00
45_I52_V1.0801.00
47_S50_G1.0791.00
13_G43_L1.0781.00
39_K58_L1.0731.00
103_Y274_F1.0621.00
187_F245_M1.0591.00
286_A289_L1.0581.00
110_F115_K1.0561.00
81_Q85_D1.0551.00
79_L98_P1.0521.00
239_E243_R1.0491.00
222_I275_L1.0471.00
81_Q84_E1.0451.00
184_K255_S1.0431.00
194_I205_I1.0411.00
155_E158_R1.0401.00
200_R204_P1.0401.00
274_F278_K1.0341.00
123_C144_F1.0331.00
229_E281_R1.0331.00
148_E151_G1.0281.00
284_L287_P1.0271.00
125_I137_H1.0271.00
161_E173_I1.0251.00
64_T67_F1.0081.00
201_P251_H1.0071.00
274_F277_E1.0051.00
206_L246_T1.0001.00
288_V291_T0.9941.00
279_A284_L0.9871.00
234_D237_L0.9861.00
15_I123_C0.9841.00
9_G12_G0.9841.00
97_I121_G0.9811.00
69_V95_V0.9761.00
72_I96_I0.9761.00
197_L299_Y0.9601.00
154_T158_R0.9591.00
183_K234_D0.9561.00
11_V123_C0.9541.00
95_V160_L0.9521.00
192_A255_S0.9471.00
148_E157_I0.9381.00
114_S118_V0.9351.00
236_A240_E0.9331.00
185_Y271_L0.9321.00
179_K183_K0.9321.00
198_F295_N0.9301.00
75_K184_K0.9291.00
214_T288_V0.9231.00
202_L252_M0.9231.00
8_A16_G0.9201.00
273_G293_Y0.9070.99
6_V70_V0.9050.99
101_N184_K0.8910.99
130_D134_E0.8900.99
128_A138_T0.8880.99
3_F24_N0.8870.99
84_E88_P0.8800.99
75_K259_D0.8750.99
128_A258_R0.8730.99
192_A258_R0.8730.99
5_V16_G0.8710.99
30_V35_A0.8700.99
17_G45_I0.8690.99
195_T205_I0.8660.99
106_Y120_G0.8600.99
100_L105_H0.8520.99
279_A285_A0.8480.99
202_L249_S0.8470.99
165_S171_V0.8450.99
78_S81_Q0.8430.99
192_A196_T0.8400.99
272_H275_L0.8400.99
194_I215_A0.8390.99
159_A162_E0.8380.99
104_R277_E0.8330.99
199_Q260_M0.8320.99
66_Q94_S0.8310.99
98_P105_H0.8300.99
279_A287_P0.8260.99
76_A105_H0.8250.99
20_S57_E0.8250.99
146_F161_E0.8230.99
269_D273_G0.8210.99
38_L42_G0.8150.99
198_F214_T0.8140.99
145_V180_D0.8140.99
187_F191_Q0.8140.99
217_T290_E0.8100.99
109_L118_V0.8080.99
71_I99_F0.8050.99
280_K286_A0.8050.99
188_I271_L0.8040.99
70_V90_I0.8040.99
4_L89_F0.8040.99
273_G277_E0.8030.99
107_E111_A0.8010.99
225_V279_A0.8000.99
204_P207_A0.7990.99
8_A13_G0.7970.99
110_F114_S0.7950.99
2_K66_Q0.7940.99
5_V26_V0.7900.99
6_V74_S0.7890.99
277_E280_K0.7890.99
121_G144_F0.7890.99
259_D267_E0.7830.98
128_A136_H0.7830.98
75_K267_E0.7830.98
70_V96_I0.7800.98
24_N163_A0.7790.98
2_K65_G0.7770.98
104_R274_F0.7760.98
253_K258_R0.7750.98
213_H217_T0.7720.98
295_N299_Y0.7680.98
258_R262_N0.7670.98
190_A219_I0.7650.98
77_Y265_T0.7650.98
249_S252_M0.7580.98
95_V117_Q0.7580.98
72_I98_P0.7560.98
185_Y275_L0.7520.98
276_I289_L0.7520.98
209_E213_H0.7460.98
14_Y125_I0.7460.98
41_T134_E0.7400.98
27_T59_I0.7390.98
139_S142_H0.7390.98
191_Q252_M0.7390.98
20_S23_G0.7370.98
14_Y137_H0.7360.98
28_F56_P0.7360.98
224_T227_R0.7360.98
127_S135_I0.7330.98
110_F149_W0.7330.98
151_G154_T0.7320.98
35_A58_L0.7320.98
102_G184_K0.7320.98
34_R129_L0.7300.98
46_H130_D0.7290.98
259_D264_Q0.7260.98
188_I255_S0.7260.98
83_I112_A0.7250.98
160_L164_F0.7240.97
183_K237_L0.7240.97
213_H216_Q0.7200.97
227_R232_P0.7190.97
179_K231_V0.7190.97
188_I258_R0.7180.97
291_T294_A0.7170.97
222_I225_V0.7150.97
192_A271_L0.7130.97
38_L133_G0.7120.97
41_T44_V0.7090.97
106_Y110_F0.7080.97
190_A193_G0.7030.97
17_G20_S0.7020.97
184_K259_D0.7010.97
70_V94_S0.7000.97
275_L289_L0.6990.97
229_E284_L0.6990.97
189_A289_L0.6950.97
18_R167_V0.6910.97
15_I144_F0.6900.97
255_S259_D0.6900.97
191_Q202_L0.6870.97
155_E159_A0.6850.96
220_G224_T0.6780.96
67_F70_V0.6770.96
2_K68_D0.6760.96
145_V172_I0.6740.96
99_F123_C0.6740.96
82_V86_V0.6730.96
186_L238_E0.6720.96
83_I109_L0.6710.96
98_P106_Y0.6700.96
226_L231_V0.6690.96
203_G257_L0.6690.96
13_G34_R0.6680.96
272_H276_I0.6650.96
223_C227_R0.6620.96
97_I119_L0.6620.96
31_R78_S0.6620.96
126_E138_T0.6620.96
146_F171_V0.6620.96
13_G28_F0.6590.96
193_G292_V0.6580.96
208_T211_G0.6570.96
224_T228_K0.6570.96
72_I109_L0.6560.96
120_G181_I0.6540.95
6_V29_L0.6520.95
146_F173_I0.6510.95
4_L27_T0.6510.95
196_T266_T0.6480.95
15_I18_R0.6470.95
211_G298_M0.6470.95
75_K255_S0.6450.95
184_K192_A0.6440.95
6_V85_D0.6430.95
119_L148_E0.6430.95
225_V284_L0.6420.95
101_N255_S0.6390.95
101_N188_I0.6380.95
224_T284_L0.6370.95
203_G251_H0.6330.95
196_T200_R0.6330.95
246_T249_S0.6330.95
122_L180_D0.6320.95
66_Q93_E0.6270.94
75_K101_N0.6270.94
101_N267_E0.6260.94
82_V85_D0.6250.94
268_G297_Q0.6240.94
214_T295_N0.6230.94
220_G235_P0.6220.94
178_E229_E0.6220.94
66_Q91_H0.6220.94
256_M266_T0.6170.94
189_A271_L0.6170.94
242_F246_T0.6150.94
194_I218_L0.6140.94
158_R173_I0.6130.94
207_A250_Y0.6120.94
200_R205_I0.6110.93
280_K285_A0.6100.93
34_R43_L0.6090.93
47_S51_N0.6040.93
90_I113_F0.6020.93
20_S28_F0.6020.93
153_R158_R0.6020.93
217_T294_A0.6020.93
211_G214_T0.6000.93
68_D93_E0.5990.93
17_G52_V0.5970.93
256_M259_D0.5950.93
174_S177_I0.5940.93
178_E181_I0.5910.92
193_G196_T0.5890.92
142_H252_M0.5840.92
14_Y18_R0.5820.92
74_S78_S0.5820.92
109_L113_F0.5800.92
74_S79_L0.5790.92
15_I71_I0.5770.91
126_E252_M0.5750.91
143_R170_E0.5750.91
42_G56_P0.5750.91
245_M248_M0.5750.91
205_I215_A0.5740.91
191_Q245_M0.5730.91
260_M299_Y0.5710.91
185_Y188_I0.5670.91
19_L71_I0.5650.91
108_Q111_A0.5650.91
9_G101_N0.5640.90
31_R35_A0.5620.90
34_R37_Q0.5620.90
226_L233_A0.5620.90
105_H181_I0.5590.90
198_F211_G0.5580.90
103_Y185_Y0.5580.90
186_L223_C0.5580.90
255_S267_E0.5570.90
104_R108_Q0.5540.90
75_K192_A0.5540.90
224_T285_A0.5540.90
129_L135_I0.5540.90
2_K27_T0.5530.90
72_I82_V0.5520.90
33_K37_Q0.5510.89
245_M249_S0.5490.89
219_I239_E0.5490.89
70_V86_V0.5490.89
107_E278_K0.5470.89
165_S170_E0.5470.89
126_E249_S0.5470.89
201_P253_K0.5460.89
120_G149_W0.5440.89
184_K188_I0.5440.89
240_E243_R0.5410.89
258_R271_L0.5410.89
288_V292_V0.5380.88
123_C142_H0.5350.88
275_L286_A0.5300.88
186_L219_I0.5290.88
103_Y181_I0.5280.87
5_V28_F0.5270.87
120_G177_I0.5270.87
193_G296_L0.5270.87
125_I142_H0.5260.87
256_M271_L0.5260.87
4_L64_T0.5240.87
187_F252_M0.5220.87
220_G238_E0.5220.87
195_T257_L0.5210.87
29_L67_F0.5200.87
52_V56_P0.5200.87
105_H109_L0.5180.86
184_K267_E0.5170.86
11_V125_I0.5140.86
276_I279_A0.5140.86
161_E171_V0.5140.86
14_Y142_H0.5110.86
255_S271_L0.5080.85
273_G289_L0.5070.85
102_G273_G0.5070.85
8_A30_V0.5060.85
124_F187_F0.5040.85
119_L160_L0.5030.85
181_I274_F0.5030.85
149_W178_E0.5020.85
14_Y45_I0.5000.84
239_E242_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wfiA 2 0.9967 100 0.311 Contact Map
2ew2A 2 0.9967 100 0.326 Contact Map
3ghyA 2 0.9901 100 0.352 Contact Map
3hn2A 2 0.9868 100 0.367 Contact Map
3egoA 2 0.9505 100 0.368 Contact Map
2qytA 1 0.9109 100 0.369 Contact Map
3i83A 2 0.9868 100 0.373 Contact Map
3hwrA 2 0.9703 100 0.382 Contact Map
4ol9A 2 0.9538 100 0.394 Contact Map
1ks9A 1 0.9472 100 0.404 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.