GREMLIN Database
YKPA - Uncharacterized ABC transporter ATP-binding protein YkpA
UniProt: O31716 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 540 (409)
Sequences: 557 (425)
Seq/√Len: 21.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_N238_D5.9421.00
322_V325_L5.2071.00
324_G339_S4.2411.00
324_G337_N4.2241.00
342_M348_I3.9691.00
4_V7_V3.8681.00
44_L208_V3.7021.00
31_G222_I3.5401.00
327_K364_I3.4581.00
2_I176_V3.1491.00
100_D103_Y3.0720.99
156_L164_V3.0160.99
98_E115_R2.9870.99
322_V340_F2.8620.99
323_E375_T2.8590.99
68_V71_Q2.7400.99
9_L54_Q2.6520.98
31_G36_N2.5360.98
224_D240_W2.4920.98
343_N346_D2.4660.98
159_S355_E2.4360.97
2_I60_M2.4250.97
96_M100_D2.4140.97
328_T372_D2.3750.97
123_F128_G2.3600.97
327_K372_D2.2770.96
325_L364_I2.2730.96
400_L405_W2.2530.96
358_V389_K2.2510.96
352_G358_V2.1920.95
81_V86_I2.1320.94
236_N239_F2.1110.94
275_N278_K2.1020.94
36_N53_P2.0650.93
364_I371_A2.0590.93
329_I360_T2.0550.93
28_N221_H2.0350.93
106_P109_S2.0220.92
209_S354_N2.0000.92
266_Q270_A1.9840.92
127_N130_E1.9800.91
6_N19_D1.9760.91
96_M103_Y1.9660.91
4_V22_I1.9610.91
4_V47_L1.9490.91
166_L194_L1.9300.90
266_Q269_V1.9270.90
86_I96_M1.9160.90
158_G389_K1.8960.90
396_E405_W1.8930.89
327_K334_V1.8790.89
151_K155_D1.8510.88
101_A168_Q1.8400.88
355_E389_K1.8340.88
321_R341_I1.8210.88
157_G389_K1.7990.87
158_G358_V1.7820.86
322_V365_I1.7760.86
360_T389_K1.7760.86
159_S357_A1.7200.84
31_G219_C1.7190.84
24_F206_I1.7150.84
272_F275_N1.7130.84
283_T286_K1.6910.83
317_N343_N1.6870.83
31_G209_S1.6700.82
36_N54_Q1.6270.81
7_V46_V1.6170.80
34_G39_G1.6170.80
156_L272_F1.5990.80
144_I156_L1.5970.80
101_A405_W1.5920.79
255_N259_E1.5920.79
157_G360_T1.5840.79
20_V230_I1.5840.79
252_Q256_K1.5810.79
101_A104_M1.5740.78
333_K336_D1.5730.78
187_D358_V1.5680.78
243_S247_A1.5630.78
352_G355_E1.5600.78
156_L160_E1.5560.78
352_G357_A1.5310.76
31_G215_L1.5310.76
157_G358_V1.5270.76
67_A71_Q1.5250.76
46_V58_V1.5220.76
6_N161_K1.5200.76
34_G40_K1.5080.75
328_T364_I1.5020.75
8_S19_D1.4940.75
323_E339_S1.4880.74
99_K103_Y1.4860.74
105_K108_F1.4830.74
148_L156_L1.4690.73
159_S389_K1.4670.73
187_D389_K1.4590.73
64_E71_Q1.4580.73
181_E210_H1.4570.73
163_K190_A1.4550.73
142_L190_A1.4460.72
268_F272_F1.4460.72
354_N358_V1.4410.72
142_L167_A1.4220.71
34_G37_G1.4160.71
325_L371_A1.4120.70
85_V88_G1.4110.70
31_G211_D1.3970.70
272_F278_K1.3950.69
269_V289_L1.3890.69
116_A123_F1.3830.69
11_F16_L1.3680.68
364_I372_D1.3600.67
110_D114_I1.3570.67
148_L151_K1.3470.67
212_R236_N1.3450.66
326_T337_N1.3440.66
7_V32_L1.3330.66
58_V228_N1.3310.66
157_G354_N1.3180.65
357_A389_K1.3030.64
37_G40_K1.2990.64
86_I100_D1.2890.63
47_L172_G1.2750.62
225_L230_I1.2730.62
335_L364_I1.2710.62
2_I402_L1.2630.61
156_L162_V1.2620.61
273_S286_K1.2510.61
338_V348_I1.2450.60
156_L279_S1.2430.60
330_D350_F1.2430.60
36_N211_D1.2430.60
195_E212_R1.2340.60
22_I223_A1.2270.59
1_M208_V1.2230.59
108_F113_G1.2230.59
102_I359_T1.2220.59
284_S291_K1.2180.59
354_N360_T1.2140.58
320_L342_M1.2090.58
116_A162_V1.2010.58
42_T174_P1.1980.57
355_E358_V1.1950.57
109_S113_G1.1860.57
266_Q294_L1.1840.56
12_A54_Q1.1830.56
91_R96_M1.1650.55
6_N21_N1.1650.55
195_E211_D1.1600.55
144_I148_L1.1590.55
354_N363_K1.1580.55
106_P110_D1.1570.55
108_F112_D1.1530.54
262_I289_L1.1480.54
371_A376_F1.1460.54
198_L205_V1.1390.53
146_E149_H1.1370.53
4_V359_T1.1340.53
325_L365_I1.1320.53
30_Y176_V1.1240.52
113_G120_E1.1230.52
114_I117_A1.1220.52
157_G357_A1.1210.52
178_L401_N1.1170.52
318_D321_R1.1160.52
1_M278_K1.1110.52
335_L338_V1.1070.51
158_G187_D1.1030.51
103_Y106_P1.0920.50
326_T373_S1.0840.50
82_L86_I1.0830.50
158_G355_E1.0800.50
338_V359_T1.0790.49
340_F361_L1.0790.49
36_N185_H1.0770.49
168_Q405_W1.0750.49
157_G355_E1.0720.49
10_R13_D1.0690.49
27_G204_T1.0670.49
276_A287_K1.0620.48
363_K369_M1.0610.48
182_P354_N1.0540.48
10_R15_K1.0470.47
316_G379_G1.0420.47
157_G160_E1.0420.47
139_L149_H1.0420.47
340_F348_I1.0400.47
69_L208_V1.0380.47
36_N212_R1.0360.47
261_Q264_Q1.0350.47
187_D360_T1.0330.46
344_R379_G1.0320.46
221_H234_V1.0310.46
85_V164_V1.0310.46
158_G185_H1.0290.46
50_E63_G1.0250.46
18_E229_K1.0200.46
183_T365_I1.0140.45
13_D225_L1.0050.45
270_A284_S0.9900.44
350_F353_R0.9880.43
268_F285_R0.9870.43
107_D110_D0.9860.43
107_D111_E0.9810.43
292_I342_M0.9780.43
352_G389_K0.9780.43
95_V103_Y0.9780.43
90_K94_E0.9770.43
150_T377_K0.9750.43
282_A287_K0.9730.42
400_L404_D0.9680.42
90_K98_E0.9670.42
66_L69_L0.9500.41
214_F354_N0.9500.41
28_N232_I0.9500.41
13_D18_E0.9490.41
96_M102_I0.9450.41
400_L408_Q0.9370.40
24_F338_V0.9370.40
265_L286_K0.9370.40
78_E88_G0.9360.40
265_L269_V0.9350.40
318_D344_R0.9350.40
53_P58_V0.9340.40
32_L225_L0.9320.40
86_I135_A0.9270.40
237_Y240_W0.9210.39
121_G168_Q0.9200.39
166_L178_L0.9200.39
28_N83_K0.9190.39
15_K18_E0.9150.39
21_N176_V0.9150.39
144_I391_N0.9080.38
239_F243_S0.9050.38
332_V370_E0.9040.38
100_D108_F0.9020.38
89_H96_M0.8990.38
9_L51_I0.8980.38
42_T401_N0.8960.38
131_A135_A0.8940.37
163_K385_A0.8930.37
86_I89_H0.8900.37
159_S358_V0.8860.37
184_N211_D0.8840.37
81_V88_G0.8830.37
107_D114_I0.8830.37
63_G401_N0.8820.37
30_Y171_F0.8810.37
268_F277_S0.8810.37
265_L268_F0.8790.37
104_M123_F0.8760.36
84_V89_H0.8730.36
80_E88_G0.8730.36
7_V53_P0.8720.36
156_L274_A0.8690.36
11_F192_Q0.8680.36
257_K342_M0.8670.36
134_E169_A0.8660.36
44_L48_S0.8650.36
19_D342_M0.8640.36
108_F115_R0.8640.36
379_G382_T0.8610.35
272_F279_S0.8600.35
179_L194_L0.8590.35
131_A153_M0.8590.35
3_A7_V0.8570.35
209_S409_Y0.8570.35
24_F90_K0.8490.35
166_L190_A0.8490.35
38_A225_L0.8450.34
329_I358_V0.8430.34
262_I292_I0.8420.34
69_L72_N0.8410.34
41_S210_H0.8400.34
278_K281_Q0.8400.34
279_S283_T0.8330.34
36_N405_W0.8330.34
251_S255_N0.8300.34
36_N209_S0.8300.34
276_A283_T0.8260.33
27_G371_A0.8240.33
3_A23_K0.8210.33
185_H353_R0.8190.33
221_H232_I0.8130.33
80_E83_K0.8120.32
47_L206_I0.8120.32
258_K295_D0.8110.32
272_F281_Q0.8100.32
44_L178_L0.8080.32
38_A356_L0.8080.32
92_L96_M0.8070.32
350_F376_F0.8040.32
223_A384_Q0.8040.32
73_H161_K0.8030.32
9_L123_F0.8020.32
401_N404_D0.8020.32
45_K153_M0.8000.32
256_K259_E0.7970.32
129_W282_A0.7930.31
277_S402_L0.7930.31
58_V341_I0.7900.31
84_V100_D0.7890.31
194_L386_Y0.7880.31
32_L351_T0.7870.31
360_T363_K0.7830.31
153_M164_V0.7820.31
329_I401_N0.7790.31
275_N286_K0.7760.30
7_V55_T0.7760.30
210_H361_L0.7710.30
8_S55_T0.7700.30
44_L135_A0.7700.30
62_P118_E0.7670.30
5_N21_N0.7660.30
154_A189_Q0.7660.30
26_P206_I0.7650.30
269_V316_G0.7630.30
249_K369_M0.7600.30
239_F242_E0.7590.29
80_E89_H0.7590.29
2_I47_L0.7580.29
185_H195_E0.7550.29
89_H359_T0.7530.29
316_G319_V0.7510.29
66_L80_E0.7500.29
167_A358_V0.7490.29
248_L252_Q0.7480.29
30_Y223_A0.7470.29
152_K226_D0.7440.29
330_D375_T0.7430.29
91_R94_E0.7410.28
87_M93_Y0.7410.28
306_Y404_D0.7390.28
65_R208_V0.7370.28
32_L307_V0.7370.28
265_L292_I0.7350.28
134_E139_L0.7320.28
105_K112_D0.7290.28
7_V232_I0.7270.28
264_Q315_I0.7230.28
224_D231_Q0.7230.28
259_E285_R0.7230.28
166_L389_K0.7220.27
81_V84_V0.7220.27
23_K43_F0.7220.27
6_N55_T0.7210.27
268_F275_N0.7190.27
5_N57_D0.7190.27
21_N81_V0.7190.27
81_V85_V0.7180.27
163_K409_Y0.7140.27
46_V356_L0.7130.27
293_T304_Y0.7130.27
86_I103_Y0.7100.27
194_L224_D0.7100.27
65_R69_L0.7090.27
235_G243_S0.7070.27
158_G354_N0.7060.27
32_L206_I0.7060.27
328_T365_I0.7050.27
162_V391_N0.7010.26
359_T363_K0.6990.26
190_A334_V0.6980.26
275_N283_T0.6980.26
141_G209_S0.6960.26
158_G190_A0.6930.26
11_F20_V0.6930.26
199_I324_G0.6920.26
239_F246_L0.6910.26
139_L176_V0.6910.26
18_E24_F0.6880.26
89_H168_Q0.6870.26
318_D359_T0.6870.26
184_N212_R0.6870.26
185_H212_R0.6860.26
156_L278_K0.6860.26
52_E123_F0.6840.26
38_A209_S0.6840.26
112_D120_E0.6840.26
170_L361_L0.6830.25
158_G360_T0.6800.25
276_A284_S0.6790.25
268_F281_Q0.6780.25
22_I43_F0.6770.25
74_F77_E0.6770.25
19_D230_I0.6760.25
187_D354_N0.6740.25
150_T373_S0.6710.25
9_L46_V0.6710.25
65_R71_Q0.6700.25
87_M380_V0.6680.25
139_L395_F0.6670.25
249_K310_T0.6640.25
155_D334_V0.6630.24
93_Y96_M0.6630.24
164_V191_I0.6620.24
355_E360_T0.6620.24
291_K315_I0.6610.24
231_Q247_A0.6610.24
162_V184_N0.6600.24
85_V165_L0.6600.24
207_V372_D0.6590.24
9_L364_I0.6580.24
258_K262_I0.6580.24
180_D357_A0.6560.24
34_G41_S0.6550.24
107_D115_R0.6550.24
59_H225_L0.6540.24
159_S352_G0.6540.24
193_W214_F0.6530.24
139_L195_E0.6520.24
327_K369_M0.6520.24
183_T193_W0.6520.24
217_K378_W0.6510.24
207_V213_H0.6500.24
90_K95_V0.6500.24
22_I53_P0.6490.24
8_S206_I0.6480.24
160_E178_L0.6480.24
161_K207_V0.6460.24
143_G297_I0.6450.24
363_K366_S0.6420.23
272_F276_A0.6410.23
6_N342_M0.6410.23
104_M229_K0.6400.23
157_G187_D0.6400.23
16_L166_L0.6380.23
333_K373_S0.6380.23
54_Q390_D0.6340.23
67_A303_R0.6340.23
365_I375_T0.6340.23
104_M119_L0.6320.23
36_N210_H0.6320.23
128_G195_E0.6310.23
40_K181_E0.6280.23
107_D112_D0.6260.23
29_C185_H0.6250.23
9_L92_L0.6240.23
194_L214_F0.6220.23
289_L309_F0.6210.22
136_A387_F0.6210.22
342_M378_W0.6200.22
39_G42_T0.6190.22
34_G42_T0.6190.22
27_G161_K0.6170.22
268_F276_A0.6160.22
88_G103_Y0.6150.22
120_E123_F0.6150.22
135_A325_L0.6140.22
224_D244_S0.6140.22
284_S287_K0.6140.22
209_S214_F0.6130.22
49_G233_Y0.6120.22
84_V96_M0.6120.22
134_E208_V0.6110.22
83_K169_A0.6090.22
119_L123_F0.6090.22
267_E271_R0.6080.22
159_S187_D0.6080.22
184_N214_F0.6070.22
331_G336_D0.6070.22
213_H365_I0.6070.22
350_F380_V0.6050.22
200_N222_I0.6040.22
109_S115_R0.6030.22
143_G219_C0.6030.22
89_H93_Y0.5990.21
108_F114_I0.5980.21
102_I190_A0.5980.21
184_N193_W0.5970.21
58_V66_L0.5970.21
183_T194_L0.5950.21
66_L169_A0.5930.21
126_L290_E0.5930.21
230_I361_L0.5910.21
47_L338_V0.5900.21
212_R354_N0.5880.21
161_K371_A0.5880.21
366_S384_Q0.5870.21
26_P253_E0.5850.21
158_G167_A0.5850.21
190_A327_K0.5850.21
168_Q330_D0.5830.21
265_L273_S0.5820.21
164_V274_A0.5820.21
161_K402_L0.5810.21
159_S180_D0.5790.21
350_F355_E0.5790.21
252_Q406_L0.5790.21
62_P256_K0.5780.21
162_V405_W0.5760.20
111_E114_I0.5760.20
166_L354_N0.5760.20
61_S260_E0.5750.20
275_N279_S0.5740.20
152_K350_F0.5730.20
233_Y247_A0.5730.20
235_G257_K0.5730.20
342_M406_L0.5720.20
33_I196_E0.5710.20
202_E368_E0.5710.20
312_E356_L0.5710.20
261_Q265_L0.5700.20
315_I379_G0.5700.20
60_M176_V0.5700.20
179_L184_N0.5690.20
113_G116_A0.5690.20
35_A45_K0.5680.20
1_M377_K0.5680.20
138_L168_Q0.5670.20
243_S246_L0.5660.20
33_I359_T0.5650.20
165_L405_W0.5630.20
188_L195_E0.5630.20
238_D328_T0.5630.20
280_K283_T0.5630.20
54_Q211_D0.5630.20
331_G339_S0.5620.20
51_I198_L0.5600.20
48_S359_T0.5590.20
223_A363_K0.5580.20
107_D118_E0.5580.20
162_V197_F0.5570.20
1_M32_L0.5570.20
128_G163_K0.5570.20
131_A365_I0.5560.20
9_L42_T0.5560.20
36_N184_N0.5550.20
257_K280_K0.5540.20
111_E119_L0.5540.20
211_D354_N0.5540.20
9_L190_A0.5500.19
109_S112_D0.5490.19
164_V231_Q0.5480.19
354_N357_A0.5480.19
38_A57_D0.5470.19
320_L356_L0.5470.19
131_A171_F0.5460.19
54_Q209_S0.5450.19
286_K290_E0.5450.19
46_V51_I0.5440.19
7_V19_D0.5430.19
167_A392_S0.5420.19
165_L351_T0.5410.19
4_V204_T0.5390.19
51_I338_V0.5380.19
114_I118_E0.5380.19
71_Q78_E0.5370.19
30_Y58_V0.5360.19
272_F284_S0.5360.19
116_A128_G0.5350.19
323_E404_D0.5340.19
329_I389_K0.5340.19
164_V186_L0.5320.19
91_R176_V0.5320.19
102_I106_P0.5310.19
111_E115_R0.5310.19
253_E256_K0.5300.19
193_W237_Y0.5290.18
182_P362_F0.5290.18
92_L123_F0.5290.18
304_Y317_N0.5280.18
35_A235_G0.5270.18
90_K93_Y0.5260.18
259_E295_D0.5240.18
58_V252_Q0.5240.18
241_Y245_Q0.5230.18
139_L163_K0.5230.18
279_S286_K0.5200.18
270_A293_T0.5200.18
183_T340_F0.5190.18
386_Y400_L0.5190.18
92_L103_Y0.5180.18
26_P323_E0.5180.18
153_M165_L0.5170.18
21_N400_L0.5160.18
153_M351_T0.5160.18
33_I392_S0.5160.18
296_D317_N0.5160.18
273_S283_T0.5160.18
160_E213_H0.5160.18
95_V102_I0.5150.18
150_T383_S0.5140.18
287_K293_T0.5120.18
29_C195_E0.5120.18
166_L382_T0.5110.18
2_I11_F0.5100.18
58_V410_S0.5090.18
292_I299_P0.5090.18
82_L85_V0.5080.18
289_L295_D0.5080.18
311_P314_E0.5070.18
47_L334_V0.5070.18
51_I79_Y0.5060.18
84_V219_C0.5060.18
185_H244_S0.5050.18
9_L205_V0.5050.18
37_G41_S0.5050.18
156_L275_N0.5040.18
167_A351_T0.5040.18
161_K213_H0.5040.18
315_I319_V0.5040.18
285_R296_D0.5030.17
108_F111_E0.5030.17
88_G100_D0.5020.17
161_K204_T0.5020.17
21_N381_T0.5020.17
180_D210_H0.5020.17
252_Q376_F0.5010.17
22_I312_E0.5000.17
1_M284_S0.5000.17
190_A389_K0.5000.17
185_H211_D0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4finA 2 0.9389 100 0.302 Contact Map
4q9hA 1 0.9148 100 0.341 Contact Map
4f4cA 1 0.8759 100 0.352 Contact Map
2iw3A 2 0.8111 100 0.359 Contact Map
1yqtA 1 0.8593 100 0.383 Contact Map
3bk7A 1 0.8722 100 0.39 Contact Map
3ozxA 1 0.8463 100 0.392 Contact Map
3j16B 1 0.8667 100 0.406 Contact Map
3ux8A 2 0.7685 100 0.421 Contact Map
2vf7A 2 0.8352 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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