K1PF - BACSU - GREMLIN Contacts

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K1PF - 1-phosphofructokinase

UniProt:	O31714	Sequences: MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSRLLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEINGQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVLDISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSMAGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSGSATAFSEELGTEEFVQQLLPEVKVTRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	303 (280)
Sequences:	22587 (16968)
Seq/√Len:	1014.0

ECOLI - PFKB RBSK K1PF YEGV YDJH YEII SQUV PSUK KDGK FRLD INGK HLDE
BACSU - K1PF IOLC KDGK YDJE RBSK FRLD
HALSA - Q9HSM7 Q9HP13 Q9HMJ3
SULSO - KDGK Q981E2 Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_V	257_A	3.236	1.00
54_K	77_E	2.588	1.00
130_V	159_V	2.577	1.00
218_M	224_L	2.564	1.00
225_L	269_F	2.514	1.00
68_K	83_V	2.453	1.00
258_G	263_L	2.452	1.00
264_P	267_E	2.315	1.00
223_A	251_V	2.281	1.00
4_T	126_G	2.196	1.00
149_E	174_K	2.154	1.00
65_E	83_V	2.116	1.00
207_V	226_F	2.053	1.00
182_H	218_M	2.052	1.00
151_C	156_A	2.028	1.00
46_L	51_V	1.980	1.00
258_G	271_L	1.963	1.00
232_Y	266_E	1.948	1.00
48_R	74_E	1.921	1.00
159_V	256_L	1.916	1.00
128_I	157_R	1.892	1.00
5_V	43_S	1.878	1.00
148_A	158_V	1.872	1.00
72_R	78_T	1.847	1.00
203_G	226_F	1.842	1.00
44_R	74_E	1.836	1.00
179_K	252_V	1.822	1.00
250_S	275_S	1.809	1.00
200_V	231_V	1.808	1.00
157_R	176_F	1.806	1.00
58_F	115_A	1.806	1.00
45_L	253_A	1.783	1.00
263_L	267_E	1.773	1.00
224_L	233_F	1.766	1.00
223_A	273_V	1.739	1.00
276_G	280_A	1.725	1.00
70_F	73_E	1.714	1.00
176_F	212_E	1.711	1.00
145_E	170_A	1.706	1.00
225_L	232_Y	1.694	1.00
254_G	275_S	1.681	1.00
247_A	280_A	1.665	1.00
255_F	268_A	1.653	1.00
128_I	159_V	1.652	1.00
177_L	213_H	1.630	1.00
266_E	270_R	1.623	1.00
69_T	73_E	1.623	1.00
215_I	255_F	1.616	1.00
68_K	72_R	1.609	1.00
205_K	209_Q	1.595	1.00
150_A	154_Q	1.593	1.00
213_H	227_T	1.589	1.00
145_E	149_E	1.585	1.00
218_M	233_F	1.583	1.00
237_P	274_T	1.576	1.00
33_K	66_Y	1.560	1.00
146_K	149_E	1.554	1.00
9_P	57_G	1.538	1.00
218_M	221_D	1.526	1.00
234_A	269_F	1.521	1.00
205_K	208_E	1.519	1.00
225_L	265_L	1.506	1.00
146_K	150_A	1.500	1.00
128_I	256_L	1.486	1.00
254_G	271_L	1.483	1.00
46_L	257_A	1.473	1.00
227_T	230_A	1.462	1.00
243_N	284_E	1.457	1.00
61_G	65_E	1.454	1.00
35_P	67_I	1.441	1.00
150_A	153_Q	1.425	1.00
186_G	192_A	1.419	1.00
157_R	177_L	1.415	1.00
152_K	176_F	1.391	1.00
234_A	273_V	1.390	1.00
191_T	205_K	1.389	1.00
237_P	270_R	1.371	1.00
40_I	71_L	1.366	1.00
11_V	66_Y	1.360	1.00
198_E	201_P	1.357	1.00
112_D	115_A	1.355	1.00
87_T	92_K	1.352	1.00
65_E	69_T	1.350	1.00
162_I	180_P	1.348	1.00
113_F	146_K	1.336	1.00
261_K	291_V	1.324	1.00
175_P	178_M	1.317	1.00
200_V	204_K	1.315	1.00
207_V	228_N	1.311	1.00
204_K	208_E	1.310	1.00
70_F	74_E	1.308	1.00
16_H	30_Y	1.306	1.00
35_P	70_F	1.306	1.00
52_A	77_E	1.303	1.00
257_A	261_K	1.300	1.00
152_K	174_K	1.297	1.00
124_Q	154_Q	1.296	1.00
223_A	269_F	1.291	1.00
161_D	217_S	1.287	1.00
239_G	281_F	1.268	1.00
169_K	209_Q	1.251	1.00
87_T	90_N	1.242	1.00
213_H	265_L	1.226	1.00
90_N	93_L	1.222	1.00
179_K	217_S	1.209	1.00
68_K	81_S	1.204	1.00
191_T	201_P	1.201	1.00
204_K	231_V	1.201	1.00
213_H	255_F	1.200	1.00
66_Y	69_T	1.200	1.00
157_R	212_E	1.200	1.00
218_M	222_G	1.199	1.00
255_F	272_G	1.196	1.00
258_G	268_A	1.195	1.00
13_Y	31_D	1.191	1.00
254_G	272_G	1.190	1.00
61_G	83_V	1.185	1.00
204_K	226_F	1.184	1.00
226_F	231_V	1.184	1.00
213_H	259_I	1.181	1.00
278_A	282_S	1.173	1.00
255_F	259_I	1.172	1.00
129_V	151_C	1.169	1.00
51_V	260_S	1.165	1.00
241_L	280_A	1.163	1.00
43_S	53_S	1.163	1.00
65_E	68_K	1.158	1.00
117_L	146_K	1.157	1.00
185_L	216_V	1.154	1.00
149_E	153_Q	1.147	1.00
278_A	281_F	1.143	1.00
237_P	273_V	1.138	1.00
258_G	261_K	1.137	1.00
3_Y	46_L	1.135	1.00
239_G	280_A	1.134	1.00
88_R	92_K	1.121	1.00
217_S	251_V	1.120	1.00
61_G	84_K	1.118	1.00
47_K	76_L	1.118	1.00
267_E	270_R	1.117	1.00
49_H	254_G	1.113	1.00
131_L	158_V	1.111	1.00
13_Y	33_K	1.107	1.00
46_L	53_S	1.107	1.00
61_G	85_G	1.103	1.00
42_V	130_V	1.103	1.00
177_L	259_I	1.096	1.00
237_P	277_S	1.094	1.00
177_L	255_F	1.089	1.00
130_V	256_L	1.087	1.00
78_T	81_S	1.078	1.00
69_T	72_R	1.074	1.00
44_R	48_R	1.070	1.00
213_H	225_L	1.068	1.00
51_V	261_K	1.066	1.00
201_P	204_K	1.065	1.00
241_L	244_S	1.063	1.00
54_K	126_G	1.060	1.00
47_K	75_N	1.045	1.00
212_E	228_N	1.039	1.00
129_V	156_A	1.033	1.00
203_G	216_V	1.023	1.00
138_S	142_D	1.023	1.00
182_H	221_D	1.021	1.00
18_E	29_S	1.019	1.00
16_H	32_T	1.011	1.00
54_K	80_F	1.001	1.00
250_S	279_T	1.000	1.00
66_Y	70_F	1.000	1.00
130_V	252_V	0.997	1.00
46_L	253_A	0.996	1.00
5_V	39_G	0.990	1.00
35_P	66_Y	0.989	1.00
255_F	265_L	0.986	1.00
179_K	255_F	0.985	1.00
160_L	175_P	0.982	1.00
142_D	146_K	0.982	1.00
98_E	102_N	0.977	1.00
68_K	82_E	0.974	1.00
242_V	283_E	0.967	1.00
273_V	276_G	0.966	1.00
45_L	250_S	0.962	1.00
185_L	202_Y	0.958	1.00
9_P	67_I	0.957	1.00
59_V	64_G	0.950	1.00
270_R	274_T	0.949	1.00
59_V	68_K	0.948	1.00
131_L	148_A	0.944	1.00
268_A	272_G	0.942	1.00
263_L	271_L	0.931	1.00
14_I	34_Y	0.929	1.00
89_I	92_K	0.928	1.00
47_K	52_A	0.928	1.00
49_H	275_S	0.927	1.00
236_V	273_V	0.922	1.00
18_E	94_K	0.920	1.00
181_N	184_E	0.915	1.00
241_L	281_F	0.915	1.00
68_K	78_T	0.914	1.00
257_A	271_L	0.907	1.00
13_Y	63_T	0.906	1.00
126_G	156_A	0.903	1.00
189_F	202_Y	0.898	1.00
84_K	87_T	0.894	1.00
259_I	268_A	0.894	1.00
113_F	142_D	0.889	1.00
182_H	186_G	0.887	1.00
234_A	270_R	0.881	1.00
59_V	81_S	0.880	1.00
131_L	144_Y	0.877	1.00
240_K	281_F	0.877	1.00
42_V	252_V	0.876	1.00
161_D	179_K	0.869	1.00
230_A	266_E	0.867	1.00
221_D	233_F	0.867	1.00
28_S	101_I	0.865	1.00
227_T	265_L	0.863	1.00
239_G	277_S	0.862	1.00
264_P	268_A	0.850	1.00
201_P	205_K	0.849	1.00
9_P	40_I	0.847	1.00
222_G	236_V	0.843	1.00
22_V	97_D	0.841	1.00
204_K	207_V	0.837	1.00
9_P	55_A	0.837	1.00
149_E	170_A	0.834	1.00
4_T	56_L	0.831	1.00
234_A	266_E	0.828	1.00
82_E	115_A	0.827	1.00
203_G	214_V	0.825	1.00
172_E	175_P	0.823	1.00
40_I	286_G	0.822	1.00
58_F	82_E	0.818	1.00
251_V	273_V	0.816	1.00
113_F	143_T	0.812	1.00
54_K	79_A	0.810	1.00
180_P	185_L	0.807	1.00
254_G	258_G	0.805	1.00
224_L	231_V	0.804	1.00
79_A	119_Q	0.795	1.00
6_T	147_I	0.794	1.00
47_K	53_S	0.794	1.00
161_D	180_P	0.793	1.00
33_K	63_T	0.791	1.00
89_I	93_L	0.791	1.00
59_V	83_V	0.781	1.00
145_E	174_K	0.780	1.00
6_T	129_V	0.776	1.00
288_E	292_Q	0.773	1.00
159_V	179_K	0.760	1.00
250_S	288_E	0.759	1.00
250_S	254_G	0.759	1.00
250_S	276_G	0.758	1.00
128_I	260_S	0.754	1.00
273_V	277_S	0.753	1.00
43_S	55_A	0.751	1.00
274_T	278_A	0.748	1.00
19_D	24_G	0.746	1.00
99_T	102_N	0.746	1.00
148_A	174_K	0.744	1.00
276_G	279_T	0.741	1.00
232_Y	269_F	0.737	1.00
141_H	145_E	0.736	1.00
32_T	283_E	0.735	1.00
170_A	173_M	0.732	1.00
70_F	286_G	0.732	1.00
123_L	126_G	0.730	1.00
4_T	54_K	0.728	1.00
199_A	218_M	0.727	1.00
200_V	226_F	0.718	1.00
58_F	84_K	0.706	1.00
159_V	177_L	0.699	1.00
271_L	291_V	0.699	1.00
44_R	286_G	0.698	1.00
16_H	283_E	0.697	1.00
99_T	103_G	0.693	1.00
200_V	233_F	0.692	1.00
21_T	24_G	0.692	1.00
227_T	232_Y	0.691	1.00
222_G	233_F	0.690	1.00
220_G	238_K	0.689	1.00
215_I	225_L	0.688	1.00
142_D	145_E	0.687	1.00
200_V	224_L	0.686	1.00
113_F	117_L	0.677	1.00
49_H	271_L	0.673	1.00
123_L	156_A	0.672	1.00
80_F	83_V	0.670	1.00
185_L	206_L	0.670	1.00
11_V	63_T	0.667	1.00
203_G	231_V	0.666	1.00
207_V	227_T	0.666	1.00
203_G	207_V	0.664	1.00
143_T	147_I	0.664	1.00
129_V	147_I	0.660	1.00
79_A	122_S	0.659	1.00
43_S	76_L	0.657	1.00
251_V	276_G	0.651	1.00
12_D	36_G	0.647	1.00
191_T	202_Y	0.644	1.00
88_R	93_L	0.643	1.00
263_L	268_A	0.642	1.00
159_V	252_V	0.641	1.00
88_R	91_V	0.640	1.00
251_V	269_F	0.638	1.00
111_E	115_A	0.637	1.00
87_T	110_D	0.637	1.00
151_C	158_V	0.635	1.00
251_V	272_G	0.632	1.00
38_K	163_S	0.632	1.00
223_A	234_A	0.631	1.00
138_S	141_H	0.628	1.00
49_H	257_A	0.627	1.00
35_P	286_G	0.626	1.00
185_L	199_A	0.625	1.00
52_A	127_D	0.625	1.00
113_F	116_F	0.624	1.00
15_V	91_V	0.618	1.00
3_Y	260_S	0.614	1.00
40_I	55_A	0.613	1.00
246_G	288_E	0.612	1.00
262_Q	268_A	0.610	1.00
145_E	148_A	0.606	1.00
97_D	100_E	0.600	1.00
234_A	237_P	0.600	1.00
117_L	150_A	0.599	1.00
199_A	202_Y	0.599	1.00
86_D	92_K	0.598	1.00
158_V	175_P	0.597	1.00
52_A	260_S	0.596	1.00
114_K	117_L	0.593	1.00
115_A	118_E	0.592	1.00
11_V	33_K	0.591	1.00
85_G	88_R	0.590	1.00
169_K	173_M	0.589	1.00
13_Y	89_I	0.589	1.00
15_V	31_D	0.587	1.00
269_F	273_V	0.586	1.00
128_I	177_L	0.583	1.00
57_G	81_S	0.581	1.00
117_L	120_F	0.580	1.00
257_A	291_V	0.579	1.00
253_A	257_A	0.578	1.00
267_E	271_L	0.577	1.00
3_Y	128_I	0.577	1.00
36_G	41_N	0.577	1.00
169_K	172_E	0.576	1.00
15_V	28_S	0.576	1.00
207_V	214_V	0.575	1.00
100_E	103_G	0.573	1.00
97_D	103_G	0.573	1.00
191_T	198_E	0.569	1.00
215_I	251_V	0.568	1.00
139_L	142_D	0.567	1.00
265_L	268_A	0.566	1.00
122_S	126_G	0.565	1.00
183_H	187_E	0.564	1.00
173_M	209_Q	0.564	1.00
65_E	72_R	0.563	1.00
179_K	215_I	0.561	1.00
127_D	156_A	0.560	1.00
207_V	210_G	0.560	1.00
49_H	253_A	0.559	1.00
85_G	90_N	0.558	1.00
42_V	256_L	0.557	1.00
10_S	107_T	0.556	1.00
101_I	104_Q	0.555	1.00
172_E	211_A	0.554	1.00
207_V	229_E	0.551	1.00
173_M	210_G	0.551	1.00
176_F	213_H	0.551	1.00
185_L	226_F	0.550	1.00
80_F	122_S	0.549	1.00
211_A	214_V	0.549	1.00
178_M	214_V	0.549	1.00
71_L	76_L	0.538	1.00
207_V	211_A	0.537	1.00
116_F	120_F	0.537	1.00
265_L	269_F	0.536	1.00
120_F	123_L	0.535	1.00
128_I	259_I	0.534	1.00
202_Y	206_L	0.534	1.00
98_E	103_G	0.534	1.00
137_S	160_L	0.534	1.00
86_D	89_I	0.534	1.00
215_I	269_F	0.533	1.00
160_L	168_L	0.532	1.00
200_V	203_G	0.531	1.00
219_A	244_S	0.529	1.00
47_K	74_E	0.528	1.00
258_G	262_Q	0.527	1.00
136_P	139_L	0.526	1.00
119_Q	122_S	0.526	1.00
42_V	253_A	0.526	1.00
148_A	171_T	0.525	1.00
199_A	203_G	0.524	1.00
175_P	211_A	0.523	1.00
103_G	106_P	0.521	1.00
171_T	175_P	0.521	1.00
42_V	46_L	0.521	1.00
71_L	78_T	0.521	1.00
11_V	67_I	0.520	1.00
161_D	249_D	0.519	1.00
87_T	93_L	0.518	1.00
114_K	118_E	0.518	1.00
182_H	219_A	0.516	1.00
282_S	290_F	0.515	1.00
11_V	35_P	0.515	1.00
245_V	285_L	0.508	1.00
288_E	291_V	0.507	1.00
104_Q	107_T	0.507	1.00
151_C	154_Q	0.507	1.00
220_G	241_L	0.505	1.00
214_V	226_F	0.505	1.00
115_A	119_Q	0.505	1.00
160_L	171_T	0.503	1.00
120_F	124_Q	0.503	1.00
55_A	71_L	0.502	1.00
23_G	27_R	0.501	1.00
79_A	82_E	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ajrA	2	0.9835	100	0.212	Contact Map
2jg5A	1	0.9868	100	0.212	Contact Map
2abqA	2	0.9868	100	0.215	Contact Map
2rbcA	2	0.9571	100	0.217	Contact Map
1rkdA	2	0.9802	100	0.219	Contact Map
3vasA	1	0.9637	100	0.22	Contact Map
2fv7A	2	0.9703	100	0.222	Contact Map
3iq0A	2	0.9604	100	0.23	Contact Map
3hj6A	2	0.8647	100	0.231	Contact Map
3ry7A	2	0.9637	100	0.232	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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