GREMLIN Database
FRUR - Uncharacterized HTH-type transcriptional regulator FruR
UniProt: O31713 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (244)
Sequences: 7652 (5644)
Seq/√Len: 361.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_D167_K3.3011.00
85_K88_S3.1571.00
107_M205_L2.9631.00
136_S143_Y2.7791.00
168_S199_A2.6441.00
13_Q28_L2.3811.00
99_D192_K2.3131.00
196_I220_A2.2561.00
208_P231_D2.2381.00
109_D129_A2.2281.00
161_D194_K2.1491.00
203_Y227_I2.1341.00
91_E94_D2.1311.00
167_K203_Y2.0591.00
13_Q17_H2.0561.00
9_L12_D2.0501.00
84_E110_F2.0231.00
97_Y165_F2.0021.00
80_L106_H2.0021.00
196_I202_A1.9931.00
158_V161_D1.9561.00
218_A221_G1.9461.00
98_L104_T1.9221.00
167_K201_H1.9171.00
234_E238_D1.8971.00
97_Y195_A1.8261.00
92_E115_K1.8161.00
201_H227_I1.8121.00
106_H109_D1.8011.00
238_D242_E1.7581.00
120_V165_F1.7571.00
158_V162_Q1.7081.00
86_A169_F1.6781.00
221_G224_D1.6671.00
165_F195_A1.6431.00
194_K197_K1.6301.00
86_A205_L1.6231.00
157_L190_L1.6021.00
139_L151_I1.5941.00
127_I139_L1.5661.00
239_N243_K1.5621.00
166_D200_K1.5461.00
75_N209_S1.5321.00
140_L159_A1.5251.00
107_M169_F1.5211.00
181_F225_A1.5131.00
181_F204_V1.4991.00
19_V57_A1.4981.00
161_D197_K1.4881.00
87_A110_F1.4871.00
31_A36_I1.4831.00
7_H46_R1.4781.00
80_L110_F1.4511.00
25_L36_I1.4501.00
156_S191_L1.4491.00
83_A110_F1.4361.00
10_I25_L1.4281.00
119_V130_L1.4271.00
9_L13_Q1.4221.00
50_K59_L1.4121.00
13_Q20_V1.4111.00
89_L229_T1.4101.00
140_L151_I1.4061.00
15_E58_K1.3971.00
8_Q12_D1.3951.00
17_H24_E1.3911.00
40_L56_A1.3861.00
89_L203_Y1.3791.00
194_K198_Q1.3761.00
75_N78_D1.3741.00
23_Q33_E1.3731.00
100_A150_A1.3661.00
92_E116_D1.3631.00
204_V225_A1.3611.00
92_E114_T1.3591.00
144_V151_I1.3541.00
78_D231_D1.3541.00
208_P233_E1.3491.00
52_V55_G1.3441.00
94_D166_D1.3341.00
76_L106_H1.3251.00
7_H42_T1.3201.00
119_V135_I1.3191.00
143_Y187_D1.3141.00
175_V211_F1.2901.00
21_K24_E1.2891.00
220_A224_D1.2821.00
11_I48_F1.2791.00
79_K102_T1.2741.00
140_L156_S1.2511.00
80_L109_D1.2491.00
9_L28_L1.2451.00
3_T7_H1.2371.00
85_K89_L1.2271.00
93_G116_D1.2191.00
201_H226_T1.2161.00
90_L111_M1.2131.00
118_V138_Y1.2081.00
211_F234_E1.2061.00
34_S38_R1.1891.00
9_L29_T1.1881.00
97_Y198_Q1.1871.00
77_H80_L1.1851.00
239_N242_E1.1761.00
197_K224_D1.1651.00
172_T206_A1.1641.00
108_I130_L1.1631.00
76_L80_L1.1491.00
41_S45_E1.1441.00
176_H179_A1.1441.00
169_F203_Y1.1381.00
14_I49_L1.1341.00
17_H28_L1.1331.00
155_A159_A1.1321.00
157_L191_L1.1211.00
227_I247_K1.1171.00
12_D16_K1.1161.00
78_D208_P1.1121.00
91_E167_K1.1041.00
50_K57_A1.1011.00
118_V136_S1.0991.00
202_A225_A1.0811.00
237_F240_Y1.0801.00
11_I14_I1.0771.00
172_T219_F1.0691.00
203_Y229_T1.0671.00
14_I58_K1.0651.00
138_Y143_Y1.0581.00
42_T46_R1.0521.00
22_I40_L1.0391.00
3_T42_T1.0351.00
49_L56_A1.0281.00
89_L227_I1.0271.00
174_G182_T1.0261.00
86_A107_M1.0031.00
120_V163_Y0.9951.00
5_E9_L0.9921.00
211_F228_I0.9901.00
90_L169_F0.9901.00
26_I33_E0.9881.00
140_L160_M0.9881.00
78_D82_I0.9871.00
68_M102_T0.9841.00
87_A90_L0.9771.00
175_V206_A0.9751.00
108_I129_A0.9741.00
223_G244_T0.9721.00
87_A107_M0.9711.00
98_L107_M0.9671.00
83_A87_A0.9561.00
190_L193_Q0.9541.00
13_Q16_K0.9531.00
155_A163_Y0.9461.00
80_L84_E0.9401.00
104_T126_H0.9401.00
42_T45_E0.9381.00
173_N183_T0.9351.00
82_I103_T0.9341.00
157_L194_K0.9271.00
107_M110_F0.9251.00
189_A217_S0.9241.00
176_H214_I0.9231.00
101_G104_T0.9151.00
168_S195_A0.9141.00
41_S44_E0.9101.00
79_K103_T0.9091.00
79_K210_K0.9051.00
103_T207_D0.9041.00
162_Q193_Q0.9011.00
172_T204_V0.9001.00
75_N207_D0.8991.00
125_M149_G0.8971.00
164_R179_A0.8951.00
104_T107_M0.8941.00
164_R200_K0.8911.00
24_E28_L0.8881.00
20_V56_A0.8881.00
83_A107_M0.8781.00
83_A106_H0.8691.00
200_K214_I0.8691.00
103_T210_K0.8681.00
26_I36_I0.8651.00
137_F144_V0.8651.00
108_I126_H0.8561.00
11_I15_E0.8561.00
163_Y186_P0.8551.00
131_I149_G0.8531.00
112_D129_A0.8501.00
155_A162_Q0.8461.00
123_G126_H0.8461.00
20_V25_L0.8431.00
148_T173_N0.8401.00
5_E8_Q0.8371.00
43_L48_F0.8351.00
12_D15_E0.8341.00
164_R218_A0.8261.00
169_F205_L0.8171.00
164_R214_I0.8171.00
160_M195_A0.8101.00
202_A226_T0.8091.00
183_T189_A0.7991.00
116_D134_E0.7861.00
81_K84_E0.7831.00
179_A214_I0.7821.00
240_Y243_K0.7811.00
129_A132_R0.7781.00
104_T205_L0.7781.00
75_N208_P0.7751.00
97_Y160_M0.7721.00
186_P217_S0.7721.00
160_M194_K0.7721.00
86_A229_T0.7711.00
41_S51_R0.7611.00
175_V181_F0.7581.00
71_K173_N0.7581.00
128_D149_G0.7581.00
105_L129_A0.7581.00
24_E27_N0.7561.00
234_E237_F0.7561.00
164_R198_Q0.7551.00
98_L108_I0.7491.00
162_Q218_A0.7451.00
112_D115_K0.7421.00
196_I219_F0.7421.00
102_T210_K0.7401.00
98_L119_V0.7361.00
77_H81_K0.7271.00
18_D58_K0.7271.00
106_H110_F0.7180.99
5_E19_V0.7180.99
145_K188_E0.7170.99
172_T181_F0.7160.99
182_T214_I0.7080.99
7_H11_I0.7080.99
183_T219_F0.7070.99
145_K152_I0.7070.99
127_I144_V0.7010.99
141_G159_A0.7010.99
153_G156_S0.7000.99
100_A148_T0.6990.99
11_I43_L0.6960.99
193_Q197_K0.6910.99
114_T117_I0.6900.99
67_D70_E0.6890.99
206_A228_I0.6880.99
52_V57_A0.6850.99
72_S105_L0.6840.99
165_F199_A0.6840.99
168_S202_A0.6810.99
96_I119_V0.6790.99
65_E71_K0.6780.99
84_E88_S0.6760.99
175_V222_I0.6760.99
181_F219_F0.6760.99
23_Q27_N0.6750.99
127_I151_I0.6730.99
115_K134_E0.6730.99
81_K85_K0.6720.99
240_Y244_T0.6720.99
207_D210_K0.6690.99
31_A34_S0.6680.99
183_T188_E0.6640.99
95_C120_V0.6610.99
132_R149_G0.6610.99
158_V190_L0.6610.99
40_L51_R0.6570.99
154_G158_V0.6560.99
154_G190_L0.6530.99
141_G156_S0.6530.99
237_F241_Q0.6480.99
96_I167_K0.6480.99
25_L40_L0.6470.99
203_Y226_T0.6420.99
170_L199_A0.6420.99
44_E51_R0.6400.99
161_D198_Q0.6390.99
105_L125_M0.6360.99
6_R39_D0.6340.99
122_N195_A0.6310.99
236_T240_Y0.6300.99
199_A202_A0.6300.99
211_F237_F0.6280.99
82_I205_L0.6260.99
22_I36_I0.6240.99
121_T127_I0.6230.99
163_Y217_S0.6220.99
173_N215_S0.6210.99
4_P7_H0.6180.98
124_V151_I0.6150.98
29_T36_I0.6140.98
14_I20_V0.6120.98
154_G157_L0.6110.98
34_S123_G0.6070.98
124_V139_L0.6030.98
44_E49_L0.6030.98
78_D233_E0.5960.98
211_F230_T0.5950.98
145_K185_D0.5930.98
189_A219_F0.5920.98
220_A225_A0.5920.98
150_A188_E0.5900.98
69_L72_S0.5860.98
170_L219_F0.5840.98
125_M128_D0.5830.98
187_D190_L0.5810.98
72_S106_H0.5790.98
120_V216_F0.5790.98
90_L107_M0.5780.98
124_V128_D0.5770.98
156_S159_A0.5750.98
120_V138_Y0.5690.97
184_P215_S0.5660.97
173_N188_E0.5650.97
95_C216_F0.5640.97
192_K219_F0.5620.97
101_G171_G0.5590.97
96_I169_F0.5590.97
81_K232_A0.5580.97
157_L161_D0.5540.97
170_L196_I0.5540.97
191_L194_K0.5540.97
151_I159_A0.5500.97
233_E238_D0.5490.97
176_H182_T0.5450.97
65_E145_K0.5440.97
99_D104_T0.5440.97
201_H247_K0.5410.96
171_G183_T0.5410.96
181_F220_A0.5390.96
170_L202_A0.5380.96
116_D136_S0.5380.96
34_S173_N0.5380.96
242_E247_K0.5380.96
212_G237_F0.5370.96
97_Y168_S0.5370.96
38_R175_V0.5350.96
79_K207_D0.5310.96
173_N184_P0.5300.96
177_T237_F0.5290.96
123_G188_E0.5290.96
238_D241_Q0.5290.96
78_D81_K0.5270.96
174_G215_S0.5270.96
97_Y120_V0.5260.96
174_G213_E0.5260.96
183_T192_K0.5240.96
98_L126_H0.5240.96
22_I26_I0.5210.96
71_K188_E0.5200.96
71_K102_T0.5180.96
100_A188_E0.5180.96
231_D234_E0.5170.95
27_N30_N0.5170.95
130_L135_I0.5120.95
10_I29_T0.5110.95
68_M149_G0.5100.95
154_G187_D0.5100.95
202_A224_D0.5090.95
96_I107_M0.5090.95
158_V193_Q0.5070.95
155_A158_V0.5060.95
101_G173_N0.5030.95
20_V52_V0.5030.95
110_F113_K0.5020.95
136_S146_H0.5010.95
208_P234_E0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9283 100 0.508 Contact Map
3rrlB 1 0.6693 100 0.527 Contact Map
2w48A 3 0.9363 100 0.586 Contact Map
3l7oA 2 0.6016 100 0.603 Contact Map
1o8bA 2 0.5896 100 0.607 Contact Map
1m0sA 2 0.6135 100 0.614 Contact Map
1lk5A 4 0.6096 100 0.616 Contact Map
1uj6A 2 0.6096 100 0.617 Contact Map
3uw1A 2 0.6215 100 0.621 Contact Map
4io1A 2 0.6135 100 0.621 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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