FRUR - BACSU - GREMLIN Contacts

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FRUR - Uncharacterized HTH-type transcriptional regulator FruR

UniProt:	O31713	Sequences: MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLEERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGTTTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAMDQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSAFAGIGDATIITTDAEELTFDNYQEKTVVKVVKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	251 (244)
Sequences:	7652 (5644)
Seq/√Len:	361.3

ECOLI - YDJF AGAR GLPR YIHW YGBI GATR SGCR SRLR ULAR YCIT DEOR FUCR
BACSU - FRUR YULB GLCR IOLR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
94_D	167_K	3.301	1.00
85_K	88_S	3.157	1.00
107_M	205_L	2.963	1.00
136_S	143_Y	2.779	1.00
168_S	199_A	2.644	1.00
13_Q	28_L	2.381	1.00
99_D	192_K	2.313	1.00
196_I	220_A	2.256	1.00
208_P	231_D	2.238	1.00
109_D	129_A	2.228	1.00
161_D	194_K	2.149	1.00
203_Y	227_I	2.134	1.00
91_E	94_D	2.131	1.00
167_K	203_Y	2.059	1.00
13_Q	17_H	2.056	1.00
9_L	12_D	2.050	1.00
84_E	110_F	2.023	1.00
97_Y	165_F	2.002	1.00
80_L	106_H	2.002	1.00
196_I	202_A	1.993	1.00
158_V	161_D	1.956	1.00
218_A	221_G	1.946	1.00
98_L	104_T	1.922	1.00
167_K	201_H	1.917	1.00
234_E	238_D	1.897	1.00
97_Y	195_A	1.826	1.00
92_E	115_K	1.816	1.00
201_H	227_I	1.812	1.00
106_H	109_D	1.801	1.00
238_D	242_E	1.758	1.00
120_V	165_F	1.757	1.00
158_V	162_Q	1.708	1.00
86_A	169_F	1.678	1.00
221_G	224_D	1.667	1.00
165_F	195_A	1.643	1.00
194_K	197_K	1.630	1.00
86_A	205_L	1.623	1.00
157_L	190_L	1.602	1.00
139_L	151_I	1.594	1.00
127_I	139_L	1.566	1.00
239_N	243_K	1.562	1.00
166_D	200_K	1.546	1.00
75_N	209_S	1.532	1.00
140_L	159_A	1.525	1.00
107_M	169_F	1.521	1.00
181_F	225_A	1.513	1.00
181_F	204_V	1.499	1.00
19_V	57_A	1.498	1.00
161_D	197_K	1.488	1.00
87_A	110_F	1.487	1.00
31_A	36_I	1.483	1.00
7_H	46_R	1.478	1.00
80_L	110_F	1.451	1.00
25_L	36_I	1.450	1.00
156_S	191_L	1.449	1.00
83_A	110_F	1.436	1.00
10_I	25_L	1.428	1.00
119_V	130_L	1.427	1.00
9_L	13_Q	1.422	1.00
50_K	59_L	1.412	1.00
13_Q	20_V	1.411	1.00
89_L	229_T	1.410	1.00
140_L	151_I	1.406	1.00
15_E	58_K	1.397	1.00
8_Q	12_D	1.395	1.00
17_H	24_E	1.391	1.00
40_L	56_A	1.386	1.00
89_L	203_Y	1.379	1.00
194_K	198_Q	1.376	1.00
75_N	78_D	1.374	1.00
23_Q	33_E	1.373	1.00
100_A	150_A	1.366	1.00
92_E	116_D	1.363	1.00
204_V	225_A	1.361	1.00
92_E	114_T	1.359	1.00
144_V	151_I	1.354	1.00
78_D	231_D	1.354	1.00
208_P	233_E	1.349	1.00
52_V	55_G	1.344	1.00
94_D	166_D	1.334	1.00
76_L	106_H	1.325	1.00
7_H	42_T	1.320	1.00
119_V	135_I	1.319	1.00
143_Y	187_D	1.314	1.00
175_V	211_F	1.290	1.00
21_K	24_E	1.289	1.00
220_A	224_D	1.282	1.00
11_I	48_F	1.279	1.00
79_K	102_T	1.274	1.00
140_L	156_S	1.251	1.00
80_L	109_D	1.249	1.00
9_L	28_L	1.245	1.00
3_T	7_H	1.237	1.00
85_K	89_L	1.227	1.00
93_G	116_D	1.219	1.00
201_H	226_T	1.216	1.00
90_L	111_M	1.213	1.00
118_V	138_Y	1.208	1.00
211_F	234_E	1.206	1.00
34_S	38_R	1.189	1.00
9_L	29_T	1.188	1.00
97_Y	198_Q	1.187	1.00
77_H	80_L	1.185	1.00
239_N	242_E	1.176	1.00
197_K	224_D	1.165	1.00
172_T	206_A	1.164	1.00
108_I	130_L	1.163	1.00
76_L	80_L	1.149	1.00
41_S	45_E	1.144	1.00
176_H	179_A	1.144	1.00
169_F	203_Y	1.138	1.00
14_I	49_L	1.134	1.00
17_H	28_L	1.133	1.00
155_A	159_A	1.132	1.00
157_L	191_L	1.121	1.00
227_I	247_K	1.117	1.00
12_D	16_K	1.116	1.00
78_D	208_P	1.112	1.00
91_E	167_K	1.104	1.00
50_K	57_A	1.101	1.00
118_V	136_S	1.099	1.00
202_A	225_A	1.081	1.00
237_F	240_Y	1.080	1.00
11_I	14_I	1.077	1.00
172_T	219_F	1.069	1.00
203_Y	229_T	1.067	1.00
14_I	58_K	1.065	1.00
138_Y	143_Y	1.058	1.00
42_T	46_R	1.052	1.00
22_I	40_L	1.039	1.00
3_T	42_T	1.035	1.00
49_L	56_A	1.028	1.00
89_L	227_I	1.027	1.00
174_G	182_T	1.026	1.00
86_A	107_M	1.003	1.00
120_V	163_Y	0.995	1.00
5_E	9_L	0.992	1.00
211_F	228_I	0.990	1.00
90_L	169_F	0.990	1.00
26_I	33_E	0.988	1.00
140_L	160_M	0.988	1.00
78_D	82_I	0.987	1.00
68_M	102_T	0.984	1.00
87_A	90_L	0.977	1.00
175_V	206_A	0.975	1.00
108_I	129_A	0.974	1.00
223_G	244_T	0.972	1.00
87_A	107_M	0.971	1.00
98_L	107_M	0.967	1.00
83_A	87_A	0.956	1.00
190_L	193_Q	0.954	1.00
13_Q	16_K	0.953	1.00
155_A	163_Y	0.946	1.00
80_L	84_E	0.940	1.00
104_T	126_H	0.940	1.00
42_T	45_E	0.938	1.00
173_N	183_T	0.935	1.00
82_I	103_T	0.934	1.00
157_L	194_K	0.927	1.00
107_M	110_F	0.925	1.00
189_A	217_S	0.924	1.00
176_H	214_I	0.923	1.00
101_G	104_T	0.915	1.00
168_S	195_A	0.914	1.00
41_S	44_E	0.910	1.00
79_K	103_T	0.909	1.00
79_K	210_K	0.905	1.00
103_T	207_D	0.904	1.00
162_Q	193_Q	0.901	1.00
172_T	204_V	0.900	1.00
75_N	207_D	0.899	1.00
125_M	149_G	0.897	1.00
164_R	179_A	0.895	1.00
104_T	107_M	0.894	1.00
164_R	200_K	0.891	1.00
24_E	28_L	0.888	1.00
20_V	56_A	0.888	1.00
83_A	107_M	0.878	1.00
83_A	106_H	0.869	1.00
200_K	214_I	0.869	1.00
103_T	210_K	0.868	1.00
26_I	36_I	0.865	1.00
137_F	144_V	0.865	1.00
108_I	126_H	0.856	1.00
11_I	15_E	0.856	1.00
163_Y	186_P	0.855	1.00
131_I	149_G	0.853	1.00
112_D	129_A	0.850	1.00
155_A	162_Q	0.846	1.00
123_G	126_H	0.846	1.00
20_V	25_L	0.843	1.00
148_T	173_N	0.840	1.00
5_E	8_Q	0.837	1.00
43_L	48_F	0.835	1.00
12_D	15_E	0.834	1.00
164_R	218_A	0.826	1.00
169_F	205_L	0.817	1.00
164_R	214_I	0.817	1.00
160_M	195_A	0.810	1.00
202_A	226_T	0.809	1.00
183_T	189_A	0.799	1.00
116_D	134_E	0.786	1.00
81_K	84_E	0.783	1.00
179_A	214_I	0.782	1.00
240_Y	243_K	0.781	1.00
129_A	132_R	0.778	1.00
104_T	205_L	0.778	1.00
75_N	208_P	0.775	1.00
97_Y	160_M	0.772	1.00
186_P	217_S	0.772	1.00
160_M	194_K	0.772	1.00
86_A	229_T	0.771	1.00
41_S	51_R	0.761	1.00
175_V	181_F	0.758	1.00
71_K	173_N	0.758	1.00
128_D	149_G	0.758	1.00
105_L	129_A	0.758	1.00
24_E	27_N	0.756	1.00
234_E	237_F	0.756	1.00
164_R	198_Q	0.755	1.00
98_L	108_I	0.749	1.00
162_Q	218_A	0.745	1.00
112_D	115_K	0.742	1.00
196_I	219_F	0.742	1.00
102_T	210_K	0.740	1.00
98_L	119_V	0.736	1.00
77_H	81_K	0.727	1.00
18_D	58_K	0.727	1.00
106_H	110_F	0.718	0.99
5_E	19_V	0.718	0.99
145_K	188_E	0.717	0.99
172_T	181_F	0.716	0.99
182_T	214_I	0.708	0.99
7_H	11_I	0.708	0.99
183_T	219_F	0.707	0.99
145_K	152_I	0.707	0.99
127_I	144_V	0.701	0.99
141_G	159_A	0.701	0.99
153_G	156_S	0.700	0.99
100_A	148_T	0.699	0.99
11_I	43_L	0.696	0.99
193_Q	197_K	0.691	0.99
114_T	117_I	0.690	0.99
67_D	70_E	0.689	0.99
206_A	228_I	0.688	0.99
52_V	57_A	0.685	0.99
72_S	105_L	0.684	0.99
165_F	199_A	0.684	0.99
168_S	202_A	0.681	0.99
96_I	119_V	0.679	0.99
65_E	71_K	0.678	0.99
84_E	88_S	0.676	0.99
175_V	222_I	0.676	0.99
181_F	219_F	0.676	0.99
23_Q	27_N	0.675	0.99
127_I	151_I	0.673	0.99
115_K	134_E	0.673	0.99
81_K	85_K	0.672	0.99
240_Y	244_T	0.672	0.99
207_D	210_K	0.669	0.99
31_A	34_S	0.668	0.99
183_T	188_E	0.664	0.99
95_C	120_V	0.661	0.99
132_R	149_G	0.661	0.99
158_V	190_L	0.661	0.99
40_L	51_R	0.657	0.99
154_G	158_V	0.656	0.99
154_G	190_L	0.653	0.99
141_G	156_S	0.653	0.99
237_F	241_Q	0.648	0.99
96_I	167_K	0.648	0.99
25_L	40_L	0.647	0.99
203_Y	226_T	0.642	0.99
170_L	199_A	0.642	0.99
44_E	51_R	0.640	0.99
161_D	198_Q	0.639	0.99
105_L	125_M	0.636	0.99
6_R	39_D	0.634	0.99
122_N	195_A	0.631	0.99
236_T	240_Y	0.630	0.99
199_A	202_A	0.630	0.99
211_F	237_F	0.628	0.99
82_I	205_L	0.626	0.99
22_I	36_I	0.624	0.99
121_T	127_I	0.623	0.99
163_Y	217_S	0.622	0.99
173_N	215_S	0.621	0.99
4_P	7_H	0.618	0.98
124_V	151_I	0.615	0.98
29_T	36_I	0.614	0.98
14_I	20_V	0.612	0.98
154_G	157_L	0.611	0.98
34_S	123_G	0.607	0.98
124_V	139_L	0.603	0.98
44_E	49_L	0.603	0.98
78_D	233_E	0.596	0.98
211_F	230_T	0.595	0.98
145_K	185_D	0.593	0.98
189_A	219_F	0.592	0.98
220_A	225_A	0.592	0.98
150_A	188_E	0.590	0.98
69_L	72_S	0.586	0.98
170_L	219_F	0.584	0.98
125_M	128_D	0.583	0.98
187_D	190_L	0.581	0.98
72_S	106_H	0.579	0.98
120_V	216_F	0.579	0.98
90_L	107_M	0.578	0.98
124_V	128_D	0.577	0.98
156_S	159_A	0.575	0.98
120_V	138_Y	0.569	0.97
184_P	215_S	0.566	0.97
173_N	188_E	0.565	0.97
95_C	216_F	0.564	0.97
192_K	219_F	0.562	0.97
101_G	171_G	0.559	0.97
96_I	169_F	0.559	0.97
81_K	232_A	0.558	0.97
157_L	161_D	0.554	0.97
170_L	196_I	0.554	0.97
191_L	194_K	0.554	0.97
151_I	159_A	0.550	0.97
233_E	238_D	0.549	0.97
176_H	182_T	0.545	0.97
65_E	145_K	0.544	0.97
99_D	104_T	0.544	0.97
201_H	247_K	0.541	0.96
171_G	183_T	0.541	0.96
181_F	220_A	0.539	0.96
170_L	202_A	0.538	0.96
116_D	136_S	0.538	0.96
34_S	173_N	0.538	0.96
242_E	247_K	0.538	0.96
212_G	237_F	0.537	0.96
97_Y	168_S	0.537	0.96
38_R	175_V	0.535	0.96
79_K	207_D	0.531	0.96
173_N	184_P	0.530	0.96
177_T	237_F	0.529	0.96
123_G	188_E	0.529	0.96
238_D	241_Q	0.529	0.96
78_D	81_K	0.527	0.96
174_G	215_S	0.527	0.96
97_Y	120_V	0.526	0.96
174_G	213_E	0.526	0.96
183_T	192_K	0.524	0.96
98_L	126_H	0.524	0.96
22_I	26_I	0.521	0.96
71_K	188_E	0.520	0.96
71_K	102_T	0.518	0.96
100_A	188_E	0.518	0.96
231_D	234_E	0.517	0.95
27_N	30_N	0.517	0.95
130_L	135_I	0.512	0.95
10_I	29_T	0.511	0.95
68_M	149_G	0.510	0.95
154_G	187_D	0.510	0.95
202_A	224_D	0.509	0.95
96_I	107_M	0.509	0.95
158_V	193_Q	0.507	0.95
155_A	158_V	0.506	0.95
101_G	173_N	0.503	0.95
20_V	52_V	0.503	0.95
110_F	113_K	0.502	0.95
136_S	146_H	0.501	0.95
208_P	234_E	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1stzA	3	0.9283	100	0.508	Contact Map
3rrlB	1	0.6693	100	0.527	Contact Map
2w48A	3	0.9363	100	0.586	Contact Map
3l7oA	2	0.6016	100	0.603	Contact Map
1o8bA	2	0.5896	100	0.607	Contact Map
1m0sA	2	0.6135	100	0.614	Contact Map
1lk5A	4	0.6096	100	0.616	Contact Map
1uj6A	2	0.6096	100	0.617	Contact Map
3uw1A	2	0.6215	100	0.621	Contact Map
4io1A	2	0.6135	100	0.621	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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