GREMLIN Database
YKNZ - Uncharacterized ABC transporter permease YknZ
UniProt: O31712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (357)
Sequences: 36529 (31326)
Seq/√Len: 1658.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V181_P3.5661.00
158_Q189_K3.5391.00
176_W181_P3.3201.00
305_I322_F3.2961.00
174_V183_E3.2651.00
158_Q162_K2.9611.00
153_V183_E2.7201.00
153_V185_I2.6521.00
170_P173_E2.6221.00
389_D392_E2.5931.00
161_A187_V2.5511.00
84_T87_D2.5491.00
301_R325_E2.5451.00
154_G202_M2.4841.00
169_S173_E2.4711.00
235_G239_A2.4061.00
334_G367_V2.3641.00
15_L18_K2.3311.00
135_K189_K2.3311.00
309_K315_R2.2991.00
314_T317_Q2.2881.00
230_D233_S2.2491.00
379_M383_N2.2471.00
155_I186_G2.2421.00
88_I92_K2.2201.00
154_G182_V2.1851.00
383_N387_K2.1441.00
59_T63_Y2.1231.00
326_S378_G2.0781.00
89_K92_K2.0311.00
156_I161_A2.0021.00
155_I188_L2.0011.00
330_T374_G1.9821.00
98_K226_E1.9621.00
337_G341_G1.9431.00
233_S237_E1.9171.00
96_G226_E1.9131.00
256_N259_E1.9081.00
29_I336_V1.8941.00
359_S362_V1.8931.00
25_M29_I1.8541.00
136_I141_T1.8241.00
36_I341_G1.8061.00
160_M164_L1.8021.00
140_R185_I1.7991.00
152_R208_M1.7881.00
85_E89_K1.7831.00
96_G237_E1.7831.00
169_S184_I1.7801.00
207_N210_K1.7361.00
90_G93_G1.7361.00
89_K93_G1.7351.00
319_L383_N1.7351.00
138_S169_S1.7251.00
205_P208_M1.7251.00
301_R304_E1.7181.00
154_G204_V1.7131.00
60_V64_Y1.7101.00
98_K224_Q1.6531.00
87_D90_G1.6371.00
182_V208_M1.6261.00
237_E240_Q1.6061.00
232_K235_G1.6051.00
204_V209_M1.5971.00
29_I340_I1.5691.00
159_K190_K1.5651.00
33_G340_I1.5631.00
156_I202_M1.5571.00
124_I128_Y1.5561.00
236_K239_A1.5531.00
47_Q51_Q1.5471.00
154_G175_V1.5371.00
317_Q320_T1.5281.00
156_I184_I1.5251.00
231_I235_G1.5181.00
12_S15_L1.5031.00
236_K240_Q1.5001.00
156_I160_M1.4991.00
25_M333_G1.4971.00
155_I185_I1.4851.00
86_N90_G1.4781.00
171_L187_V1.4661.00
225_V234_A1.4551.00
157_S188_L1.4551.00
159_K162_K1.4541.00
137_E158_Q1.4461.00
206_F210_K1.4381.00
360_W364_C1.4381.00
204_V208_M1.4371.00
157_S160_M1.4191.00
140_R153_V1.4071.00
94_I237_E1.3941.00
316_G320_T1.3941.00
315_R386_A1.3901.00
333_G337_G1.3851.00
112_Y115_E1.3831.00
237_E241_L1.3791.00
152_R180_Q1.3781.00
382_A386_A1.3621.00
343_G347_L1.3511.00
361_Q365_G1.3461.00
377_F381_P1.3371.00
14_V21_S1.3361.00
20_R300_E1.3311.00
43_Q359_S1.3271.00
232_K236_K1.3201.00
13_S325_E1.3191.00
330_T334_G1.3151.00
52_S55_G1.3121.00
302_T393_A1.3081.00
138_S170_P1.3041.00
29_I33_G1.2961.00
276_G280_G1.2821.00
221_V225_V1.2811.00
32_V337_G1.2801.00
129_M141_T1.2631.00
99_Q224_Q1.2631.00
313_A317_Q1.2631.00
83_F87_D1.2621.00
305_I318_I1.2561.00
137_E189_K1.2541.00
86_N89_K1.2461.00
141_T155_I1.2411.00
262_A266_K1.2341.00
343_G346_A1.2301.00
85_E88_I1.2221.00
103_S220_N1.2201.00
142_F185_I1.2101.00
28_I333_G1.2101.00
304_E308_R1.2021.00
339_G343_G1.1921.00
47_Q357_L1.1901.00
33_G344_G1.1831.00
40_A345_A1.1821.00
306_G310_S1.1791.00
142_F153_V1.1791.00
157_S200_S1.1711.00
227_S230_D1.1611.00
302_T388_L1.1611.00
10_A324_I1.1601.00
94_I241_L1.1591.00
308_R313_A1.1561.00
164_L169_S1.1551.00
159_K163_E1.1531.00
142_F155_I1.1521.00
127_G130_N1.1521.00
320_T324_I1.1511.00
287_G377_F1.1501.00
96_G234_A1.1481.00
33_G341_G1.1471.00
335_L339_G1.1461.00
136_I186_G1.1431.00
61_E64_Y1.1331.00
165_F169_S1.1301.00
19_M22_I1.1201.00
341_G345_A1.1201.00
33_G337_G1.1201.00
171_L185_I1.1201.00
306_G393_A1.1161.00
140_R143_T1.1131.00
384_K387_K1.1131.00
364_C368_L1.1121.00
239_A243_N1.1051.00
51_Q54_S1.1041.00
97_I100_V1.1041.00
308_R321_Q1.1041.00
158_Q190_K1.0991.00
46_E50_K1.0961.00
221_V224_Q1.0951.00
51_Q55_G1.0941.00
36_I366_G1.0791.00
156_I187_V1.0671.00
31_G279_A1.0671.00
357_L360_W1.0601.00
21_S329_L1.0551.00
47_Q50_K1.0521.00
255_M260_I1.0521.00
273_T277_S1.0501.00
209_M213_F1.0351.00
294_M326_S1.0341.00
165_F170_P1.0301.00
43_Q46_E1.0291.00
94_I97_I1.0281.00
200_S203_Y1.0241.00
17_H300_E1.0231.00
383_N386_A1.0231.00
201_E204_V1.0211.00
336_V339_G1.0211.00
46_E272_T1.0201.00
347_L350_A1.0181.00
238_A241_L1.0171.00
233_S236_K1.0161.00
87_D91_L1.0131.00
43_Q362_V1.0101.00
334_G370_S1.0051.00
11_L15_L0.9891.00
225_V231_I0.9871.00
240_Q243_N0.9861.00
43_Q47_Q0.9821.00
361_Q364_C0.9801.00
90_G241_L0.9781.00
176_W179_G0.9751.00
347_L351_I0.9731.00
330_T370_S0.9661.00
58_N61_E0.9641.00
48_M52_S0.9571.00
22_I26_L0.9571.00
388_L392_E0.9551.00
138_S171_L0.9511.00
346_A350_A0.9431.00
25_M332_I0.9431.00
225_V228_A0.9411.00
234_A237_E0.9391.00
282_S289_G0.9381.00
94_I234_A0.9371.00
338_I363_V0.9371.00
319_L379_M0.9361.00
269_A273_T0.9321.00
58_N65_M0.9311.00
99_Q131_V0.9291.00
358_I363_V0.9281.00
235_G256_N0.9211.00
25_M336_V0.9151.00
291_M295_L0.9151.00
208_M211_S0.9071.00
265_G269_A0.9071.00
327_V375_V0.9051.00
301_R322_F0.9041.00
384_K388_L0.9021.00
29_I32_V0.8991.00
229_D233_S0.8981.00
382_A385_A0.8981.00
92_K100_V0.8931.00
287_G373_I0.8851.00
157_S190_K0.8851.00
58_N63_Y0.8851.00
100_V103_S0.8841.00
50_K54_S0.8791.00
255_M259_E0.8751.00
28_I32_V0.8741.00
266_K269_A0.8721.00
243_N250_D0.8641.00
370_S374_G0.8631.00
326_S330_T0.8601.00
302_T306_G0.8601.00
257_M260_I0.8581.00
268_T272_T0.8541.00
339_G342_Y0.8521.00
380_L383_N0.8501.00
27_G31_G0.8501.00
313_A318_I0.8481.00
17_H20_R0.8421.00
188_L192_T0.8361.00
27_G289_G0.8311.00
32_V370_S0.8301.00
40_A44_G0.8271.00
234_A238_A0.8261.00
88_I102_A0.8241.00
201_E205_P0.8231.00
88_I91_L0.8221.00
309_K390_P0.8161.00
200_S205_P0.8161.00
315_R387_K0.8151.00
315_R319_L0.8151.00
261_A265_G0.8141.00
130_N141_T0.8141.00
103_S222_S0.8131.00
157_S201_E0.8111.00
345_A356_S0.8101.00
29_I333_G0.8071.00
138_S187_V0.8011.00
231_I234_A0.8011.00
345_A349_S0.8001.00
263_G266_K0.7941.00
388_L393_A0.7931.00
102_A125_N0.7931.00
101_V125_N0.7931.00
390_P393_A0.7911.00
365_G368_L0.7901.00
84_T88_I0.7881.00
366_G370_S0.7871.00
368_L372_L0.7831.00
226_E230_D0.7821.00
338_I367_V0.7791.00
391_I394_L0.7711.00
60_V63_Y0.7701.00
170_P187_V0.7691.00
235_G241_L0.7671.00
323_L375_V0.7611.00
61_E65_M0.7611.00
117_T163_E0.7601.00
134_L188_L0.7601.00
35_V39_V0.7601.00
292_N296_V0.7591.00
37_V344_G0.7511.00
309_K318_I0.7511.00
327_V374_G0.7491.00
59_T65_M0.7481.00
319_L382_A0.7481.00
229_D234_A0.7471.00
319_L386_A0.7461.00
136_I188_L0.7441.00
125_N128_Y0.7421.00
372_L376_I0.7421.00
158_Q161_A0.7401.00
123_G209_M0.7381.00
342_Y358_I0.7371.00
156_I175_V0.7311.00
99_Q130_N0.7311.00
363_V367_V0.7311.00
177_I182_V0.7301.00
298_V305_I0.7291.00
83_F86_N0.7281.00
171_L186_G0.7261.00
48_M51_Q0.7221.00
209_M212_S0.7211.00
125_N206_F0.7211.00
299_T302_T0.7201.00
334_G338_I0.7191.00
324_I327_V0.7191.00
291_M377_F0.7171.00
58_N62_L0.7171.00
303_R307_I0.7151.00
165_F173_E0.7131.00
334_G374_G0.7101.00
280_G284_L0.7091.00
234_A241_L0.7081.00
13_S301_R0.7041.00
297_S301_R0.7021.00
362_V365_G0.7011.00
203_Y206_F0.7011.00
180_Q211_S0.7011.00
369_F372_L0.6981.00
98_K101_V0.6981.00
119_A160_M0.6981.00
332_I335_L0.6981.00
19_M23_L0.6971.00
226_E229_D0.6961.00
380_L384_K0.6961.00
324_I328_V0.6941.00
54_S57_G0.6901.00
175_V182_V0.6901.00
120_T123_G0.6881.00
108_M121_V0.6871.00
214_G217_D0.6851.00
340_I343_G0.6841.00
222_S225_V0.6831.00
109_K112_Y0.6831.00
58_N64_Y0.6801.00
88_I100_V0.6801.00
100_V223_L0.6791.00
270_I274_I0.6791.00
156_I169_S0.6791.00
346_A356_S0.6751.00
297_S325_E0.6741.00
121_V204_V0.6741.00
18_K22_I0.6731.00
119_A202_M0.6731.00
98_K102_A0.6731.00
362_V366_G0.6731.00
53_I57_G0.6721.00
91_L238_A0.6711.00
367_V371_M0.6711.00
97_I223_L0.6701.00
24_T293_I0.6691.00
279_A283_L0.6691.00
251_S254_V0.6681.00
218_F221_V0.6681.00
121_V202_M0.6661.00
378_G382_A0.6661.00
9_M13_S0.6661.00
286_G289_G0.6651.00
13_S304_E0.6641.00
206_F209_M0.6641.00
42_G272_T0.6601.00
131_V224_Q0.6601.00
220_N223_L0.6601.00
142_F145_N0.6601.00
152_R183_E0.6591.00
53_I56_P0.6571.00
259_E262_A0.6571.00
63_Y255_M0.6561.00
365_G369_F0.6541.00
342_Y346_A0.6541.00
307_I310_S0.6521.00
157_S199_L0.6511.00
289_G292_N0.6491.00
132_N135_K0.6481.00
326_S374_G0.6461.00
306_G390_P0.6461.00
24_T27_G0.6441.00
182_V204_V0.6431.00
381_P385_A0.6431.00
9_M321_Q0.6411.00
23_L27_G0.6411.00
172_G183_E0.6401.00
326_S381_P0.6401.00
136_I155_I0.6381.00
369_F373_I0.6371.00
28_I290_V0.6371.00
109_K116_E0.6351.00
294_M297_S0.6351.00
9_M308_R0.6351.00
102_A218_F0.6321.00
169_S175_V0.6281.00
27_G292_N0.6281.00
254_V257_M0.6261.00
331_L371_M0.6251.00
127_G131_V0.6251.00
298_V385_A0.6211.00
235_G259_E0.6211.00
88_I221_V0.6211.00
92_K95_E0.6201.00
262_A265_G0.6181.00
145_N152_R0.6181.00
111_R115_E0.6171.00
239_A254_V0.6171.00
357_L361_Q0.6161.00
220_N224_Q0.6151.00
334_G371_M0.6151.00
49_L52_S0.6141.00
140_R144_D0.6141.00
101_V104_T0.6111.00
60_V235_G0.6101.00
136_I140_R0.6101.00
141_T145_N0.6101.00
154_G184_I0.6091.00
158_Q187_V0.6081.00
330_T378_G0.6071.00
110_A113_H0.6071.00
258_E262_A0.6061.00
293_I297_S0.6061.00
298_V322_F0.6051.00
111_R114_E0.6041.00
31_G289_G0.6031.00
60_V225_V0.6031.00
225_V229_D0.6021.00
266_K270_I0.6021.00
99_Q102_A0.6001.00
137_E188_L0.5991.00
325_E328_V0.5991.00
253_Q256_N0.5971.00
307_I311_L0.5961.00
321_Q324_I0.5961.00
348_V352_A0.5951.00
219_S223_L0.5951.00
342_Y363_V0.5951.00
360_W363_V0.5941.00
238_A242_V0.5911.00
49_L53_I0.5901.00
235_G254_V0.5891.00
37_V341_G0.5881.00
326_S382_A0.5881.00
59_T224_Q0.5851.00
346_A349_S0.5841.00
184_I187_V0.5821.00
381_P386_A0.5811.00
323_L379_M0.5801.00
10_A321_Q0.5781.00
373_I377_F0.5751.00
104_T209_M0.5751.00
139_G142_F0.5751.00
103_S106_E0.5751.00
304_E307_I0.5741.00
282_S286_G0.5741.00
161_A170_P0.5741.00
136_I189_K0.5721.00
46_E49_L0.5721.00
138_S161_A0.5701.00
151_N183_E0.5691.00
90_G94_I0.5691.00
188_L203_Y0.5671.00
299_T384_K0.5671.00
285_V289_G0.5671.00
252_Y255_M0.5671.00
272_T276_G0.5651.00
33_G37_V0.5651.00
29_I337_G0.5641.00
188_L191_V0.5631.00
348_V351_I0.5611.00
121_V124_I0.5611.00
358_I362_V0.5611.00
294_M378_G0.5601.00
319_L323_L0.5561.00
123_G126_D0.5561.00
36_I40_A0.5541.00
161_A169_S0.5521.00
18_K21_S0.5511.00
268_T271_M0.5501.00
11_L328_V0.5491.00
225_V230_D0.5481.00
322_F326_S0.5471.00
302_T384_K0.5461.00
113_H116_E0.5421.00
104_T107_S0.5401.00
199_L204_V0.5391.00
304_E321_Q0.5391.00
110_A119_A0.5391.00
111_R176_W0.5371.00
92_K99_Q0.5341.00
152_R182_V0.5331.00
274_I278_I0.5331.00
310_S390_P0.5321.00
161_A184_I0.5321.00
24_T28_I0.5311.00
304_E325_E0.5311.00
95_E98_K0.5301.00
59_T64_Y0.5291.00
132_N222_S0.5291.00
128_Y131_V0.5281.00
129_M134_L0.5281.00
31_G34_S0.5261.00
36_I337_G0.5261.00
155_I203_Y0.5231.00
39_V43_Q0.5231.00
287_G291_M0.5181.00
227_S231_I0.5181.00
99_Q127_G0.5181.00
374_G377_F0.5171.00
171_L184_I0.5131.00
40_A341_G0.5121.00
309_K393_A0.5111.00
123_G206_F0.5101.00
323_L327_V0.5081.00
43_Q361_Q0.5081.00
376_I380_L0.5071.00
143_T185_I0.5061.00
202_M205_P0.5051.00
162_K190_K0.5041.00
126_D129_M0.5041.00
199_L202_M0.5041.00
35_V366_G0.5041.00
111_R116_E0.5041.00
271_M275_I0.5031.00
326_S377_F0.5031.00
286_G370_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ftjA 1 0.5315 99.6 0.693 Contact Map
3is6A 2 0.5491 99.2 0.748 Contact Map
4av3A 2 0.272 29.5 0.939 Contact Map
4k0jA 3 0.8539 26.1 0.94 Contact Map
4mt1A 3 0.8287 16.1 0.946 Contact Map
2kogA 1 0.1033 15.8 0.946 Contact Map
3w9iA 3 0.806 15.4 0.946 Contact Map
3ne5A 3 0.8665 14.5 0.947 Contact Map
4pl0A 2 0.2418 13.4 0.948 Contact Map
4dx5A 3 0.8615 9.2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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