GREMLIN Database
YKNX - Putative efflux system component YknX
UniProt: O31710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (344)
Sequences: 22589 (18149)
Seq/√Len: 978.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_K335_K3.2251.00
76_D93_T3.0241.00
90_A183_E2.8291.00
340_K353_E2.6901.00
325_Y336_R2.6881.00
41_S360_Q2.6811.00
86_K189_E2.5541.00
107_Q176_A2.4161.00
20_I23_Y2.4101.00
337_V359_D2.3681.00
328_T337_V2.3261.00
58_K222_S2.3131.00
314_S349_T2.2821.00
256_S284_K2.2811.00
311_T348_L2.1791.00
323_Q338_D2.1421.00
44_E357_Q2.1391.00
238_K252_K2.1341.00
93_T183_E2.1071.00
45_N348_L2.0931.00
253_G283_V2.0931.00
96_N100_S2.0641.00
114_R169_E2.0541.00
44_E308_K2.0501.00
78_K93_T2.0321.00
68_E181_D2.0041.00
86_K89_T1.9901.00
90_A185_K1.9721.00
121_Q125_K1.9381.00
84_K191_T1.9181.00
240_T252_K1.8991.00
240_T250_T1.8881.00
193_I214_G1.8841.00
128_D132_R1.8841.00
249_K291_E1.8731.00
45_N311_T1.8731.00
78_K90_A1.8701.00
103_K172_R1.8681.00
356_T359_D1.8541.00
342_G350_E1.8201.00
223_G300_M1.7981.00
222_S280_P1.7921.00
148_E152_T1.7851.00
333_K374_E1.7561.00
155_Q159_K1.7471.00
335_K371_D1.7311.00
50_T301_N1.7231.00
57_L221_V1.7141.00
166_K169_E1.7041.00
126_A130_K1.6821.00
104_E107_Q1.6801.00
220_V282_Q1.6731.00
105_Q171_Q1.6721.00
87_K189_E1.6721.00
342_G352_K1.6611.00
341_I349_T1.6551.00
340_K352_K1.6521.00
239_V283_V1.6391.00
112_S164_E1.6221.00
74_L197_Q1.6201.00
111_E114_R1.5711.00
223_G283_V1.5541.00
64_Y209_P1.5331.00
103_K176_A1.5171.00
107_Q111_E1.5091.00
110_S172_R1.5041.00
319_K324_Y1.5021.00
100_S104_E1.5001.00
334_A362_I1.4991.00
121_Q162_E1.4931.00
158_K162_E1.4811.00
343_E350_E1.4811.00
159_K162_E1.4631.00
42_V310_N1.4621.00
114_R118_D1.4541.00
162_E166_K1.4491.00
74_L92_V1.4441.00
221_V298_F1.4431.00
110_S165_L1.4401.00
173_Q176_A1.4371.00
19_G23_Y1.4301.00
110_S114_R1.4261.00
19_G22_I1.4241.00
103_K107_Q1.4231.00
320_E336_R1.4221.00
243_S298_F1.4211.00
118_D121_Q1.4181.00
117_I121_Q1.4141.00
52_M301_N1.4131.00
169_E173_Q1.4131.00
117_I162_E1.4091.00
238_K254_T1.4081.00
80_K83_D1.4071.00
215_N218_D1.4001.00
328_T359_D1.3971.00
100_S179_V1.3941.00
224_K280_P1.3921.00
262_P279_Y1.3841.00
314_S347_D1.3841.00
61_N215_N1.3821.00
326_V339_V1.3781.00
105_Q109_T1.3761.00
151_R155_Q1.3761.00
38_Q364_N1.3701.00
46_E307_R1.3641.00
119_Q123_K1.3591.00
117_I165_L1.3561.00
75_E95_T1.3371.00
39_T329_V1.3311.00
52_M299_I1.3201.00
240_T301_N1.3191.00
42_V358_D1.3191.00
57_L219_L1.3071.00
62_E212_H1.3011.00
72_G94_Y1.2991.00
114_R165_L1.2901.00
124_L128_D1.2841.00
117_I158_K1.2801.00
40_G363_L1.2771.00
128_D155_Q1.2761.00
263_D275_Q1.2741.00
125_K128_D1.2731.00
226_S229_D1.2681.00
242_T250_T1.2681.00
165_L169_E1.2671.00
240_T303_E1.2671.00
46_E308_K1.2631.00
309_A350_E1.2631.00
242_T301_N1.2531.00
39_T360_Q1.2511.00
91_L211_I1.2491.00
107_Q172_R1.2451.00
192_V211_I1.2441.00
312_L361_V1.2401.00
254_T284_K1.2361.00
218_D284_K1.2331.00
102_E105_Q1.2301.00
172_R176_A1.2171.00
186_S213_I1.2081.00
102_E178_R1.2051.00
71_K206_I1.1961.00
99_L182_L1.1941.00
64_Y212_H1.1921.00
121_Q158_K1.1881.00
113_N168_T1.1811.00
194_S212_H1.1731.00
257_A282_Q1.1691.00
109_T112_S1.1661.00
90_A93_T1.1641.00
110_S169_E1.1581.00
310_N357_Q1.1511.00
79_V89_T1.1461.00
195_V198_E1.1421.00
112_S116_Q1.1401.00
109_T171_Q1.1401.00
329_V360_Q1.1341.00
241_L285_I1.1251.00
221_V300_M1.1231.00
92_V211_I1.1191.00
314_S344_V1.1161.00
174_S178_R1.1151.00
104_E173_Q1.1151.00
76_D199_A1.1111.00
127_L154_L1.0961.00
339_V351_I1.0941.00
18_V22_I1.0931.00
102_E174_S1.0921.00
195_V211_I1.0901.00
60_S218_D1.0841.00
176_A180_S1.0771.00
106_N168_T1.0761.00
118_D122_E1.0711.00
259_G280_P1.0641.00
222_S282_Q1.0641.00
246_I251_W1.0601.00
255_V283_V1.0591.00
328_T335_K1.0561.00
230_T279_Y1.0481.00
157_Q160_T1.0461.00
111_E166_K1.0461.00
80_K195_V1.0441.00
92_V184_V1.0401.00
330_K333_K1.0371.00
120_I161_A1.0361.00
123_K127_L1.0331.00
81_E194_S1.0331.00
324_Y341_I1.0321.00
254_T286_K1.0251.00
116_Q164_E1.0201.00
320_E323_Q1.0201.00
229_D232_K1.0091.00
75_E93_T1.0091.00
103_K179_V1.0071.00
317_V349_T1.0061.00
330_K337_V1.0061.00
157_Q161_A1.0041.00
344_V349_T1.0011.00
221_V241_L0.9991.00
17_F20_I0.9951.00
317_V324_Y0.9921.00
96_N182_L0.9911.00
68_E73_T0.9811.00
124_L151_R0.9801.00
41_S358_D0.9751.00
152_T155_Q0.9731.00
57_L292_G0.9691.00
63_Q188_I0.9651.00
263_D276_A0.9641.00
48_S303_E0.9621.00
131_E148_E0.9561.00
345_T348_L0.9491.00
56_T277_V0.9471.00
287_G290_P0.9471.00
133_E145_K0.9461.00
67_Y184_V0.9391.00
125_K129_S0.9371.00
220_V284_K0.9361.00
16_L20_I0.9211.00
124_L158_K0.9201.00
106_N175_L0.9201.00
150_E153_E0.9181.00
71_K205_D0.9161.00
74_L204_S0.9151.00
17_F21_N0.9071.00
186_S189_E0.9071.00
116_Q119_Q0.9071.00
205_D208_E0.9051.00
218_D286_K0.9031.00
57_L298_F0.9021.00
60_S220_V0.9011.00
108_L170_L0.9001.00
204_S210_V0.8981.00
77_I199_A0.8921.00
124_L155_Q0.8901.00
129_S132_R0.8881.00
329_V332_G0.8791.00
332_G374_E0.8781.00
242_T299_I0.8761.00
241_L253_G0.8751.00
20_I24_R0.8721.00
153_E157_Q0.8721.00
196_N212_H0.8711.00
329_V334_A0.8701.00
127_L146_Q0.8671.00
164_E167_Q0.8621.00
118_D159_K0.8621.00
48_S306_K0.8601.00
116_Q160_T0.8591.00
83_D89_T0.8581.00
312_L326_V0.8581.00
190_G213_I0.8581.00
146_Q150_E0.8571.00
49_S232_K0.8551.00
113_N161_A0.8541.00
84_K290_P0.8521.00
246_I249_K0.8501.00
92_V195_V0.8501.00
50_T303_E0.8481.00
79_V211_I0.8461.00
149_S153_E0.8441.00
35_K373_M0.8421.00
196_N209_P0.8401.00
109_T113_N0.8401.00
101_L177_N0.8371.00
177_N181_D0.8371.00
46_E306_K0.8341.00
96_N183_E0.8311.00
92_V210_V0.8301.00
131_E151_R0.8291.00
102_E175_L0.8251.00
155_Q158_K0.8231.00
43_E357_Q0.8221.00
243_S246_I0.8211.00
101_L170_L0.8211.00
330_K359_D0.8161.00
234_K237_Q0.8151.00
327_Y336_R0.8141.00
303_E306_K0.8141.00
93_T96_N0.8131.00
225_L281_L0.8101.00
79_V195_V0.8101.00
84_K189_E0.8091.00
336_R371_D0.8081.00
70_D99_L0.8071.00
342_G349_T0.8071.00
255_V281_L0.8061.00
327_Y371_D0.8061.00
123_K126_A0.8051.00
362_I369_V0.8011.00
144_E148_E0.7981.00
168_T171_Q0.7961.00
44_E310_N0.7941.00
177_N180_S0.7941.00
77_I92_V0.7921.00
59_F294_P0.7871.00
318_K325_Y0.7841.00
75_E96_N0.7821.00
79_V192_V0.7821.00
160_T164_E0.7821.00
188_I213_I0.7811.00
245_V249_K0.7791.00
122_E125_K0.7781.00
327_Y334_A0.7761.00
219_L294_P0.7751.00
97_E177_N0.7741.00
242_T248_G0.7741.00
320_E325_Y0.7701.00
60_S284_K0.7661.00
337_V356_T0.7621.00
128_D151_R0.7601.00
40_G313_P0.7581.00
81_E195_V0.7581.00
129_S133_E0.7561.00
334_A369_V0.7551.00
18_V23_Y0.7511.00
47_I345_T0.7511.00
73_T202_K0.7501.00
225_L233_V0.7481.00
109_T167_Q0.7451.00
170_L173_Q0.7441.00
34_G374_E0.7441.00
53_V223_G0.7381.00
98_Q102_E0.7361.00
67_Y92_V0.7341.00
55_G298_F0.7331.00
68_E98_Q0.7301.00
164_E168_T0.7301.00
127_L130_K0.7281.00
84_K216_P0.7231.00
315_K364_N0.7221.00
171_Q175_L0.7201.00
130_K133_E0.7191.00
223_G302_I0.7191.00
37_V362_I0.7161.00
109_T164_E0.7161.00
61_N199_A0.7111.00
154_L157_Q0.7111.00
326_V361_V0.7101.00
108_L163_I0.7101.00
113_N116_Q0.7091.00
325_Y338_D0.7091.00
175_L178_R0.7081.00
161_A164_E0.7071.00
238_K303_E0.7031.00
144_E147_I0.7011.00
244_D299_I0.7011.00
329_V362_I0.7011.00
40_G43_E0.7001.00
167_Q171_Q0.6991.00
351_I355_L0.6951.00
51_V229_D0.6911.00
370_T373_M0.6891.00
105_Q174_S0.6881.00
65_V187_E0.6871.00
67_Y204_S0.6851.00
58_K220_V0.6841.00
17_F23_Y0.6841.00
49_S305_D0.6831.00
191_T216_P0.6831.00
62_E214_G0.6831.00
106_N109_T0.6811.00
15_A18_V0.6761.00
171_Q174_S0.6721.00
264_Q275_Q0.6721.00
342_G354_G0.6711.00
256_S282_Q0.6691.00
103_K175_L0.6661.00
241_L300_M0.6651.00
42_V355_L0.6641.00
60_S215_N0.6631.00
258_V281_L0.6631.00
106_N110_S0.6591.00
341_I351_I0.6581.00
312_L316_A0.6501.00
71_K202_K0.6461.00
98_Q178_R0.6451.00
156_M160_T0.6441.00
102_E106_N0.6421.00
220_V256_S0.6401.00
74_L210_V0.6391.00
293_K296_F0.6371.00
263_D280_P0.6361.00
116_Q120_I0.6361.00
337_V354_G0.6361.00
348_L352_K0.6351.00
114_R117_I0.6341.00
53_V225_L0.6301.00
168_T172_R0.6281.00
224_K263_D0.6281.00
245_V251_W0.6271.00
327_Y369_V0.6261.00
18_V21_N0.6251.00
119_Q126_A0.6231.00
99_L175_L0.6211.00
123_K153_E0.6211.00
75_E78_K0.6201.00
61_N198_E0.6191.00
224_K278_Q0.6171.00
51_V304_T0.6171.00
53_V229_D0.6141.00
243_S292_G0.6131.00
53_V302_I0.6131.00
235_K258_V0.6101.00
100_S103_K0.6101.00
43_E348_L0.6081.00
85_V91_L0.6061.00
119_Q157_Q0.6061.00
61_N188_I0.6051.00
42_V359_D0.6051.00
107_Q110_S0.6011.00
312_L317_V0.6001.00
25_S28_P0.6001.00
11_A18_V0.5971.00
156_M159_K0.5971.00
241_L283_V0.5951.00
39_T363_L0.5941.00
49_S304_T0.5911.00
262_P277_V0.5891.00
109_T168_T0.5881.00
96_N179_V0.5881.00
313_P316_A0.5851.00
41_S44_E0.5851.00
133_E144_E0.5831.00
103_K106_N0.5811.00
66_F209_P0.5811.00
316_A363_L0.5811.00
111_E115_L0.5811.00
209_P212_H0.5791.00
241_L298_F0.5781.00
217_K290_P0.5781.00
150_E154_L0.5771.00
40_G312_L0.5731.00
58_K62_E0.5711.00
40_G348_L0.5711.00
116_Q161_A0.5661.00
65_V211_I0.5651.00
332_G360_Q0.5651.00
64_Y201_S0.5641.00
277_V297_K0.5631.00
53_V300_M0.5631.00
198_E201_S0.5631.00
147_I150_E0.5621.00
236_G254_T0.5611.00
79_V83_D0.5611.00
47_I343_E0.5581.00
221_V285_I0.5581.00
245_V248_G0.5571.00
49_S343_E0.5551.00
310_N354_G0.5551.00
227_E245_V0.5551.00
99_L178_R0.5551.00
197_Q201_S0.5541.00
63_Q187_E0.5531.00
279_Y296_F0.5521.00
67_Y210_V0.5521.00
14_V17_F0.5521.00
120_I157_Q0.5511.00
9_G13_I0.5511.00
145_K149_S0.5501.00
318_K327_Y0.5481.00
47_I311_T0.5481.00
328_T361_V0.5471.00
67_Y94_Y0.5451.00
59_F214_G0.5441.00
113_N117_I0.5441.00
180_S185_K0.5441.00
239_V302_I0.5441.00
326_V354_G0.5431.00
178_R181_D0.5431.00
311_T350_E0.5431.00
317_V339_V0.5431.00
119_Q156_M0.5431.00
55_G221_V0.5421.00
233_V255_V0.5421.00
316_A361_V0.5411.00
47_I350_E0.5411.00
251_W292_G0.5401.00
59_F62_E0.5371.00
99_L103_K0.5351.00
67_Y70_D0.5341.00
175_L179_V0.5321.00
57_L243_S0.5291.00
217_K288_N0.5281.00
195_V199_A0.5271.00
249_K289_L0.5271.00
44_E356_T0.5271.00
88_G185_K0.5271.00
119_Q122_E0.5231.00
317_V341_I0.5231.00
173_Q177_N0.5221.00
219_L285_I0.5221.00
179_V182_L0.5201.00
216_P294_P0.5191.00
126_A133_E0.5191.00
101_L104_E0.5161.00
56_T295_G0.5161.00
223_G239_V0.5151.00
78_K89_T0.5151.00
162_E165_L0.5141.00
77_I195_V0.5141.00
214_G294_P0.5141.00
104_E108_L0.5141.00
119_Q153_E0.5131.00
40_G44_E0.5131.00
63_Q213_I0.5121.00
124_L131_E0.5121.00
227_E297_K0.5111.00
123_K154_L0.5111.00
239_V253_G0.5111.00
252_K286_K0.5101.00
235_K256_S0.5091.00
106_N171_Q0.5091.00
283_V300_M0.5081.00
326_V355_L0.5021.00
43_E311_T0.5011.00
148_E155_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dk0A 5 0.8382 100 0.198 Contact Map
3lnnA 6 0.8886 100 0.221 Contact Map
3fppA 3 0.687 100 0.229 Contact Map
1vf7A 5 0.5968 100 0.23 Contact Map
3ne5B 3 0.809 100 0.231 Contact Map
4l8jA 2 0.8223 100 0.257 Contact Map
4kkuA 1 0.6631 100 0.301 Contact Map
2f1mA 2 0.618 100 0.395 Contact Map
4tkoB 1 0.6366 100 0.465 Contact Map
2k32A 1 0.305 99.8 0.714 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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