GREMLIN Database
YKNW - Membrane protein YknW
UniProt: O31709 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (207)
Sequences: 326 (273)
Seq/√Len: 19.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_T179_E3.5801.00
103_F122_Y3.5661.00
135_I188_L3.1600.99
47_A141_L3.0060.99
190_A205_W2.8330.99
128_L192_G2.7760.98
51_V59_G2.4430.96
128_L131_F2.4170.96
181_F192_G2.3580.95
103_F126_L2.2800.95
142_V200_S2.2730.94
133_S138_L2.2710.94
32_I192_G2.1770.93
104_I107_L2.1480.93
22_I38_V2.0530.91
181_F184_W2.0320.90
25_P192_G2.0040.90
25_P184_W1.9890.89
141_L218_F1.9680.89
95_I99_I1.9580.89
49_I96_I1.9390.88
55_L149_T1.8900.87
28_Q212_F1.8630.86
151_D180_I1.8360.85
106_P221_F1.7800.83
132_V189_L1.7440.82
16_P28_Q1.7420.82
23_T206_I1.7120.81
94_A126_L1.6880.80
30_E195_K1.6600.78
50_I91_M1.6440.78
96_I146_V1.6330.77
190_A207_S1.6330.77
125_M196_T1.6130.76
53_A94_A1.6050.76
44_I173_S1.5650.74
106_P122_Y1.5480.73
79_M84_T1.5270.72
18_L39_W1.4720.69
19_F22_I1.4690.69
17_S31_R1.4620.69
108_I128_L1.4260.67
22_I202_K1.4200.67
135_I201_K1.4160.66
32_I210_I1.4160.66
104_I206_I1.3930.65
141_L204_G1.3920.65
95_I209_I1.3840.64
39_W188_L1.3710.64
83_A142_V1.3680.64
120_T124_K1.3590.63
116_S199_I1.3570.63
107_L122_Y1.3450.62
184_W192_G1.3350.62
111_L134_L1.3300.61
20_G28_Q1.3210.61
78_Q108_I1.3180.61
153_N214_I1.3040.60
104_I213_G1.3010.60
34_E188_L1.2910.59
16_P19_F1.2630.57
50_I54_V1.2540.57
93_G97_G1.2360.56
141_L145_I1.2330.55
174_V206_I1.2150.54
21_V162_A1.2080.54
79_M157_S1.2070.54
32_I38_V1.2060.54
207_S217_V1.2060.54
35_R43_L1.1990.53
36_P114_K1.1940.53
42_L167_S1.1900.53
30_E180_I1.1890.53
18_L188_L1.1850.52
89_G142_V1.1810.52
63_S77_E1.1780.52
139_G156_Y1.1750.52
81_T94_A1.1740.52
146_V203_A1.1740.52
89_G93_G1.1740.52
96_I202_K1.1730.52
98_G129_S1.1730.52
109_Y122_Y1.1670.51
92_A96_I1.1620.51
120_T196_T1.1600.51
110_W125_M1.1420.50
128_L132_V1.1380.49
31_R104_I1.1370.49
37_A163_G1.1350.49
46_A137_S1.1330.49
159_T192_G1.1300.49
76_A80_E1.1220.48
73_G82_V1.1110.48
45_V206_I1.1100.48
23_T104_I1.1040.47
31_R147_A1.0980.47
132_V207_S1.0850.46
166_P175_L1.0730.45
98_G122_Y1.0680.45
113_V118_G1.0660.45
20_G135_I1.0600.44
120_T197_G1.0560.44
35_R126_L1.0550.44
52_G164_I1.0520.44
84_T157_S1.0470.44
102_L189_L1.0330.43
24_S122_Y1.0300.43
164_I184_W1.0150.42
98_G144_G1.0040.41
28_Q38_V1.0030.41
85_I206_I1.0010.41
171_L196_T0.9990.41
104_I129_S0.9960.41
144_G217_V0.9830.40
63_S111_L0.9730.39
81_T223_G0.9720.39
96_I215_L0.9710.39
107_L110_W0.9700.39
132_V185_S0.9690.39
63_S79_M0.9640.39
162_A166_P0.9580.38
102_L188_L0.9570.38
23_T92_A0.9560.38
30_E33_R0.9550.38
60_T104_I0.9540.38
39_W44_I0.9530.38
35_R92_A0.9470.38
45_V176_N0.9470.38
196_T211_L0.9430.37
27_V31_R0.9400.37
44_I100_A0.9390.37
194_H212_F0.9320.37
161_L203_A0.9290.37
113_V197_G0.9250.36
127_S130_L0.9240.36
172_A213_G0.9140.36
38_V187_V0.9140.36
148_F213_G0.9100.35
171_L189_L0.9100.35
120_T125_M0.9080.35
51_V215_L0.9070.35
122_Y126_L0.8980.35
74_L136_S0.8970.35
107_L131_F0.8940.34
74_L99_I0.8940.34
29_F188_L0.8930.34
41_P109_Y0.8890.34
100_A219_S0.8870.34
197_G212_F0.8830.34
181_F187_V0.8830.34
103_F107_L0.8700.33
110_W120_T0.8680.33
195_K211_L0.8670.33
22_I162_A0.8660.33
21_V134_L0.8660.33
25_P106_P0.8660.33
128_L212_F0.8560.32
72_Q214_I0.8500.32
135_I211_L0.8450.32
114_K146_V0.8410.32
128_L211_L0.8410.32
190_A201_K0.8410.32
108_I131_F0.8390.31
53_A90_G0.8370.31
32_I165_I0.8360.31
50_I58_L0.8340.31
16_P31_R0.8330.31
88_F209_I0.8280.31
44_I176_N0.8280.31
108_I171_L0.8260.31
24_S193_L0.8220.30
38_V183_I0.8200.30
45_V198_G0.8160.30
95_I214_I0.8140.30
25_P41_P0.8140.30
76_A104_I0.8090.30
115_V148_F0.8070.30
119_V166_P0.8020.29
127_S196_T0.7990.29
50_I140_L0.7830.28
102_L132_V0.7830.28
158_T163_G0.7830.28
42_L130_L0.7810.28
207_S211_L0.7810.28
111_L217_V0.7810.28
110_W179_E0.7800.28
42_L62_Y0.7600.27
96_I148_F0.7540.27
114_K183_I0.7540.27
51_V198_G0.7470.27
101_A218_F0.7460.27
217_V222_S0.7330.26
93_G214_I0.7270.26
141_L186_F0.7230.25
38_V130_L0.7230.25
194_H199_I0.7230.25
63_S173_S0.7190.25
17_S134_L0.7180.25
54_V100_A0.7160.25
76_A94_A0.7140.25
39_W42_L0.7100.25
134_L188_L0.7070.25
43_L106_P0.7040.25
142_V188_L0.7040.25
199_I210_I0.7040.25
36_P128_L0.7000.24
64_E127_S0.6990.24
113_V199_I0.6930.24
144_G174_V0.6910.24
109_Y166_P0.6900.24
85_I214_I0.6800.23
146_V193_L0.6780.23
57_S117_G0.6780.23
197_G211_L0.6770.23
41_P122_Y0.6730.23
158_T164_I0.6720.23
16_P38_V0.6710.23
50_I167_S0.6690.23
50_I191_I0.6650.23
45_V138_L0.6610.23
51_V97_G0.6600.23
45_V153_N0.6570.22
186_F216_V0.6570.22
167_S175_L0.6540.22
47_A147_A0.6490.22
26_S197_G0.6480.22
124_K198_G0.6470.22
39_W197_G0.6420.22
35_R127_S0.6420.22
131_F134_L0.6390.22
81_T213_G0.6360.22
178_F194_H0.6340.21
100_A142_V0.6330.21
138_L174_V0.6320.21
52_G117_G0.6300.21
167_S172_A0.6280.21
25_P122_Y0.6280.21
35_R145_I0.6270.21
48_I223_G0.6270.21
113_V196_T0.6250.21
137_S156_Y0.6240.21
18_L37_A0.6230.21
43_L214_I0.6230.21
178_F183_I0.6220.21
112_C180_I0.6200.21
16_P20_G0.6200.21
48_I207_S0.6120.21
92_A111_L0.6110.20
73_G106_P0.6100.20
36_P107_L0.6090.20
117_G198_G0.6020.20
129_S187_V0.6010.20
92_A112_C0.5990.20
22_I104_I0.5980.20
45_V106_P0.5960.20
27_V44_I0.5910.20
108_I156_Y0.5870.20
109_Y152_V0.5860.19
107_L216_V0.5860.19
118_G217_V0.5850.19
36_P127_S0.5850.19
122_Y184_W0.5820.19
42_L144_G0.5780.19
100_A192_G0.5780.19
141_L203_A0.5770.19
93_G99_I0.5750.19
104_I155_L0.5750.19
129_S133_S0.5720.19
177_T180_I0.5680.19
173_S179_E0.5660.19
171_L208_A0.5660.19
108_I215_L0.5650.19
56_Q96_I0.5570.18
107_L218_F0.5530.18
102_L133_S0.5520.18
22_I115_V0.5510.18
109_Y149_T0.5510.18
51_V55_L0.5490.18
82_V86_T0.5490.18
91_M144_G0.5470.18
143_N183_I0.5440.18
199_I224_L0.5410.18
47_A178_F0.5410.18
97_G200_S0.5390.18
98_G140_L0.5380.18
40_G147_A0.5290.17
95_I108_I0.5280.17
78_Q101_A0.5280.17
30_E183_I0.5280.17
103_F170_A0.5280.17
31_R110_W0.5260.17
32_I149_T0.5230.17
159_T193_L0.5230.17
180_I217_V0.5230.17
190_A195_K0.5200.17
80_E142_V0.5200.17
25_P135_I0.5190.17
126_L172_A0.5180.17
53_A93_G0.5170.17
139_G181_F0.5150.17
39_W163_G0.5140.17
121_T130_L0.5130.17
124_K213_G0.5120.17
16_P205_W0.5090.17
102_L197_G0.5080.17
41_P127_S0.5070.17
78_Q188_L0.5040.16
82_V96_I0.5030.16
121_T137_S0.5020.16
47_A77_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ww9A 1 0.6623 8.5 0.953 Contact Map
2kogA 1 0.2597 5.6 0.956 Contact Map
4zrlB 1 0.2381 5 0.957 Contact Map
3pjzA 2 0.4156 4.5 0.958 Contact Map
2jwaA 2 0.1905 4.5 0.958 Contact Map
3mp7B 1 0.2294 3.9 0.96 Contact Map
3fymA 1 0.0649 3.7 0.96 Contact Map
1dofA 4 0.381 3.7 0.96 Contact Map
1pfiA 7 0.1991 3.5 0.961 Contact Map
2l2tA 2 0.1905 3.4 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.