GREMLIN Database
MOAD - Molybdopterin synthase sulfur carrier subunit
UniProt: O31706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 77 (77)
Sequences: 161 (116)
Seq/√Len: 13.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_V60_T3.5040.99
11_A55_Y3.0980.97
42_E51_V2.9900.97
3_K18_A2.9200.96
36_K45_D2.1440.83
31_I62_V2.0510.80
6_L32_K1.9510.76
55_Y60_T1.8510.72
12_E58_E1.7660.69
6_L58_E1.7470.68
31_I58_E1.6930.65
19_I35_L1.6720.64
40_G67_T1.6310.62
5_L48_M1.5780.60
6_L70_I1.5640.59
6_L19_I1.5570.59
49_I70_I1.4550.53
10_L53_E1.3500.48
54_S68_V1.3290.47
24_E70_I1.3160.46
4_I28_T1.3140.46
20_E28_T1.3110.46
1_M8_A1.2840.44
12_E56_V1.2620.43
14_A47_A1.2500.43
2_I68_V1.2150.41
6_L48_M1.1740.39
27_T56_V1.1680.38
19_I32_K1.1420.37
41_L45_D1.1420.37
4_I63_S1.1320.37
47_A70_I1.1230.36
31_I36_K1.1120.36
16_T22_D1.1030.35
25_Q64_S1.0880.35
34_S59_N1.0770.34
27_T50_A1.0550.33
19_I39_Y1.0490.33
32_K48_M1.0350.32
50_A69_A0.9920.30
25_Q62_V0.9620.29
16_T38_Q0.9600.29
44_I68_V0.9350.28
20_E56_V0.9260.27
6_L41_L0.9260.27
14_A36_K0.9230.27
2_I62_V0.9110.27
37_E47_A0.9090.27
12_E18_A0.9020.26
28_T64_S0.8860.26
4_I70_I0.8710.25
37_E45_D0.8680.25
1_M6_L0.8670.25
6_L35_L0.8660.25
23_M60_T0.8510.24
8_A62_V0.8460.24
5_L67_T0.8240.23
27_T36_K0.8150.23
4_I41_L0.7980.22
27_T61_S0.7920.22
9_G40_G0.7910.22
27_T71_I0.7890.22
21_I63_S0.7850.22
30_E57_K0.7780.22
41_L44_I0.7770.22
45_D61_S0.7750.21
56_V61_S0.7720.21
42_E45_D0.7570.21
3_K60_T0.7530.21
12_E38_Q0.7500.21
11_A60_T0.7490.21
21_I25_Q0.7270.20
54_S59_N0.7260.20
26_A55_Y0.7200.20
41_L57_K0.7170.19
2_I58_E0.7070.19
9_G55_Y0.6960.19
37_E57_K0.6930.19
37_E46_T0.6920.19
10_L30_E0.6850.18
14_A24_E0.6820.18
28_T31_I0.6810.18
37_E62_V0.6770.18
39_Y42_E0.6670.18
8_A69_A0.6470.17
13_Q68_V0.6470.17
36_K67_T0.6430.17
3_K22_D0.6380.17
28_T61_S0.6370.17
3_K35_L0.6360.17
17_Q37_E0.6360.17
28_T34_S0.6320.17
14_A57_K0.6310.17
32_K70_I0.6310.17
38_Q49_I0.6190.16
4_I17_Q0.6180.16
19_I48_M0.6020.16
15_G70_I0.5990.16
1_M70_I0.5950.16
30_E38_Q0.5890.16
15_G27_T0.5890.16
13_Q17_Q0.5690.15
62_V70_I0.5520.15
19_I40_G0.5520.15
4_I35_L0.5510.15
6_L49_I0.5510.15
13_Q62_V0.5490.14
2_I23_M0.5450.14
9_G65_G0.5430.14
17_Q70_I0.5400.14
1_M32_K0.5240.14
16_T55_Y0.5200.14
8_A70_I0.5180.14
2_I6_L0.5130.14
19_I57_K0.5080.13
36_K44_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k9xA 1 0.987 99.7 0.468 Contact Map
1fm0D 1 1 99.7 0.47 Contact Map
2qjlA 1 1 99.7 0.471 Contact Map
1vjkA 1 0.961 99.7 0.473 Contact Map
1wgkA 1 1 99.7 0.475 Contact Map
1v8cA 3 0.961 99.7 0.496 Contact Map
2q5wD 1 0.987 99.7 0.496 Contact Map
4hroA 1 0.974 99.7 0.498 Contact Map
2g1eA 1 0.987 99.7 0.498 Contact Map
2m19A 1 1 99.7 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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