GREMLIN Database
MOAE - Molybdopterin synthase catalytic subunit
UniProt: O31705 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (134)
Sequences: 2702 (1724)
Seq/√Len: 148.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_K109_E2.8771.00
59_M62_Q2.8751.00
46_R84_V2.7861.00
48_E84_V2.5601.00
105_Y108_N2.5441.00
10_P90_A2.4501.00
106_E109_E2.3401.00
12_N15_N2.1751.00
64_G76_A2.1401.00
29_T108_N2.0391.00
35_V85_L2.0061.00
20_V95_A1.9681.00
114_R118_I1.9671.00
61_A65_A1.9651.00
16_I77_A1.8501.00
60_L78_I1.8471.00
102_K106_E1.8471.00
66_E118_I1.8471.00
48_E124_K1.8331.00
16_I79_T1.8141.00
14_E18_K1.8101.00
64_G78_I1.7861.00
46_R126_I1.7391.00
29_T105_Y1.7221.00
43_R128_E1.6791.00
92_V115_I1.6501.00
6_I82_I1.5571.00
25_A74_A1.4871.00
17_I30_T1.4811.00
67_I111_A1.4771.00
92_V112_I1.4561.00
70_K110_Y1.3971.00
29_T104_A1.3951.00
98_S104_A1.3711.00
63_I111_A1.3611.00
94_I112_I1.3611.00
54_P57_V1.3421.00
76_A96_V1.3401.00
71_W107_A1.3321.00
39_T44_T1.3181.00
103_A106_E1.3061.00
65_A69_E1.3001.00
67_I110_Y1.2951.00
71_W110_Y1.2881.00
59_M118_I1.2681.00
66_E69_E1.2451.00
96_V107_A1.2361.00
62_Q66_E1.2291.00
49_Y91_A1.2201.00
85_L89_E1.2201.00
66_E114_R1.2151.00
8_K82_I1.1951.00
13_T17_I1.1841.00
114_R117_Q1.1801.00
76_A111_A1.1661.00
25_A97_S1.1561.00
16_I93_V1.1040.99
11_I79_T1.0810.99
49_Y121_I1.0770.99
17_I95_A1.0760.99
21_E34_T1.0710.99
78_I111_A1.0400.99
23_R88_G1.0260.99
8_K53_E1.0240.99
53_E57_V1.0240.99
105_Y109_E1.0230.99
42_K129_D1.0230.99
64_G68_E1.0110.99
15_N19_K1.0100.99
66_E70_K1.0080.99
48_E126_I1.0030.99
85_L91_A1.0010.99
11_I93_V0.9980.99
72_E103_A0.9910.99
105_Y112_I0.9800.99
57_V61_A0.9750.98
96_V105_Y0.9650.98
74_A99_P0.9580.98
32_I93_V0.9510.98
24_E37_E0.9350.98
73_G107_A0.9310.98
17_I32_I0.9260.98
58_Q62_Q0.9180.98
59_M119_V0.9160.98
110_Y114_R0.9060.98
77_A95_A0.8900.97
12_N18_K0.8880.97
84_V126_I0.8870.97
35_V47_L0.8860.97
13_T90_A0.8820.97
20_V77_A0.8760.97
127_W132_Q0.8730.97
25_A75_S0.8730.97
58_Q61_A0.8670.97
28_I97_S0.8530.96
16_I19_K0.8510.96
51_A82_I0.8500.96
52_Y55_M0.8490.96
108_N112_I0.8480.96
57_V60_L0.8380.96
78_I115_I0.8340.96
42_K132_Q0.8340.96
71_W106_E0.8250.96
42_K131_E0.8250.96
65_A68_E0.8210.96
27_A96_V0.7930.95
24_E74_A0.7890.95
45_V128_E0.7830.94
94_I113_E0.7820.94
126_I131_E0.7770.94
59_M120_P0.7740.94
104_A108_N0.7730.94
86_D89_E0.7720.94
28_I34_T0.7660.94
67_I71_W0.7650.94
68_E71_W0.7580.93
42_K127_W0.7470.93
21_E90_A0.7470.93
68_E75_S0.7470.93
29_T32_I0.7380.92
110_Y113_E0.7360.92
36_R100_H0.7340.92
15_N18_K0.7290.92
35_V91_A0.7240.92
46_R86_D0.7200.91
34_T92_V0.7170.91
7_T11_I0.7130.91
59_M114_R0.7130.91
109_E113_E0.7100.91
98_S103_A0.7100.91
6_I51_A0.7100.91
68_E73_G0.7030.90
5_E79_T0.7000.90
50_E55_M0.7000.90
5_E16_I0.6970.90
24_E38_W0.6960.90
68_E76_A0.6950.90
23_R37_E0.6930.90
37_E43_R0.6890.90
19_K77_A0.6770.89
81_R85_L0.6770.89
91_A115_I0.6770.89
20_V97_S0.6710.88
18_K21_E0.6710.88
22_K75_S0.6690.88
62_Q65_A0.6630.88
4_F64_G0.6570.87
30_T95_A0.6540.87
60_L63_I0.6500.87
60_L119_V0.6450.86
35_V56_A0.6420.86
109_E112_I0.6390.86
87_I114_R0.6380.86
63_I114_R0.6370.86
20_V75_S0.6310.85
96_V108_N0.6260.85
5_E57_V0.6260.85
63_I118_I0.6230.84
55_M58_Q0.6200.84
21_E88_G0.6190.84
50_E124_K0.6150.84
56_A119_V0.6140.83
68_E72_E0.6140.83
39_T134_I0.6080.83
30_T93_V0.6030.82
37_E44_T0.5980.82
13_T32_I0.5970.82
77_A93_V0.5970.82
39_T125_E0.5930.81
117_Q137_Q0.5930.81
32_I90_A0.5880.81
90_A93_V0.5870.81
108_N122_W0.5750.79
77_A97_S0.5750.79
51_A56_A0.5670.78
62_Q118_I0.5650.78
108_N134_I0.5630.78
53_E82_I0.5630.78
56_A121_I0.5630.78
72_E99_P0.5600.78
63_I113_E0.5560.77
96_V111_A0.5540.77
63_I110_Y0.5470.76
6_I60_L0.5460.76
52_Y125_E0.5440.75
55_M125_E0.5370.75
5_E77_A0.5370.75
67_I73_G0.5320.74
39_T52_Y0.5320.74
6_I57_V0.5310.74
19_K75_S0.5240.73
40_N43_R0.5230.73
19_K79_T0.5220.72
7_T15_N0.5170.72
42_K45_V0.5130.71
47_L134_I0.5130.71
13_T93_V0.5120.71
43_R65_A0.5060.70
7_T79_T0.5050.70
38_W99_P0.5020.70
73_G98_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fm0E 2 0.8917 100 0.135 Contact Map
2q5wE 2 0.8662 100 0.138 Contact Map
2omdA 2 0.8726 100 0.15 Contact Map
2wp4A 2 0.7962 100 0.159 Contact Map
4ap8A 2 0.8217 100 0.199 Contact Map
3rpfA 2 0.9045 100 0.247 Contact Map
2xexA 1 0.4331 38.3 0.936 Contact Map
4usiA 3 0.5987 34.1 0.937 Contact Map
2dy1A 1 0.4459 27.9 0.94 Contact Map
4kiyV 1 0.4076 23.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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