GREMLIN Database
MOBB - Probable molybdopterin-guanine dinucleotide biosynthesis adapter protein
UniProt: O31704 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (154)
Sequences: 1377 (1035)
Seq/√Len: 83.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E61_R5.4881.00
40_C62_Y3.8081.00
16_Q57_K3.4111.00
157_D160_A3.1571.00
32_S68_D3.1021.00
34_Q162_D2.8921.00
39_G100_T2.7951.00
135_A139_R2.7871.00
133_I139_R2.7781.00
77_V83_R2.7041.00
14_G18_S2.3641.00
136_I139_R2.2831.00
39_G95_Y2.1931.00
63_K83_R2.1551.00
135_A138_Y2.1551.00
50_P81_T2.1371.00
30_K159_V2.1291.00
30_K34_Q2.1261.00
133_I138_Y1.9631.00
11_Q113_Y1.9401.00
24_I62_Y1.9161.00
60_D64_A1.9131.00
28_L40_C1.8511.00
34_Q165_L1.7931.00
9_I92_I1.6991.00
36_V165_L1.6731.00
44_H48_G1.6521.00
69_V82_A1.6121.00
134_I139_R1.5661.00
30_K158_P1.5591.00
134_I138_Y1.5541.00
48_G74_G1.5521.00
105_I113_Y1.5020.99
27_I161_V1.4980.99
133_I136_I1.4790.99
11_Q105_I1.4570.99
87_D90_R1.4530.99
71_A80_L1.3830.99
137_I140_K1.3830.99
47_G76_G1.3750.99
23_F161_V1.3700.99
153_F163_F1.3570.99
7_F103_L1.3190.99
59_T72_V1.3150.99
22_T158_P1.3110.98
133_I137_I1.3100.98
48_G72_V1.2750.98
51_Q56_G1.2500.98
133_I140_K1.2400.98
30_K33_E1.2370.98
24_I29_E1.2350.98
151_P163_F1.2000.97
108_F111_A1.1730.97
41_L103_L1.1450.96
109_K115_K1.1370.96
48_G81_T1.1360.96
136_I140_K1.1170.96
120_S155_A1.1060.96
41_L88_L1.0940.95
18_S118_I1.0930.95
92_I103_L1.0700.95
17_N57_K1.0680.95
69_V96_Q1.0670.95
73_E91_L1.0650.95
51_Q60_D1.0490.94
48_G79_Q1.0480.94
78_L82_A1.0450.94
12_V27_I1.0400.94
71_A91_L1.0370.94
24_I104_L1.0300.94
117_V129_Q1.0240.93
30_K162_D1.0200.93
159_V162_D1.0110.93
134_I140_K0.9980.92
40_C67_A0.9980.92
10_V167_Q0.9950.92
36_V102_C0.9900.92
154_H157_D0.9760.92
116_V135_A0.9670.91
72_V79_Q0.9590.91
50_P79_Q0.9480.90
25_E64_A0.9420.90
132_N135_A0.9380.90
75_A85_N0.9370.90
14_G70_T0.9250.89
31_A165_L0.9230.89
10_V104_L0.9220.89
10_V116_V0.9170.89
9_I103_L0.9120.89
12_V116_V0.9050.88
90_R93_E0.8920.88
119_L127_A0.8900.87
148_Q151_P0.8880.87
48_G51_Q0.8740.86
15_F109_K0.8700.86
24_I28_L0.8660.86
31_A104_L0.8600.86
132_N136_I0.8600.86
132_N139_R0.8580.85
25_E65_A0.8480.85
9_I113_Y0.8390.84
153_F161_V0.8320.84
26_R158_P0.8220.83
158_P161_V0.8160.82
56_G60_D0.8120.82
95_Y100_T0.8070.82
117_V130_A0.8050.82
148_Q152_V0.8000.81
44_H74_G0.7950.81
27_I31_A0.7900.80
82_A96_Q0.7860.80
153_F158_P0.7820.80
154_H160_A0.7800.80
63_K77_V0.7800.80
10_V164_V0.7790.79
38_L102_C0.7750.79
39_G62_Y0.7740.79
69_V94_L0.7660.78
87_D111_A0.7620.78
147_H151_P0.7600.78
132_N140_K0.7550.77
44_H62_Y0.7450.76
44_H49_E0.7360.75
8_P102_C0.7220.74
49_E77_V0.7220.74
59_T62_Y0.7200.74
43_H74_G0.7200.74
91_L108_F0.7170.74
45_G73_E0.7100.73
73_E85_N0.7100.73
162_D166_S0.7040.72
89_A111_A0.7040.72
135_A140_K0.7030.72
14_G62_Y0.7010.72
45_G59_T0.6930.71
11_Q45_G0.6920.71
72_V77_V0.6890.71
51_Q55_E0.6890.71
43_H115_K0.6870.70
14_G107_G0.6820.70
36_V101_D0.6740.69
71_A86_W0.6720.69
88_L111_A0.6680.68
14_G118_I0.6670.68
29_E32_S0.6620.68
47_G75_A0.6560.67
84_R90_R0.6500.66
26_R156_D0.6500.66
149_G152_V0.6480.66
44_H72_V0.6460.66
96_Q99_E0.6430.65
71_A95_Y0.6390.65
43_H109_K0.6360.64
153_F167_Q0.6350.64
15_F115_K0.6340.64
164_V168_L0.6270.63
43_H46_H0.6250.63
135_A153_F0.6220.63
147_H166_S0.6200.62
129_Q149_G0.6160.62
39_G69_V0.6160.62
62_Y65_A0.6130.62
43_H58_D0.6130.62
43_H107_G0.6090.61
69_V80_L0.6060.61
11_Q111_A0.6020.60
165_L168_L0.6010.60
22_T31_A0.5960.59
146_E149_G0.5940.59
153_F156_D0.5920.59
41_L134_I0.5920.59
7_F14_G0.5900.59
80_L94_L0.5870.58
95_Y103_L0.5820.58
16_Q118_I0.5780.57
95_Y99_E0.5760.57
28_L62_Y0.5750.57
8_P18_S0.5750.57
44_H47_G0.5710.56
82_A94_L0.5660.56
14_G19_G0.5640.55
10_V24_I0.5620.55
47_G110_K0.5610.55
105_I108_F0.5560.54
44_H76_G0.5540.54
41_L91_L0.5530.54
14_G20_K0.5530.54
85_N121_E0.5520.54
15_F127_A0.5520.54
36_V92_I0.5510.54
22_T26_R0.5490.53
56_G103_L0.5470.53
93_E166_S0.5470.53
29_E40_C0.5460.53
64_A144_M0.5460.53
69_V99_E0.5450.53
61_R64_A0.5440.53
95_Y126_E0.5440.53
75_A100_T0.5430.53
16_Q24_I0.5420.52
69_V95_Y0.5410.52
88_L128_L0.5390.52
58_D109_K0.5340.51
27_I158_P0.5340.51
46_H137_I0.5340.51
117_V123_E0.5330.51
12_V26_R0.5330.51
93_E122_K0.5310.51
50_P75_A0.5310.51
44_H75_A0.5300.51
69_V100_T0.5280.51
37_H68_D0.5270.50
30_K157_D0.5250.50
40_C113_Y0.5230.50
82_A99_E0.5230.50
28_L70_T0.5210.50
31_A36_V0.5170.49
38_L68_D0.5160.49
55_E64_A0.5150.49
119_L124_D0.5150.49
91_L95_Y0.5140.49
156_D160_A0.5100.48
23_F116_V0.5100.48
17_N24_I0.5090.48
132_N137_I0.5070.48
118_I155_A0.5050.48
74_G77_V0.5040.47
93_E168_L0.5030.47
109_K114_P0.5030.47
28_L102_C0.5010.47
117_V125_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nkrA 2 0.9364 100 0.394 Contact Map
1xjcA 2 0.8208 100 0.46 Contact Map
1np6A 2 0.9364 99.7 0.673 Contact Map
2f1rA 2 0.8382 99.5 0.723 Contact Map
4ehxA 1 0.948 99.2 0.762 Contact Map
2wsmA 2 0.896 98.7 0.806 Contact Map
4a0gA 2 0.9017 98.7 0.81 Contact Map
3fgnA 2 0.8613 98.5 0.819 Contact Map
3of5A 2 0.9422 98.4 0.825 Contact Map
3kl4A 1 0.9017 98.4 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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