GREMLIN Database
MOEA - Molybdopterin molybdenumtransferase
UniProt: O31703 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 430 (395)
Sequences: 5333 (4072)
Seq/√Len: 204.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_G252_V3.5471.00
221_A226_A3.4821.00
27_E37_R3.4471.00
41_E181_P3.0981.00
172_L180_V3.0581.00
165_T168_V3.0571.00
242_F275_K3.0041.00
79_E98_Q2.9981.00
28_W179_S2.9271.00
340_E407_Q2.8441.00
108_I144_I2.7681.00
162_T168_V2.7561.00
53_D146_K2.7241.00
95_G98_Q2.6901.00
340_E405_T2.6331.00
401_E404_R2.5291.00
48_H147_T2.3851.00
354_T392_I2.3711.00
346_D401_E2.3641.00
63_R66_D2.3001.00
343_L400_Y2.2501.00
42_D159_T2.2461.00
342_V367_K2.2451.00
48_H153_K2.2171.00
157_L175_F2.2091.00
205_E208_K2.2061.00
42_D156_V2.1781.00
304_F321_V2.1631.00
44_T156_V2.1481.00
346_D402_S2.1401.00
25_E184_R2.1301.00
53_D147_T2.0971.00
42_D160_K2.0891.00
354_T395_G2.0881.00
77_R131_F2.0871.00
31_L173_A2.0611.00
26_T181_P2.0341.00
77_R133_S2.0301.00
39_L158_L1.9911.00
341_A408_V1.9881.00
28_W181_P1.9861.00
122_Q133_S1.9581.00
229_L252_V1.9451.00
279_D297_H1.8831.00
15_R19_H1.8671.00
362_H371_T1.8591.00
359_A389_A1.8581.00
48_H152_Q1.8471.00
389_A408_V1.8431.00
338_C407_Q1.8221.00
359_A391_I1.7771.00
158_L168_V1.7661.00
170_A216_M1.7631.00
10_V356_F1.7591.00
238_L272_I1.7491.00
152_Q155_S1.7401.00
82_D100_V1.7031.00
29_V37_R1.6981.00
61_A112_A1.6871.00
322_K326_Q1.6851.00
198_L208_K1.6841.00
117_M120_L1.6761.00
342_V405_T1.6711.00
93_E110_E1.6681.00
317_F321_V1.6671.00
238_L271_A1.6611.00
247_E251_K1.6551.00
21_Q324_I1.6411.00
54_R145_S1.6311.00
344_T369_L1.6251.00
256_I321_V1.6191.00
341_A370_A1.5811.00
62_V114_A1.5811.00
33_D222_I1.5791.00
224_A317_F1.5781.00
254_F325_I1.5771.00
64_A114_A1.5731.00
344_T371_T1.5721.00
187_V227_T1.5671.00
304_F324_I1.5671.00
85_G266_F1.5551.00
185_K227_T1.5501.00
64_A113_D1.5391.00
156_V159_T1.5321.00
285_V320_F1.5221.00
121_T132_M1.5131.00
360_L371_T1.5001.00
27_E184_R1.4691.00
30_A33_D1.4481.00
52_F107_Q1.4461.00
190_I218_Y1.4451.00
81_I98_Q1.4401.00
314_Y384_L1.4341.00
216_M314_Y1.4281.00
235_S240_K1.4191.00
164_V168_V1.3941.00
238_L275_K1.3931.00
94_L112_A1.3861.00
254_F304_F1.3781.00
360_L388_N1.3601.00
339_A410_L1.3511.00
237_E240_K1.3491.00
122_Q135_K1.3471.00
115_V143_N1.3381.00
43_I172_L1.3291.00
221_A228_P1.3241.00
9_P12_E1.3191.00
341_A361_V1.3181.00
116_V121_T1.3061.00
18_C327_T1.3051.00
273_Y303_L1.3021.00
10_V320_F1.2981.00
326_Q331_N1.2921.00
189_G231_L1.2901.00
12_E15_R1.2891.00
391_I406_V1.2871.00
47_H210_R1.2861.00
46_D177_Y1.2861.00
234_I244_A1.2851.00
118_I263_V1.2821.00
242_F246_K1.2761.00
342_V369_L1.2711.00
220_Q317_F1.2701.00
116_V134_L1.2691.00
287_M320_F1.2591.00
159_T162_T1.2551.00
293_T320_F1.2541.00
204_L207_G1.2511.00
63_R113_D1.2471.00
397_T404_R1.2451.00
82_D90_S1.2451.00
46_D175_F1.2351.00
315_V390_F1.2221.00
338_C409_L1.2191.00
319_L409_L1.2191.00
65_C113_D1.2191.00
139_Q142_D1.2161.00
243_A247_E1.2121.00
35_L222_I1.2111.00
102_I106_A1.2051.00
34_S180_V1.2041.00
169_T219_A1.1981.00
79_E131_F1.1951.00
85_G88_A1.1901.00
146_K149_E1.1891.00
62_V67_T1.1881.00
257_T303_L1.1881.00
83_H266_F1.1871.00
200_V215_S1.1861.00
169_T215_S1.1851.00
352_P396_G1.1781.00
231_L252_V1.1741.00
123_A130_S1.1711.00
238_L242_F1.1681.00
249_M301_M1.1651.00
187_V229_L1.1631.00
345_K372_P1.1591.00
10_V287_M1.1571.00
114_A138_F1.1561.00
359_A370_A1.1521.00
30_A179_S1.1521.00
294_T305_G1.1501.00
101_R118_I1.1501.00
88_A195_T1.1461.00
26_T184_R1.1411.00
231_L251_K1.1401.00
26_T40_A1.1361.00
246_K276_L1.1351.00
224_A322_K1.1311.00
164_V169_T1.1261.00
220_Q318_E1.1261.00
53_D110_E1.1241.00
11_D354_T1.1231.00
370_A408_V1.1211.00
16_R281_L1.1201.00
163_R331_N1.1201.00
155_S382_T1.1181.00
214_A230_Y1.1181.00
363_H366_G1.1171.00
242_F276_L1.1171.00
370_A389_A1.1141.00
17_V295_V1.1121.00
79_E130_S1.1121.00
83_H265_D1.1111.00
190_I221_A1.1101.00
390_F411_I1.1071.00
231_L248_A1.1061.00
361_V388_N1.1021.00
20_F295_V1.0991.00
343_L347_F1.0971.00
35_L169_T1.0951.00
191_I234_I1.0951.00
67_T75_P1.0941.00
108_I115_V1.0941.00
29_V34_S1.0931.00
64_A140_T1.0851.00
361_V370_A1.0821.00
38_F163_R1.0751.00
198_L204_L1.0681.00
188_V221_A1.0651.00
356_F392_I1.0651.00
117_M143_N1.0581.00
364_Q367_K1.0561.00
193_T269_L1.0541.00
101_R265_D1.0481.00
84_I100_V1.0441.00
192_A258_T1.0311.00
239_D243_A1.0271.00
255_L301_M1.0271.00
240_K243_A1.0221.00
221_A317_F1.0171.00
361_V408_V1.0161.00
170_A381_V1.0131.00
393_L400_Y1.0121.00
201_S210_R1.0121.00
121_T134_L1.0111.00
56_P145_S1.0111.00
122_Q128_G1.0071.00
38_F331_N1.0051.00
84_I90_S1.0021.00
166_P223_E0.9971.00
318_E322_K0.9971.00
295_V304_F0.9941.00
34_S164_V0.9931.00
84_I89_V0.9871.00
271_A274_E0.9871.00
56_P143_N0.9841.00
288_R355_R0.9831.00
226_A325_I0.9761.00
57_Y117_M0.9741.00
281_L297_H0.9661.00
128_G131_F0.9631.00
361_V389_A0.9631.00
103_M266_F0.9500.99
57_Y143_N0.9490.99
229_L251_K0.9480.99
188_V226_A0.9470.99
345_K371_T0.9410.99
191_I244_A0.9330.99
270_P283_N0.9290.99
218_Y222_I0.9280.99
254_F302_L0.9280.99
41_E177_Y0.9260.99
8_I16_R0.9240.99
242_F272_I0.9210.99
63_R96_P0.9190.99
120_L136_R0.9190.99
211_N214_A0.9180.99
35_L219_A0.9170.99
372_P391_I0.9160.99
103_M265_D0.9130.99
184_R253_D0.9130.99
287_M316_G0.9080.99
7_P291_S0.9070.99
37_R185_K0.9050.99
345_K402_S0.9050.99
244_A247_E0.9050.99
190_I228_P0.9010.99
360_L386_D0.8980.99
318_E336_S0.8980.99
40_A183_V0.8970.99
311_S358_R0.8940.99
90_S100_V0.8880.99
45_A175_F0.8860.99
392_I407_Q0.8850.99
186_P226_A0.8840.99
168_V385_A0.8840.99
204_L210_R0.8820.99
60_F123_A0.8810.99
60_F118_I0.8810.99
183_V329_L0.8800.99
51_A209_I0.8730.99
358_R376_D0.8700.99
26_T41_E0.8690.99
189_G248_A0.8680.99
176_G210_R0.8660.99
60_F121_T0.8660.99
240_K244_A0.8630.99
217_V317_F0.8610.99
375_L380_S0.8600.99
189_G255_L0.8590.99
16_R19_H0.8580.99
94_L100_V0.8490.99
222_I228_P0.8460.99
192_A214_A0.8370.99
118_I121_T0.8350.99
234_I240_K0.8340.99
113_D140_T0.8320.99
35_L223_E0.8280.98
79_E95_G0.8200.98
149_E377_K0.8190.98
82_D92_K0.8160.98
199_N202_D0.8160.98
164_V172_L0.8140.98
248_A252_V0.8140.98
56_P149_E0.8130.98
192_A232_G0.8090.98
36_H223_E0.8090.98
338_C392_I0.8060.98
26_T183_V0.8060.98
248_A255_L0.8040.98
239_D242_F0.8010.98
238_L241_S0.7990.98
254_F328_W0.7970.98
297_H300_D0.7950.98
199_N211_N0.7940.98
80_V99_A0.7930.98
11_D15_R0.7930.98
158_L162_T0.7930.98
62_V116_V0.7930.98
348_P399_G0.7900.98
172_L177_Y0.7900.98
8_I13_A0.7870.98
103_M118_I0.7860.98
47_H204_L0.7810.98
295_V302_L0.7770.98
273_Y296_A0.7750.98
81_I94_L0.7750.98
220_Q314_Y0.7740.98
53_D108_I0.7730.98
241_S272_I0.7720.98
306_L321_V0.7710.98
246_K299_N0.7710.98
282_F295_V0.7710.98
211_N215_S0.7690.98
316_G320_F0.7660.97
363_H369_L0.7660.97
18_C323_P0.7640.97
262_S292_V0.7640.97
195_T235_S0.7620.97
222_I227_T0.7600.97
150_D380_S0.7570.97
107_Q206_P0.7540.97
198_L205_E0.7530.97
307_S312_A0.7520.97
291_S312_A0.7480.97
28_W41_E0.7480.97
12_E16_R0.7470.97
285_V293_T0.7460.97
261_V305_G0.7430.97
359_A408_V0.7400.97
319_L356_F0.7390.97
67_T114_A0.7370.97
43_I181_P0.7340.97
218_Y228_P0.7320.97
80_V132_M0.7320.97
37_R182_V0.7310.97
64_A67_T0.7300.97
89_V107_Q0.7280.97
160_K183_V0.7250.97
84_I102_I0.7200.96
244_A248_A0.7190.96
387_A411_I0.7180.96
318_E390_F0.7180.96
145_S307_S0.7150.96
198_L202_D0.7140.96
297_H302_L0.7140.96
293_T316_G0.7120.96
370_A391_I0.7090.96
75_P78_F0.7080.96
66_D78_F0.7060.96
400_Y404_R0.7050.96
241_S268_F0.7050.96
339_A368_L0.7040.96
250_K299_N0.7040.96
190_I217_V0.7040.96
359_A388_N0.7030.96
389_A411_I0.7030.96
196_E236_D0.7020.96
92_K100_V0.7020.96
25_E183_V0.7000.96
373_V387_A0.6990.96
192_A233_K0.6990.96
357_V372_P0.6980.96
64_A138_F0.6980.96
346_D399_G0.6970.96
191_I255_L0.6960.96
199_N215_S0.6960.96
286_A395_G0.6960.96
150_D311_S0.6920.95
80_V123_A0.6910.95
269_L303_L0.6900.95
151_A157_L0.6890.95
344_T362_H0.6870.95
270_P274_E0.6840.95
66_D97_F0.6840.95
245_V255_L0.6830.95
221_A224_A0.6830.95
394_P397_T0.6820.95
232_G244_A0.6820.95
283_N294_T0.6820.95
81_I95_G0.6810.95
45_A48_H0.6810.95
249_M255_L0.6780.95
43_I177_Y0.6770.95
280_V294_T0.6750.95
238_L268_F0.6750.95
380_S383_S0.6740.95
324_I328_W0.6740.95
288_R353_F0.6730.95
67_T78_F0.6720.95
342_V403_G0.6710.95
377_K380_S0.6680.95
86_A106_A0.6680.95
197_L211_N0.6670.94
24_G183_V0.6670.94
114_A140_T0.6650.94
257_T261_V0.6640.94
17_V324_I0.6630.94
220_Q224_A0.6610.94
8_I282_F0.6610.94
281_L295_V0.6610.94
21_Q328_W0.6600.94
349_K393_L0.6600.94
246_K250_K0.6590.94
9_P395_G0.6590.94
382_T386_D0.6570.94
270_P294_T0.6560.94
362_H369_L0.6520.94
39_L180_V0.6520.94
298_A302_L0.6510.94
104_T119_E0.6500.94
42_D162_T0.6500.94
65_C140_T0.6480.94
192_A211_N0.6470.94
178_A200_V0.6430.93
89_V207_G0.6430.93
21_Q302_L0.6410.93
103_M106_A0.6400.93
16_R20_F0.6390.93
66_D96_P0.6390.93
191_I232_G0.6370.93
85_G103_M0.6350.93
32_E218_Y0.6330.93
256_I317_F0.6320.93
9_P286_A0.6290.93
63_R95_G0.6260.92
363_H367_K0.6240.92
257_T269_L0.6240.92
104_T292_V0.6230.92
272_I276_L0.6220.92
280_V296_A0.6220.92
218_Y230_Y0.6220.92
51_A148_G0.6220.92
116_V138_F0.6140.92
149_E379_S0.6140.92
114_A142_D0.6140.92
14_V18_C0.6130.92
191_I231_L0.6130.92
78_F132_M0.6110.91
167_G314_Y0.6110.91
197_L210_R0.6100.91
203_P210_R0.6100.91
49_V151_A0.6100.91
217_V256_I0.6090.91
211_N233_K0.6090.91
347_F391_I0.6090.91
189_G232_G0.6080.91
24_G328_W0.6070.91
158_L172_L0.6030.91
213_N258_T0.6030.91
247_E250_K0.6020.91
53_D144_I0.6020.91
83_H101_R0.6010.91
358_R380_S0.6000.91
47_H51_A0.5990.91
189_G229_L0.5970.91
39_L42_D0.5950.90
292_V378_S0.5940.90
249_M298_A0.5940.90
359_A406_V0.5930.90
221_A227_T0.5920.90
49_V150_D0.5910.90
84_I88_A0.5890.90
184_R187_V0.5870.90
32_E35_L0.5860.90
195_T233_K0.5860.90
291_S353_F0.5840.90
67_T76_V0.5840.90
108_I111_G0.5840.90
94_L98_Q0.5840.90
349_K355_R0.5840.90
150_D174_T0.5820.89
331_N334_P0.5800.89
195_T266_F0.5800.89
20_F297_H0.5780.89
32_E222_I0.5760.89
63_R112_A0.5760.89
81_I100_V0.5760.89
52_F209_I0.5740.89
37_R184_R0.5740.89
143_N149_E0.5730.89
193_T236_D0.5730.89
311_S384_L0.5710.89
86_A103_M0.5710.89
268_F271_A0.5700.88
20_F279_D0.5700.88
150_D382_T0.5700.88
199_N233_K0.5660.88
392_I395_G0.5650.88
260_G269_L0.5640.88
62_V78_F0.5640.88
173_A215_S0.5640.88
67_T138_F0.5630.88
157_L171_L0.5630.88
123_A129_K0.5620.88
60_F132_M0.5610.88
187_V252_V0.5610.88
78_F99_A0.5600.88
216_M313_C0.5580.87
81_I90_S0.5580.87
178_A201_S0.5570.87
29_V182_V0.5560.87
85_G265_D0.5560.87
271_A275_K0.5530.87
121_T135_K0.5520.87
145_S270_P0.5490.87
54_R270_P0.5490.87
8_I12_E0.5470.86
132_M135_K0.5470.86
221_A325_I0.5460.86
200_V210_R0.5430.86
362_H365_E0.5420.86
224_A326_Q0.5410.86
302_L324_I0.5400.86
155_S386_D0.5400.86
10_V354_T0.5390.86
263_V284_K0.5390.86
186_P328_W0.5380.85
296_A305_G0.5370.85
364_Q369_L0.5350.85
312_A378_S0.5340.85
51_A147_T0.5320.85
54_R379_S0.5310.85
245_V272_I0.5310.85
367_K405_T0.5310.85
234_I241_S0.5300.85
267_D291_S0.5290.84
343_L404_R0.5290.84
65_C96_P0.5290.84
189_G251_K0.5290.84
57_Y145_S0.5290.84
60_F80_V0.5290.84
272_I275_K0.5290.84
397_T400_Y0.5280.84
326_Q329_L0.5280.84
309_N378_S0.5270.84
60_F99_A0.5270.84
17_V320_F0.5260.84
10_V14_V0.5260.84
55_S102_I0.5250.84
27_E182_V0.5250.84
39_L162_T0.5250.84
354_T394_P0.5240.84
355_R358_R0.5230.84
64_A68_A0.5230.84
18_C21_Q0.5230.84
258_T313_C0.5230.84
162_T165_T0.5220.84
307_S355_R0.5220.84
370_A406_V0.5210.84
103_M261_V0.5210.84
361_V368_L0.5210.84
236_D260_G0.5210.84
46_D153_K0.5200.83
400_Y406_V0.5200.83
99_A132_M0.5200.83
136_R142_D0.5190.83
57_Y104_T0.5180.83
343_L406_V0.5170.83
117_M142_D0.5170.83
167_G381_V0.5160.83
55_S309_N0.5160.83
249_M299_N0.5150.83
225_G228_P0.5140.83
14_V335_H0.5130.83
41_E160_K0.5120.83
341_A362_H0.5120.83
66_D98_Q0.5120.83
171_L382_T0.5100.82
273_Y298_A0.5080.82
145_S309_N0.5070.82
249_M303_L0.5060.82
191_I248_A0.5060.82
39_L159_T0.5030.81
75_P137_R0.5030.81
57_Y309_N0.5020.81
339_A408_V0.5020.81
57_Y291_S0.5020.81
10_V319_L0.5010.81
252_V255_L0.5000.81
292_V307_S0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uz5A 1 0.9093 100 0.174 Contact Map
1g8lA 2 0.9302 100 0.175 Contact Map
4pd0A 2 0.9349 100 0.177 Contact Map
1wu2A 2 0.886 100 0.191 Contact Map
3rfqA 5 0.3372 100 0.692 Contact Map
1jljA 3 0.3558 100 0.7 Contact Map
3iwtA 4 0.3488 100 0.722 Contact Map
4lhbA 4 0.3349 100 0.723 Contact Map
1y5eA 4 0.3395 100 0.725 Contact Map
4xcwA 3 0.3698 100 0.734 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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