GREMLIN Database
MOEB - Molybdopterin-synthase adenylyltransferase
UniProt: O31702 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (298)
Sequences: 1949 (1326)
Seq/√Len: 76.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_T97_H4.3341.00
120_V137_A4.1761.00
86_K90_S4.0651.00
79_M87_E3.7491.00
44_S96_I3.6901.00
119_V202_A3.6201.00
32_A53_I3.6101.00
29_I40_A3.5381.00
166_C169_C3.4451.00
72_E94_S3.3981.00
121_I202_A3.3691.00
26_H50_T3.2941.00
240_C243_C3.2811.00
86_K100_A3.2381.00
70_Y84_A3.1011.00
89_L98_I3.0571.00
166_C240_C2.9861.00
166_C243_C2.9771.00
50_T99_E2.9701.00
37_T69_L2.7951.00
201_E204_K2.7561.00
73_S91_A2.7161.00
69_L85_A2.4761.00
169_C243_C2.4471.00
26_H52_T2.4101.00
71_T88_H2.3691.00
147_G194_V2.3551.00
169_C240_C2.3161.00
56_R104_E2.2621.00
39_G121_I2.2381.00
80_P102_V2.2371.00
52_T117_A2.2211.00
260_A263_L2.0881.00
116_K142_T2.0561.00
71_T91_A2.0141.00
22_L203_L1.9861.00
145_V202_A1.9801.00
14_I18_G1.9471.00
259_K263_L1.9351.00
25_S206_L1.9011.00
30_V133_I1.8921.00
82_A102_V1.8811.00
44_S51_I1.7461.00
285_I289_K1.7261.00
135_D168_S1.7191.00
52_T101_Y1.7171.00
111_E139_K1.6841.00
111_E140_T1.6621.00
44_S89_L1.6601.00
5_Y93_N1.6251.00
40_A53_I1.6151.00
74_D79_M1.6141.00
6_S10_R1.5860.99
124_T129_T1.5760.99
8_Q65_Q1.5640.99
105_G110_L1.5620.99
28_L114_I1.5600.99
32_A70_Y1.5360.99
44_S98_I1.5350.99
119_V206_L1.5080.99
86_K98_I1.5050.99
244_G247_A1.5040.99
260_A264_C1.4540.99
14_I207_T1.4470.99
83_M102_V1.4350.99
126_N129_T1.4330.99
197_Y227_H1.4330.99
137_A144_W1.4300.99
149_C190_A1.4240.99
200_A220_F1.4110.99
284_L288_L1.3950.99
285_I296_A1.3900.99
5_Y96_I1.3880.99
83_M87_E1.3780.99
156_F197_Y1.3630.98
121_I147_G1.3370.98
61_W77_L1.3360.98
260_A265_G1.3150.98
158_T205_L1.3150.98
284_L298_A1.3050.98
160_I163_E1.2770.98
21_R208_G1.2770.98
20_K24_D1.2760.98
21_R24_D1.2690.98
124_T133_I1.2620.97
261_A265_G1.2580.97
101_Y117_A1.2520.97
138_Q242_S1.2520.97
11_F152_S1.2450.97
28_L54_I1.2380.97
88_H91_A1.2260.97
28_L117_A1.2260.97
38_A195_S1.2000.97
279_I284_L1.1880.96
283_E287_R1.1790.96
103_T112_P1.1770.96
240_C244_G1.1630.96
280_P283_E1.1560.96
278_R281_K1.1540.96
40_A89_L1.1490.96
32_A40_A1.1410.95
80_P83_M1.1390.95
172_E237_R1.1370.95
105_G114_I1.1340.95
147_G198_Q1.1320.95
93_N96_I1.1310.95
136_L140_T1.1290.95
32_A82_A1.1230.95
193_I200_A1.1050.94
160_I164_T1.1020.94
238_E245_A1.1000.94
158_T204_K1.0960.94
131_M172_E1.0920.94
73_S77_L1.0920.94
209_Q212_A1.0880.94
278_R282_Q1.0810.94
114_I120_V1.0650.93
42_G199_Q1.0650.93
42_G192_H1.0630.93
8_Q19_Q1.0580.93
282_Q285_I1.0550.93
247_A252_L1.0520.93
38_A68_Q1.0510.93
283_E286_K1.0500.93
158_T201_E1.0360.92
195_S199_Q1.0180.92
192_H196_A1.0090.91
306_E309_R1.0060.91
23_A95_E1.0040.91
40_A85_A0.9950.91
281_K284_L0.9940.91
111_E136_L0.9840.90
119_V145_V0.9820.90
70_Y74_D0.9690.90
41_E68_Q0.9670.89
115_E140_T0.9660.89
247_A250_P0.9660.89
304_F307_D0.9650.89
69_L89_L0.9630.89
286_K289_K0.9590.89
37_T41_E0.9540.89
54_I105_G0.9540.89
45_R65_Q0.9520.89
279_I283_E0.9510.89
38_A192_H0.9510.89
284_L287_R0.9490.89
82_A100_A0.9490.89
192_H195_S0.9450.88
280_P284_L0.9420.88
59_V84_A0.9410.88
29_I43_L0.9400.88
279_I282_Q0.9330.88
49_G93_N0.9300.88
39_G199_Q0.9250.87
255_W258_P0.9250.87
9_I16_E0.9220.87
216_G229_K0.9220.87
197_Y218_V0.9190.87
275_S278_R0.9160.87
22_L207_T0.9060.86
57_D66_R0.9050.86
90_S96_I0.9020.86
163_E210_K0.9010.86
69_L88_H0.9000.86
110_L136_L0.8990.86
301_L304_F0.8990.86
114_I140_T0.8920.85
35_L147_G0.8920.85
304_F308_F0.8890.85
90_S98_I0.8870.85
23_A94_S0.8770.84
120_V133_I0.8750.84
63_N67_Q0.8710.84
73_S87_E0.8710.84
161_P164_T0.8700.84
74_D88_H0.8640.83
133_I144_W0.8630.83
154_G194_V0.8610.83
138_Q159_V0.8600.83
193_I222_V0.8580.83
63_N81_K0.8500.82
114_I137_A0.8490.82
287_R291_I0.8480.82
69_L84_A0.8480.82
276_L279_I0.8470.82
263_L267_D0.8440.82
30_V54_I0.8400.82
200_A222_V0.8390.82
83_M86_K0.8370.81
189_P196_A0.8360.81
19_Q22_L0.8320.81
191_V196_A0.8200.80
39_G123_A0.8080.79
279_I287_R0.8060.79
156_F218_V0.8050.79
250_P254_D0.8050.79
31_G36_G0.8050.79
152_S223_W0.8050.79
148_A186_I0.8030.79
221_D224_N0.8000.78
189_P203_L0.7970.78
277_K280_P0.7920.78
281_K286_K0.7910.78
52_T99_E0.7910.78
114_I136_L0.7900.77
286_K291_I0.7880.77
242_S251_Y0.7840.77
295_E303_I0.7830.77
164_T214_Q0.7800.77
74_D84_A0.7780.76
127_F167_L0.7770.76
101_Y113_L0.7760.76
68_Q192_H0.7750.76
54_I113_L0.7730.76
38_A41_E0.7720.76
83_M100_A0.7710.76
255_W259_K0.7700.76
277_K283_E0.7670.75
79_M83_M0.7660.75
29_I53_I0.7650.75
84_A88_H0.7650.75
255_W263_L0.7580.75
297_N300_L0.7530.74
186_I191_V0.7490.74
150_V184_A0.7480.74
29_I208_G0.7470.73
121_I145_V0.7460.73
236_R244_G0.7460.73
127_F146_Y0.7450.73
295_E298_A0.7440.73
161_P214_Q0.7430.73
71_T74_D0.7410.73
277_K284_L0.7390.73
66_R81_K0.7340.72
30_V110_L0.7320.72
141_K162_G0.7310.72
8_Q191_V0.7300.72
110_L132_L0.7280.72
119_V205_L0.7270.71
189_P193_I0.7260.71
277_K282_Q0.7240.71
63_N66_R0.7190.71
274_E277_K0.7170.70
50_T101_Y0.7160.70
166_C244_G0.7150.70
192_H199_Q0.7150.70
25_S208_G0.7140.70
186_I190_A0.7140.70
252_L259_K0.7130.70
33_G36_G0.7120.70
275_S279_I0.7110.70
282_Q286_K0.7110.70
21_R207_T0.7110.70
4_R8_Q0.7100.70
276_L282_Q0.7050.69
45_R92_I0.7050.69
27_V119_V0.7020.69
270_Q273_S0.6990.68
131_M168_S0.6940.68
273_S276_L0.6940.68
157_M213_I0.6920.68
37_T144_W0.6910.68
14_I203_L0.6900.67
266_R269_V0.6900.67
247_A251_Y0.6890.67
54_I114_I0.6850.67
179_A184_A0.6830.67
276_L283_E0.6810.66
87_E91_A0.6790.66
213_I216_G0.6760.66
218_V227_H0.6740.66
110_L114_I0.6730.65
302_H307_D0.6700.65
163_E218_V0.6650.65
41_E92_I0.6640.64
252_L255_W0.6640.64
30_V120_V0.6630.64
275_S282_Q0.6590.64
228_M235_V0.6580.64
53_I89_L0.6560.64
285_I288_L0.6560.64
282_Q289_K0.6520.63
30_V105_G0.6520.63
151_S184_A0.6510.63
275_S280_P0.6510.63
6_S9_I0.6500.63
23_A207_T0.6480.63
122_D185_G0.6480.63
193_I197_Y0.6470.62
8_Q190_A0.6470.62
41_E45_R0.6440.62
143_P206_L0.6440.62
105_G132_L0.6430.62
267_D270_Q0.6420.62
273_S278_R0.6410.62
255_W265_G0.6410.62
174_I177_G0.6410.62
21_R25_S0.6400.62
30_V101_Y0.6390.61
40_A69_L0.6380.61
149_C179_A0.6380.61
132_L168_S0.6350.61
157_M186_I0.6300.60
155_M167_L0.6290.60
26_H99_E0.6290.60
259_K265_G0.6270.60
61_W107_A0.6270.60
4_R72_E0.6240.60
288_L298_A0.6240.60
38_A42_G0.6230.60
42_G68_Q0.6210.59
287_R295_E0.6210.59
276_L281_K0.6190.59
146_Y167_L0.6180.59
188_P192_H0.6180.59
10_R16_E0.6120.58
284_L289_K0.6120.58
303_I308_F0.6110.58
249_Y253_Q0.6080.58
14_I187_I0.6030.57
210_K223_W0.6020.57
248_V252_L0.6010.57
78_R172_E0.6000.57
281_K285_I0.6000.57
17_E20_K0.6000.57
297_N302_H0.5990.57
149_C186_I0.5980.56
34_A155_M0.5980.56
74_D87_E0.5980.56
17_E21_R0.5950.56
109_T140_T0.5920.56
169_C244_G0.5920.56
27_V202_A0.5910.56
16_E20_K0.5890.55
279_I285_I0.5880.55
40_A166_C0.5880.55
34_A57_D0.5870.55
132_L186_I0.5840.55
20_K23_A0.5830.55
57_D81_K0.5830.55
118_D141_K0.5820.54
5_Y8_Q0.5810.54
62_S66_R0.5810.54
301_L308_F0.5810.54
57_D64_L0.5800.54
81_K125_D0.5790.54
279_I291_I0.5790.54
54_I274_E0.5780.54
277_K281_K0.5770.54
107_A132_L0.5760.54
67_Q85_A0.5760.54
259_K262_V0.5750.54
83_M98_I0.5750.54
265_G269_V0.5750.54
14_I22_L0.5750.54
26_H97_H0.5740.53
79_M84_A0.5730.53
114_I142_T0.5710.53
66_R125_D0.5710.53
106_T109_T0.5700.53
167_L172_E0.5690.53
282_Q296_A0.5680.53
289_K296_A0.5670.53
112_P115_E0.5660.52
11_F14_I0.5660.52
251_Y255_W0.5640.52
146_Y198_Q0.5640.52
134_N166_C0.5640.52
58_Y80_P0.5630.52
65_Q223_W0.5620.52
263_L266_R0.5600.52
181_C185_G0.5600.52
120_V142_T0.5600.52
182_D222_V0.5590.52
60_E239_E0.5580.51
275_S286_K0.5560.51
305_Y308_F0.5560.51
48_V106_T0.5550.51
51_I306_E0.5550.51
53_I59_V0.5550.51
42_G188_P0.5540.51
302_H305_Y0.5530.51
280_P287_R0.5520.51
187_I222_V0.5520.51
275_S281_K0.5500.50
85_A89_L0.5500.50
44_S92_I0.5480.50
291_I305_Y0.5480.50
249_Y252_L0.5440.50
25_S118_D0.5430.49
156_F194_V0.5430.49
289_K295_E0.5430.49
123_A305_Y0.5420.49
295_E304_F0.5410.49
258_P265_G0.5400.49
200_A203_L0.5390.49
28_L101_Y0.5380.49
260_A266_R0.5370.49
207_T223_W0.5360.49
105_G109_T0.5360.49
285_I297_N0.5340.48
32_A51_I0.5320.48
165_P170_L0.5300.48
52_T142_T0.5290.48
36_G55_D0.5280.48
133_I167_L0.5280.48
37_T59_V0.5270.47
155_M181_C0.5270.47
301_L307_D0.5250.47
226_S229_K0.5250.47
248_V251_Y0.5250.47
34_A38_A0.5230.47
149_C166_C0.5230.47
27_V206_L0.5230.47
56_R266_R0.5230.47
205_L214_Q0.5220.47
128_E151_S0.5210.47
201_E213_I0.5210.47
124_T146_Y0.5210.47
103_T113_L0.5210.47
157_M232_V0.5190.46
10_R37_T0.5190.46
99_E117_A0.5180.46
239_E245_A0.5170.46
256_N263_L0.5170.46
45_R152_S0.5160.46
286_K290_T0.5150.46
242_S249_Y0.5150.46
290_T296_A0.5130.46
14_I46_A0.5130.46
291_I303_I0.5130.46
165_P169_C0.5120.46
120_V140_T0.5120.46
259_K264_C0.5110.45
100_A111_E0.5090.45
256_N274_E0.5080.45
53_I226_S0.5070.45
78_R188_P0.5070.45
124_T144_W0.5060.45
278_R283_E0.5060.45
263_L301_L0.5060.45
50_T98_I0.5060.45
105_G148_A0.5060.45
152_S222_V0.5040.45
29_I121_I0.5020.44
193_I220_F0.5000.44
54_I103_T0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ruiA 2 0.8142 100 0.372 Contact Map
1zud1 2 0.6932 100 0.375 Contact Map
4gslA 2 0.7788 100 0.378 Contact Map
1tt5B 1 0.9115 100 0.38 Contact Map
1jw9B 2 0.6873 100 0.383 Contact Map
3h8vA 2 0.6254 100 0.384 Contact Map
2nvuB 1 0.9587 100 0.392 Contact Map
3h5nA 3 0.6962 100 0.421 Contact Map
1y8qB 1 0.9469 100 0.443 Contact Map
4nnjA 2 0.9263 100 0.471 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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