GREMLIN Database
MOBA - Probable molybdenum cofactor guanylyltransferase
UniProt: O31701 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (181)
Sequences: 3452 (2748)
Seq/√Len: 204.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R36_E4.8961.00
6_V81_A3.0651.00
21_A95_C3.0451.00
29_M32_E3.0191.00
4_V87_G2.9011.00
16_F23_V2.8171.00
91_T105_M2.7321.00
99_L189_L2.7321.00
152_R155_D2.4251.00
85_T90_Y2.3751.00
5_N38_L2.1981.00
83_K143_Y2.1871.00
23_V186_F2.1121.00
117_D161_S1.9321.00
118_A160_I1.8781.00
127_V164_Y1.8611.00
72_M151_L1.8281.00
28_R32_E1.7791.00
4_V42_T1.7751.00
89_L112_M1.7611.00
79_Y143_Y1.7321.00
182_T185_D1.7271.00
79_Y83_K1.7111.00
6_V90_Y1.6551.00
78_I92_V1.6441.00
82_F90_Y1.6441.00
89_L135_H1.6281.00
4_V85_T1.6271.00
150_R155_D1.6151.00
97_T131_I1.5981.00
9_A45_I1.5731.00
78_I153_I1.5711.00
18_E23_V1.5581.00
89_L133_I1.5521.00
100_I131_I1.5261.00
12_A71_G1.5151.00
16_F183_R1.5061.00
117_D135_H1.5011.00
122_I164_Y1.4921.00
143_Y147_S1.4781.00
38_L93_L1.4681.00
28_R33_C1.4571.00
122_I166_Q1.4531.00
13_S21_A1.4311.00
118_A162_V1.4121.00
44_I63_Y1.4111.00
145_Q150_R1.4091.00
42_T61_E1.3851.00
46_S81_A1.3811.00
94_S97_T1.3771.00
13_S16_F1.3191.00
32_E36_E1.3131.00
93_L100_I1.3111.00
13_S18_E1.3021.00
104_T176_E1.3001.00
145_Q156_L1.2961.00
24_K27_G1.2911.00
144_D148_E1.2721.00
118_A157_L1.2711.00
186_F190_E1.2671.00
123_S128_Q1.2651.00
180_I189_L1.2641.00
141_V160_I1.2541.00
142_L156_L1.2351.00
35_K43_V1.2291.00
30_L34_A1.2071.00
60_N65_D1.1811.00
76_A80_T1.1751.00
101_Q176_E1.1691.00
94_S131_I1.1681.00
91_T133_I1.1621.00
111_L163_C1.1511.00
117_D137_R1.1301.00
138_I160_I1.1271.00
187_S190_E1.1231.00
178_I189_L1.1171.00
117_D162_V1.1131.00
25_W30_L1.1091.00
94_S134_Y1.1051.00
47_R62_V1.0841.00
6_V46_S1.0611.00
112_M119_V1.0571.00
121_P167_A1.0571.00
156_L160_I1.0431.00
85_T136_K1.0411.00
180_I186_F1.0211.00
35_K60_N1.0211.00
7_L35_K1.0191.00
141_V159_R1.0191.00
148_E159_R1.0151.00
30_L180_I1.0151.00
101_Q104_T1.0061.00
5_N34_A1.0051.00
123_S126_Q1.0021.00
34_A37_A0.9961.00
116_A163_C0.9941.00
99_L178_I0.9891.00
6_V92_V0.9741.00
141_V156_L0.9671.00
7_L31_Y0.9671.00
58_G61_E0.9671.00
120_V127_V0.9590.99
106_L110_R0.9460.99
19_P22_F0.9410.99
83_K139_M0.9400.99
34_A93_L0.9360.99
120_V164_Y0.9360.99
24_K29_M0.9330.99
141_V144_D0.9300.99
112_M135_H0.9270.99
62_V65_D0.9060.99
136_K139_M0.9050.99
4_V44_I0.9020.99
90_Y136_K0.9020.99
145_Q155_D0.8980.99
63_Y80_T0.8970.99
122_I127_V0.8970.99
73_G76_A0.8960.99
29_M33_C0.8920.99
184_D188_C0.8910.99
33_C37_A0.8900.99
167_A177_F0.8810.99
26_K33_C0.8810.99
23_V183_R0.8790.99
109_K133_I0.8760.99
155_D158_G0.8730.99
184_D187_S0.8700.99
72_M149_K0.8670.99
68_P79_Y0.8660.99
72_M146_L0.8610.99
116_A161_S0.8590.99
154_S158_G0.8570.99
123_S174_P0.8520.99
71_G76_A0.8480.99
144_D147_S0.8480.99
21_A31_Y0.8480.99
18_E183_R0.8470.99
75_L142_L0.8430.99
81_A90_Y0.8400.99
138_I141_V0.8280.98
69_F72_M0.8210.98
92_V134_Y0.8200.98
24_K28_R0.8190.98
157_L162_V0.8140.98
120_V132_A0.8040.98
185_D188_C0.8010.98
10_G77_G0.7910.98
178_I188_C0.7820.98
88_D135_H0.7790.98
97_T130_L0.7760.98
74_P77_G0.7710.98
120_V162_V0.7680.98
115_G161_S0.7660.97
72_M76_A0.7650.97
42_T87_G0.7630.97
132_A157_L0.7620.97
109_K112_M0.7620.97
24_K190_E0.7620.97
16_F180_I0.7600.97
118_A121_P0.7550.97
103_R107_E0.7540.97
111_L119_V0.7520.97
104_T121_P0.7460.97
88_D136_K0.7400.97
3_H109_K0.7340.97
52_D55_Q0.7330.97
11_G15_R0.7240.96
41_Q87_G0.7240.96
130_L134_Y0.7230.96
10_G74_P0.7210.96
75_L156_L0.7210.96
124_D166_Q0.7180.96
47_R50_F0.7170.96
58_G65_D0.7140.96
115_G119_V0.7140.96
78_I134_Y0.7070.96
61_E65_D0.7060.96
22_F54_F0.7040.96
31_Y35_K0.7010.96
37_A102_R0.7010.96
44_I84_K0.6970.96
76_A79_Y0.6960.96
130_L153_I0.6940.95
7_L43_V0.6870.95
183_R187_S0.6850.95
63_Y84_K0.6850.95
141_V145_Q0.6840.95
25_W33_C0.6820.95
44_I85_T0.6820.95
82_F85_T0.6820.95
65_D181_N0.6810.95
129_P154_S0.6810.95
40_E102_R0.6740.95
41_Q46_S0.6690.95
81_A85_T0.6630.94
42_T46_S0.6610.94
21_A54_F0.6600.94
35_K39_G0.6600.94
16_F19_P0.6530.94
93_L105_M0.6500.94
126_Q154_S0.6450.93
26_K190_E0.6440.93
75_L146_L0.6410.93
38_L91_T0.6410.93
104_T108_L0.6410.93
120_V157_L0.6390.93
37_A100_I0.6350.93
140_P143_Y0.6350.93
13_S186_F0.6330.93
13_S19_P0.6270.92
53_R56_E0.6250.92
49_E54_F0.6240.92
3_H133_I0.6200.92
123_S167_A0.6180.92
48_P73_G0.6150.92
122_I125_G0.6100.91
127_V154_S0.6090.91
99_L175_A0.5980.91
3_H105_M0.5970.90
140_P144_D0.5970.90
55_Q64_Q0.5950.90
25_W189_L0.5940.90
119_V165_V0.5930.90
19_P49_E0.5900.90
10_G15_R0.5900.90
145_Q159_R0.5880.90
48_P51_I0.5870.90
7_L34_A0.5830.89
108_L119_V0.5800.89
4_V90_Y0.5770.89
34_A100_I0.5750.89
108_L133_I0.5750.89
10_G130_L0.5740.89
20_K96_D0.5700.88
144_D159_R0.5690.88
154_S157_L0.5600.87
30_L186_F0.5590.87
79_Y146_L0.5560.87
134_Y157_L0.5560.87
77_G81_A0.5500.87
22_F58_G0.5500.87
88_D137_R0.5460.86
30_L189_L0.5460.86
65_D77_G0.5460.86
51_I64_Q0.5450.86
69_F76_A0.5450.86
150_R159_R0.5400.86
139_M143_Y0.5400.86
34_A107_E0.5380.85
6_V44_I0.5370.85
19_P48_P0.5360.85
46_S74_P0.5360.85
128_Q153_I0.5330.85
7_L38_L0.5320.85
30_L95_C0.5300.84
19_P54_F0.5260.84
94_S132_A0.5250.84
18_E21_A0.5230.84
13_S183_R0.5220.84
35_K58_G0.5200.83
40_E43_V0.5180.83
102_R106_L0.5130.83
5_N91_T0.5130.83
144_D149_K0.5130.83
22_F31_Y0.5120.82
65_D179_N0.5100.82
16_F185_D0.5080.82
32_E56_E0.5060.82
73_G151_L0.5040.81
8_L11_G0.5030.81
129_P153_I0.5000.81
177_F181_N0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e5kA 1 0.9196 100 0.327 Contact Map
3ngwA 2 0.9497 100 0.36 Contact Map
2e8bA 1 0.8744 100 0.362 Contact Map
2weeA 1 0.9045 100 0.391 Contact Map
3d5nA 2 0.8744 100 0.396 Contact Map
2wawA 1 0.9296 100 0.405 Contact Map
2px7A 2 0.8844 99.9 0.522 Contact Map
3rsbA 1 0.8241 99.9 0.527 Contact Map
2xmeA 3 0.8794 99.9 0.535 Contact Map
1vpaA 2 0.9548 99.9 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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