GREMLIN Database
YKUV - Thiol-disulfide oxidoreductase YkuV
UniProt: O31699 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (131)
Sequences: 13879 (10371)
Seq/√Len: 906.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_P119_K3.8911.00
11_T21_V2.6741.00
16_W20_E2.6551.00
52_N91_T2.5951.00
30_K63_N2.5391.00
118_D122_Q2.4941.00
78_P82_K2.3731.00
118_D124_R2.3171.00
15_A21_V2.3011.00
11_T23_R2.2141.00
6_P122_Q2.0661.00
117_F123_L2.0551.00
17_L85_A2.0061.00
7_M106_F1.9941.00
23_R26_L1.9811.00
52_N56_D1.9341.00
22_T27_I1.8711.00
57_K137_E1.8541.00
32_T63_N1.8151.00
16_W22_T1.7481.00
55_R59_Q1.7211.00
9_E25_Q1.6841.00
137_E141_N1.6701.00
66_A92_Q1.6261.00
45_K88_H1.5561.00
77_D80_K1.5051.00
48_M90_I1.5051.00
35_H47_A1.4901.00
33_L116_V1.4871.00
82_K86_A1.4251.00
9_E23_R1.3911.00
113_A126_F1.3701.00
31_P124_R1.3651.00
35_H114_Y1.3561.00
69_M103_T1.3361.00
50_Q53_E1.3281.00
69_M100_H1.2791.00
125_H139_R1.2581.00
101_A105_A1.2491.00
31_P116_V1.2471.00
53_E133_M1.2191.00
55_R91_T1.2001.00
68_H81_I1.1991.00
45_K87_E1.1981.00
78_P96_V1.1871.00
45_K84_T1.1631.00
115_Y123_L1.1371.00
33_L114_Y1.1351.00
12_G95_F1.1261.00
32_T117_F1.1241.00
84_T88_H1.1221.00
54_F136_L1.1191.00
139_R142_R1.1161.00
79_G83_E1.1031.00
41_C88_H1.1011.00
31_P62_L1.0991.00
27_I32_T1.0721.00
27_I65_V1.0691.00
38_S111_V1.0641.00
33_L62_L1.0591.00
135_M138_K1.0571.00
63_N93_P1.0501.00
36_F106_F1.0291.00
135_M139_R1.0271.00
47_A114_Y1.0221.00
59_Q63_N1.0191.00
25_Q28_G1.0181.00
50_Q133_M1.0031.00
33_L51_V1.0021.00
39_I81_I1.0001.00
22_T26_L0.9961.00
54_F57_K0.9931.00
52_N92_Q0.9921.00
46_E130_G0.9701.00
40_S81_I0.9661.00
70_P76_L0.9531.00
32_T65_V0.9481.00
83_E86_A0.9321.00
9_E24_E0.9111.00
85_A94_I0.9101.00
133_M137_E0.9081.00
83_E87_E0.9041.00
16_W95_F0.8961.00
34_I117_F0.8751.00
56_D59_Q0.8741.00
81_I96_V0.8731.00
29_E121_G0.8661.00
55_R63_N0.8641.00
36_F67_V0.8631.00
48_M84_T0.8601.00
46_E49_P0.8491.00
125_H142_R0.8481.00
49_P53_E0.8371.00
97_D100_H0.8301.00
12_G102_L0.8231.00
15_A78_P0.8211.00
100_H104_D0.8201.00
51_V64_V0.8201.00
10_L102_L0.8201.00
29_E119_K0.8141.00
18_N82_K0.8131.00
24_E32_T0.8101.00
53_E56_D0.8081.00
16_W93_P0.7921.00
53_E57_K0.7861.00
52_N89_D0.7841.00
41_C44_C0.7751.00
58_Y137_E0.7721.00
27_I63_N0.7681.00
58_Y141_N0.7671.00
58_Y61_Q0.7671.00
102_L105_A0.7621.00
56_D91_T0.7611.00
117_F121_G0.7581.00
101_A104_D0.7561.00
138_K142_R0.7531.00
12_G15_A0.7501.00
123_L126_F0.7491.00
108_N113_A0.7471.00
69_M111_V0.7421.00
7_M117_F0.7401.00
79_G82_K0.7361.00
50_Q54_F0.7321.00
136_L139_R0.7311.00
35_H48_M0.7301.00
10_L24_E0.7281.00
132_G135_M0.7281.00
39_I84_T0.7241.00
6_P28_G0.7241.00
138_K141_N0.7231.00
7_M24_E0.7121.00
48_M88_H0.7071.00
35_H43_L0.7051.00
17_L82_K0.6961.00
36_F108_N0.6911.00
134_K138_K0.6901.00
22_T95_F0.6891.00
100_H103_T0.6861.00
24_E27_I0.6841.00
134_K137_E0.6791.00
49_P52_N0.6721.00
54_F58_Y0.6641.00
116_V127_Q0.6631.00
110_Y113_A0.6621.00
41_C80_K0.6531.00
42_H46_E0.6491.00
103_T108_N0.6491.00
28_G121_G0.6481.00
11_T15_A0.6451.00
113_A128_A0.6441.00
58_Y62_L0.6431.00
50_Q130_G0.6431.00
29_E118_D0.6341.00
47_A51_V0.6161.00
24_E28_G0.6141.00
16_W19_G0.6141.00
48_M52_N0.6131.00
85_A90_I0.6131.00
116_V125_H0.6131.00
49_P88_H0.6101.00
37_W94_I0.6071.00
35_H92_Q0.5961.00
10_L106_F0.5961.00
33_L64_V0.5951.00
52_N88_H0.5941.00
66_A90_I0.5931.00
102_L106_F0.5901.00
80_K83_E0.5891.00
28_G32_T0.5851.00
15_A18_N0.5751.00
136_L140_V0.5741.00
32_T121_G0.5701.00
37_W81_I0.5701.00
127_Q139_R0.5701.00
104_D109_E0.5661.00
66_A94_I0.5651.00
36_F102_L0.5621.00
54_F137_E0.5571.00
52_N55_R0.5571.00
67_V102_L0.5541.00
40_S43_L0.5541.00
81_I94_I0.5521.00
40_S111_V0.5501.00
50_Q134_K0.5291.00
41_C87_E0.5241.00
30_K119_K0.5231.00
35_H51_V0.5201.00
127_Q131_S0.5161.00
131_S136_L0.5161.00
43_L130_G0.5131.00
55_R92_Q0.5091.00
57_K133_M0.5071.00
70_P100_H0.5041.00
39_I80_K0.5021.00
5_Q126_F0.5001.00
42_H45_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3eytA 4 0.9797 100 0.222 Contact Map
3lorA 3 0.973 100 0.222 Contact Map
2b5xA 1 0.9865 100 0.229 Contact Map
3fw2A 2 0.9257 100 0.234 Contact Map
2p5qA 3 0.9527 100 0.239 Contact Map
2hyxA 2 0.9865 100 0.24 Contact Map
2f9sA 1 0.9324 100 0.245 Contact Map
3hczA 2 0.9459 100 0.245 Contact Map
3gl3A 3 0.9324 100 0.246 Contact Map
2f8aA 3 0.9527 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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