GREMLIN Database
YKUL - CBS domain-containing protein YkuL
UniProt: O31698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 147 (122)
Sequences: 13267 (9526)
Seq/√Len: 862.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_N35_H3.0141.00
29_V58_H2.1961.00
98_H101_D2.1951.00
29_V87_E2.1481.00
99_I120_N2.1161.00
101_D105_K2.0971.00
27_V31_N2.0851.00
97_L101_D2.0701.00
27_V50_V1.9821.00
14_V106_G1.9731.00
97_L118_V1.9691.00
95_P113_N1.9311.00
27_V48_I1.9281.00
36_A86_V1.9201.00
49_P57_L1.8621.00
52_D56_R1.8481.00
85_T88_E1.8291.00
28_Q31_N1.7681.00
25_A43_T1.7521.00
27_V36_A1.7391.00
84_I88_E1.6121.00
99_I126_E1.6091.00
97_L106_G1.5951.00
36_A61_I1.5921.00
95_P115_F1.5861.00
29_V52_D1.5731.00
109_M113_N1.5541.00
30_G87_E1.4391.00
39_V43_T1.4361.00
13_T16_Q1.4361.00
36_A48_I1.4271.00
15_G99_I1.4211.00
32_N35_H1.3831.00
38_L42_K1.3561.00
28_Q53_P1.3541.00
52_D58_H1.3511.00
46_T63_T1.3031.00
27_V86_V1.2971.00
26_H51_L1.2861.00
63_T67_M1.2781.00
97_L116_V1.2561.00
101_D109_M1.2351.00
106_G116_V1.2301.00
19_I133_V1.2261.00
17_F103_I1.2201.00
117_C125_F1.2171.00
35_H38_L1.2141.00
34_E38_L1.2011.00
91_L94_I1.2011.00
17_F129_F1.1851.00
47_A60_L1.1681.00
95_P109_M1.1661.00
65_M91_L1.1601.00
15_G100_N1.1571.00
61_I86_V1.1441.00
80_K83_Q1.1431.00
34_E82_D1.1111.00
108_G112_N1.1091.00
60_L117_C1.1041.00
120_N124_V1.0921.00
61_I66_I1.0911.00
31_N39_V1.0901.00
102_P105_K1.0861.00
97_L109_M1.0861.00
120_N126_E1.0731.00
84_I89_V1.0691.00
61_I89_V1.0651.00
50_V90_M1.0651.00
98_H121_D1.0611.00
49_P125_F1.0561.00
25_A39_V1.0501.00
37_L66_I1.0451.00
33_L89_V1.0121.00
57_L94_I1.0101.00
96_R119_E1.0081.00
106_G129_F0.9971.00
51_L58_H0.9731.00
14_V97_L0.9711.00
111_I136_K0.9641.00
27_V39_V0.9611.00
39_V42_K0.9521.00
25_A45_Y0.9421.00
57_L125_F0.9301.00
105_K109_M0.9231.00
46_T131_R0.9171.00
55_Y124_V0.9021.00
45_Y48_I0.8901.00
87_E90_M0.8841.00
132_R136_K0.8791.00
51_L55_Y0.8781.00
71_F74_E0.8731.00
56_R123_Q0.8681.00
39_V48_I0.8611.00
104_M108_G0.8571.00
109_M112_N0.8471.00
116_V120_N0.8421.00
109_M116_V0.8391.00
57_L117_C0.8381.00
40_L48_I0.8311.00
35_H39_V0.8151.00
19_I22_D0.7991.00
47_A131_R0.7901.00
96_R123_Q0.7851.00
82_D85_T0.7811.00
33_L37_L0.7771.00
129_F134_V0.7711.00
47_A62_G0.7701.00
67_M71_F0.7571.00
28_Q51_L0.7551.00
17_F137_E0.7521.00
110_V118_V0.7461.00
66_I71_F0.7381.00
46_T64_N0.7371.00
37_L63_T0.7341.00
81_L84_I0.7261.00
59_G90_M0.7231.00
103_I134_V0.7221.00
56_R124_V0.7201.00
47_A128_I0.7011.00
98_H120_N0.7001.00
13_T102_P0.6991.00
45_Y133_V0.6901.00
73_L84_I0.6881.00
13_T100_N0.6721.00
14_V18_M0.6691.00
105_K108_G0.6651.00
73_L79_E0.6611.00
106_G110_V0.6551.00
99_I121_D0.6511.00
49_P117_C0.6491.00
63_T132_R0.6491.00
24_V49_P0.6461.00
26_H55_Y0.6401.00
133_V136_K0.6391.00
101_D106_G0.6371.00
80_K84_I0.6341.00
30_G85_T0.6301.00
18_M22_D0.6261.00
19_I23_K0.6261.00
34_E83_Q0.6251.00
46_T49_P0.6221.00
98_H119_E0.6141.00
18_M127_G0.6111.00
25_A48_I0.6091.00
31_N48_I0.6071.00
33_L61_I0.6031.00
69_S72_G0.5981.00
14_V129_F0.5921.00
110_V131_R0.5921.00
69_S89_V0.5891.00
60_L91_L0.5861.00
41_T73_L0.5781.00
131_R135_L0.5781.00
36_A40_L0.5731.00
117_C128_I0.5701.00
111_I135_L0.5631.00
110_V116_V0.5571.00
72_G81_L0.5571.00
46_T132_R0.5461.00
49_P58_H0.5461.00
56_R122_E0.5461.00
123_Q126_E0.5431.00
15_G120_N0.5421.00
32_N85_T0.5411.00
98_H102_P0.5411.00
19_I128_I0.5401.00
79_E84_I0.5401.00
18_M118_V0.5381.00
74_E79_E0.5381.00
49_P128_I0.5341.00
24_V125_F0.5341.00
33_L36_A0.5311.00
50_V58_H0.5311.00
41_T68_N0.5261.00
98_H123_Q0.5251.00
119_E125_F0.5171.00
106_G109_M0.5151.00
60_L94_I0.5141.00
55_Y58_H0.5131.00
58_H90_M0.5081.00
132_R135_L0.5071.00
51_L57_L0.5011.00
103_I129_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lqnA 2 0.9388 99.9 0.239 Contact Map
3k6eA 2 0.9932 99.9 0.255 Contact Map
4cooA 2 0.9184 99.9 0.259 Contact Map
3pc3A 2 0.932 99.9 0.261 Contact Map
1yavA 2 0.932 99.9 0.261 Contact Map
2emqA 2 0.9252 99.9 0.279 Contact Map
4uuuA 2 0.9184 99.8 0.292 Contact Map
3l2bA 2 0.8299 99.8 0.305 Contact Map
2p9mA 2 0.8707 99.8 0.327 Contact Map
2nycA 2 0.8367 99.8 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.