GREMLIN Database
GLCT - PtsGHI operon antiterminator
UniProt: O31691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (266)
Sequences: 3607 (3125)
Seq/√Len: 191.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_N151_C4.7901.00
88_R139_E4.3841.00
232_M267_V3.1251.00
191_E197_K3.0351.00
254_Q260_P3.0321.00
236_K243_Y2.9231.00
193_S248_K2.8961.00
110_K114_Q2.8831.00
80_D147_K2.8241.00
236_K263_E2.7561.00
242_C274_Y2.7181.00
11_L17_I2.7121.00
185_Q256_T2.5761.00
246_A270_T2.4901.00
18_A26_V2.3361.00
190_I208_L2.3061.00
81_V140_V2.3031.00
47_G51_M2.2511.00
138_K157_I2.2501.00
227_E230_K2.2421.00
45_D51_M2.2141.00
218_R265_E2.0871.00
104_H163_H2.0761.00
222_E259_K2.0671.00
189_V252_I2.0391.00
31_K35_F2.0061.00
246_A266_A1.9931.00
84_H143_M1.9601.00
190_I273_L1.9421.00
242_C246_A1.8731.00
32_G35_F1.8431.00
11_L15_V1.8061.00
84_H139_E1.7981.00
11_L14_N1.7531.00
250_I266_A1.7471.00
247_W263_E1.7301.00
123_L158_G1.7241.00
85_I140_V1.6851.00
135_Q138_K1.6751.00
138_K154_E1.6681.00
201_E276_L1.6541.00
184_A205_Y1.6391.00
112_Q152_L1.6171.00
242_C273_L1.5921.00
14_N18_A1.5851.00
186_L249_L1.5761.00
28_L31_K1.5651.00
141_I145_N1.5431.00
194_F245_T1.5391.00
15_V18_A1.5351.00
244_N247_W1.5321.00
190_I245_T1.4861.00
41_D45_D1.4741.00
235_L270_T1.4681.00
12_N20_H1.4641.00
44_E47_G1.4581.00
10_V14_N1.4551.00
247_W266_A1.4481.00
42_V46_K1.4301.00
141_I157_I1.4251.00
71_D74_L1.4151.00
211_H272_H1.4111.00
246_A250_I1.4091.00
112_Q153_P1.4001.00
234_L238_E1.3931.00
188_E192_D1.3881.00
227_E267_V1.3731.00
15_V20_H1.3681.00
82_I102_T1.3631.00
187_V205_Y1.3431.00
100_A163_H1.3411.00
251_K254_Q1.3361.00
153_P156_E1.3251.00
204_N276_L1.3221.00
232_M263_E1.3111.00
137_A157_I1.2901.00
198_V273_L1.2821.00
10_V38_K1.2531.00
133_E161_A1.2531.00
226_K264_A1.2501.00
216_I220_K1.2461.00
96_H100_A1.2431.00
225_T268_Y1.2431.00
74_L78_S1.2401.00
109_I113_Q1.2311.00
215_T219_I1.2271.00
100_A104_H1.2081.00
230_K264_A1.2071.00
77_I147_K1.2071.00
12_N15_V1.2061.00
250_I269_L1.2051.00
85_I136_I1.1931.00
14_N17_I1.1901.00
215_T262_H1.1841.00
22_K26_V1.1741.00
81_V85_I1.1661.00
227_E264_A1.1501.00
134_Y161_A1.1451.00
37_K41_D1.1451.00
20_H26_V1.1421.00
41_D47_G1.1271.00
45_D50_K1.1231.00
74_L106_A1.1141.00
42_V47_G1.1091.00
77_I148_A1.1091.00
47_G50_K1.1041.00
109_I152_L1.1031.00
264_A267_V1.0831.00
243_Y263_E1.0821.00
25_E32_G1.0751.00
190_I246_A1.0721.00
16_L28_L1.0661.00
12_N18_A1.0611.00
12_N19_S1.0591.00
183_M209_I1.0571.00
22_K28_L1.0551.00
227_E231_L1.0541.00
98_H102_T1.0531.00
247_W251_K1.0441.00
11_L18_A1.0421.00
86_S93_L1.0421.00
15_V19_S1.0401.00
42_V45_D1.0361.00
77_I143_M1.0311.00
105_I144_I1.0301.00
134_Y157_I1.0301.00
246_A269_L1.0281.00
141_I160_I1.0221.00
11_L19_S1.0201.00
189_V192_D1.0151.00
84_H88_R1.0131.00
86_S89_T1.0111.00
246_A273_L1.0071.00
198_V276_L1.0071.00
18_A28_L1.0011.00
246_A249_L0.9910.99
145_N148_A0.9910.99
45_D49_D0.9860.99
142_D151_C0.9840.99
18_A22_K0.9830.99
33_I40_D0.9780.99
233_L237_N0.9770.99
36_G39_Q0.9710.99
249_L252_I0.9650.99
243_Y270_T0.9580.99
61_K64_K0.9570.99
29_I32_G0.9490.99
232_M243_Y0.9470.99
26_V31_K0.9460.99
139_E142_D0.9450.99
76_D79_N0.9420.99
28_L35_F0.9350.99
78_S82_I0.9310.99
216_I257_L0.9270.99
30_G36_G0.9210.99
19_S26_V0.9210.99
243_Y247_W0.9210.99
36_G40_D0.9180.99
191_E198_V0.9130.99
190_I194_F0.9070.99
29_I35_F0.9050.99
212_I215_T0.8990.99
194_F198_V0.8980.99
24_S31_K0.8920.99
215_T261_V0.8900.99
215_T218_R0.8870.99
144_I152_L0.8860.99
97_I167_A0.8860.99
181_Q256_T0.8850.99
179_H216_I0.8850.99
13_N20_H0.8850.99
207_R275_R0.8840.99
22_K32_G0.8760.99
189_V193_S0.8730.99
29_I36_G0.8720.99
89_T139_E0.8690.99
183_M186_L0.8670.99
250_I261_V0.8650.99
138_K142_D0.8600.99
10_V18_A0.8580.98
87_N90_N0.8570.98
183_M212_I0.8570.98
235_L267_V0.8500.98
164_I168_L0.8500.98
28_L32_G0.8500.98
11_L28_L0.8480.98
267_V270_T0.8470.98
25_E33_I0.8460.98
46_K49_D0.8430.98
205_Y209_I0.8380.98
105_I160_I0.8370.98
74_L109_I0.8360.98
137_A140_V0.8350.98
117_D153_P0.8340.98
81_V143_M0.8260.98
25_E36_G0.8250.98
131_P134_Y0.8250.98
161_A165_H0.8240.98
191_E201_E0.8230.98
29_I37_K0.8210.98
24_S35_F0.8120.98
204_N208_L0.8110.98
185_Q252_I0.8070.98
245_T249_L0.8070.98
20_H24_S0.8060.98
140_V143_M0.8050.98
141_I144_I0.8030.98
272_H275_R0.8010.98
193_S245_T0.7980.98
139_E143_M0.7970.98
79_N98_H0.7930.97
78_S102_T0.7900.97
208_L269_L0.7860.97
76_D80_D0.7850.97
241_L246_A0.7840.97
253_L257_L0.7830.97
25_E38_K0.7820.97
230_K234_L0.7770.97
70_V106_A0.7740.97
132_E135_Q0.7700.97
210_R214_F0.7690.97
25_E39_Q0.7650.97
78_S105_I0.7630.97
186_L252_I0.7630.97
145_N152_L0.7620.97
123_L159_F0.7600.97
249_L273_L0.7590.97
46_K51_M0.7590.97
137_A161_A0.7580.97
186_L273_L0.7570.97
45_D48_Y0.7550.97
242_C270_T0.7540.97
243_Y246_A0.7530.97
85_I164_I0.7530.97
26_V35_F0.7500.96
27_V32_G0.7490.96
79_N99_I0.7470.96
91_H271_L0.7410.96
18_A25_E0.7390.96
83_Y98_H0.7380.96
10_V15_V0.7350.96
11_L20_H0.7350.96
185_Q188_E0.7340.96
268_Y272_H0.7330.96
22_K27_V0.7320.96
106_A110_K0.7310.96
41_D51_M0.7310.96
167_A215_T0.7310.96
25_E31_K0.7300.96
121_P162_L0.7300.96
241_L244_N0.7300.96
32_G37_K0.7250.96
77_I81_V0.7230.96
22_K35_F0.7200.96
47_G111_R0.7150.95
252_I256_T0.7150.95
31_K39_Q0.7110.95
10_V39_Q0.7100.95
14_N19_S0.7080.95
140_V164_I0.7070.95
74_L77_I0.7060.95
19_S23_Y0.7030.95
134_Y138_K0.7020.95
10_V13_N0.7010.95
213_R217_E0.6950.95
15_V29_I0.6930.95
16_L34_G0.6900.94
189_V249_L0.6890.94
219_I259_K0.6880.94
25_E30_G0.6850.94
182_L212_I0.6840.94
120_N126_T0.6810.94
35_F39_Q0.6810.94
46_K50_K0.6800.94
134_Y158_G0.6800.94
31_K40_D0.6780.94
108_A112_Q0.6730.94
243_Y266_A0.6720.94
25_E28_L0.6710.94
30_G34_G0.6690.93
33_I38_K0.6680.93
173_L176_V0.6650.93
22_K25_E0.6640.93
32_G36_G0.6630.93
214_F217_E0.6610.93
85_I143_M0.6600.93
35_F38_K0.6580.93
207_R272_H0.6580.93
180_S209_I0.6580.93
155_G158_G0.6580.93
118_M156_E0.6550.93
218_R225_T0.6540.93
16_L43_I0.6530.93
156_E268_Y0.6520.93
232_M264_A0.6510.93
251_K255_Q0.6510.93
18_A31_K0.6500.93
31_K36_G0.6490.92
25_E40_D0.6470.92
216_I259_K0.6460.92
31_K45_D0.6450.92
24_S28_L0.6450.92
32_G38_K0.6440.92
73_K147_K0.6410.92
182_L257_L0.6380.92
10_V40_D0.6360.92
91_H168_L0.6350.92
27_V31_K0.6350.92
120_N158_G0.6310.91
256_T259_K0.6290.91
93_L164_I0.6280.91
124_M128_S0.6250.91
104_H108_A0.6240.91
180_S205_Y0.6230.91
79_N83_Y0.6220.91
83_Y86_S0.6220.91
15_V31_K0.6130.90
233_L236_K0.6130.90
207_R276_L0.6110.90
247_W250_I0.6090.90
26_V36_G0.6080.90
84_H136_I0.6050.90
230_K267_V0.6020.89
244_N248_K0.6010.89
112_Q117_D0.5990.89
20_H25_E0.5950.89
160_I163_H0.5930.89
16_L24_S0.5890.88
18_A40_D0.5890.88
22_K33_I0.5880.88
32_G39_Q0.5870.88
234_L237_N0.5870.88
89_T93_L0.5820.88
110_K113_Q0.5810.88
43_I47_G0.5810.88
93_L97_I0.5780.87
129_L154_E0.5780.87
113_Q142_D0.5740.87
12_N17_I0.5730.87
187_V190_I0.5720.87
104_H156_E0.5650.86
253_L259_K0.5650.86
16_L20_H0.5650.86
211_H268_Y0.5640.86
96_H167_A0.5640.86
14_N22_K0.5620.86
126_T158_G0.5600.86
182_L186_L0.5590.86
176_V180_S0.5580.86
14_N33_I0.5550.85
230_K238_E0.5540.85
239_Y274_Y0.5530.85
13_N18_A0.5530.85
14_N40_D0.5520.85
14_N41_D0.5520.85
183_M187_V0.5490.85
120_N155_G0.5490.85
15_V34_G0.5490.85
125_E158_G0.5480.84
78_S81_V0.5480.84
223_E227_E0.5470.84
74_L113_Q0.5470.84
253_L261_V0.5460.84
133_E165_H0.5460.84
31_K37_K0.5460.84
14_N32_G0.5400.84
232_M236_K0.5380.83
137_A160_I0.5370.83
26_V32_G0.5350.83
111_R159_F0.5340.83
181_Q185_Q0.5310.83
188_E199_N0.5310.83
16_L30_G0.5300.82
210_R264_A0.5300.82
19_S22_K0.5300.82
242_C277_T0.5260.82
189_V248_K0.5250.82
175_E178_Q0.5240.82
14_N20_H0.5240.82
82_I97_I0.5200.81
113_Q149_G0.5200.81
138_K151_C0.5190.81
85_I89_T0.5190.81
144_I148_A0.5180.81
15_V159_F0.5180.81
94_N168_L0.5160.81
18_A27_V0.5150.81
109_I144_I0.5130.80
106_A274_Y0.5120.80
178_Q181_Q0.5110.80
38_K41_D0.5090.80
28_L37_K0.5080.80
262_H265_E0.5060.80
89_T136_I0.5050.79
97_I101_L0.5050.79
188_E191_E0.5040.79
97_I215_T0.5020.79
56_D59_E0.5000.79
80_D83_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h99A 2 0.7794 100 0.334 Contact Map
4r6iA 2 0.968 100 0.336 Contact Map
3sqnA 2 0.9324 100 0.458 Contact Map
3rioA 1 0.5907 99.9 0.586 Contact Map
3ufeA 2 0.3808 99.8 0.652 Contact Map
3nufA 2 0.4093 96.6 0.874 Contact Map
1l1cA 2 0.1957 94.7 0.891 Contact Map
1auuA 2 0.1957 94.4 0.892 Contact Map
2y1nA 1 0.2669 12.9 0.95 Contact Map
3d5pA 2 0.1779 12.1 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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