GREMLIN Database
YKVZ - Uncharacterized HTH-type transcriptional regulator YkvZ
UniProt: O31690 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (316)
Sequences: 36516 (26315)
Seq/√Len: 1480.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_Q196_E3.3901.00
172_H235_T3.2021.00
10_K42_S3.1461.00
258_S261_D3.0811.00
163_G266_L2.6171.00
118_G297_L2.5651.00
191_I195_K2.5401.00
172_H264_A2.5141.00
270_N283_D2.5021.00
150_P300_R2.4461.00
161_R200_E2.3431.00
221_K254_N2.2561.00
30_E34_K2.2361.00
38_E42_S2.2041.00
84_A87_E2.1961.00
34_K38_E2.1811.00
84_A295_A2.1481.00
225_H255_Q2.0941.00
168_I201_I2.0631.00
161_R196_E2.0551.00
292_Q295_A2.0451.00
165_D197_A2.0171.00
161_R197_A2.0051.00
158_E162_N1.9911.00
85_A294_F1.9601.00
21_V36_V1.9371.00
225_H251_E1.9311.00
80_G290_G1.9171.00
33_R37_F1.8931.00
157_Q192_K1.8801.00
165_D169_A1.8801.00
160_F164_L1.8761.00
159_A268_V1.8741.00
22_I40_M1.8451.00
229_T255_Q1.8381.00
252_A263_L1.8341.00
167_L236_A1.8251.00
84_A291_K1.8241.00
299_K304_Q1.8231.00
5_K15_V1.8141.00
220_G247_G1.8111.00
160_F238_F1.7661.00
283_D314_R1.7661.00
83_D287_R1.7451.00
165_D201_I1.7391.00
278_G319_S1.7251.00
164_L194_Y1.7251.00
161_R165_D1.6731.00
11_A39_A1.6681.00
221_K251_E1.6521.00
174_K206_R1.6471.00
10_K39_A1.6401.00
257_V262_E1.6391.00
285_Q288_E1.6391.00
224_F248_L1.6141.00
63_G116_V1.6131.00
177_I240_A1.6071.00
176_A234_P1.6051.00
292_Q309_K1.5981.00
80_G287_R1.5951.00
258_S262_E1.5911.00
166_Y170_K1.5901.00
239_V248_L1.5801.00
162_N313_Y1.5691.00
84_A88_S1.5591.00
251_E255_Q1.5361.00
174_K233_K1.5161.00
141_C293_A1.5161.00
37_F41_E1.5151.00
192_K196_E1.5011.00
158_E161_R1.4911.00
155_P158_E1.4731.00
88_S298_E1.4711.00
168_I197_A1.4691.00
211_I226_K1.4591.00
21_V40_M1.4521.00
166_Y169_A1.4421.00
288_E292_Q1.4411.00
7_I39_A1.4381.00
251_E254_N1.4321.00
37_F40_M1.4211.00
270_N318_R1.3971.00
189_F192_K1.3891.00
288_E291_K1.3861.00
84_A294_F1.3701.00
60_N117_D1.3681.00
195_K199_E1.3661.00
129_E133_E1.3571.00
224_F237_I1.3511.00
164_L168_I1.3451.00
166_Y317_E1.3361.00
225_H254_N1.3311.00
176_A227_W1.3191.00
252_A257_V1.3191.00
197_A200_E1.3111.00
159_A313_Y1.3001.00
221_K225_H1.3001.00
164_L193_A1.2891.00
10_K43_L1.2871.00
160_F193_A1.2871.00
221_K250_L1.2811.00
174_K235_T1.2781.00
298_E302_Q1.2671.00
5_K9_E1.2651.00
295_A299_K1.2631.00
164_L197_A1.2621.00
206_R209_W1.2581.00
60_N90_V1.2571.00
29_S32_K1.2481.00
30_E33_R1.2471.00
214_A219_D1.2451.00
172_H236_A1.2441.00
62_I85_A1.2421.00
6_D9_E1.2321.00
193_A197_A1.2321.00
224_F252_A1.2271.00
63_G111_L1.2271.00
20_R25_H1.2221.00
225_H229_T1.2151.00
7_I11_A1.2151.00
35_R39_A1.2151.00
249_F265_I1.2151.00
162_N165_D1.2041.00
95_F107_A1.1981.00
120_I293_A1.1951.00
226_K230_W1.1941.00
157_Q161_R1.1941.00
95_F111_L1.1871.00
165_D200_E1.1841.00
39_A42_S1.1801.00
85_A92_L1.1761.00
39_A43_L1.1761.00
81_I294_F1.1741.00
64_V81_I1.1641.00
266_L280_T1.1631.00
231_K234_P1.1581.00
81_I120_I1.1561.00
173_K235_T1.1541.00
157_Q189_F1.1521.00
7_I43_L1.1441.00
32_K35_R1.1361.00
287_R291_K1.1331.00
4_I15_V1.1281.00
218_N222_A1.1241.00
194_Y198_L1.1191.00
247_G251_E1.1081.00
175_I198_L1.1051.00
88_S295_A1.1021.00
178_C248_L1.0971.00
157_Q193_A1.0841.00
48_N54_L1.0821.00
196_E200_E1.0821.00
64_V92_L1.0811.00
170_K317_E1.0781.00
237_I248_L1.0761.00
38_E41_E1.0751.00
4_I18_V1.0751.00
109_S130_K1.0691.00
61_M91_H1.0661.00
163_G238_F1.0641.00
177_I191_I1.0611.00
290_G294_F1.0601.00
21_V28_V1.0591.00
198_L203_E1.0551.00
292_Q296_I1.0541.00
197_A201_I1.0511.00
34_K37_F1.0501.00
296_I309_K1.0451.00
82_A86_A1.0421.00
61_M93_S1.0401.00
168_I203_E1.0331.00
242_D281_T1.0321.00
216_T219_D1.0311.00
223_L226_K1.0271.00
242_D267_S1.0261.00
169_A201_I1.0221.00
24_N33_R1.0181.00
192_K195_K1.0111.00
222_A226_K1.0041.00
50_H53_H1.0011.00
220_G224_F0.9981.00
174_K232_E0.9971.00
194_Y238_F0.9941.00
105_I109_S0.9941.00
239_V244_V0.9891.00
239_V245_S0.9851.00
291_K295_A0.9801.00
88_S302_Q0.9801.00
217_I250_L0.9781.00
40_M43_L0.9781.00
48_N51_A0.9641.00
86_A103_K0.9641.00
211_I223_L0.9621.00
182_K212_E0.9611.00
90_V298_E0.9601.00
297_L301_I0.9581.00
219_D222_A0.9541.00
51_A54_L0.9511.00
292_Q311_L0.9481.00
249_F277_L0.9471.00
188_H192_K0.9361.00
224_F228_N0.9351.00
158_E312_D0.9321.00
163_G282_I0.9311.00
175_I236_A0.9301.00
150_P296_I0.9301.00
170_K264_A0.9281.00
87_E291_K0.9271.00
11_A18_V0.9221.00
249_F259_V0.9171.00
314_R317_E0.8991.00
285_Q311_L0.8961.00
120_I297_L0.8951.00
79_A83_D0.8931.00
83_D291_K0.8921.00
185_M189_F0.8861.00
154_I285_Q0.8811.00
164_L198_L0.8801.00
47_R52_V0.8761.00
168_I173_K0.8761.00
24_N37_F0.8711.00
183_K188_H0.8621.00
242_D270_N0.8601.00
81_I290_G0.8591.00
257_V263_L0.8571.00
180_A215_I0.8541.00
174_K209_W0.8531.00
151_T308_R0.8531.00
62_I120_I0.8521.00
176_A237_I0.8511.00
64_V78_I0.8491.00
155_P310_V0.8481.00
228_N251_E0.8461.00
152_I296_I0.8451.00
103_K106_F0.8441.00
78_I82_A0.8431.00
252_A265_I0.8431.00
267_S281_T0.8371.00
222_A225_H0.8351.00
158_E313_Y0.8351.00
283_D316_I0.8331.00
109_S113_Q0.8331.00
195_K205_F0.8311.00
21_V37_F0.8241.00
237_I263_L0.8211.00
81_I92_L0.8171.00
73_Y286_T0.8151.00
154_I313_Y0.8111.00
118_G301_I0.8091.00
155_P312_D0.8081.00
296_I299_K0.8071.00
112_K134_W0.8061.00
31_D34_K0.8021.00
213_K244_V0.8011.00
233_K257_V0.7991.00
130_K133_E0.7971.00
167_L266_L0.7971.00
209_W230_W0.7941.00
59_S117_D0.7931.00
196_E199_E0.7931.00
173_K203_E0.7921.00
166_Y280_T0.7901.00
77_L141_C0.7891.00
153_S310_V0.7861.00
83_D87_E0.7861.00
76_E287_R0.7851.00
191_I210_V0.7831.00
154_I284_I0.7811.00
246_A277_L0.7811.00
285_Q314_R0.7811.00
253_K278_G0.7801.00
156_H190_R0.7761.00
13_V36_V0.7761.00
17_T20_R0.7741.00
294_F298_E0.7731.00
198_L205_F0.7721.00
80_G291_K0.7701.00
153_S308_R0.7701.00
129_E132_M0.7681.00
219_D223_L0.7641.00
49_I52_V0.7631.00
61_M114_R0.7611.00
270_N316_I0.7581.00
224_F227_W0.7581.00
80_G84_A0.7561.00
178_C239_V0.7551.00
67_P74_F0.7531.00
100_E103_K0.7531.00
16_T20_R0.7421.00
31_D35_R0.7411.00
235_T264_A0.7401.00
166_Y315_L0.7401.00
131_L138_I0.7371.00
177_I238_F0.7351.00
106_F109_S0.7301.00
78_I94_L0.7301.00
269_D284_I0.7301.00
224_F251_E0.7301.00
58_F117_D0.7291.00
228_N255_Q0.7281.00
179_L191_I0.7241.00
20_R26_P0.7221.00
93_S116_V0.7191.00
20_R27_Y0.7181.00
189_F193_A0.7171.00
63_G119_L0.7171.00
211_I227_W0.7161.00
46_T113_Q0.7161.00
238_F266_L0.7141.00
242_D245_S0.7131.00
79_A82_A0.7111.00
245_S267_S0.7071.00
162_N282_I0.7051.00
270_N274_S0.7051.00
62_I294_F0.7031.00
230_W234_P0.7031.00
102_Q106_F0.6981.00
82_A92_L0.6981.00
65_V107_A0.6961.00
118_G139_L0.6941.00
252_A259_V0.6931.00
299_K303_G0.6841.00
226_K229_T0.6831.00
230_W233_K0.6791.00
250_L278_G0.6791.00
98_N103_K0.6781.00
168_I198_L0.6761.00
132_M148_R0.6741.00
250_L253_K0.6741.00
161_R193_A0.6711.00
82_A96_Q0.6701.00
278_G318_R0.6661.00
103_K107_A0.6651.00
211_I230_W0.6621.00
34_K41_E0.6621.00
58_F302_Q0.6611.00
224_F247_G0.6601.00
175_I235_T0.6581.00
205_F208_D0.6561.00
112_K136_G0.6561.00
21_V33_R0.6551.00
213_K219_D0.6511.00
140_L149_F0.6501.00
5_K55_S0.6491.00
220_G223_L0.6491.00
46_T109_S0.6441.00
132_M138_I0.6441.00
187_S215_I0.6421.00
120_I141_C0.6381.00
138_I149_F0.6351.00
118_G293_A0.6351.00
177_I194_Y0.6331.00
274_S281_T0.6321.00
132_M149_F0.6311.00
27_Y32_K0.6301.00
246_A273_I0.6281.00
108_L119_L0.6251.00
35_R38_E0.6241.00
41_E44_E0.6241.00
241_N269_D0.6221.00
162_N166_Y0.6221.00
176_A209_W0.6211.00
252_A255_Q0.6201.00
215_I240_A0.6201.00
250_L254_N0.6191.00
77_L286_T0.6191.00
71_L243_Q0.6181.00
18_V21_V0.6131.00
175_I194_Y0.6071.00
7_I18_V0.6061.00
161_R164_L0.6061.00
142_Q156_H0.6041.00
76_E286_T0.6041.00
79_A287_R0.6021.00
18_V40_M0.5991.00
287_R290_G0.5991.00
167_L238_F0.5991.00
215_I244_V0.5981.00
280_T315_L0.5971.00
180_A187_S0.5961.00
205_F210_V0.5951.00
90_V301_I0.5931.00
80_G286_T0.5931.00
93_S114_R0.5921.00
13_V32_K0.5911.00
156_H189_F0.5891.00
300_R303_G0.5891.00
139_L300_R0.5881.00
249_F253_K0.5871.00
217_I273_I0.5861.00
241_N244_V0.5821.00
142_Q186_N0.5821.00
217_I247_G0.5811.00
163_G236_A0.5801.00
246_A271_H0.5791.00
139_L152_I0.5791.00
90_V117_D0.5781.00
20_R28_V0.5781.00
73_Y77_L0.5781.00
218_N221_K0.5761.00
195_K210_V0.5751.00
238_F268_V0.5731.00
195_K207_E0.5711.00
194_Y205_F0.5661.00
62_I90_V0.5611.00
191_I212_E0.5611.00
85_A90_V0.5601.00
268_V284_I0.5591.00
139_L297_L0.5581.00
253_K258_S0.5581.00
46_T50_H0.5571.00
221_K247_G0.5561.00
62_I118_G0.5541.00
101_V105_I0.5531.00
97_T104_E0.5521.00
221_K224_F0.5521.00
239_V267_S0.5511.00
25_H28_V0.5471.00
228_N252_A0.5471.00
59_S91_H0.5451.00
139_L293_A0.5451.00
270_N275_Q0.5451.00
296_I300_R0.5441.00
18_V36_V0.5441.00
242_D271_H0.5441.00
111_L116_V0.5431.00
166_Y266_L0.5421.00
72_P243_Q0.5411.00
119_L136_G0.5411.00
112_K115_Q0.5401.00
130_K134_W0.5401.00
250_L275_Q0.5391.00
52_V56_K0.5381.00
62_I301_I0.5341.00
95_F110_Q0.5331.00
140_L151_T0.5321.00
13_V18_V0.5271.00
152_I292_Q0.5251.00
234_P257_V0.5251.00
259_V262_E0.5241.00
85_A298_E0.5241.00
61_M117_D0.5241.00
223_L227_W0.5221.00
280_T317_E0.5221.00
84_A298_E0.5211.00
76_E272_E0.5211.00
129_E134_W0.5211.00
187_S240_A0.5201.00
139_L296_I0.5191.00
53_H56_K0.5181.00
154_I159_A0.5181.00
184_G187_S0.5181.00
11_A21_V0.5151.00
178_C223_L0.5151.00
16_T25_H0.5151.00
275_Q278_G0.5141.00
289_M311_L0.5141.00
116_V119_L0.5131.00
179_L182_K0.5111.00
274_S279_I0.5091.00
170_K235_T0.5091.00
137_P301_I0.5091.00
174_K234_P0.5081.00
140_L144_S0.5071.00
174_K231_K0.5071.00
191_I205_F0.5041.00
154_I268_V0.5021.00
121_F140_L0.5021.00
179_L212_E0.5021.00
199_E202_G0.5011.00
174_K204_A0.5011.00
213_K220_G0.5011.00
11_A36_V0.5001.00
248_L252_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.8255 100 0.081 Contact Map
3ctpA 2 0.8069 100 0.085 Contact Map
2hsgA 1 0.9907 100 0.091 Contact Map
3kjxA 2 1 100 0.096 Contact Map
1qpzA 2 0.9969 100 0.097 Contact Map
2o20A 2 0.8287 100 0.098 Contact Map
3e3mA 2 0.8069 100 0.105 Contact Map
4o5aA 2 0.8037 100 0.105 Contact Map
3h5oA 2 0.8131 100 0.106 Contact Map
1jyeA 2 0.81 100 0.106 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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