GREMLIN Database
YKVY - Putative dipeptidase YkvY
UniProt: O31689 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (339)
Sequences: 11008 (8050)
Seq/√Len: 437.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_K351_V5.2151.00
319_E347_K4.3481.00
265_S345_V3.2021.00
143_I344_H3.0731.00
246_K334_I2.7901.00
252_E256_Q2.5741.00
148_E151_K2.5011.00
155_Y184_K2.4611.00
25_E302_S2.4151.00
159_V180_E2.4151.00
246_K249_A2.3441.00
179_Y183_K2.3431.00
260_A281_I2.3421.00
244_N247_Q2.3411.00
176_Q179_Y2.3401.00
270_R273_D2.2901.00
169_S212_T2.2531.00
137_I318_Q2.2441.00
275_D279_R2.2421.00
259_K263_E2.2371.00
16_H101_A2.2301.00
245_P249_A2.2151.00
199_E211_A2.2011.00
146_L322_V2.1851.00
272_G314_D2.1741.00
261_A278_A2.1561.00
280_G284_K2.1481.00
264_A277_T2.1331.00
113_E116_K2.1121.00
299_L342_D2.1021.00
99_M123_Q2.0231.00
253_T285_A2.0051.00
147_K151_K1.9751.00
215_K241_K1.9711.00
145_L228_D1.9461.00
260_A263_E1.9011.00
10_W13_E1.9011.00
163_A176_Q1.8891.00
214_K217_D1.8881.00
213_L240_Y1.8561.00
178_E182_K1.8081.00
85_L88_K1.7971.00
250_I335_G1.7741.00
248_E252_E1.7571.00
346_T351_V1.7081.00
250_I337_V1.6971.00
180_E183_K1.6801.00
270_R316_L1.6781.00
211_A217_D1.6741.00
325_I343_V1.6741.00
218_F247_Q1.6691.00
276_L280_G1.6681.00
256_Q260_A1.6511.00
254_V337_V1.6361.00
239_A243_I1.6211.00
161_T238_F1.6181.00
262_I343_V1.6001.00
180_E184_K1.5901.00
169_S172_E1.5861.00
281_I285_A1.5821.00
99_M125_V1.5791.00
47_F50_E1.5771.00
255_L259_K1.5631.00
266_K269_V1.5521.00
282_I329_I1.5501.00
63_Q67_A1.5251.00
195_V219_V1.5231.00
154_D356_Y1.5181.00
318_Q321_M1.5181.00
190_S231_C1.5171.00
171_V210_T1.5171.00
261_A274_L1.4611.00
175_A179_Y1.4581.00
55_V89_A1.4541.00
57_P60_E1.4501.00
31_T45_F1.4491.00
222_D233_D1.4471.00
324_T342_D1.4281.00
344_H353_L1.4241.00
44_L47_F1.4121.00
136_L321_M1.4061.00
158_E162_A1.4051.00
166_E215_K1.3981.00
233_D340_E1.3911.00
218_F239_A1.3911.00
173_V213_L1.3911.00
197_F211_A1.3891.00
10_W14_A1.3721.00
159_V184_K1.3721.00
258_E262_I1.3681.00
140_D144_R1.3631.00
226_I231_C1.3631.00
159_V162_A1.3571.00
144_R148_E1.3441.00
250_I331_V1.3221.00
17_T98_H1.3201.00
12_K49_E1.3031.00
28_F229_G1.3021.00
257_A281_I1.3021.00
269_V273_D1.2961.00
176_Q180_E1.2911.00
197_F213_L1.2871.00
61_A65_R1.2871.00
267_P319_E1.2781.00
16_H125_V1.2751.00
278_A295_L1.2721.00
43_G47_F1.2631.00
30_L134_F1.2371.00
251_Y339_I1.2351.00
249_A285_A1.2331.00
222_D340_E1.2291.00
173_V219_V1.2241.00
245_P248_E1.2211.00
172_E183_K1.2191.00
283_E288_G1.2161.00
256_Q285_A1.2071.00
258_E341_D1.2041.00
317_L323_Y1.2031.00
260_A277_T1.2011.00
174_L178_E1.1971.00
273_D276_L1.1921.00
272_G276_L1.1891.00
262_I352_A1.1881.00
317_L345_V1.1801.00
146_L150_A1.1741.00
137_I321_M1.1721.00
148_E227_L1.1681.00
153_A234_I1.1671.00
81_N84_E1.1601.00
112_A116_K1.1571.00
152_L229_G1.1541.00
157_V234_I1.1511.00
256_Q284_K1.1491.00
256_Q281_I1.1451.00
17_T99_M1.1441.00
133_Q318_Q1.1421.00
249_A252_E1.1331.00
141_N145_L1.1321.00
151_K155_Y1.1301.00
109_L112_A1.1291.00
249_A253_T1.1201.00
265_S274_L1.1191.00
11_L16_H1.1001.00
176_Q183_K1.0971.00
218_F237_T1.0821.00
269_V277_T1.0791.00
261_A277_T1.0771.00
152_L186_I1.0761.00
141_N144_R1.0731.00
168_I172_E1.0691.00
264_A269_V1.0691.00
346_T349_G1.0671.00
159_V176_Q1.0651.00
322_V344_H1.0641.00
262_I325_I1.0631.00
26_N103_E1.0591.00
144_R147_K1.0591.00
253_T281_I1.0561.00
197_F217_D1.0561.00
150_A154_D1.0551.00
320_G344_H1.0551.00
159_V183_K1.0481.00
343_V352_A1.0451.00
283_E286_G1.0451.00
88_K92_K1.0451.00
332_P335_G1.0411.00
87_E91_K1.0401.00
196_L206_G1.0391.00
89_A92_K1.0331.00
168_I176_Q1.0261.00
198_G217_D1.0221.00
178_E193_T1.0201.00
246_K331_V1.0191.00
30_L131_L1.0191.00
331_V334_I1.0121.00
147_K344_H1.0121.00
275_D295_L1.0111.00
257_A282_I1.0101.00
265_S325_I1.0071.00
260_A264_A1.0051.00
178_E189_M1.0041.00
21_I30_L1.0031.00
76_Y80_E1.0031.00
171_V175_A1.0031.00
101_A127_A0.9961.00
221_F238_F0.9951.00
109_L113_E0.9931.00
253_T256_Q0.9911.00
211_A214_K0.9861.00
127_A130_T0.9791.00
75_G80_E0.9741.00
277_T280_G0.9731.00
265_S343_V0.9721.00
150_A342_D0.9691.00
186_I225_V0.9651.00
47_F52_P0.9641.00
253_T282_I0.9591.00
323_Y345_V0.9571.00
274_L277_T0.9541.00
299_L322_V0.9541.00
89_A93_R0.9491.00
26_N132_N0.9471.00
156_G180_E0.9451.00
200_K206_G0.9411.00
219_V240_Y0.9401.00
164_L238_F0.9391.00
154_D355_Q0.9371.00
51_E72_E0.9361.00
274_L317_L0.9361.00
272_G312_A0.9361.00
11_L18_A0.9341.00
189_M193_T0.9311.00
74_I78_D0.9271.00
200_K203_Q0.9221.00
157_V238_F0.9181.00
81_N85_L0.9101.00
173_V195_V0.9071.00
158_E356_Y0.9061.00
148_E152_L0.9031.00
140_D346_T0.9001.00
192_S207_N0.8981.00
145_L148_E0.8961.00
177_I181_L0.8961.00
164_L173_V0.8961.00
280_G283_E0.8951.00
201_S220_L0.8941.00
165_R168_I0.8891.00
310_S313_N0.8841.00
159_V163_A0.8831.00
252_E255_L0.8821.00
21_I131_L0.8791.00
264_A274_L0.8781.00
148_E228_D0.8781.00
113_E117_H0.8771.00
277_T281_I0.8751.00
271_I317_L0.8751.00
269_V274_L0.8741.00
246_K250_I0.8711.00
267_P346_T0.8711.00
343_V350_A0.8711.00
200_K211_A0.8681.00
19_A127_A0.8631.00
104_K113_E0.8631.00
181_L225_V0.8601.00
298_G307_P0.8591.00
153_A232_S0.8551.00
42_M46_I0.8541.00
255_L339_I0.8511.00
344_H351_V0.8511.00
155_Y158_E0.8501.00
196_L201_S0.8481.00
43_G46_I0.8471.00
239_A247_Q0.8451.00
298_G305_E0.8451.00
27_V43_G0.8451.00
77_A80_E0.8361.00
143_I147_K0.8331.00
278_A291_F0.8321.00
262_I350_A0.8311.00
261_A325_I0.8271.00
265_S350_A0.8241.00
345_V350_A0.8231.00
290_Y332_P0.8061.00
150_A354_T0.8061.00
267_P347_K0.8031.00
162_A166_E0.8011.00
257_A261_A0.8001.00
270_R314_D0.7991.00
29_Y134_F0.7991.00
133_Q315_T0.7981.00
166_E240_Y0.7961.00
28_F301_I0.7931.00
10_W133_Q0.7931.00
260_A278_A0.7871.00
152_L227_L0.7861.00
88_K91_K0.7841.00
130_T133_Q0.7831.00
54_F64_A0.7811.00
168_I173_V0.7791.00
243_I248_E0.7791.00
282_I287_Y0.7781.00
136_L318_Q0.7781.00
42_M45_F0.7731.00
309_M323_Y0.7731.00
102_V109_L0.7711.00
267_P318_Q0.7711.00
12_K48_Q0.7711.00
142_E230_Y0.7701.00
236_R341_D0.7681.00
346_T350_A0.7681.00
251_Y255_L0.7661.00
326_E340_E0.7651.00
42_M47_F0.7641.00
68_G72_E0.7641.00
315_T318_Q0.7621.00
204_P293_H0.7571.00
150_A353_L0.7571.00
222_D326_E0.7571.00
163_A180_E0.7561.00
197_F240_Y0.7551.00
281_I284_K0.7541.00
299_L324_T0.7531.00
177_I221_F0.7531.00
170_E200_K0.7511.00
152_L184_K0.7461.00
160_G221_F0.7451.00
273_D277_T0.7451.00
53_F74_I0.7451.00
225_V232_S0.7431.00
145_L227_L0.7421.00
11_L19_A0.7421.00
108_S111_R0.7411.00
15_G99_M0.7371.00
151_K154_D0.7341.00
201_S218_F0.7341.00
257_A277_T0.7331.00
154_D158_E0.7331.00
75_G78_D0.7321.00
260_A280_G0.7301.00
330_Y338_R0.7281.00
216_G242_T0.7281.00
150_A232_S0.7281.00
158_E357_P0.7231.00
107_I112_A0.7231.00
79_H82_P0.7221.00
105_D108_S0.7201.00
266_K350_A0.7201.00
31_T52_P0.7191.00
250_I253_T0.7121.00
313_N316_L0.7111.00
233_D297_H0.7101.00
156_G181_L0.7091.00
175_A182_K0.7081.00
199_E333_E0.7071.00
216_G240_Y0.7061.00
85_L89_A0.7051.00
18_A100_L0.7051.00
64_A67_A0.7031.00
114_Q117_H0.7011.00
250_I287_Y0.7001.00
160_G173_V0.6991.00
191_F224_G0.6991.00
264_A267_P0.6981.00
297_H340_E0.6981.00
179_Y182_K0.6981.00
82_P85_L0.6961.00
110_S114_Q0.6951.00
279_R291_F0.6951.00
267_P345_V0.6941.00
70_N73_I0.6921.00
205_H304_H0.6921.00
328_G338_R0.6901.00
203_Q206_G0.6891.00
140_D320_G0.6881.00
62_G66_N0.6861.00
243_I247_Q0.6851.00
201_S336_G0.6851.00
76_Y79_H0.6841.00
172_E175_A0.6811.00
157_V160_G0.6761.00
177_I223_L0.6751.00
319_E346_T0.6751.00
217_D247_Q0.6741.00
169_S210_T0.6741.00
157_V223_L0.6731.00
258_E325_I0.6721.00
53_F89_A0.6701.00
218_F243_I0.6701.00
233_D326_E0.6681.00
261_A264_A0.6661.00
231_C303_V0.6651.00
79_H83_W0.6641.00
117_H120_G0.6561.00
136_L315_T0.6551.00
189_M192_S0.6520.99
153_A156_G0.6510.99
267_P350_A0.6460.99
25_E301_I0.6450.99
247_Q334_I0.6450.99
152_L225_V0.6440.99
26_N131_L0.6420.99
18_A45_F0.6400.99
107_I111_R0.6370.99
150_A234_I0.6360.99
261_A295_L0.6360.99
156_G177_I0.6320.99
104_K126_S0.6310.99
316_L319_E0.6300.99
97_I100_L0.6300.99
291_F294_R0.6300.99
48_Q52_P0.6280.99
84_E88_K0.6280.99
143_I322_V0.6260.99
58_G66_N0.6250.99
160_G176_Q0.6220.99
195_V221_F0.6210.99
352_A355_Q0.6210.99
331_V335_G0.6200.99
28_F34_Y0.6200.99
265_S317_L0.6200.99
274_L295_L0.6190.99
14_A17_T0.6180.99
259_K262_I0.6170.99
73_I76_Y0.6160.99
53_F81_N0.6150.99
330_Y336_G0.6130.99
153_A223_L0.6100.99
149_A153_A0.6050.99
24_K27_V0.6050.99
164_L219_V0.6000.99
133_Q136_L0.6000.99
315_T321_M0.5990.99
116_K120_G0.5980.99
322_V342_D0.5980.99
300_G305_E0.5970.99
160_G163_A0.5950.99
308_S312_A0.5950.99
268_G318_Q0.5940.99
18_A48_Q0.5930.99
235_T340_E0.5930.99
83_W86_I0.5900.99
253_T287_Y0.5900.99
297_H300_G0.5890.99
257_A278_A0.5890.99
267_P349_G0.5890.99
239_A244_N0.5880.99
256_Q259_K0.5860.99
201_S239_A0.5860.99
253_T329_I0.5850.99
144_R151_K0.5840.99
58_G292_P0.5820.99
49_E52_P0.5820.99
11_L14_A0.5810.99
244_N334_I0.5740.99
82_P90_L0.5710.99
234_I342_D0.5700.99
164_L240_Y0.5690.99
132_N306_Y0.5670.99
65_R68_G0.5660.99
293_H304_H0.5650.99
22_H25_E0.5650.99
157_V161_T0.5640.99
257_A260_A0.5640.99
64_A68_G0.5640.99
188_G192_S0.5620.98
10_W134_F0.5590.98
268_G316_L0.5590.98
222_D297_H0.5590.98
284_K287_Y0.5590.98
17_T48_Q0.5560.98
201_S204_P0.5560.98
155_Y180_E0.5540.98
26_N29_Y0.5530.98
71_H75_G0.5500.98
27_V31_T0.5500.98
282_I288_G0.5490.98
173_V221_F0.5480.98
275_D294_R0.5470.98
215_K242_T0.5450.98
75_G79_H0.5450.98
68_G71_H0.5440.98
351_V355_Q0.5440.98
140_D319_E0.5430.98
137_I319_E0.5420.98
81_N89_A0.5410.98
276_L311_Q0.5400.98
266_K348_D0.5390.98
138_K142_E0.5350.98
56_C61_A0.5320.98
166_E214_K0.5310.98
153_A224_G0.5310.98
154_D354_T0.5290.98
231_C301_I0.5290.98
76_Y82_P0.5280.98
35_T63_Q0.5280.98
253_T257_A0.5280.98
54_F68_G0.5270.98
33_F63_Q0.5220.98
328_G336_G0.5210.98
148_E229_G0.5200.98
33_F36_E0.5200.98
342_D354_T0.5170.97
184_K187_Q0.5160.97
108_S112_A0.5150.97
171_V187_Q0.5150.97
271_I296_G0.5150.97
62_G65_R0.5150.97
160_G177_I0.5150.97
250_I329_I0.5150.97
20_F100_L0.5140.97
199_E202_G0.5140.97
278_A281_I0.5130.97
234_I354_T0.5130.97
72_E75_G0.5130.97
153_A225_V0.5120.97
272_G313_N0.5100.97
104_K108_S0.5100.97
102_V124_F0.5090.97
59_M64_A0.5060.97
222_D235_T0.5060.97
98_H123_Q0.5060.97
271_I315_T0.5060.97
348_D351_V0.5050.97
156_G225_V0.5030.97
82_P86_I0.5030.97
155_Y159_V0.5010.97
185_G228_D0.5000.97
297_H326_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fkcA 2 0.9917 100 0.128 Contact Map
1wn1A 2 0.9752 100 0.141 Contact Map
2zsgA 2 0.9752 100 0.143 Contact Map
3q6dA 1 0.9725 100 0.147 Contact Map
4r60A 2 0.989 100 0.155 Contact Map
4egeA 2 0.9835 100 0.165 Contact Map
1wy2A 2 0.9559 100 0.166 Contact Map
1kp0A 2 0.8871 100 0.19 Contact Map
1chmA 2 0.9917 100 0.192 Contact Map
3ig4A 4 0.9697 100 0.195 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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