ZOSA - BACSU - GREMLIN Contacts

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ZOSA - Zinc-transporting ATPase

UniProt:	O31688	Sequences: MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGWLLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWAEGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGDMIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRVTKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGWSWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMIAFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVNQSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFVKKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVVAECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMVLMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGSTILVILNGLRLLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	637 (561)
Sequences:	23914 (14452)
Seq/√Len:	610.2

ECOLI - COPA ATZN ATKB ATMA
BACSU - ZOSA COPA CADA ATCL
HALSA - Q9HRH2 Q9HN90 Q9HSN5 ATKB
SULSO - Q97VH4 Q97UU7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
332_Q	528_G	4.126	1.00
174_G	216_V	4.102	1.00
492_E	496_Q	3.935	1.00
139_E	150_R	3.416	1.00
175_I	217_R	3.333	1.00
469_E	571_D	3.242	1.00
181_T	214_L	3.226	1.00
521_K	545_A	3.218	1.00
331_V	531_A	3.160	1.00
178_S	215_T	3.107	1.00
524_K	545_A	2.963	1.00
143_M	215_T	2.959	1.00
414_A	453_D	2.945	1.00
519_E	522_R	2.883	1.00
452_K	457_A	2.880	1.00
483_K	506_T	2.868	1.00
144_V	149_K	2.813	1.00
141_T	150_R	2.762	1.00
370_I	409_A	2.748	1.00
488_T	495_A	2.717	1.00
400_E	408_M	2.674	1.00
492_E	510_E	2.626	1.00
515_Q	518_N	2.611	1.00
499_A	507_V	2.576	1.00
344_K	468_P	2.538	1.00
471_K	475_E	2.501	1.00
344_K	465_Q	2.492	1.00
142_L	149_K	2.490	1.00
349_V	385_Y	2.462	1.00
496_Q	500_K	2.439	1.00
436_T	439_D	2.427	1.00
508_V	519_E	2.404	1.00
351_T	445_H	2.402	1.00
315_N	577_N	2.396	1.00
161_M	177_E	2.392	1.00
161_M	215_T	2.390	1.00
203_V	216_V	2.358	1.00
172_A	218_V	2.355	1.00
398_S	410_E	2.354	1.00
181_T	209_N	2.340	1.00
148_T	163_V	2.337	1.00
405_F	426_E	2.331	1.00
385_Y	389_R	2.318	1.00
475_E	479_R	2.268	1.00
144_V	147_E	2.259	1.00
531_A	550_I	2.230	1.00
478_N	505_T	2.228	1.00
143_M	148_T	2.195	1.00
141_T	168_E	2.195	1.00
161_M	217_R	2.182	1.00
524_K	547_D	2.169	1.00
177_E	217_R	2.132	1.00
141_T	148_T	2.132	1.00
476_E	580_R	2.117	1.00
360_E	389_R	2.087	1.00
363_V	458_G	2.066	1.00
483_K	528_G	2.028	1.00
408_M	415_K	1.983	1.00
162_I	174_G	1.967	1.00
163_V	215_T	1.964	1.00
369_A	394_S	1.957	1.00
268_F	285_A	1.920	1.00
342_V	502_A	1.901	1.00
440_V	461_A	1.891	1.00
174_G	203_V	1.862	1.00
351_T	443_S	1.854	1.00
449_F	456_I	1.852	1.00
70_K	74_E	1.848	1.00
480_L	580_R	1.839	1.00
414_A	452_K	1.819	1.00
366_A	416_W	1.789	1.00
472_E	476_E	1.774	1.00
442_Q	493_D	1.755	1.00
170_V	183_L	1.752	1.00
144_V	160_D	1.750	1.00
335_A	523_L	1.744	1.00
385_Y	388_S	1.740	1.00
487_L	519_E	1.732	1.00
416_W	452_K	1.731	1.00
335_A	487_L	1.729	1.00
175_I	219_T	1.727	1.00
362_E	365_E	1.722	1.00
334_I	531_A	1.721	1.00
521_K	525_E	1.718	1.00
466_I	502_A	1.715	1.00
447_I	459_C	1.715	1.00
417_K	427_E	1.703	1.00
332_Q	529_T	1.695	1.00
182_S	196_E	1.688	1.00
349_V	460_I	1.684	1.00
185_E	197_K	1.682	1.00
159_G	217_R	1.679	1.00
176_I	214_L	1.678	1.00
424_I	451_K	1.663	1.00
141_T	165_K	1.655	1.00
202_T	219_T	1.650	1.00
312_G	581_L	1.637	1.00
232_K	236_S	1.620	1.00
156_L	172_A	1.614	1.00
162_I	216_V	1.614	1.00
487_L	511_C	1.594	1.00
198_N	201_D	1.587	1.00
333_M	485_A	1.585	1.00
434_K	438_S	1.581	1.00
350_E	463_K	1.568	1.00
478_N	484_T	1.560	1.00
380_Q	384_A	1.558	1.00
517_V	545_A	1.557	1.00
183_L	209_N	1.555	1.00
156_L	162_I	1.547	1.00
158_A	221_A	1.540	1.00
452_K	455_Q	1.536	1.00
367_V	450_V	1.528	1.00
486_M	495_A	1.519	1.00
333_M	528_G	1.518	1.00
437_A	449_F	1.516	1.00
384_A	388_S	1.502	1.00
268_F	272_F	1.497	1.00
438_S	442_Q	1.497	1.00
250_R	254_A	1.494	1.00
142_L	160_D	1.491	1.00
417_K	451_K	1.491	1.00
473_V	576_V	1.486	1.00
518_N	521_K	1.486	1.00
382_I	460_I	1.486	1.00
472_E	573_K	1.475	1.00
603_L	607_N	1.475	1.00
156_L	218_V	1.474	1.00
471_K	501_E	1.474	1.00
139_E	152_P	1.472	1.00
496_Q	507_V	1.462	1.00
439_D	443_S	1.457	1.00
418_V	450_V	1.456	1.00
93_I	97_L	1.448	1.00
445_H	461_A	1.448	1.00
262_A	266_L	1.441	1.00
311_N	315_N	1.439	1.00
184_D	210_R	1.439	1.00
151_V	155_D	1.438	1.00
554_G	570_N	1.438	1.00
518_N	522_R	1.435	1.00
368_Y	386_A	1.420	1.00
522_R	526_E	1.418	1.00
353_R	436_T	1.413	1.00
188_L	204_F	1.412	1.00
402_T	423_F	1.411	1.00
272_F	278_W	1.409	1.00
330_S	529_T	1.406	1.00
348_A	384_A	1.405	1.00
463_K	501_E	1.405	1.00
202_T	220_K	1.404	1.00
152_P	155_D	1.390	1.00
175_I	202_T	1.389	1.00
335_A	520_I	1.386	1.00
174_G	219_T	1.384	1.00
476_E	479_R	1.375	1.00
435_Q	439_D	1.369	1.00
362_E	452_K	1.366	1.00
607_N	610_Q	1.361	1.00
162_I	218_V	1.361	1.00
469_E	573_K	1.358	1.00
348_A	465_Q	1.354	1.00
569_K	574_K	1.352	1.00
89_I	93_I	1.347	1.00
142_L	151_V	1.338	1.00
266_L	270_P	1.337	1.00
277_S	280_E	1.335	1.00
308_L	585_M	1.334	1.00
359_S	362_E	1.331	1.00
180_S	196_E	1.325	1.00
410_E	415_K	1.322	1.00
472_E	475_E	1.321	1.00
183_L	214_L	1.318	1.00
469_E	472_E	1.316	1.00
344_K	348_A	1.305	1.00
417_K	424_I	1.304	1.00
143_M	163_V	1.302	1.00
241_V	249_E	1.297	1.00
521_K	524_K	1.286	1.00
350_E	445_H	1.285	1.00
448_V	462_L	1.282	1.00
365_E	412_S	1.275	1.00
488_T	509_A	1.272	1.00
345_G	464_D	1.264	1.00
508_V	522_R	1.263	1.00
321_G	564_D	1.259	1.00
319_V	565_M	1.256	1.00
420_K	423_F	1.251	1.00
358_F	457_A	1.250	1.00
551_A	563_A	1.247	1.00
408_M	417_K	1.244	1.00
594_V	598_A	1.244	1.00
522_R	525_E	1.244	1.00
543_L	559_A	1.241	1.00
550_I	575_L	1.241	1.00
271_H	281_T	1.236	1.00
485_A	506_T	1.233	1.00
220_K	224_D	1.227	1.00
163_V	213_S	1.223	1.00
116_A	120_Y	1.218	1.00
529_T	547_D	1.209	1.00
438_S	493_D	1.207	1.00
495_A	509_A	1.201	1.00
433_M	456_I	1.200	1.00
261_I	265_L	1.198	1.00
431_Q	435_Q	1.196	1.00
435_Q	438_S	1.195	1.00
351_T	360_E	1.194	1.00
180_S	198_N	1.187	1.00
336_F	484_T	1.184	1.00
269_V	273_A	1.182	1.00
421_A	425_G	1.171	1.00
183_L	203_V	1.166	1.00
157_Q	160_D	1.164	1.00
361_A	389_R	1.162	1.00
492_E	509_A	1.159	1.00
164_I	170_V	1.158	1.00
367_V	460_I	1.155	1.00
375_S	401_E	1.152	1.00
365_E	369_A	1.151	1.00
421_A	449_F	1.151	1.00
497_A	501_E	1.147	1.00
327_Q	529_T	1.147	1.00
165_K	168_E	1.141	1.00
431_Q	434_K	1.139	1.00
221_A	224_D	1.138	1.00
346_Q	384_A	1.138	1.00
586_N	590_K	1.134	1.00
349_V	462_L	1.133	1.00
267_L	284_R	1.132	1.00
144_V	151_V	1.124	1.00
329_G	586_N	1.117	1.00
485_A	523_L	1.117	1.00
514_D	518_N	1.114	1.00
508_V	511_C	1.114	1.00
162_I	171_A	1.111	1.00
417_K	423_F	1.107	1.00
416_W	457_A	1.107	1.00
336_F	342_V	1.106	1.00
371_E	379_A	1.102	1.00
482_I	579_C	1.101	1.00
351_T	461_A	1.100	1.00
182_S	211_N	1.100	1.00
384_A	387_E	1.095	1.00
399_I	407_V	1.095	1.00
92_A	108_I	1.092	1.00
229_K	232_K	1.091	1.00
354_I	458_G	1.087	1.00
440_V	445_H	1.084	1.00
311_N	314_R	1.083	1.00
603_L	610_Q	1.082	1.00
411_V	414_A	1.081	1.00
333_M	523_L	1.080	1.00
430_A	434_K	1.077	1.00
402_T	408_M	1.075	1.00
366_A	457_A	1.074	1.00
483_K	505_T	1.071	1.00
476_E	480_L	1.070	1.00
120_Y	124_K	1.069	1.00
579_C	583_R	1.065	1.00
358_F	363_V	1.063	1.00
450_V	458_G	1.059	1.00
366_A	452_K	1.055	1.00
86_L	90_F	1.052	1.00
495_A	507_V	1.052	1.00
229_K	514_D	1.052	1.00
469_E	473_V	1.051	1.00
407_V	415_K	1.050	1.00
356_E	455_Q	1.048	1.00
511_C	515_Q	1.046	1.00
143_M	161_M	1.041	1.00
226_L	229_K	1.033	1.00
364_L	385_Y	1.031	1.00
71_E	74_E	1.028	1.00
353_R	440_V	1.025	1.00
178_S	199_T	1.022	1.00
270_P	274_L	1.020	1.00
175_I	200_G	1.018	1.00
246_A	250_R	1.018	1.00
170_V	203_V	1.016	1.00
327_Q	547_D	1.016	1.00
333_M	483_K	1.013	1.00
304_A	588_I	1.012	1.00
176_I	179_G	1.011	1.00
164_I	216_V	1.009	1.00
416_W	450_V	1.009	1.00
591_Q	631_N	1.005	1.00
520_I	532_M	1.005	1.00
342_V	466_I	1.002	1.00
378_L	462_L	1.001	1.00
363_V	367_V	1.000	1.00
437_A	441_I	0.991	1.00
354_I	363_V	0.987	1.00
466_I	498_I	0.986	1.00
475_E	478_N	0.985	1.00
127_R	130_T	0.983	1.00
355_A	433_M	0.983	1.00
421_A	437_A	0.979	1.00
317_M	574_K	0.978	1.00
331_V	529_T	0.976	1.00
218_V	221_A	0.975	1.00
90_F	261_I	0.972	1.00
480_L	583_R	0.972	1.00
144_V	157_Q	0.970	1.00
517_V	521_K	0.968	1.00
492_E	507_V	0.964	1.00
477_L	576_V	0.962	1.00
140_A	156_L	0.956	1.00
328_L	578_M	0.952	1.00
354_I	360_E	0.952	1.00
157_Q	221_A	0.952	1.00
544_K	562_T	0.949	1.00
407_V	417_K	0.949	1.00
436_T	440_V	0.948	1.00
486_M	504_M	0.947	1.00
318_L	568_M	0.946	1.00
402_T	405_F	0.945	1.00
329_G	582_S	0.944	1.00
348_A	388_S	0.943	1.00
424_I	429_A	0.942	1.00
206_G	227_F	0.940	1.00
334_I	482_I	0.940	1.00
347_P	378_L	0.939	1.00
474_M	478_N	0.938	1.00
176_I	183_L	0.938	1.00
369_A	393_Q	0.934	1.00
328_L	548_V	0.932	1.00
370_I	418_V	0.929	1.00
426_E	429_A	0.929	1.00
470_A	474_M	0.927	1.00
304_A	632_G	0.924	1.00
588_I	632_G	0.924	1.00
365_E	394_S	0.923	1.00
588_I	591_Q	0.920	1.00
372_T	387_E	0.919	1.00
422_G	510_E	0.914	1.00
148_T	215_T	0.914	1.00
150_R	168_E	0.912	1.00
370_I	407_V	0.912	1.00
603_L	606_A	0.910	1.00
164_I	209_N	0.909	1.00
480_L	576_V	0.905	1.00
222_N	225_S	0.905	1.00
584_K	587_R	0.903	1.00
176_I	203_V	0.903	1.00
449_F	459_C	0.903	1.00
491_H	510_E	0.899	1.00
552_M	555_G	0.898	1.00
316_G	569_K	0.897	1.00
397_I	410_E	0.895	1.00
176_I	216_V	0.894	1.00
362_E	366_A	0.891	1.00
441_I	493_D	0.888	1.00
82_L	86_L	0.886	1.00
364_L	367_V	0.881	1.00
332_Q	527_F	0.880	1.00
476_E	576_V	0.879	1.00
355_A	456_I	0.878	1.00
369_A	396_Y	0.876	1.00
404_G	407_V	0.874	1.00
425_G	428_M	0.873	1.00
153_V	156_L	0.873	1.00
170_V	209_N	0.872	1.00
370_I	416_W	0.871	1.00
524_K	530_I	0.871	1.00
443_S	501_E	0.871	1.00
425_G	434_K	0.869	1.00
603_L	608_F	0.868	1.00
213_S	373_Q	0.867	1.00
450_V	460_I	0.865	1.00
353_R	459_C	0.865	1.00
142_L	156_L	0.863	1.00
480_L	579_C	0.863	1.00
474_M	504_M	0.858	1.00
466_I	471_K	0.858	1.00
574_K	577_N	0.857	1.00
96_A	104_G	0.856	1.00
415_K	453_D	0.855	1.00
352_I	460_I	0.855	1.00
476_E	573_K	0.854	1.00
124_K	127_R	0.853	1.00
187_A	207_T	0.852	1.00
406_G	409_A	0.850	1.00
185_E	195_V	0.849	1.00
149_K	155_D	0.849	1.00
351_T	440_V	0.848	1.00
363_V	450_V	0.845	1.00
248_I	301_I	0.843	1.00
83_N	86_L	0.840	1.00
203_V	214_L	0.839	1.00
439_D	442_Q	0.838	1.00
169_R	208_V	0.838	1.00
257_K	262_A	0.838	1.00
358_F	361_A	0.837	1.00
328_L	579_C	0.834	1.00
352_I	385_Y	0.828	1.00
419_G	423_F	0.828	1.00
368_Y	393_Q	0.827	1.00
204_F	207_T	0.825	1.00
127_R	131_S	0.825	1.00
81_T	86_L	0.824	1.00
183_L	197_K	0.824	1.00
232_K	235_E	0.823	1.00
123_N	127_R	0.822	1.00
512_L	515_Q	0.818	1.00
487_L	508_V	0.818	1.00
396_Y	411_V	0.816	1.00
142_L	162_I	0.813	1.00
197_K	201_D	0.812	1.00
424_I	449_F	0.810	1.00
623_G	627_L	0.810	1.00
188_L	226_L	0.806	1.00
131_S	134_Q	0.806	1.00
321_G	324_F	0.805	1.00
270_P	273_A	0.804	1.00
396_Y	399_I	0.804	1.00
415_K	454_D	0.804	1.00
226_L	514_D	0.803	1.00
327_Q	330_S	0.803	1.00
211_N	400_E	0.801	1.00
185_E	207_T	0.796	1.00
171_A	216_V	0.793	1.00
499_A	504_M	0.793	1.00
486_M	499_A	0.792	1.00
148_T	165_K	0.790	1.00
473_V	573_K	0.790	1.00
78_E	81_T	0.789	1.00
440_V	443_S	0.789	1.00
315_N	580_R	0.787	1.00
543_L	549_G	0.786	1.00
179_G	199_T	0.786	1.00
291_V	603_L	0.786	1.00
484_T	504_M	0.784	1.00
485_A	519_E	0.783	1.00
474_M	484_T	0.781	1.00
491_H	494_T	0.781	1.00
140_A	171_A	0.780	1.00
177_E	215_T	0.779	1.00
366_A	370_I	0.778	1.00
140_A	153_V	0.775	1.00
493_D	496_Q	0.774	1.00
138_E	169_R	0.770	1.00
463_K	466_I	0.769	1.00
264_A	268_F	0.768	1.00
96_A	101_W	0.768	1.00
77_L	80_K	0.767	1.00
476_E	577_N	0.767	1.00
432_F	436_T	0.766	1.00
85_E	88_M	0.766	1.00
269_V	272_F	0.765	1.00
385_Y	460_I	0.765	1.00
319_V	578_M	0.763	1.00
328_L	331_V	0.762	1.00
392_N	395_G	0.762	1.00
470_A	502_A	0.761	1.00
421_A	441_I	0.761	1.00
141_T	163_V	0.760	1.00
166_P	209_N	0.759	1.00
160_D	218_V	0.757	1.00
494_T	497_A	0.757	1.00
334_I	533_V	0.757	1.00
216_V	219_T	0.754	1.00
176_I	201_D	0.753	1.00
404_G	420_K	0.753	1.00
278_W	282_F	0.752	1.00
335_A	485_A	0.752	1.00
401_E	404_G	0.751	1.00
323_V	327_Q	0.750	1.00
162_I	172_A	0.749	1.00
354_I	357_G	0.748	1.00
164_I	171_A	0.748	1.00
405_F	422_G	0.747	1.00
494_T	498_I	0.745	1.00
442_Q	496_Q	0.743	1.00
473_V	572_L	0.742	1.00
405_F	512_L	0.741	1.00
535_D	538_N	0.739	1.00
533_V	575_L	0.738	1.00
394_S	412_S	0.738	1.00
107_L	618_V	0.738	1.00
577_N	580_R	0.737	1.00
254_A	258_G	0.735	1.00
183_L	207_T	0.735	1.00
485_A	508_V	0.735	1.00
582_S	586_N	0.734	1.00
316_G	568_M	0.734	1.00
272_F	281_T	0.734	1.00
166_P	181_T	0.732	1.00
587_R	591_Q	0.731	1.00
354_I	358_F	0.731	1.00
411_V	416_W	0.727	1.00
331_V	579_C	0.726	1.00
386_A	391_V	0.725	1.00
342_V	474_M	0.724	1.00
165_K	213_S	0.721	1.00
72_G	76_T	0.718	1.00
397_I	413_G	0.717	1.00
96_A	99_G	0.717	1.00
352_I	364_L	0.717	1.00
456_I	459_C	0.716	1.00
312_G	319_V	0.714	1.00
253_N	257_K	0.712	1.00
368_Y	383_T	0.711	1.00
437_A	459_C	0.711	1.00
251_F	593_I	0.709	1.00
373_Q	380_Q	0.708	1.00
396_Y	409_A	0.707	1.00
311_N	581_L	0.706	1.00
276_W	280_E	0.705	1.00
80_K	115_G	0.704	1.00
421_A	434_K	0.704	1.00
131_S	558_V	0.704	1.00
328_L	565_M	0.704	1.00
119_T	123_N	0.704	1.00
364_L	386_A	0.703	1.00
125_S	310_S	0.703	1.00
367_V	371_E	0.702	1.00
82_L	85_E	0.701	1.00
565_M	578_M	0.701	1.00
220_K	229_K	0.700	1.00
305_A	326_E	0.699	1.00
366_A	369_A	0.699	1.00
130_T	134_Q	0.698	1.00
268_F	281_T	0.698	1.00
134_Q	138_E	0.697	1.00
166_P	401_E	0.696	1.00
334_I	484_T	0.696	1.00
441_I	447_I	0.696	1.00
263_V	608_F	0.694	1.00
475_E	503_G	0.693	1.00
350_E	501_E	0.693	1.00
478_N	506_T	0.692	1.00
70_K	73_I	0.692	1.00
164_I	168_E	0.691	1.00
367_V	418_V	0.691	1.00
375_S	399_I	0.690	1.00
437_A	447_I	0.689	1.00
471_K	502_A	0.688	1.00
158_A	224_D	0.687	1.00
540_A	562_T	0.687	1.00
520_I	530_I	0.687	1.00
382_I	462_L	0.687	1.00
268_F	278_W	0.686	1.00
265_L	268_F	0.685	1.00
138_E	154_S	0.683	1.00
79_S	82_L	0.683	1.00
123_N	126_S	0.681	1.00
474_M	502_A	0.681	1.00
317_M	578_M	0.678	1.00
158_A	220_K	0.678	1.00
424_I	428_M	0.676	1.00
551_A	555_G	0.676	1.00
223_E	232_K	0.676	1.00
358_F	362_E	0.674	1.00
105_A	109_F	0.674	1.00
365_E	391_V	0.670	1.00
189_T	195_V	0.669	1.00
380_Q	383_T	0.668	1.00
331_V	482_I	0.667	1.00
584_K	588_I	0.667	1.00
557_D	560_L	0.667	1.00
443_S	500_K	0.665	1.00
506_T	526_E	0.663	1.00
576_V	580_R	0.663	1.00
408_M	427_E	0.660	1.00
241_V	246_A	0.660	1.00
432_F	435_Q	0.657	1.00
192_S	494_T	0.656	1.00
348_A	463_K	0.655	1.00
172_A	225_S	0.655	1.00
170_V	214_L	0.654	1.00
336_F	477_L	0.654	1.00
342_V	470_A	0.653	1.00
176_I	181_T	0.653	1.00
618_V	622_E	0.652	1.00
346_Q	380_Q	0.651	1.00
280_E	284_R	0.648	1.00
406_G	411_V	0.648	1.00
603_L	616_F	0.648	1.00
142_L	157_Q	0.647	1.00
403_S	407_V	0.646	1.00
488_T	507_V	0.646	1.00
368_Y	371_E	0.645	1.00
310_S	314_R	0.643	1.00
209_N	214_L	0.643	1.00
434_K	437_A	0.642	1.00
470_A	572_L	0.641	1.00
417_K	454_D	0.640	1.00
334_I	579_C	0.639	1.00
497_A	500_K	0.639	1.00
511_C	519_E	0.638	1.00
225_S	228_R	0.638	1.00
606_A	610_Q	0.638	1.00
281_T	285_A	0.638	1.00
74_E	78_E	0.637	1.00
233_L	514_D	0.634	1.00
176_I	197_K	0.634	1.00
370_I	450_V	0.631	1.00
76_T	80_K	0.630	1.00
205_T	225_S	0.628	1.00
222_N	228_R	0.628	1.00
366_A	450_V	0.627	1.00
556_T	559_A	0.627	1.00
264_A	289_M	0.626	1.00
613_E	616_F	0.626	1.00
355_A	436_T	0.626	1.00
83_N	88_M	0.626	1.00
438_S	441_I	0.625	1.00
267_L	285_A	0.625	1.00
430_A	433_M	0.625	1.00
182_S	210_R	0.619	1.00
617_G	620_G	0.618	1.00
592_N	596_S	0.618	1.00
350_E	461_A	0.618	1.00
571_D	574_K	0.616	1.00
576_V	579_C	0.616	1.00
301_I	589_I	0.616	1.00
440_V	447_I	0.616	1.00
79_S	86_L	0.615	1.00
221_A	225_S	0.614	1.00
155_D	158_A	0.612	1.00
470_A	473_V	0.611	1.00
605_C	608_F	0.611	1.00
335_A	511_C	0.611	1.00
240_S	524_K	0.611	1.00
177_E	199_T	0.610	1.00
72_G	82_L	0.608	1.00
376_H	379_A	0.607	1.00
349_V	382_I	0.605	1.00
397_I	407_V	0.605	1.00
334_I	477_L	0.603	1.00
540_A	558_V	0.601	1.00
625_T	629_I	0.601	1.00
265_L	269_V	0.600	1.00
108_I	112_S	0.599	1.00
362_E	414_A	0.599	1.00
113_L	117_L	0.595	1.00
331_V	548_V	0.595	1.00
477_L	484_T	0.595	1.00
143_M	146_G	0.594	1.00
367_V	386_A	0.593	1.00
250_R	253_N	0.593	1.00
355_A	358_F	0.592	1.00
477_L	575_L	0.592	1.00
319_V	325_L	0.592	1.00
433_M	436_T	0.590	1.00
367_V	385_Y	0.590	1.00
436_T	459_C	0.590	1.00
168_E	375_S	0.589	1.00
342_V	486_M	0.589	1.00
164_I	214_L	0.587	1.00
336_F	575_L	0.587	1.00
88_M	91_A	0.587	1.00
560_L	566_V	0.587	1.00
581_L	584_K	0.587	1.00
423_F	427_E	0.587	1.00
587_R	590_K	0.587	1.00
244_A	586_N	0.586	1.00
308_L	581_L	0.586	1.00
419_G	451_K	0.585	1.00
355_A	459_C	0.585	1.00
153_V	172_A	0.585	1.00
548_V	565_M	0.585	1.00
489_G	536_G	0.585	1.00
606_A	609_L	0.584	1.00
467_R	570_N	0.584	1.00
445_H	463_K	0.583	1.00
429_A	451_K	0.583	1.00
160_D	172_A	0.582	1.00
178_S	213_S	0.582	1.00
110_I	114_S	0.581	1.00
284_R	287_V	0.581	1.00
368_Y	391_V	0.580	1.00
352_I	363_V	0.580	1.00
371_E	382_I	0.578	1.00
176_I	198_N	0.578	1.00
405_F	423_F	0.577	1.00
328_L	582_S	0.576	1.00
363_V	457_A	0.576	1.00
487_L	532_M	0.575	1.00
440_V	459_C	0.575	1.00
626_I	630_L	0.575	1.00
329_G	583_R	0.573	1.00
223_E	228_R	0.573	1.00
426_E	430_A	0.572	1.00
304_A	589_I	0.572	1.00
95_S	104_G	0.571	1.00
262_A	269_V	0.571	1.00
95_S	286_M	0.571	1.00
369_A	411_V	0.570	1.00
603_L	620_G	0.570	1.00
344_K	469_E	0.570	1.00
220_K	226_L	0.570	1.00
179_G	214_L	0.569	1.00
169_R	561_E	0.569	1.00
418_V	448_V	0.569	1.00
523_L	526_E	0.567	1.00
371_E	418_V	0.567	1.00
477_L	482_I	0.567	1.00
409_A	415_K	0.567	1.00
375_S	380_Q	0.566	1.00
363_V	460_I	0.565	1.00
367_V	370_I	0.565	1.00
131_S	314_R	0.565	1.00
254_A	257_K	0.565	1.00
76_T	86_L	0.562	1.00
125_S	318_L	0.562	1.00
187_A	537_I	0.562	1.00
348_A	385_Y	0.561	1.00
614_L	618_V	0.561	1.00
364_L	389_R	0.561	1.00
131_S	561_E	0.560	1.00
304_A	585_M	0.559	1.00
310_S	313_A	0.558	1.00
556_T	560_L	0.556	1.00
267_L	272_F	0.556	1.00
422_G	425_G	0.556	1.00
172_A	222_N	0.556	1.00
498_I	501_E	0.555	1.00
351_T	439_D	0.555	1.00
334_I	474_M	0.554	1.00
151_V	160_D	0.553	1.00
371_E	383_T	0.553	1.00
102_A	105_A	0.552	1.00
621_H	625_T	0.551	0.99
82_L	88_M	0.551	0.99
415_K	427_E	0.551	0.99
261_I	264_A	0.550	0.99
320_K	561_E	0.550	0.99
194_P	210_R	0.550	0.99
387_E	392_N	0.550	0.99
407_V	410_E	0.548	0.99
180_S	199_T	0.548	0.99
276_W	281_T	0.547	0.99
282_F	286_M	0.547	0.99
331_V	334_I	0.546	0.99
471_K	503_G	0.546	0.99
372_T	395_G	0.545	0.99
180_S	398_S	0.545	0.99
341_T	538_N	0.545	0.99
328_L	531_A	0.544	0.99
498_I	502_A	0.543	0.99
454_D	457_A	0.543	0.99
365_E	392_N	0.542	0.99
76_T	119_T	0.542	0.99
73_I	77_L	0.542	0.99
597_L	601_C	0.542	0.99
410_E	413_G	0.542	0.99
508_V	523_L	0.542	0.99
104_G	108_I	0.540	0.99
138_E	152_P	0.540	0.99
268_F	271_H	0.539	0.99
424_I	427_E	0.539	0.99
327_Q	548_V	0.539	0.99
332_Q	530_I	0.538	0.99
179_G	203_V	0.537	0.99
210_R	380_Q	0.536	0.99
149_K	160_D	0.535	0.99
595_F	599_V	0.535	0.99
410_E	416_W	0.535	0.99
559_A	562_T	0.535	0.99
347_P	462_L	0.535	0.99
425_G	429_A	0.534	0.99
258_G	262_A	0.534	0.99
339_T	489_G	0.533	0.99
169_R	184_D	0.533	0.99
233_L	517_V	0.533	0.99
339_T	536_G	0.533	0.99
395_G	412_S	0.533	0.99
588_I	631_N	0.531	0.99
480_L	484_T	0.530	0.99
382_I	448_V	0.530	0.99
354_I	359_S	0.530	0.99
417_K	429_A	0.529	0.99
281_T	284_R	0.529	0.99
429_A	456_I	0.529	0.99
169_R	557_D	0.528	0.99
259_V	292_A	0.527	0.99
347_P	379_A	0.527	0.99
489_G	538_N	0.526	0.99
337_D	341_T	0.526	0.99
203_V	209_N	0.525	0.99
341_T	489_G	0.524	0.99
332_Q	335_A	0.524	0.99
473_V	476_E	0.523	0.99
133_M	560_L	0.523	0.99
182_S	193_M	0.523	0.99
553_G	570_N	0.523	0.99
493_D	497_A	0.523	0.99
170_V	216_V	0.523	0.99
94_G	286_M	0.522	0.99
103_E	107_L	0.522	0.99
404_G	409_A	0.522	0.99
370_I	396_Y	0.521	0.99
567_L	574_K	0.521	0.99
259_V	263_V	0.521	0.99
137_P	154_S	0.521	0.99
387_E	390_G	0.520	0.99
402_T	514_D	0.520	0.99
84_V	88_M	0.519	0.99
211_N	401_E	0.519	0.99
353_R	461_A	0.516	0.99
241_V	245_Q	0.515	0.99
400_E	404_G	0.514	0.99
406_G	418_V	0.513	0.99
91_A	95_S	0.513	0.99
211_N	403_S	0.513	0.99
151_V	156_L	0.513	0.99
230_I	541_P	0.513	0.99
85_E	89_I	0.513	0.99
622_E	625_T	0.512	0.99
367_V	382_I	0.511	0.99
482_I	531_A	0.511	0.99
278_W	281_T	0.511	0.99
378_L	382_I	0.511	0.99
80_K	83_N	0.511	0.99
101_W	104_G	0.511	0.99
166_P	400_E	0.510	0.99
247_F	250_R	0.510	0.99
156_L	160_D	0.510	0.99
140_A	162_I	0.510	0.99
72_G	119_T	0.510	0.99
283_Y	287_V	0.510	0.99
247_F	251_F	0.510	0.99
365_E	371_E	0.509	0.99
621_H	624_S	0.508	0.99
326_E	330_S	0.508	0.99
101_W	105_A	0.508	0.99
404_G	411_V	0.508	0.99
598_A	602_L	0.507	0.99
137_P	152_P	0.506	0.99
354_I	367_V	0.506	0.99
362_E	412_S	0.506	0.99
138_E	153_V	0.505	0.99
295_C	625_T	0.505	0.99
451_K	456_I	0.505	0.99
262_A	265_L	0.504	0.99
379_A	382_I	0.503	0.99
444_G	497_A	0.503	0.99
499_A	503_G	0.502	0.99
567_L	575_L	0.501	0.99
82_L	95_S	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bbjA	1	0.9749	100	0.136	Contact Map
3j09A	2	0.9843	100	0.173	Contact Map
3j08A	2	0.9608	100	0.183	Contact Map
4umwA	1	0.9419	100	0.185	Contact Map
1mhsA	2	0.9874	100	0.214	Contact Map
3b8cA	1	0.9576	100	0.228	Contact Map
2zxeA	1	0.9623	100	0.229	Contact Map
3ixzA	1	0.967	100	0.233	Contact Map
3ar4A	1	0.9623	100	0.249	Contact Map
3skxA	1	0.4097	100	0.722	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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