GREMLIN Database
STOA - Sporulation thiol-disulfide oxidoreductase A
UniProt: O31687 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (133)
Sequences: 11758 (8968)
Seq/√Len: 777.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K142_E3.9381.00
41_T45_E2.9701.00
76_Q114_T2.7301.00
54_Q88_K2.6351.00
101_Q105_E2.6331.00
38_L46_D2.5781.00
141_N145_E2.5531.00
141_N147_E2.4721.00
40_K46_D2.3721.00
140_L146_I2.1451.00
38_L48_S2.0721.00
48_S51_N2.0261.00
76_Q80_D2.0181.00
56_T88_K1.9961.00
59_H71_E1.8801.00
41_T47_I1.8761.00
33_V145_E1.8161.00
91_T115_F1.7871.00
42_I108_I1.7511.00
69_K111_N1.7481.00
34_P129_Y1.7451.00
57_I139_L1.6751.00
79_Y83_P1.5951.00
81_A160_K1.5821.00
36_V50_P1.5261.00
29_K32_A1.4971.00
100_N103_V1.4811.00
59_H137_S1.4271.00
77_S156_A1.4091.00
105_E109_K1.4031.00
74_Q77_S1.3731.00
124_E128_E1.3541.00
36_V48_S1.3531.00
72_L113_L1.3521.00
55_K147_E1.3401.00
55_K139_L1.3341.00
74_Q156_A1.3071.00
94_L126_M1.2961.00
158_Q161_E1.2941.00
136_T149_T1.2881.00
102_Q106_D1.2861.00
93_N104_V1.2851.00
39_M118_V1.2571.00
156_A160_K1.2571.00
69_K110_A1.2401.00
101_Q119_L1.2231.00
107_F111_N1.2091.00
155_T158_Q1.2071.00
57_I75_F1.1971.00
57_I137_S1.1781.00
65_C68_C1.1651.00
69_K107_F1.1501.00
56_T140_L1.1331.00
71_E137_S1.1311.00
47_I51_N1.1231.00
65_C111_N1.1211.00
88_K116_P1.1181.00
57_I87_V1.1171.00
138_F146_I1.1041.00
62_T134_I1.0991.00
77_S80_D1.0951.00
64_W104_V1.0871.00
63_S104_V1.0791.00
94_L123_G1.0691.00
78_F159_L1.0461.00
83_P88_K1.0361.00
37_F125_L1.0361.00
108_I117_I1.0341.00
80_D83_P1.0181.00
28_E31_P1.0061.00
53_G142_E1.0041.00
31_P145_E1.0041.00
75_F89_L0.9981.00
106_D109_K0.9961.00
60_F129_Y0.9921.00
106_D110_A0.9921.00
104_V119_L0.9791.00
79_Y114_T0.9751.00
83_P86_S0.9721.00
77_S81_A0.9701.00
131_I136_T0.9661.00
58_L140_L0.9661.00
70_K153_P0.9541.00
40_K101_Q0.9431.00
120_D123_G0.9351.00
124_E127_K0.9311.00
94_L134_I0.9181.00
157_E160_K0.9051.00
56_T90_V0.9041.00
42_I105_E0.9001.00
78_F81_A0.8951.00
76_Q115_F0.8841.00
41_T118_V0.8821.00
79_Y88_K0.8761.00
102_Q105_E0.8711.00
63_S107_F0.8621.00
59_H67_P0.8541.00
139_L150_K0.8531.00
78_F82_H0.8501.00
36_V49_I0.8451.00
66_P70_K0.8441.00
76_Q112_K0.8421.00
52_K56_T0.8361.00
39_M125_L0.8281.00
60_F92_V0.8141.00
30_Q148_K0.8141.00
81_A156_A0.8031.00
139_L148_K0.7991.00
73_P77_S0.7971.00
41_T116_P0.7771.00
150_K154_M0.7721.00
72_L76_Q0.7651.00
74_Q153_P0.7581.00
86_S142_E0.7571.00
72_L111_N0.7561.00
123_G127_K0.7501.00
61_W117_I0.7481.00
60_F131_I0.7411.00
49_I56_T0.7411.00
28_E32_A0.7401.00
43_E105_E0.7351.00
140_L144_G0.7341.00
82_H87_V0.7311.00
64_W134_I0.7221.00
82_H85_D0.7161.00
126_M131_I0.7131.00
108_I113_L0.7111.00
70_K73_P0.7091.00
146_I149_T0.7001.00
55_K87_V0.6991.00
74_Q78_F0.6861.00
150_K153_P0.6851.00
82_H160_K0.6851.00
53_G144_G0.6851.00
125_L128_E0.6781.00
95_V123_G0.6761.00
72_L107_F0.6721.00
67_P134_I0.6721.00
157_E161_E0.6621.00
125_L129_Y0.6521.00
103_V106_D0.6461.00
37_F49_I0.6451.00
60_F125_L0.6441.00
133_T136_T0.6371.00
30_Q149_T0.6361.00
40_K121_S0.6311.00
91_T117_I0.6301.00
47_I118_V0.6251.00
52_K144_G0.6211.00
63_S67_P0.6111.00
66_P69_K0.6071.00
80_D114_T0.6051.00
127_K132_I0.6001.00
104_V117_I0.5991.00
73_P76_Q0.5941.00
93_N96_N0.5931.00
67_P153_P0.5931.00
76_Q111_N0.5881.00
136_T151_I0.5861.00
62_T67_P0.5861.00
55_K86_S0.5781.00
75_F137_S0.5761.00
61_W93_N0.5721.00
59_H75_F0.5711.00
76_Q79_Y0.5701.00
65_C110_A0.5691.00
75_F91_T0.5691.00
96_N103_V0.5661.00
57_I89_L0.5641.00
91_T113_L0.5631.00
56_T144_G0.5591.00
59_H72_L0.5581.00
34_P140_L0.5571.00
79_Y82_H0.5551.00
113_L117_I0.5431.00
156_A159_L0.5431.00
33_V52_K0.5391.00
82_H86_S0.5371.00
62_T65_C0.5371.00
138_F149_T0.5361.00
63_S103_V0.5331.00
65_C103_V0.5291.00
49_I52_K0.5281.00
108_I112_K0.5281.00
67_P73_P0.5281.00
96_N100_N0.5261.00
123_G126_M0.5221.00
154_M157_E0.5201.00
104_V107_F0.5181.00
72_L115_F0.5181.00
70_K74_Q0.5181.00
58_L129_Y0.5171.00
120_D126_M0.5161.00
92_V125_L0.5151.00
62_T66_P0.5111.00
78_F89_L0.5071.00
35_A138_F0.5061.00
53_G56_T0.5051.00
68_C71_E0.5001.00
105_E108_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hyxA 2 0.9879 100 0.275 Contact Map
3eytA 4 0.8303 100 0.326 Contact Map
3eurA 1 0.8121 100 0.328 Contact Map
3lorA 3 0.8303 100 0.329 Contact Map
4nmuA 2 0.8667 100 0.333 Contact Map
2p5qA 3 0.8121 100 0.334 Contact Map
3erwA 1 0.8121 100 0.336 Contact Map
2f9sA 1 0.8121 100 0.337 Contact Map
2h30A 1 0.8242 100 0.337 Contact Map
4yodA 1 0.9636 100 0.34 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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