GREMLIN Database
YKVU - Sporulation protein YkvU
UniProt: O31686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (400)
Sequences: 15999 (13632)
Seq/√Len: 681.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_Q303_I5.0481.00
218_K222_A3.5921.00
100_A103_F3.3281.00
140_K143_K3.1171.00
344_Q348_Q2.9361.00
372_F375_E2.8501.00
327_F348_Q2.7831.00
338_F341_P2.7391.00
139_Q294_E2.7161.00
374_K378_Y2.6091.00
372_F427_A2.3751.00
75_H78_M2.3541.00
383_S416_L2.3351.00
241_E266_L2.3191.00
331_G335_H2.3031.00
339_H342_E2.3021.00
330_A344_Q2.3001.00
67_I137_G2.2781.00
325_V329_F2.2571.00
330_A348_Q2.1351.00
349_L403_L2.1341.00
356_F414_I2.1161.00
295_A303_I2.1081.00
346_Y402_M2.0951.00
214_K218_K2.0791.00
241_E391_M2.0731.00
229_G377_F2.0631.00
294_E298_L2.0621.00
306_K310_Q2.0321.00
173_A176_I2.0251.00
10_L142_G2.0241.00
379_H419_L2.0041.00
112_P116_G1.9851.00
34_G37_G1.9801.00
78_M82_A1.9681.00
390_M408_G1.9311.00
400_L407_L1.9041.00
65_K69_E1.8991.00
386_V415_L1.8921.00
66_F223_V1.8651.00
338_F342_E1.8491.00
301_Y305_L1.8311.00
31_R339_H1.8301.00
332_P335_H1.7861.00
349_L410_N1.7651.00
98_S116_G1.7571.00
329_F332_P1.7541.00
334_T347_L1.7141.00
244_L397_M1.6961.00
319_G358_L1.6921.00
42_M267_A1.6861.00
213_G216_V1.6841.00
331_G348_Q1.6841.00
397_M405_I1.6761.00
244_L391_M1.6751.00
296_Y370_M1.6531.00
30_A269_V1.6491.00
308_L366_C1.6451.00
41_Y45_L1.5981.00
233_F381_V1.5851.00
43_S246_K1.5851.00
323_V355_L1.5851.00
245_V263_Y1.5821.00
331_G344_Q1.5811.00
303_I306_K1.5751.00
329_F333_L1.5471.00
349_L407_L1.5351.00
262_Q402_M1.5311.00
134_Y138_V1.5261.00
241_E409_M1.5231.00
394_L400_L1.5101.00
80_R84_R1.5061.00
172_M176_I1.4971.00
334_T343_A1.4961.00
176_I180_V1.4901.00
142_G146_I1.4831.00
244_L392_Y1.4781.00
102_P112_P1.4771.00
404_G408_G1.4751.00
79_L82_A1.4741.00
139_Q291_S1.4701.00
387_A391_M1.4691.00
250_L262_Q1.4691.00
353_Y410_N1.4671.00
101_L116_G1.4631.00
249_L262_Q1.4611.00
309_K313_F1.4601.00
345_Y348_Q1.4581.00
356_F417_T1.4531.00
394_L408_G1.4481.00
305_L309_K1.4421.00
69_E371_G1.4361.00
345_Y403_L1.4341.00
78_M81_H1.4321.00
304_V366_C1.4241.00
155_Q184_S1.4191.00
346_Y406_I1.4191.00
389_S393_V1.4121.00
349_L406_I1.4071.00
295_A307_R1.4001.00
379_H423_T1.3961.00
326_M351_W1.3891.00
35_E264_G1.3811.00
418_S422_A1.3811.00
378_Y382_W1.3801.00
408_G412_G1.3721.00
44_I118_V1.3701.00
26_N272_T1.3691.00
35_E265_M1.3671.00
82_A86_T1.3661.00
302_D306_K1.3631.00
42_M264_G1.3621.00
288_M311_S1.3611.00
226_P377_F1.3581.00
140_K199_A1.3551.00
274_G350_L1.3441.00
393_V398_E1.3391.00
81_H85_M1.3381.00
154_I187_V1.3351.00
303_I307_R1.3301.00
17_F149_V1.3301.00
401_Q404_G1.3241.00
245_V405_I1.2981.00
292_I304_V1.2981.00
225_I229_G1.2971.00
62_S223_V1.2901.00
98_S102_P1.2891.00
114_I178_L1.2831.00
261_D265_M1.2801.00
240_I388_L1.2751.00
16_F20_C1.2751.00
239_A242_P1.2501.00
301_Y370_M1.2491.00
334_T344_Q1.2411.00
379_H420_H1.2381.00
108_D112_P1.2361.00
158_C180_V1.2311.00
27_M31_R1.2291.00
39_G261_D1.2261.00
78_M85_M1.2151.00
316_L320_I1.2141.00
270_A346_Y1.2081.00
157_L161_L1.2081.00
25_V156_L1.2071.00
245_V266_L1.2071.00
233_F384_H1.2061.00
190_V194_S1.1961.00
394_L399_N1.1951.00
393_V399_N1.1891.00
23_F27_M1.1891.00
265_M343_A1.1791.00
270_A343_A1.1781.00
326_M347_L1.1731.00
394_L398_E1.1661.00
14_A145_A1.1651.00
403_L406_I1.1641.00
323_V327_F1.1591.00
308_L363_L1.1581.00
88_I92_F1.1541.00
160_F164_Q1.1481.00
18_A152_K1.1401.00
391_M409_M1.1341.00
387_A409_M1.1271.00
90_T94_T1.1261.00
39_G264_G1.1231.00
124_V186_V1.1191.00
352_P410_N1.1181.00
296_Y304_V1.1181.00
43_S263_Y1.1171.00
346_Y403_L1.1161.00
68_A137_G1.1121.00
219_R371_G1.1111.00
41_Y177_S1.1101.00
103_F106_V1.1071.00
110_Y113_F1.1021.00
233_F377_F1.0931.00
226_P374_K1.0911.00
245_V249_L1.0891.00
147_A191_Y1.0881.00
386_V390_M1.0871.00
78_M86_T1.0861.00
246_K263_Y1.0811.00
292_I369_G1.0801.00
56_S60_P1.0801.00
270_A350_L1.0771.00
269_V338_F1.0741.00
391_M397_M1.0731.00
249_L402_M1.0711.00
102_P116_G1.0701.00
141_M287_V1.0671.00
381_V385_I1.0641.00
120_G182_V1.0641.00
237_V387_A1.0591.00
120_G123_P1.0581.00
20_C24_V1.0581.00
101_L104_I1.0561.00
103_F107_F1.0541.00
124_V189_L1.0471.00
400_L404_G1.0471.00
363_L421_Y1.0451.00
159_L180_V1.0451.00
8_I287_V1.0431.00
7_G139_Q1.0411.00
330_A347_L1.0401.00
34_G341_P1.0401.00
179_F183_V1.0391.00
324_W328_Q1.0371.00
97_A119_I1.0371.00
72_P298_L1.0361.00
359_F417_T1.0351.00
38_M42_M1.0331.00
123_P126_A1.0291.00
26_N338_F1.0271.00
289_I293_S1.0271.00
419_L422_A1.0231.00
223_V373_V1.0181.00
67_I138_V1.0171.00
30_A338_F1.0171.00
175_L178_L1.0141.00
390_M394_L1.0121.00
387_A412_G1.0121.00
69_E219_R1.0061.00
4_F8_I1.0021.00
333_L337_F0.9971.00
37_G40_L0.9961.00
399_N403_L0.9901.00
378_Y381_V0.9881.00
29_L177_S0.9851.00
11_L287_V0.9831.00
270_A347_L0.9831.00
327_F330_A0.9821.00
8_I284_L0.9781.00
221_L224_S0.9751.00
66_F219_R0.9711.00
245_V402_M0.9711.00
302_D305_L0.9681.00
241_E387_A0.9651.00
230_L376_A0.9631.00
363_L420_H0.9631.00
102_P106_V0.9611.00
348_Q352_P0.9601.00
158_C162_F0.9581.00
422_A426_K0.9531.00
32_E164_Q0.9531.00
327_F352_P0.9531.00
27_M30_A0.9461.00
131_A193_Y0.9451.00
62_S224_S0.9441.00
44_I114_I0.9441.00
366_C424_I0.9401.00
385_I389_S0.9381.00
147_A192_L0.9381.00
116_G120_G0.9381.00
62_S220_L0.9361.00
291_S294_E0.9341.00
353_Y356_F0.9331.00
105_P111_H0.9311.00
415_L419_L0.9281.00
28_I32_E0.9281.00
65_K371_G0.9271.00
49_F53_V0.9271.00
410_N413_M0.9261.00
334_T338_F0.9241.00
69_E73_K0.9211.00
15_A19_E0.9191.00
161_L164_Q0.9161.00
21_L156_L0.9161.00
81_H84_R0.9141.00
76_E80_R0.9131.00
66_F69_E0.9111.00
99_I103_F0.9111.00
236_V384_H0.9111.00
226_P373_V0.8961.00
382_W419_L0.8941.00
212_R217_R0.8921.00
35_E261_D0.8921.00
62_S66_F0.8901.00
162_F172_M0.8891.00
215_D218_K0.8891.00
87_A91_A0.8881.00
113_F175_L0.8861.00
143_K195_Q0.8761.00
81_H213_G0.8751.00
368_I376_A0.8731.00
179_F182_V0.8721.00
64_S133_G0.8721.00
321_P324_W0.8661.00
8_I12_S0.8651.00
310_Q313_F0.8621.00
295_A300_Q0.8611.00
119_I123_P0.8591.00
11_L145_A0.8591.00
304_V370_M0.8581.00
353_Y406_I0.8571.00
422_A425_C0.8551.00
193_Y197_I0.8531.00
63_I67_I0.8521.00
88_I91_A0.8491.00
343_A346_Y0.8491.00
322_A325_V0.8481.00
375_E423_T0.8471.00
70_S75_H0.8421.00
392_Y398_E0.8391.00
264_G267_A0.8391.00
71_N79_L0.8391.00
35_E341_P0.8371.00
242_P263_Y0.8371.00
327_F331_G0.8351.00
350_L406_I0.8341.00
32_E163_F0.8341.00
241_E271_V0.8331.00
317_G321_P0.8311.00
221_L225_I0.8291.00
9_I13_I0.8281.00
264_G269_V0.8281.00
12_S283_S0.8281.00
158_C183_V0.8261.00
233_F380_N0.8261.00
227_T373_V0.8261.00
113_F116_G0.8261.00
266_L350_L0.8231.00
94_T97_A0.8221.00
27_M338_F0.8221.00
390_M393_V0.8181.00
391_M394_L0.8171.00
121_L185_D0.8101.00
377_F381_V0.8081.00
367_L376_A0.8081.00
407_L411_T0.8081.00
216_V219_R0.8071.00
58_E224_S0.8071.00
85_M217_R0.8071.00
82_A85_M0.8051.00
313_F317_G0.8051.00
98_S101_L0.8041.00
77_S81_H0.8031.00
269_V272_T0.8031.00
375_E378_Y0.8021.00
6_K142_G0.8001.00
180_V184_S0.7991.00
29_L159_L0.7981.00
388_L392_Y0.7961.00
407_L410_N0.7911.00
367_L423_T0.7881.00
307_R311_S0.7871.00
267_A272_T0.7871.00
321_P325_V0.7871.00
5_V9_I0.7861.00
132_R136_M0.7841.00
243_F247_G0.7811.00
92_F95_A0.7811.00
80_R83_F0.7801.00
184_S188_V0.7781.00
240_I244_L0.7761.00
151_K155_Q0.7751.00
101_L112_P0.7711.00
158_C161_L0.7661.00
379_H383_S0.7651.00
191_Y195_Q0.7641.00
46_P242_P0.7641.00
97_A101_L0.7631.00
352_P355_L0.7631.00
223_V227_T0.7621.00
28_I160_F0.7611.00
41_Y174_V0.7611.00
222_A225_I0.7611.00
293_S297_A0.7601.00
182_V185_D0.7601.00
272_T276_F0.7581.00
38_M264_G0.7541.00
78_M84_R0.7521.00
274_G354_F0.7491.00
222_A374_K0.7481.00
397_M404_G0.7451.00
291_S295_A0.7451.00
352_P356_F0.7441.00
52_I56_S0.7441.00
376_A380_N0.7431.00
67_I79_L0.7421.00
220_L224_S0.7421.00
13_I17_F0.7411.00
390_M411_T0.7411.00
7_G287_V0.7401.00
398_E405_I0.7361.00
181_L185_D0.7361.00
83_F86_T0.7331.00
403_L407_L0.7311.00
289_I365_A0.7301.00
251_A261_D0.7281.00
194_S198_M0.7281.00
423_T426_K0.7251.00
222_A226_P0.7251.00
250_L263_Y0.7241.00
117_I182_V0.7231.00
135_F196_F0.7221.00
12_S16_F0.7211.00
289_I369_G0.7211.00
232_I236_V0.7201.00
69_E297_A0.7161.00
235_A239_A0.7151.00
109_T113_F0.7151.00
27_M337_F0.7151.00
391_M405_I0.7101.00
78_M216_V0.7101.00
156_L160_F0.7091.00
295_A298_L0.7071.00
81_H217_R0.7041.00
153_I157_L0.7021.00
311_S362_P0.6981.00
63_I86_T0.6971.00
287_V290_P0.6971.00
38_M269_V0.6961.00
155_Q159_L0.6951.00
155_Q180_V0.6941.00
83_F131_A0.6941.00
92_F96_A0.6931.00
94_T98_S0.6881.00
230_L377_F0.6861.00
381_V384_H0.6851.00
124_V182_V0.6851.00
125_V185_D0.6841.00
10_L14_A0.6841.00
96_A100_A0.6831.00
21_L25_V0.6821.00
271_V275_S0.6821.00
373_V376_A0.6771.00
26_N30_A0.6771.00
239_A243_F0.6751.00
327_F351_W0.6751.00
101_L105_P0.6751.00
28_I164_Q0.6751.00
192_L195_Q0.6741.00
273_I338_F0.6741.00
79_L86_T0.6741.00
230_L380_N0.6721.00
363_L417_T0.6711.00
365_A368_I0.6691.00
128_T189_L0.6691.00
48_I122_I0.6681.00
281_A285_M0.6661.00
217_R221_L0.6661.00
102_P105_P0.6611.00
315_T358_L0.6591.00
93_S97_A0.6561.00
64_S68_A0.6551.00
315_T362_P0.6541.00
33_L174_V0.6531.00
26_N38_M0.6521.00
45_L49_F0.6511.00
49_F52_I0.6501.00
79_L83_F0.6481.00
263_Y267_A0.6481.00
335_H344_Q0.6471.00
353_Y413_M0.6451.00
5_V8_I0.6431.00
90_T126_A0.6431.00
143_K146_I0.6431.00
131_A192_L0.6411.00
136_M144_I0.6401.00
99_I102_P0.6391.00
65_K373_V0.6361.00
272_T275_S0.6351.00
105_P112_P0.6341.00
182_V186_V0.6341.00
33_L37_G0.6321.00
215_D219_R0.6321.00
105_P115_K0.6311.00
64_S137_G0.6311.00
365_A369_G0.6281.00
35_E342_E0.6261.00
65_K369_G0.6251.00
227_T368_I0.6241.00
394_L397_M0.6241.00
194_S197_I0.6231.00
36_H251_A0.6211.00
330_A351_W0.6201.00
39_G263_Y0.6201.00
117_I179_F0.6171.00
334_T342_E0.6151.00
117_I175_L0.6131.00
116_G119_I0.6131.00
272_T338_F0.6111.00
197_I200_R0.6111.00
391_M408_G0.6101.00
274_G277_P0.6101.00
269_V343_A0.6091.00
70_S78_M0.6081.00
91_A95_A0.6071.00
409_M412_G0.6051.00
40_L251_A0.6031.00
239_A275_S0.6031.00
419_L423_T0.6021.00
95_A99_I0.5981.00
70_S216_V0.5971.00
195_Q199_A0.5971.00
332_P336_L0.5961.00
43_S46_P0.5941.00
22_E26_N0.5891.00
70_S73_K0.5871.00
266_L406_I0.5851.00
150_L191_Y0.5851.00
318_Y321_P0.5851.00
34_G342_E0.5841.00
406_I410_N0.5831.00
421_Y425_C0.5831.00
414_I418_S0.5831.00
199_A202_A0.5821.00
79_L134_Y0.5801.00
115_K119_I0.5791.00
242_P267_A0.5781.00
87_A90_T0.5761.00
55_A126_A0.5761.00
133_G137_G0.5751.00
170_L173_A0.5741.00
82_A220_L0.5741.00
9_I16_F0.5731.00
295_A304_V0.5691.00
146_I150_L0.5671.00
48_I52_I0.5661.00
77_S80_R0.5661.00
132_R148_N0.5641.00
154_I158_C0.5641.00
117_I178_L0.5631.00
230_L233_F0.5631.00
11_L15_A0.5621.00
413_M417_T0.5611.00
360_V417_T0.5601.00
113_F117_I0.5591.00
282_H286_V0.5591.00
367_L424_I0.5581.00
81_H216_V0.5581.00
386_V389_S0.5581.00
356_F410_N0.5571.00
176_I179_F0.5551.00
127_F189_L0.5541.00
120_G124_V0.5541.00
147_A188_V0.5511.00
357_H361_M0.5501.00
17_F153_I0.5491.00
284_L288_M0.5481.00
394_L404_G0.5481.00
335_H339_H0.5481.00
107_F247_G0.5471.00
29_L38_M0.5451.00
237_V384_H0.5441.00
283_S286_V0.5441.00
413_M416_L0.5431.00
316_L355_L0.5421.00
14_A17_F0.5421.00
197_I201_R0.5411.00
364_Q376_A0.5401.00
269_V334_T0.5401.00
22_E27_M0.5391.00
200_R203_L0.5391.00
159_L163_F0.5381.00
30_A38_M0.5381.00
231_R235_A0.5381.00
117_I121_L0.5381.00
60_P133_G0.5371.00
315_T319_G0.5361.00
389_S392_Y0.5341.00
147_A151_K0.5321.00
71_N138_V0.5321.00
230_L234_H0.5321.00
355_L358_L0.5311.00
50_L235_A0.5311.00
347_L351_W0.5311.00
288_M292_I0.5291.00
71_N139_Q0.5271.00
142_G145_A0.5261.00
324_W327_F0.5261.00
135_F143_K0.5261.00
387_A390_M0.5241.00
41_Y178_L0.5231.00
21_L24_V0.5231.00
33_L38_M0.5231.00
43_S247_G0.5221.00
66_F220_L0.5180.99
175_L179_F0.5170.99
382_W385_I0.5160.99
63_I133_G0.5150.99
100_A104_I0.5140.99
138_V199_A0.5140.99
241_E244_L0.5130.99
363_L424_I0.5130.99
109_T112_P0.5130.99
181_L184_S0.5120.99
188_V191_Y0.5120.99
398_E404_G0.5110.99
17_F20_C0.5100.99
188_V192_L0.5080.99
17_F21_L0.5070.99
14_A149_V0.5070.99
112_P115_K0.5050.99
177_S181_L0.5030.99
6_K9_I0.5020.99
423_T427_A0.5010.99
335_H340_S0.5010.99
43_S242_P0.5010.99
44_I178_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9371 100 0.304 Contact Map
4humA 1 0.9573 100 0.326 Contact Map
3w4tA 1 0.9258 100 0.333 Contact Map
3mktA 1 0.9573 100 0.343 Contact Map
2cfqA 1 0.8697 41.2 0.94 Contact Map
3o7qA 1 0.8157 26.5 0.946 Contact Map
3wdoA 1 0.8674 24.3 0.947 Contact Map
4xnjA 1 0.8472 23.7 0.947 Contact Map
1pw4A 1 0.4337 21.7 0.948 Contact Map
4tphA 2 0.8404 18 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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