GREMLIN Database
YKVQ - Putative glycosylase YkvQ
UniProt: O31682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (208)
Sequences: 5426 (3955)
Seq/√Len: 274.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_R122_L3.3291.00
124_R128_P3.2341.00
185_E189_Q3.1741.00
153_D156_Y3.0811.00
87_K126_S2.9161.00
137_V161_A2.7621.00
91_H95_E2.6801.00
86_A122_L2.5921.00
34_F64_P2.4851.00
121_R160_Y2.3401.00
182_G185_E2.2661.00
89_I101_V2.1921.00
83_V87_K2.1741.00
158_A197_S2.1671.00
112_D115_L2.1301.00
120_I157_L2.0741.00
179_A206_P2.0641.00
103_I120_I2.0451.00
192_L198_P2.0131.00
184_V203_L2.0091.00
76_R112_D1.9801.00
166_V188_I1.9291.00
158_A164_L1.9061.00
94_E131_K1.8691.00
124_R135_V1.8341.00
83_V122_L1.8311.00
139_A191_V1.7971.00
117_T156_Y1.7241.00
47_A50_D1.7231.00
117_T153_D1.7221.00
93_I133_V1.7161.00
83_V126_S1.7051.00
86_A123_V1.7021.00
90_S126_S1.6481.00
190_Y194_Q1.6341.00
86_A126_S1.6241.00
37_R41_S1.6141.00
61_K99_D1.6081.00
188_I203_L1.5621.00
63_V134_S1.5301.00
121_R156_Y1.5021.00
79_L119_F1.4951.00
120_I161_A1.4921.00
158_A200_K1.4921.00
9_S12_G1.4661.00
168_A203_L1.4451.00
161_A164_L1.4421.00
114_N153_D1.4031.00
122_L126_S1.3841.00
171_E180_S1.3781.00
17_Q20_D1.3701.00
127_I133_V1.3591.00
118_D121_R1.3551.00
163_Y202_V1.3371.00
50_D62_V1.3361.00
189_Q193_T1.3361.00
137_V157_L1.3231.00
156_Y159_K1.3211.00
30_S65_F1.3171.00
158_A196_I1.2851.00
63_V136_A1.2841.00
139_A164_L1.2791.00
64_P92_A1.2751.00
86_A90_S1.2701.00
35_Y71_D1.2611.00
103_I123_V1.2581.00
117_T160_Y1.2521.00
94_E133_V1.2361.00
121_R125_K1.2361.00
28_V63_V1.2121.00
106_E167_M1.2111.00
93_I101_V1.2091.00
104_D167_M1.1991.00
63_V100_G1.1911.00
120_I160_Y1.1881.00
138_A167_M1.1851.00
54_A58_R1.1831.00
78_A81_N1.1791.00
30_S165_M1.1631.00
196_I201_L1.1521.00
171_E187_S1.1481.00
80_M115_L1.1381.00
77_F80_M1.1371.00
113_R153_D1.1311.00
114_N118_D1.1311.00
164_L196_I1.1311.00
102_N138_A1.1301.00
87_K91_H1.1231.00
169_Y204_G1.1161.00
102_N136_A1.1161.00
48_N52_I1.1131.00
28_V134_S1.1121.00
47_A51_V1.0961.00
171_E184_V1.0951.00
154_Y196_I1.0931.00
82_R118_D1.0881.00
113_R151_S1.0871.00
40_G43_L1.0871.00
142_F147_G1.0851.00
52_I55_L1.0811.00
19_V49_P1.0681.00
122_L125_K1.0621.00
90_S94_E1.0611.00
125_K160_Y1.0591.00
116_F137_V1.0521.00
79_L105_I1.0231.00
75_G79_L1.0151.00
23_N57_R1.0151.00
165_M202_V1.0091.00
128_P132_E1.0031.00
188_I192_L1.0021.00
102_N165_M0.9971.00
170_D210_R0.9961.00
154_Y191_V0.9961.00
181_V185_E0.9921.00
197_S200_K0.9841.00
62_V99_D0.9821.00
52_I56_H0.9791.00
178_T210_R0.9791.00
38_K42_L0.9791.00
37_R44_L0.9751.00
155_E159_K0.9731.00
92_A96_L0.9731.00
167_M208_Y0.9691.00
22_T25_V0.9541.00
30_S63_V0.9511.00
136_A165_M0.9491.00
53_K57_R0.9491.00
48_N51_V0.9491.00
189_Q192_L0.9431.00
41_S45_R0.9421.00
50_D53_K0.9391.00
113_R117_T0.9311.00
109_T112_D0.9291.00
51_V62_V0.9231.00
118_D122_L0.9221.00
123_V127_I0.9211.00
188_I201_L0.9181.00
124_R160_Y0.9151.00
106_E138_A0.9051.00
134_S163_Y0.9031.00
28_V61_K0.8871.00
126_S129_R0.8791.00
56_H99_D0.8771.00
71_D74_L0.8731.00
190_Y193_T0.8561.00
64_P98_L0.8511.00
141_P187_S0.8501.00
78_A85_L0.8491.00
85_L89_I0.8471.00
37_R42_L0.8411.00
79_L115_L0.8341.00
39_D42_L0.8331.00
116_F120_I0.8321.00
53_K60_L0.8280.99
23_N60_L0.8210.99
16_I22_T0.8200.99
23_N26_L0.8200.99
75_G78_A0.8180.99
157_L161_A0.8160.99
154_Y194_Q0.8090.99
101_V135_V0.8090.99
28_V163_Y0.8030.99
78_A86_A0.7880.99
54_A57_R0.7870.99
84_L88_Q0.7820.99
38_K41_S0.7810.99
106_E169_Y0.7810.99
33_F106_E0.7810.99
34_F66_L0.7790.99
82_R86_A0.7740.99
84_L87_K0.7730.99
32_D65_F0.7680.99
120_I137_V0.7640.99
69_H107_N0.7620.99
33_F65_F0.7620.99
61_K134_S0.7590.99
76_R80_M0.7590.99
57_R60_L0.7570.99
140_N151_S0.7560.99
164_L191_V0.7480.99
119_F123_V0.7460.99
111_K115_L0.7460.99
172_S176_G0.7440.99
155_E158_A0.7420.99
157_L164_L0.7410.99
89_I123_V0.7360.99
93_I97_D0.7280.99
129_R132_E0.7270.99
77_F81_N0.7260.99
24_G57_R0.7260.99
80_M111_K0.7240.99
176_G212_W0.7220.99
91_H94_E0.7190.99
127_I135_V0.7140.98
71_D75_G0.7120.98
76_R79_L0.7110.98
53_K58_R0.7110.98
90_S133_V0.7100.98
134_S162_D0.7100.98
66_L85_L0.7090.98
117_T121_R0.7040.98
148_W151_S0.7030.98
37_R40_G0.7030.98
40_G44_L0.6990.98
186_K190_Y0.6950.98
82_R115_L0.6930.98
36_I78_A0.6920.98
168_A202_V0.6910.98
34_F96_L0.6900.98
139_A154_Y0.6880.98
136_A163_Y0.6870.98
76_R115_L0.6860.98
166_V191_V0.6860.98
38_K45_R0.6850.98
202_V206_P0.6820.98
39_D43_L0.6760.98
54_A60_L0.6760.98
216_Q219_S0.6740.98
18_H21_Q0.6730.98
141_P171_E0.6720.98
120_I124_R0.6720.98
170_D208_Y0.6700.98
147_G151_S0.6650.98
138_A169_Y0.6640.98
152_Y157_L0.6630.98
13_W17_Q0.6630.98
146_K150_G0.6600.97
115_L118_D0.6540.97
156_Y160_Y0.6530.97
191_V201_L0.6530.97
55_L59_K0.6510.97
90_S127_I0.6490.97
33_F138_A0.6450.97
50_D54_A0.6440.97
54_A62_V0.6430.97
37_R43_L0.6380.97
40_G84_L0.6370.97
49_P53_K0.6360.97
31_P98_L0.6330.97
41_S84_L0.6270.97
104_D138_A0.6270.97
104_D208_Y0.6240.97
89_I93_I0.6200.96
83_V125_K0.6100.96
16_I20_D0.6100.96
74_L78_A0.6090.96
76_R109_T0.6080.96
65_F68_N0.6070.96
90_S93_I0.6030.96
140_N149_H0.5990.96
47_A52_I0.5980.96
140_N152_Y0.5970.96
90_S128_P0.5960.95
87_K90_S0.5910.95
48_N53_K0.5910.95
73_D77_F0.5900.95
128_P131_K0.5900.95
29_V60_L0.5860.95
167_M170_D0.5860.95
177_P180_S0.5860.95
101_V123_V0.5830.95
187_S191_V0.5820.95
55_L58_R0.5790.95
34_F92_A0.5780.95
101_V127_I0.5750.95
26_L29_V0.5720.94
114_N156_Y0.5690.94
86_A118_D0.5690.94
121_R159_K0.5670.94
102_N106_E0.5670.94
68_N75_G0.5610.94
75_G103_I0.5600.94
72_Q76_R0.5590.94
56_H62_V0.5570.94
183_W186_K0.5550.93
30_S163_Y0.5540.93
63_V165_M0.5530.93
192_L201_L0.5530.93
155_E195_K0.5520.93
157_L160_Y0.5520.93
103_I119_F0.5500.93
114_N121_R0.5490.93
107_N148_W0.5450.93
80_M112_D0.5400.92
175_A215_G0.5350.92
113_R157_L0.5350.92
10_G14_D0.5320.92
9_S17_Q0.5320.92
135_V161_A0.5320.92
94_E132_E0.5310.92
34_F98_L0.5310.92
93_I98_L0.5310.92
69_H72_Q0.5300.92
35_Y43_L0.5280.92
65_F102_N0.5280.92
105_I119_F0.5270.92
179_A184_V0.5270.92
104_D169_Y0.5230.91
12_G15_F0.5220.91
36_I85_L0.5190.91
172_S177_P0.5150.91
199_Q202_V0.5120.90
100_G205_L0.5110.90
63_V209_G0.5090.90
132_E162_D0.5060.90
125_K129_R0.5050.90
51_V98_L0.5040.90
107_N167_M0.5030.90
50_D60_L0.5010.89
125_K128_P0.5010.89
92_A95_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4rA 1 0.9914 100 0.156 Contact Map
1itxA 1 0.9871 100 0.158 Contact Map
1vf8A 1 0.9828 100 0.162 Contact Map
1wb0A 2 0.9828 100 0.163 Contact Map
3fy1A 1 0.9828 100 0.163 Contact Map
4wkaA 1 0.9828 100 0.17 Contact Map
3arxA 1 0.9871 100 0.177 Contact Map
1ll7A 1 0.9698 100 0.177 Contact Map
1edqA 1 0.9784 100 0.179 Contact Map
1w9pA 1 0.9698 100 0.179 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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