GREMLIN Database
YKVP - Spore protein YkvP
UniProt: O31681 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (309)
Sequences: 25949 (21422)
Seq/√Len: 1218.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_A224_A4.7011.00
184_R207_W3.5121.00
104_F124_A3.3141.00
51_V319_L3.1971.00
227_I244_I2.9541.00
147_D186_D2.7571.00
145_S184_R2.7261.00
181_K283_K2.6141.00
2_K26_T2.6051.00
177_P279_L2.5241.00
194_K198_Y2.4871.00
25_H316_L2.4641.00
302_A305_N2.4621.00
173_T200_G2.3431.00
146_C286_L2.3371.00
150_V168_S2.2851.00
186_D209_H2.2741.00
28_M47_P2.2621.00
179_I205_R2.2421.00
113_C117_E2.2121.00
175_I185_I2.1521.00
28_M45_F2.1161.00
177_P276_K2.0991.00
263_F269_L2.0801.00
288_H291_E2.0711.00
167_R170_S2.0571.00
173_T275_P2.0451.00
23_A313_E2.0201.00
248_G300_K1.9621.00
255_D260_R1.9451.00
4_L47_P1.9331.00
104_F318_V1.9171.00
281_K284_Y1.8881.00
292_R296_Q1.8781.00
284_Y291_E1.8691.00
264_K267_R1.8331.00
255_D273_S1.8281.00
147_D184_R1.8271.00
188_W220_V1.8031.00
124_A321_S1.8001.00
270_I281_K1.7951.00
148_I226_I1.7791.00
273_S277_E1.7741.00
23_A316_L1.7731.00
200_G204_P1.7661.00
4_L30_S1.7431.00
268_D302_A1.7421.00
200_G203_I1.6861.00
316_L320_K1.6751.00
176_R204_P1.6721.00
284_Y288_H1.6691.00
110_P113_C1.6611.00
147_D223_S1.6391.00
171_L228_I1.6371.00
227_I249_G1.6171.00
186_D207_W1.6121.00
51_V81_W1.6111.00
190_R194_K1.6071.00
310_H314_R1.5901.00
146_C225_K1.5881.00
283_K287_N1.5831.00
129_A308_Y1.5691.00
80_Y102_P1.5591.00
171_L185_I1.5401.00
113_C125_H1.5381.00
291_E294_K1.5291.00
264_K302_A1.5211.00
151_V217_A1.5201.00
212_L216_E1.5201.00
274_S277_E1.5181.00
19_G312_A1.5161.00
19_G22_E1.5141.00
175_I183_I1.5021.00
301_K304_K1.4961.00
267_R298_N1.4951.00
113_C123_A1.4801.00
19_G309_R1.4691.00
5_F53_M1.4681.00
148_I282_V1.4551.00
5_F20_F1.4511.00
106_F318_V1.4471.00
216_E219_K1.4331.00
294_K298_N1.4281.00
110_P261_G1.4271.00
277_E281_K1.4221.00
212_L220_V1.4101.00
178_L283_K1.4051.00
272_S281_K1.4041.00
106_F315_M1.3991.00
107_T123_A1.3911.00
270_I284_Y1.3731.00
14_Y18_N1.3441.00
52_S78_L1.3411.00
154_A187_F1.3401.00
142_A145_S1.3321.00
213_D216_E1.3321.00
275_P279_L1.3021.00
104_F321_S1.2921.00
193_E196_S1.2791.00
21_R24_G1.2741.00
314_R317_E1.2711.00
195_M198_Y1.2591.00
201_R204_P1.2541.00
253_T259_V1.2491.00
148_I228_I1.2451.00
264_K268_D1.2431.00
188_W209_H1.2421.00
298_N301_K1.2241.00
5_F17_P1.2211.00
170_S275_P1.2111.00
110_P125_H1.1901.00
201_R208_I1.1791.00
147_D225_K1.1721.00
241_T259_V1.1641.00
277_E280_E1.1601.00
110_P114_K1.1531.00
293_K297_I1.1521.00
285_Y295_I1.1511.00
253_T271_V1.1481.00
198_Y203_I1.1451.00
224_A249_G1.1431.00
186_D220_V1.1431.00
177_P275_P1.1381.00
296_Q299_G1.1381.00
199_I203_I1.1331.00
149_A188_W1.1311.00
198_Y201_R1.1201.00
289_D292_R1.1181.00
167_R232_N1.1081.00
237_L242_Y1.1061.00
188_W212_L1.1051.00
135_H247_S1.0991.00
291_E295_I1.0871.00
146_C226_I1.0851.00
150_V171_L1.0851.00
310_H313_E1.0831.00
3_I25_H1.0831.00
265_P281_K1.0701.00
157_N234_E1.0621.00
114_K117_E1.0581.00
248_G297_I1.0571.00
270_I295_I1.0541.00
198_Y202_E1.0531.00
174_L278_T1.0491.00
311_R314_R1.0441.00
134_I218_Y1.0391.00
186_D224_A1.0381.00
168_S187_F1.0381.00
217_A221_Y1.0341.00
12_W239_Q1.0321.00
249_G296_Q1.0311.00
176_R180_R1.0271.00
231_Q235_S1.0271.00
146_C182_G1.0261.00
17_P21_R1.0241.00
53_M83_T1.0221.00
2_K28_M1.0171.00
108_V236_Q1.0161.00
169_S200_G1.0141.00
124_A318_V1.0121.00
209_H212_L1.0111.00
307_S310_H1.0051.00
214_Y217_A1.0001.00
254_S272_S1.0001.00
108_V128_F0.9951.00
253_T263_F0.9951.00
114_K118_S0.9921.00
145_S182_G0.9911.00
270_I285_Y0.9851.00
238_T259_V0.9821.00
229_G241_T0.9811.00
132_E307_S0.9811.00
107_T113_C0.9801.00
229_G240_R0.9741.00
19_G23_A0.9701.00
149_A220_V0.9651.00
177_P181_K0.9641.00
169_S173_T0.9601.00
222_S247_S0.9571.00
230_L278_T0.9531.00
83_T239_Q0.9531.00
41_M45_F0.9521.00
135_H218_Y0.9511.00
190_R211_Y0.9501.00
79_V322_R0.9491.00
308_Y311_R0.9471.00
146_C183_I0.9461.00
245_L299_G0.9441.00
17_P29_I0.9411.00
12_W83_T0.9341.00
52_S80_Y0.9301.00
177_P180_R0.9291.00
221_Y247_S0.9291.00
296_Q300_K0.9261.00
176_R179_I0.9221.00
186_D223_S0.9191.00
115_T118_S0.9191.00
170_S254_S0.9131.00
297_I301_K0.9101.00
178_L183_I0.9091.00
235_S238_T0.9081.00
258_A261_G0.9011.00
218_Y247_S0.9001.00
36_E40_E0.8941.00
218_Y222_S0.8911.00
293_K296_Q0.8891.00
147_D224_A0.8861.00
195_M199_I0.8801.00
126_L318_V0.8741.00
102_P105_V0.8721.00
155_Y192_W0.8711.00
244_I249_G0.8691.00
153_N157_N0.8691.00
226_I285_Y0.8661.00
78_L102_P0.8611.00
151_V221_Y0.8611.00
280_E284_Y0.8571.00
289_D293_K0.8571.00
276_K280_E0.8541.00
245_L251_L0.8521.00
295_I298_N0.8501.00
279_L283_K0.8381.00
39_T73_K0.8351.00
270_I291_E0.8341.00
227_I240_R0.8321.00
183_I286_L0.8311.00
313_E316_L0.8301.00
13_L53_M0.8291.00
313_E317_E0.8281.00
174_L279_L0.8271.00
107_T116_Y0.8271.00
191_N194_K0.8251.00
106_F126_L0.8231.00
128_F239_Q0.8211.00
5_F27_V0.8171.00
7_E13_L0.8161.00
131_H135_H0.8131.00
79_V106_F0.8131.00
49_L319_L0.8071.00
148_I175_I0.8061.00
11_M15_G0.8021.00
124_A314_R0.8001.00
170_S173_T0.7981.00
131_H134_I0.7971.00
209_H220_V0.7961.00
16_L315_M0.7931.00
311_R315_M0.7901.00
178_L282_V0.7891.00
12_W128_F0.7891.00
15_G308_Y0.7861.00
108_V112_L0.7701.00
127_D261_G0.7701.00
151_V188_W0.7701.00
146_C289_D0.7671.00
226_I282_V0.7651.00
175_I205_R0.7641.00
250_F296_Q0.7631.00
15_G18_N0.7521.00
196_S200_G0.7511.00
71_T78_L0.7501.00
126_L315_M0.7481.00
173_T176_R0.7471.00
129_A311_R0.7451.00
268_D299_G0.7451.00
21_R27_V0.7441.00
229_G259_V0.7431.00
39_T43_D0.7391.00
228_I282_V0.7381.00
149_A221_Y0.7371.00
150_V187_F0.7351.00
172_K201_R0.7321.00
295_I299_G0.7321.00
79_V319_L0.7291.00
42_I47_P0.7271.00
104_F322_R0.7271.00
196_S199_I0.7221.00
66_W69_N0.7221.00
257_P260_R0.7211.00
107_T112_L0.7201.00
201_R206_N0.7141.00
2_K47_P0.7111.00
5_F319_L0.7101.00
181_K287_N0.7091.00
238_T241_T0.7031.00
250_F285_Y0.6981.00
317_E320_K0.6971.00
138_I222_S0.6961.00
150_V227_I0.6951.00
255_D271_V0.6931.00
272_S278_T0.6931.00
148_I183_I0.6921.00
178_L286_L0.6901.00
95_P99_K0.6841.00
252_L281_K0.6831.00
1_M25_H0.6821.00
83_T128_F0.6821.00
241_T262_K0.6821.00
171_L230_L0.6801.00
51_V315_M0.6791.00
4_L50_I0.6781.00
185_I206_N0.6781.00
65_A68_R0.6781.00
150_V230_L0.6751.00
229_G238_T0.6731.00
143_K146_C0.6731.00
302_A306_D0.6711.00
226_I292_R0.6711.00
220_V223_S0.6671.00
108_V239_Q0.6671.00
184_R205_R0.6651.00
167_R230_L0.6631.00
241_T251_L0.6611.00
47_P76_I0.6611.00
23_A312_A0.6611.00
266_G284_Y0.6601.00
23_A309_R0.6591.00
245_L302_A0.6591.00
15_G19_G0.6571.00
290_S294_K0.6571.00
53_M81_W0.6571.00
221_Y240_R0.6541.00
241_T253_T0.6531.00
285_Y292_R0.6521.00
280_E283_K0.6521.00
77_P103_D0.6521.00
294_K297_I0.6511.00
221_Y244_I0.6501.00
317_E321_S0.6501.00
170_S278_T0.6501.00
127_D311_R0.6491.00
142_A184_R0.6491.00
263_F268_D0.6481.00
174_L275_P0.6471.00
245_L296_Q0.6471.00
269_L272_S0.6471.00
272_S277_E0.6451.00
35_R39_T0.6441.00
299_G302_A0.6431.00
219_K222_S0.6411.00
178_L279_L0.6381.00
288_H292_R0.6381.00
127_D314_R0.6371.00
32_P36_E0.6361.00
240_R244_I0.6341.00
115_T119_M0.6321.00
52_S58_E0.6291.00
12_W315_M0.6281.00
127_D306_D0.6281.00
307_S311_R0.6271.00
172_K206_N0.6261.00
225_K292_R0.6221.00
146_C149_A0.6221.00
214_Y218_Y0.6201.00
199_I202_E0.6201.00
152_A168_S0.6181.00
15_G131_H0.6171.00
245_L268_D0.6171.00
156_P193_E0.6161.00
318_V321_S0.6151.00
221_Y227_I0.6141.00
110_P127_D0.6141.00
252_L282_V0.6141.00
242_Y306_D0.6131.00
315_M319_L0.6121.00
300_K303_V0.6111.00
5_F51_V0.6081.00
181_K280_E0.6081.00
94_I98_K0.6061.00
91_N94_I0.6061.00
117_E120_G0.6051.00
154_A194_K0.6041.00
309_R313_E0.6041.00
173_T204_P0.6021.00
11_M214_Y0.6021.00
173_T177_P0.6021.00
43_D74_V0.6011.00
252_L272_S0.5991.00
50_I76_I0.5961.00
284_Y287_N0.5921.00
49_L79_V0.5921.00
4_L28_M0.5901.00
221_Y249_G0.5881.00
318_V322_R0.5871.00
228_I278_T0.5861.00
40_E44_E0.5861.00
242_Y303_V0.5851.00
268_D298_N0.5831.00
169_S196_S0.5821.00
308_Y312_A0.5821.00
265_P270_I0.5811.00
12_W81_W0.5781.00
182_G205_R0.5721.00
154_A191_N0.5711.00
265_P268_D0.5701.00
71_T74_V0.5681.00
13_L29_I0.5681.00
74_V77_P0.5661.00
290_S293_K0.5641.00
112_L236_Q0.5621.00
151_V227_I0.5611.00
117_E123_A0.5601.00
276_K279_L0.5571.00
17_P27_V0.5571.00
50_I71_T0.5561.00
149_A249_G0.5541.00
250_F299_G0.5541.00
226_I252_L0.5511.00
252_L285_Y0.5491.00
146_C292_R0.5481.00
111_S114_K0.5471.00
49_L323_G0.5471.00
174_L282_V0.5471.00
181_K279_L0.5451.00
158_F235_S0.5441.00
90_Q94_I0.5441.00
33_V37_N0.5431.00
25_H320_K0.5421.00
82_A112_L0.5411.00
156_P169_S0.5411.00
152_A158_F0.5391.00
22_E309_R0.5371.00
83_T108_V0.5361.00
305_N310_H0.5361.00
11_M14_Y0.5351.00
8_S56_T0.5341.00
305_N314_R0.5341.00
109_T112_L0.5341.00
219_K223_S0.5331.00
12_W16_L0.5321.00
158_F240_R0.5321.00
132_E246_G0.5301.00
212_L217_A0.5301.00
244_I251_L0.5291.00
263_F271_V0.5261.00
237_L306_D0.5251.00
260_R271_V0.5231.00
81_W106_F0.5221.00
298_N302_A0.5211.00
144_Y182_G0.5211.00
169_S232_N0.5191.00
54_G57_P0.5181.00
19_G308_Y0.5181.00
81_W319_L0.5171.00
175_I178_L0.5171.00
28_M41_M0.5161.00
111_S260_R0.5161.00
197_K208_I0.5151.00
176_R203_I0.5151.00
8_S54_G0.5141.00
30_S41_M0.5131.00
135_H246_G0.5131.00
12_W53_M0.5131.00
15_G239_Q0.5081.00
150_V185_I0.5081.00
158_F231_Q0.5061.00
84_E157_N0.5051.00
21_R25_H0.5041.00
84_E87_L0.5031.00
231_Q240_R0.5031.00
95_P98_K0.5031.00
153_N158_F0.5021.00
226_I286_L0.5011.00
12_W108_V0.5001.00
179_I183_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.7719 100 0.424 Contact Map
4n9wA 1 0.7544 100 0.426 Contact Map
1rzuA 1 0.7719 100 0.43 Contact Map
2qzsA 1 0.7619 100 0.431 Contact Map
3c48A 2 0.787 100 0.442 Contact Map
3froA 3 0.7845 100 0.443 Contact Map
3oy2A 2 0.7769 100 0.457 Contact Map
2x6qA 1 0.7544 100 0.459 Contact Map
2x0dA 2 0.7243 100 0.463 Contact Map
3okpA 1 0.7619 100 0.463 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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