GREMLIN Database
QUEF - NADPH-dependent 7-cyano-7-deazaguanine reductase
UniProt: O31678 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (133)
Sequences: 695 (218)
Seq/√Len: 18.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_R106_N4.1581.00
33_S76_K4.0891.00
22_Y88_F3.8041.00
42_D115_R3.6671.00
38_H106_N3.2380.99
12_V32_E3.0740.99
101_M121_G2.6940.98
36_N121_G2.4950.97
103_I107_D2.3700.96
69_I83_L2.3250.95
13_T32_E2.2450.94
86_Y107_D2.2270.94
102_N105_M2.2100.94
54_S100_C2.2060.93
109_I137_Y2.1540.93
105_M109_I2.1370.92
108_L112_M2.0470.91
105_M117_I2.0160.90
122_K132_D1.9210.88
86_Y103_I1.8810.86
41_R105_M1.8760.86
49_C87_L1.8050.84
33_S111_L1.8040.84
26_Y58_K1.8000.84
45_V77_M1.7130.81
33_S112_M1.6380.77
74_D113_D1.6000.76
41_R102_N1.5810.75
101_M133_P1.5330.72
24_F28_P1.5270.72
105_M135_T1.4850.70
36_N43_Y1.4380.67
78_V111_L1.4140.66
42_D72_I1.3760.64
58_K94_G1.3150.60
74_D115_R1.3140.60
74_D139_K1.3130.60
59_T96_F1.2910.59
46_K120_W1.2750.58
61_Q96_F1.2690.57
120_W132_D1.2440.56
38_H99_D1.2420.56
45_V73_P1.2380.56
40_N115_R1.2300.55
78_V108_L1.2060.54
82_S87_L1.1940.53
65_A140_P1.1590.51
78_V112_M1.1370.49
28_P40_N1.1200.48
9_L12_V1.1150.48
80_S131_I1.1140.48
96_F128_G1.1010.47
17_N35_P1.0770.45
12_V45_V1.0750.45
44_F72_I1.0570.44
10_E13_T1.0560.44
35_P75_E1.0450.43
57_P94_G1.0230.42
67_I119_V1.0050.41
109_I135_T0.9960.40
89_S131_I0.9890.40
120_W134_Y0.9690.39
97_H100_C0.9680.39
46_K70_S0.9610.38
30_V86_Y0.9610.38
83_L87_L0.9560.38
12_V99_D0.9550.38
70_S130_S0.9500.38
42_D74_D0.9240.36
90_F99_D0.9220.36
11_G17_N0.9060.35
67_I101_M0.9020.35
57_P81_K0.8900.34
47_F132_D0.8770.33
76_K113_D0.8620.33
66_T123_F0.8580.32
86_Y110_E0.8480.32
34_F77_M0.8450.32
10_E74_D0.8440.32
137_Y141_G0.8430.32
13_T17_N0.8420.32
59_T128_G0.8380.31
138_G142_T0.8270.31
61_Q128_G0.8250.31
35_P110_E0.8250.31
11_G20_T0.8200.30
17_N60_G0.8200.30
47_F131_I0.8060.30
10_E33_S0.8010.29
11_G37_K0.7810.28
21_N67_I0.7800.28
77_M106_N0.7790.28
10_E21_N0.7740.28
41_R77_M0.7700.28
68_Y122_K0.7700.28
125_P130_S0.7680.28
60_G73_P0.7670.28
109_I117_I0.7630.27
14_L60_G0.7580.27
23_L27_A0.7570.27
38_H103_I0.7450.27
57_P95_D0.7450.27
46_K138_G0.7380.26
37_K95_D0.7250.26
39_V74_D0.7190.25
51_E84_K0.7190.25
26_Y118_E0.7130.25
116_Y125_P0.7130.25
97_H131_I0.7120.25
70_S122_K0.7110.25
44_F90_F0.7100.25
10_E75_E0.7040.25
117_I135_T0.7020.24
77_M112_M0.7010.24
90_F140_P0.6980.24
61_Q131_I0.6910.24
91_R128_G0.6860.24
100_C131_I0.6800.23
54_S59_T0.6780.23
70_S118_E0.6750.23
103_I110_E0.6750.23
9_L17_N0.6740.23
46_K132_D0.6610.23
99_D103_I0.6590.22
11_G75_E0.6580.22
40_N106_N0.6560.22
15_L59_T0.6560.22
36_N101_M0.6550.22
48_N130_S0.6520.22
26_Y80_S0.6510.22
38_H104_I0.6510.22
67_I140_P0.6490.22
75_E113_D0.6480.22
76_K112_M0.6470.22
81_K84_K0.6450.22
53_T57_P0.6430.22
46_K134_Y0.6420.22
50_P125_P0.6420.22
13_T35_P0.6400.22
76_K111_L0.6360.22
69_I87_L0.6300.21
33_S105_M0.6250.21
53_T81_K0.6240.21
9_L103_I0.6150.21
32_E82_S0.6130.21
86_Y137_Y0.6120.20
95_D103_I0.6120.20
46_K122_K0.6090.20
79_E84_K0.6050.20
17_N42_D0.5980.20
77_M99_D0.5950.20
32_E81_K0.5890.20
124_T133_P0.5860.19
79_E92_N0.5850.19
111_L115_R0.5850.19
13_T113_D0.5760.19
40_N74_D0.5740.19
33_S74_D0.5690.19
128_G131_I0.5660.19
53_T64_F0.5560.18
73_P84_K0.5540.18
102_N123_F0.5520.18
61_Q80_S0.5500.18
43_Y73_P0.5480.18
12_V58_K0.5470.18
28_P99_D0.5470.18
100_C124_T0.5460.18
64_F85_L0.5450.18
61_Q95_D0.5440.18
49_C121_G0.5430.18
102_N119_V0.5420.18
9_L99_D0.5410.18
49_C129_I0.5410.18
24_F135_T0.5380.18
53_T80_S0.5360.18
78_V92_N0.5320.17
119_V135_T0.5290.17
45_V102_N0.5280.17
90_F108_L0.5270.17
43_Y121_G0.5260.17
43_Y50_P0.5190.17
51_E81_K0.5180.17
95_D99_D0.5180.17
34_F76_K0.5170.17
13_T21_N0.5160.17
35_P76_K0.5150.17
113_D139_K0.5140.17
107_D110_E0.5120.17
90_F103_I0.5100.17
25_E28_P0.5100.17
96_F131_I0.5100.17
90_F107_D0.5100.17
95_D100_C0.5080.17
23_L29_D0.5060.16
50_P73_P0.5040.16
38_H100_C0.5040.16
82_S141_G0.5030.16
11_G103_I0.5020.16
70_S124_T0.5000.16
10_E40_N0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f8bA 5 0.8788 100 0.106 Contact Map
3uxjA 2 0.8788 100 0.32 Contact Map
1wurA 6 0.8909 99.8 0.709 Contact Map
1a8rA 7 0.9576 38.4 0.952 Contact Map
4uqfA 5 0.9152 29.3 0.955 Contact Map
1is8A 5 0.903 29.3 0.955 Contact Map
1j23A 2 0.6242 12.5 0.962 Contact Map
2zbkA 2 0.7455 6.7 0.966 Contact Map
2mcqA 1 0.3939 6.6 0.966 Contact Map
1gupA 2 0.6727 6.6 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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