GREMLIN Database
QUEE - 7-carboxy-7-deazaguanine synthase
UniProt: O31677 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (196)
Sequences: 2644 (1751)
Seq/√Len: 125.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_K101_N3.8741.00
66_E69_D3.3711.00
35_D110_Q3.3171.00
61_E97_L2.9761.00
170_L220_D2.6101.00
174_K220_D2.5301.00
59_T62_E2.4221.00
99_K122_D2.3681.00
10_I66_E2.3321.00
24_Q104_R2.3031.00
217_V228_V2.2581.00
158_V183_I2.1201.00
78_V98_L2.0851.00
215_D219_V2.0281.00
26_T77_H1.9251.00
35_D112_T1.9151.00
167_D171_E1.8841.00
86_A115_Q1.8831.00
109_T126_I1.8821.00
58_M66_E1.8761.00
211_E215_D1.8561.00
216_K220_D1.8551.00
80_I90_Q1.8391.00
26_T79_T1.8111.00
40_W165_F1.7921.00
62_E65_A1.7891.00
31_T80_I1.7861.00
171_E174_K1.7601.00
21_V77_H1.7141.00
10_I63_I1.7091.00
20_M159_S1.7031.00
64_F97_L1.6951.00
20_M186_Y1.6931.00
186_Y227_R1.6691.00
24_Q227_R1.6511.00
80_I98_L1.6431.00
66_E70_I1.6361.00
165_F190_G1.6351.00
230_P235_L1.6191.00
214_V236_L1.6171.00
12_G75_F1.6041.00
27_M67_L1.5961.00
29_V67_L1.5811.00
22_I232_L1.5611.00
96_E100_E1.5611.00
115_Q124_L1.5351.00
215_D218_A1.5201.00
35_D87_L1.5091.00
58_M63_I1.4931.00
99_K105_A1.4831.00
60_A97_L1.4371.00
43_S46_T1.4281.00
175_T178_K1.3761.00
10_I27_M1.3581.00
167_D216_K1.3571.00
164_I187_L1.3561.00
12_G25_K1.3531.00
60_A93_A1.3381.00
61_E65_A1.3361.00
96_E99_K1.3291.00
170_L174_K1.3171.00
7_V58_M1.3081.00
8_L49_G1.2701.00
67_L80_I1.2701.00
40_W130_P1.2631.00
231_Q234_T1.2631.00
96_E120_L1.2491.00
77_H104_R1.2471.00
95_I105_A1.2140.99
35_D113_V1.2080.99
175_T179_R1.1980.99
188_Q231_Q1.1970.99
132_S166_N1.1950.99
67_L98_L1.1890.99
80_I91_L1.1890.99
77_H106_A1.1820.99
20_M184_P1.1790.99
29_V78_V1.1740.99
44_A47_W1.1690.99
171_E175_T1.1540.99
27_M70_I1.1500.99
64_F68_K1.1500.99
125_T159_S1.1420.99
168_E171_E1.1400.99
31_T91_L1.1350.99
76_S103_I1.1160.99
211_E214_V1.1160.99
37_S47_W1.1100.99
5_I31_T1.1090.99
209_K212_A1.1060.99
56_R66_E1.0980.99
21_V104_R1.0910.99
145_I149_L1.0840.99
97_L100_E1.0690.99
12_G70_I1.0660.98
26_T106_A1.0620.98
97_L101_N1.0600.98
90_Q93_A1.0520.98
91_L95_I1.0490.98
64_F101_N1.0480.98
95_I118_F1.0420.98
12_G218_A1.0360.98
36_Y110_Q1.0330.98
162_V187_L1.0240.98
214_V218_A1.0160.98
42_D108_E1.0140.98
173_A187_L1.0140.98
65_A101_N1.0090.98
106_A125_T1.0060.98
92_D96_E1.0040.98
5_I60_A0.9890.98
126_I146_L0.9830.97
148_S152_N0.9810.97
29_V80_I0.9750.97
123_D159_S0.9740.97
178_K225_L0.9720.97
10_I58_M0.9670.97
79_T106_A0.9670.97
210_Y214_V0.9620.97
78_V105_A0.9520.97
170_L216_K0.9510.97
146_L149_L0.9420.97
24_Q77_H0.9400.97
65_A68_K0.9320.96
132_S165_F0.9320.96
220_D225_L0.9300.96
51_A66_E0.9190.96
92_D119_T0.9180.96
148_S151_E0.9130.96
80_I105_A0.9040.96
177_H185_F0.8980.96
60_A64_F0.8970.96
15_I214_V0.8960.96
14_T79_T0.8850.95
176_V179_R0.8720.95
106_A159_S0.8660.95
30_R42_D0.8620.95
212_A215_D0.8580.94
21_V24_Q0.8570.94
115_Q136_V0.8560.94
93_A97_L0.8540.94
124_L150_Q0.8470.94
99_K121_I0.8400.94
107_L124_L0.8370.94
130_P172_F0.8190.93
62_E66_E0.8140.93
58_M62_E0.8130.93
188_Q191_N0.8130.93
176_V180_Y0.8130.93
63_I94_F0.8080.92
71_G75_F0.8020.92
188_Q229_L0.8000.92
19_G79_T0.7940.92
208_G212_A0.7940.92
8_L45_F0.7920.92
65_A69_D0.7920.92
60_A94_F0.7850.91
86_A113_V0.7850.91
22_I230_P0.7830.91
118_F124_L0.7810.91
68_K103_I0.7790.91
10_I29_V0.7750.91
131_P168_E0.7740.91
187_L217_V0.7640.90
16_Q128_P0.7550.90
81_S85_P0.7430.89
167_D219_V0.7390.89
21_V125_T0.7390.89
174_K178_K0.7370.89
146_L176_V0.7340.88
21_V106_A0.7340.88
11_F14_T0.7290.88
64_F67_L0.7270.88
8_L46_T0.7270.88
31_T63_I0.7220.87
87_L113_V0.7190.87
209_K213_L0.7170.87
95_I99_K0.7090.87
79_T127_S0.7090.87
169_D177_H0.7090.87
7_V31_T0.7070.86
169_D213_L0.7030.86
77_H107_L0.6990.86
220_D226_V0.6990.86
109_T124_L0.6950.85
86_A107_L0.6930.85
63_I66_E0.6920.85
107_L118_F0.6910.85
20_M125_T0.6900.85
181_P185_F0.6870.85
79_T229_L0.6860.85
167_D212_A0.6850.85
51_A57_W0.6840.85
21_V159_S0.6790.84
67_L78_V0.6770.84
5_I91_L0.6720.83
187_L216_K0.6700.83
8_L32_A0.6690.83
159_S186_Y0.6640.83
164_I169_D0.6640.83
174_K216_K0.6630.83
6_P33_G0.6570.82
174_K226_V0.6540.82
16_Q106_A0.6520.82
130_P190_G0.6510.82
36_Y112_T0.6470.81
37_S132_S0.6430.81
164_I216_K0.6420.81
164_I213_L0.6390.80
188_Q228_V0.6370.80
98_L105_A0.6340.80
230_P234_T0.6330.80
10_I67_L0.6330.80
30_R108_E0.6300.79
178_K219_V0.6280.79
48_D51_A0.6250.79
169_D176_V0.6250.79
6_P56_R0.6250.79
16_Q79_T0.6220.79
68_K76_S0.6190.78
192_D209_K0.6190.78
114_Y135_M0.6180.78
28_F42_D0.6160.78
80_I94_F0.6160.78
22_I229_L0.6150.78
24_Q76_S0.6150.78
57_W66_E0.6070.77
145_I148_S0.6030.76
107_L115_Q0.5980.76
104_R123_D0.5980.76
130_P162_V0.5940.75
192_D195_H0.5900.75
99_K119_T0.5900.75
92_D120_L0.5900.75
31_T106_A0.5890.75
190_G193_D0.5880.75
84_N110_Q0.5870.74
65_A100_E0.5840.74
99_K120_L0.5810.74
226_V229_L0.5780.73
191_N234_T0.5770.73
26_T81_S0.5760.73
42_D161_K0.5750.73
5_I94_F0.5730.73
163_V190_G0.5690.72
135_M138_N0.5680.72
78_V103_I0.5640.71
93_A96_E0.5630.71
61_E101_N0.5620.71
107_L121_I0.5610.71
188_Q214_V0.5610.71
146_L158_V0.5550.70
18_E30_R0.5510.70
79_T123_D0.5500.70
63_I71_G0.5460.69
30_R161_K0.5440.69
6_P57_W0.5420.68
45_F213_L0.5380.68
18_E42_D0.5360.68
115_Q121_I0.5360.68
128_P172_F0.5360.68
24_Q103_I0.5360.68
25_K218_A0.5340.67
48_D52_K0.5340.67
134_K180_Y0.5320.67
149_L152_N0.5320.67
70_I75_F0.5300.67
208_G219_V0.5290.67
29_V63_I0.5280.66
65_A151_E0.5250.66
114_Y148_S0.5250.66
169_D175_T0.5240.66
30_R43_S0.5230.66
22_I210_Y0.5200.65
32_A186_Y0.5190.65
152_N182_G0.5190.65
18_E23_G0.5170.65
162_V169_D0.5170.65
210_Y236_L0.5160.65
111_G126_I0.5150.65
21_V123_D0.5150.65
45_F49_G0.5140.64
5_I93_A0.5130.64
39_S134_K0.5130.64
100_E219_V0.5130.64
188_Q234_T0.5120.64
232_L235_L0.5110.64
40_W229_L0.5090.64
44_A48_D0.5050.63
15_I217_V0.5050.63
59_T65_A0.5030.63
162_V185_F0.5020.63
40_W187_L0.5010.62
115_Q126_I0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4njhA 2 0.8025 100 0.442 Contact Map
3c8fA 1 0.8848 100 0.629 Contact Map
2yx0A 1 0.9383 99.8 0.723 Contact Map
3rfaA 1 0.8971 99.8 0.733 Contact Map
2z2uA 1 0.8642 99.8 0.737 Contact Map
1tv8A 2 0.9053 99.7 0.746 Contact Map
2qgqA 1 0.8107 99.7 0.761 Contact Map
3canA 2 0.5844 99.6 0.765 Contact Map
4k36A 1 0.893 99.6 0.767 Contact Map
2a5hA 4 0.9259 99.6 0.772 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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