GREMLIN Database
QUED - 6-carboxy-5,6,7,8-tetrahydropterin synthase
UniProt: O31676 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (116)
Sequences: 2344 (1348)
Seq/√Len: 125.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_S44_T3.3251.00
53_G62_L3.0011.00
124_Q138_R2.7011.00
126_F136_V2.6231.00
20_D46_T2.3641.00
124_Q136_V2.3211.00
48_N126_F2.3101.00
20_D48_N2.2691.00
16_E52_A2.2311.00
28_F80_L2.2151.00
103_K107_D2.1891.00
75_N108_N2.1031.00
18_N50_T2.0551.00
76_Y104_T2.0161.00
47_V127_V1.9451.00
52_A123_V1.9411.00
18_N134_Y1.7301.00
76_Y105_I1.7091.00
106_Y137_Y1.7001.00
16_E50_T1.6311.00
36_A66_S1.6271.00
39_R79_T1.6171.00
40_V80_L1.6071.00
48_N128_R1.5381.00
49_I72_V1.5271.00
49_I109_V1.5161.00
50_T124_Q1.5051.00
110_Q139_P1.5051.00
102_A125_V1.4931.00
104_T108_N1.4801.00
51_V68_L1.4791.00
23_I47_V1.4251.00
106_Y139_P1.3991.00
51_V63_V1.3891.00
100_V103_K1.3871.00
18_N126_F1.3851.00
103_K137_Y1.3801.00
30_P38_S1.3701.00
26_A80_L1.3191.00
21_M72_V1.2751.00
22_H132_T1.2581.00
16_E123_V1.2260.99
85_E88_S1.2090.99
21_M69_K1.2010.99
18_N48_N1.1990.99
82_N96_P1.1960.99
16_E136_V1.1950.99
64_N67_V1.1930.99
45_Y98_T1.1900.99
60_G100_V1.1570.99
44_T131_P1.1390.99
50_T126_F1.1030.99
15_F103_K1.0870.99
102_A135_C1.0500.98
32_E35_G1.0480.98
126_F134_Y1.0390.98
19_K132_T1.0370.98
108_N111_A1.0260.98
61_F97_T1.0190.98
114_D117_E0.9860.97
46_T131_P0.9670.97
25_A81_L0.9340.97
22_H44_T0.9220.96
105_I125_V0.9140.96
94_S104_T0.9110.96
76_Y101_V0.9030.96
38_S97_T0.9010.96
66_S69_K0.9000.96
22_H46_T0.8990.96
37_C129_E0.8970.96
17_L134_Y0.8900.95
37_C78_H0.8880.95
16_E124_Q0.8800.95
19_K133_S0.8780.95
22_H131_P0.8750.95
46_T128_R0.8690.95
44_T128_R0.8500.94
28_F38_S0.8280.93
105_I109_V0.8260.93
23_I127_V0.8260.93
56_L59_S0.8250.93
110_Q114_D0.8180.93
24_S131_P0.8040.92
34_A38_S0.8040.92
65_F133_S0.7990.92
63_V71_L0.7950.92
18_N136_V0.7920.92
16_E138_R0.7800.91
21_M73_H0.7700.91
106_Y125_V0.7690.90
67_V70_K0.7670.90
127_V135_C0.7490.89
63_V67_V0.7430.89
47_V72_V0.7370.89
116_L122_C0.7350.88
19_K130_T0.7340.88
27_H99_E0.7320.88
25_A45_Y0.7260.88
128_R134_Y0.7250.88
98_T135_C0.7220.87
55_E103_K0.7210.87
123_V138_R0.7150.87
44_T132_T0.7150.87
82_N85_E0.7130.87
20_D131_P0.7110.87
84_H88_S0.7100.87
106_Y122_C0.7080.86
101_V105_I0.7070.86
102_A127_V0.7060.86
107_D110_Q0.7050.86
68_L113_L0.7020.86
103_K106_Y0.6960.86
49_I125_V0.6950.85
33_S61_F0.6920.85
112_Y115_T0.6870.85
107_D139_P0.6840.85
36_A74_G0.6830.84
76_Y108_N0.6810.84
98_T131_P0.6810.84
65_F69_K0.6780.84
30_P95_L0.6770.84
20_D132_T0.6640.83
45_Y127_V0.6600.82
26_A40_V0.6330.80
29_I130_T0.6330.80
15_F56_L0.6300.79
69_K73_H0.6200.78
15_F55_E0.6190.78
105_I127_V0.6170.78
28_F40_V0.6160.78
15_F137_Y0.6150.78
19_K72_V0.6120.77
32_E59_S0.6080.77
29_I95_L0.6040.76
71_L112_Y0.6040.76
107_D111_A0.5960.76
59_S97_T0.5950.75
41_H129_E0.5940.75
40_V65_F0.5930.75
26_A130_T0.5910.75
82_N101_V0.5900.75
76_Y86_D0.5860.74
51_V109_V0.5850.74
71_L109_V0.5820.74
86_D89_Q0.5780.73
98_T101_V0.5740.73
34_A59_S0.5730.73
106_Y110_Q0.5710.72
71_L113_L0.5700.72
98_T133_S0.5640.72
70_K73_H0.5630.71
98_T129_E0.5630.71
110_Q122_C0.5610.71
65_F96_P0.5530.70
47_V109_V0.5520.70
50_T123_V0.5510.70
63_V116_L0.5430.69
35_G61_F0.5380.68
104_T107_D0.5340.67
114_D123_V0.5310.67
37_C65_F0.5240.66
23_I51_V0.5180.65
108_N116_L0.5180.65
84_H87_F0.5170.65
112_Y117_E0.5150.65
30_P88_S0.5070.63
109_V122_C0.5070.63
45_Y133_S0.5050.63
66_S70_K0.5040.63
17_L26_A0.5030.63
17_L135_C0.5030.63
54_D111_A0.5010.63
106_Y130_T0.5000.62
64_N78_H0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d7jA 4 0.8699 100 0.25 Contact Map
1b66A 4 0.8425 100 0.261 Contact Map
2g64A 4 0.863 100 0.267 Contact Map
2obaA 4 0.8014 100 0.279 Contact Map
4ntkA 4 0.7945 100 0.285 Contact Map
3jygA 4 0.8562 100 0.285 Contact Map
1y13A 5 0.8699 100 0.307 Contact Map
3lx3A 4 0.8699 100 0.309 Contact Map
2dj6A 3 0.7671 100 0.315 Contact Map
1gqpA 2 0.5342 10.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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