GREMLIN Database
QUEC - 7-cyano-7-deazaguanine synthase
UniProt: O31675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 219 (204)
Sequences: 2267 (1321)
Seq/√Len: 92.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_L172_E3.5631.00
116_H155_H3.3491.00
34_T45_V3.1541.00
36_H42_S2.9391.00
36_H63_D2.8751.00
139_S143_T2.7761.00
165_E168_K2.7381.00
206_K210_E2.7051.00
54_K182_N2.6821.00
5_K29_E2.6301.00
134_D138_K2.5691.00
74_A91_S2.5481.00
122_C166_T2.4361.00
22_W169_L2.4221.00
43_Q184_L2.3871.00
121_V137_V2.3631.00
106_S144_V2.2831.00
190_I193_D2.2221.00
171_D213_V2.0951.00
205_S209_E2.0541.00
108_L112_I1.9611.00
32_T57_V1.9301.00
7_I114_A1.9231.00
162_N165_E1.8691.00
21_L55_L1.8101.00
31_E108_L1.7881.00
17_T51_I1.7841.00
138_K142_V1.7811.00
29_E58_K1.7131.00
50_S182_N1.7061.00
35_F101_F1.6811.00
168_K172_E1.6551.00
25_K172_E1.6541.00
49_K61_L1.6531.00
49_K53_E1.6421.00
194_G205_S1.6041.00
31_E112_I1.5961.00
34_T59_N1.5481.00
99_L136_F1.5241.00
100_V107_I1.5221.00
64_M104_F1.5201.00
14_Q167_W1.5121.00
32_T52_A1.4971.00
143_T147_A1.4801.00
164_A210_E1.4761.00
65_S68_N1.4481.00
4_E28_E1.4390.99
141_N153_V1.4280.99
198_C201_C1.4120.99
189_G192_A1.4020.99
43_Q189_G1.3970.99
10_F32_T1.3760.99
4_E116_H1.3650.99
161_L169_L1.3640.99
19_C118_I1.3640.99
137_V156_T1.3630.99
21_L175_A1.3530.99
4_E115_R1.3510.99
195_C201_C1.3180.99
20_L30_V1.3160.99
106_S140_C1.3100.99
96_G99_L1.3070.99
26_E118_I1.2880.99
195_C198_C1.2720.99
171_D211_Y1.2690.99
140_C143_T1.2680.99
106_S143_T1.2610.99
145_N151_P1.2600.99
184_L189_G1.2490.99
186_C201_C1.2430.98
17_T175_A1.2400.98
22_W26_E1.2360.98
33_V108_L1.2300.98
25_K169_L1.2280.98
186_C195_C1.2230.98
186_C198_C1.2200.98
206_K209_E1.2190.98
208_Y215_K1.2170.98
26_E155_H1.2120.98
24_L30_V1.1940.98
22_W25_K1.1940.98
52_A57_V1.1740.98
134_D160_W1.1660.98
20_L32_T1.1620.98
65_S69_Q1.1570.98
116_H153_V1.1560.98
46_E49_K1.1530.98
80_I91_S1.1520.97
52_A56_G1.1470.97
141_N145_N1.1460.97
99_L147_A1.1410.97
140_C154_I1.1250.97
156_T159_M1.0970.97
208_Y212_M1.0910.97
5_K114_A1.0830.96
20_L55_L1.0760.96
110_Y148_M1.0730.96
43_Q47_V1.0600.96
71_A77_R1.0580.96
28_E118_I1.0560.96
96_G107_I1.0500.96
95_P110_Y1.0410.95
22_W118_I1.0350.95
10_F17_T1.0340.95
77_R80_I1.0340.95
50_S53_E1.0280.95
41_H189_G1.0240.95
170_A208_Y1.0180.95
129_Y132_C1.0040.94
175_A183_T0.9860.94
135_E138_K0.9810.94
47_V51_I0.9800.94
102_L140_C0.9760.94
99_L143_T0.9630.93
197_E202_H0.9610.93
92_T129_Y0.9590.93
48_A52_A0.9590.93
167_W211_Y0.9500.93
18_T170_A0.9450.92
83_E202_H0.9240.92
46_E50_S0.9020.91
118_I155_H0.9010.91
8_V30_V0.8930.90
184_L207_G0.8910.90
35_F104_F0.8900.90
139_S142_V0.8900.90
202_H206_K0.8860.90
99_L106_S0.8850.90
10_F52_A0.8820.90
115_R150_K0.8820.90
60_H108_L0.8790.89
102_L119_T0.8780.89
100_V104_F0.8770.89
119_T137_V0.8760.89
54_K181_N0.8700.89
142_V146_L0.8650.89
42_S46_E0.8630.89
126_F133_R0.8590.88
123_E134_D0.8540.88
168_K210_E0.8510.88
185_T200_A0.8510.88
51_I54_K0.8470.88
21_L173_L0.8430.87
76_T80_I0.8380.87
183_T204_R0.8300.87
162_N210_E0.8260.86
140_C144_V0.8180.86
83_E86_D0.8150.86
125_D132_C0.8060.85
34_T41_H0.8000.85
31_E59_N0.7970.84
19_C158_L0.7960.84
50_S54_K0.7950.84
17_T183_T0.7900.84
142_V145_N0.7870.84
184_L188_N0.7870.84
130_P166_T0.7870.84
33_V105_A0.7810.83
47_V50_S0.7650.82
96_G148_M0.7650.82
19_C23_A0.7640.82
5_K113_G0.7640.82
90_P128_G0.7630.82
128_G203_L0.7630.82
73_N76_T0.7610.81
203_L207_G0.7600.81
72_P77_R0.7570.81
137_V159_M0.7550.81
143_T152_F0.7550.81
33_V62_L0.7540.81
115_R155_H0.7520.81
129_Y187_Y0.7470.80
188_N197_E0.7430.80
212_M215_K0.7420.80
67_L71_A0.7380.79
27_F116_H0.7360.79
164_A168_K0.7350.79
142_V153_V0.7320.79
10_F20_L0.7270.78
84_V202_H0.7250.78
43_Q190_I0.7220.78
158_L169_L0.7210.78
31_E58_K0.7180.78
95_P150_K0.7170.77
6_A118_I0.7150.77
167_W208_Y0.7130.77
23_A118_I0.7120.77
117_I154_I0.7110.77
136_F140_C0.7070.76
143_T146_L0.7060.76
18_T173_L0.7050.76
205_S214_M0.7050.76
132_C187_Y0.7000.76
34_T48_A0.6990.76
99_L103_S0.6930.75
6_A28_E0.6880.75
8_V20_L0.6870.74
45_V61_L0.6850.74
62_L104_F0.6820.74
115_R152_F0.6790.74
102_L137_V0.6770.73
139_S146_L0.6750.73
168_K211_Y0.6700.73
127_S149_E0.6700.73
125_D133_R0.6700.73
121_V156_T0.6680.72
74_A92_T0.6670.72
40_R82_I0.6660.72
138_K141_N0.6650.72
82_I91_S0.6540.71
27_F155_H0.6540.71
36_H45_V0.6520.71
119_T156_T0.6460.70
84_V87_G0.6430.69
92_T132_C0.6420.69
184_L192_A0.6400.69
43_Q192_A0.6360.69
168_K171_D0.6330.68
125_D129_Y0.6280.68
60_H112_I0.6250.67
82_I188_N0.6240.67
17_T21_L0.6230.67
19_C22_W0.6230.67
35_F64_M0.6230.67
35_F61_L0.6210.67
96_G147_A0.6200.67
184_L190_I0.6190.67
113_G116_H0.6120.66
83_E88_E0.6090.65
158_L207_G0.6070.65
144_V154_I0.6070.65
205_S213_V0.6050.65
67_L104_F0.6020.64
70_L107_I0.6010.64
8_V23_A0.6000.64
43_Q46_E0.5990.64
63_D68_N0.5980.64
37_Y97_R0.5900.63
94_V187_Y0.5890.63
161_L165_E0.5860.62
181_N212_M0.5850.62
58_K112_I0.5800.62
164_A207_G0.5800.62
45_V49_K0.5770.61
41_H92_T0.5760.61
185_T195_C0.5710.60
183_T208_Y0.5700.60
41_H132_C0.5700.60
85_K88_E0.5670.60
89_L126_F0.5660.60
21_L54_K0.5650.60
31_E60_H0.5640.59
11_S16_S0.5640.59
18_T65_S0.5620.59
47_V184_L0.5580.59
141_N151_P0.5580.59
8_V19_C0.5580.59
20_L57_V0.5560.58
102_L154_I0.5560.58
187_Y200_A0.5550.58
7_I108_L0.5520.58
26_E169_L0.5500.58
106_S136_F0.5490.57
117_I152_F0.5480.57
144_V147_A0.5480.57
142_V151_P0.5470.57
136_F146_L0.5430.57
89_L149_E0.5410.56
28_E116_H0.5410.56
41_H125_D0.5390.56
72_P80_I0.5390.56
92_T187_Y0.5370.56
75_L94_V0.5370.56
19_C120_G0.5340.55
113_G145_N0.5330.55
171_D194_G0.5320.55
72_P111_Q0.5310.55
24_L57_V0.5310.55
74_A80_I0.5310.55
43_Q188_N0.5310.55
67_L70_L0.5290.55
13_G16_S0.5250.54
174_G181_N0.5240.54
19_C28_E0.5230.54
89_L93_F0.5220.54
94_V132_C0.5180.53
93_F128_G0.5160.53
208_Y213_V0.5160.53
68_N71_A0.5150.53
18_T167_W0.5140.53
102_L121_V0.5130.52
90_P127_S0.5110.52
59_N108_L0.5100.52
19_C67_L0.5100.52
204_R208_Y0.5100.52
115_R153_V0.5090.52
58_K168_K0.5090.52
60_H67_L0.5080.52
211_Y215_K0.5080.52
135_E146_L0.5070.52
120_G200_A0.5070.52
9_V35_F0.5050.51
41_H48_A0.5020.51
10_F51_I0.5010.51
102_L143_T0.5000.51
196_G201_C0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pg3A 2 0.9543 100 0.4 Contact Map
3bl5A 3 0.8767 100 0.509 Contact Map
1vl2A 4 0.8904 99.9 0.682 Contact Map
4xfjA 4 0.895 99.9 0.684 Contact Map
1k92A 4 0.9269 99.9 0.688 Contact Map
3k32A 2 0.8265 99.9 0.695 Contact Map
1korA 4 0.863 99.9 0.705 Contact Map
3rjzA 2 0.726 99.9 0.706 Contact Map
4nzpA 4 0.8447 99.9 0.707 Contact Map
2hmaA 2 0.9178 99.9 0.708 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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