YKVI - BACSU - GREMLIN Contacts

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YKVI - Uncharacterized membrane protein YkvI

UniProt:	O31674	Sequences: MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFGILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVMLSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVADSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGALIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSVIGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIGALLCKKAPRRRSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	347 (336)
Sequences:	892 (730)
Seq/√Len:	39.8

BACSU - YKVI YYAD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
132_V	273_F	8.028	1.00
16_V	224_M	5.712	1.00
101_V	317_L	5.338	1.00
41_G	233_F	4.759	1.00
35_L	233_F	4.509	1.00
65_R	211_E	4.107	1.00
246_D	315_G	4.024	1.00
28_R	32_E	3.893	1.00
88_N	286_Q	3.857	1.00
41_G	44_G	3.764	1.00
80_G	84_G	3.639	1.00
49_G	226_T	3.525	1.00
117_S	120_I	3.383	1.00
15_Y	56_G	3.336	1.00
218_A	222_G	3.217	1.00
104_S	313_G	2.926	1.00
12_A	220_I	2.665	1.00
304_I	308_I	2.628	1.00
217_G	221_G	2.381	1.00
192_L	196_L	2.358	1.00
193_N	225_L	2.317	1.00
17_G	22_A	2.296	1.00
42_F	233_F	2.280	1.00
96_L	100_S	2.265	1.00
53_T	222_G	2.224	1.00
8_A	216_K	2.205	0.99
40_F	43_F	2.053	0.99
203_P	271_E	2.014	0.99
15_Y	221_G	1.931	0.99
28_R	31_V	1.902	0.98
130_L	303_M	1.895	0.98
55_L	333_I	1.864	0.98
117_S	138_K	1.851	0.98
26_T	76_I	1.843	0.98
310_S	313_G	1.803	0.98
92_L	287_V	1.776	0.98
154_F	267_I	1.743	0.97
81_A	85_R	1.737	0.97
52_F	193_N	1.697	0.97
108_A	246_D	1.666	0.96
8_A	220_I	1.660	0.96
83_A	86_I	1.651	0.96
216_K	220_I	1.627	0.96
257_A	260_V	1.619	0.96
17_G	148_V	1.612	0.96
26_T	226_T	1.612	0.96
160_A	164_I	1.595	0.95
232_S	253_V	1.588	0.95
165_F	168_S	1.582	0.95
57_A	218_A	1.564	0.95
267_I	294_K	1.563	0.95
127_G	334_G	1.543	0.94
235_S	252_V	1.526	0.94
81_A	320_T	1.522	0.94
7_S	10_Q	1.520	0.94
200_V	203_P	1.519	0.94
57_A	215_K	1.515	0.94
44_G	182_W	1.488	0.93
15_Y	19_V	1.480	0.93
33_F	79_F	1.462	0.93
148_V	271_E	1.456	0.92
56_G	221_G	1.449	0.92
99_T	280_L	1.432	0.92
148_V	274_T	1.420	0.91
96_L	306_A	1.400	0.91
307_Y	311_Q	1.383	0.90
19_V	225_L	1.381	0.90
157_I	263_I	1.376	0.90
127_G	131_I	1.367	0.90
70_S	73_E	1.366	0.90
51_M	190_G	1.365	0.90
22_A	149_P	1.363	0.90
14_V	135_R	1.354	0.89
129_S	276_V	1.340	0.89
20_V	271_E	1.338	0.89
102_M	272_V	1.336	0.89
126_I	303_M	1.335	0.89
54_L	340_K	1.333	0.89
76_I	85_R	1.322	0.88
144_N	271_E	1.317	0.88
210_S	213_V	1.305	0.87
249_M	264_Y	1.300	0.87
271_E	274_T	1.298	0.87
262_L	304_I	1.295	0.87
26_T	247_I	1.294	0.87
36_K	177_P	1.293	0.87
215_K	219_L	1.293	0.87
28_R	105_G	1.286	0.87
107_G	121_G	1.281	0.86
109_L	265_L	1.275	0.86
131_I	220_I	1.273	0.86
98_V	106_A	1.272	0.86
89_V	223_T	1.271	0.86
192_L	281_Y	1.268	0.86
88_N	148_V	1.261	0.86
226_T	318_I	1.259	0.85
94_V	192_L	1.250	0.85
17_G	37_F	1.231	0.84
13_F	18_T	1.230	0.84
149_P	314_Y	1.224	0.84
104_S	150_L	1.222	0.84
11_L	158_V	1.221	0.84
224_M	228_V	1.219	0.84
75_N	151_L	1.216	0.83
30_I	233_F	1.215	0.83
116_M	124_I	1.205	0.83
18_T	271_E	1.201	0.83
245_Y	251_Q	1.199	0.83
106_A	269_F	1.194	0.82
25_A	277_I	1.187	0.82
158_V	163_F	1.179	0.81
56_G	222_G	1.178	0.81
14_V	145_V	1.175	0.81
227_I	255_L	1.173	0.81
55_L	190_G	1.168	0.81
186_A	190_G	1.168	0.81
182_W	329_S	1.164	0.81
185_S	299_F	1.161	0.80
13_F	281_Y	1.160	0.80
270_G	300_A	1.159	0.80
52_F	190_G	1.158	0.80
106_A	264_Y	1.153	0.80
229_L	268_I	1.145	0.79
283_L	302_I	1.143	0.79
157_I	220_I	1.139	0.79
76_I	187_V	1.132	0.79
26_T	228_V	1.131	0.79
43_F	47_V	1.122	0.78
110_F	124_I	1.116	0.78
19_V	193_N	1.110	0.77
159_V	235_S	1.109	0.77
9_S	50_G	1.102	0.77
191_A	330_L	1.094	0.76
158_V	324_L	1.093	0.76
27_G	34_F	1.092	0.76
104_S	302_I	1.090	0.76
294_K	297_Y	1.082	0.75
105_G	149_P	1.079	0.75
104_S	112_E	1.074	0.75
102_M	149_P	1.065	0.74
52_F	225_L	1.059	0.74
45_I	229_L	1.059	0.74
158_V	253_V	1.058	0.74
93_F	292_P	1.056	0.74
127_G	169_R	1.052	0.73
68_A	278_G	1.046	0.73
12_A	221_G	1.043	0.73
33_F	325_F	1.039	0.72
156_M	163_F	1.033	0.72
17_G	249_M	1.031	0.72
17_G	228_V	1.030	0.72
169_R	173_Q	1.030	0.72
63_S	68_A	1.029	0.72
61_I	64_K	1.028	0.72
18_T	144_N	1.025	0.71
33_F	323_P	1.025	0.71
93_F	170_N	1.010	0.70
47_V	112_E	1.008	0.70
143_V	294_K	1.006	0.70
130_L	134_T	1.001	0.70
50_G	59_L	0.986	0.68
151_L	182_W	0.978	0.68
148_V	281_Y	0.978	0.68
270_G	274_T	0.975	0.68
259_S	266_L	0.974	0.67
22_A	148_V	0.973	0.67
149_P	323_P	0.970	0.67
29_E	102_M	0.967	0.67
172_A	240_P	0.961	0.66
284_E	295_S	0.959	0.66
17_G	144_N	0.959	0.66
196_L	283_L	0.958	0.66
52_F	235_S	0.950	0.66
61_I	215_K	0.945	0.65
14_V	18_T	0.938	0.65
50_G	89_V	0.937	0.64
133_M	299_F	0.935	0.64
63_S	205_A	0.928	0.64
28_R	314_Y	0.928	0.64
288_Q	298_I	0.925	0.63
301_A	305_T	0.923	0.63
71_Y	286_Q	0.923	0.63
111_E	118_A	0.922	0.63
86_I	231_A	0.917	0.63
164_I	304_I	0.914	0.62
24_F	52_F	0.914	0.62
88_N	285_K	0.912	0.62
145_V	237_S	0.911	0.62
29_E	193_N	0.899	0.61
77_F	339_K	0.895	0.61
79_F	192_L	0.894	0.61
56_G	197_A	0.888	0.60
102_M	276_V	0.887	0.60
149_P	273_F	0.887	0.60
93_F	334_G	0.882	0.60
119_Q	311_Q	0.881	0.60
25_A	275_S	0.880	0.60
45_I	53_T	0.880	0.60
74_M	280_L	0.875	0.59
171_A	183_L	0.874	0.59
263_I	293_V	0.874	0.59
288_Q	294_K	0.872	0.59
53_T	191_A	0.870	0.59
102_M	222_G	0.870	0.59
314_Y	323_P	0.869	0.59
102_M	314_Y	0.854	0.57
160_A	231_A	0.850	0.57
133_M	277_I	0.849	0.57
150_L	304_I	0.845	0.56
28_R	315_G	0.845	0.56
151_L	233_F	0.845	0.56
46_L	334_G	0.844	0.56
137_V	202_V	0.842	0.56
17_G	271_E	0.840	0.56
287_V	298_I	0.837	0.56
268_I	276_V	0.836	0.56
63_S	74_M	0.835	0.55
316_R	320_T	0.834	0.55
24_F	228_V	0.831	0.55
222_G	323_P	0.825	0.55
157_I	243_F	0.823	0.54
188_S	197_A	0.823	0.54
24_F	229_L	0.820	0.54
148_V	200_V	0.816	0.54
268_I	309_T	0.814	0.54
46_L	50_G	0.812	0.53
165_F	330_L	0.809	0.53
195_S	332_F	0.808	0.53
187_V	247_I	0.806	0.53
140_I	143_V	0.805	0.53
15_Y	125_T	0.803	0.53
274_T	280_L	0.802	0.52
35_L	98_V	0.802	0.52
254_Y	261_H	0.801	0.52
143_V	299_F	0.799	0.52
143_V	146_F	0.799	0.52
236_L	247_I	0.798	0.52
171_A	175_V	0.795	0.52
45_I	60_M	0.795	0.52
15_Y	222_G	0.794	0.52
213_V	216_K	0.794	0.52
47_V	301_A	0.793	0.52
263_I	320_T	0.789	0.51
35_L	42_F	0.788	0.51
271_E	279_N	0.785	0.51
8_A	242_V	0.783	0.51
220_I	224_M	0.782	0.51
214_I	218_A	0.781	0.51
17_G	278_G	0.781	0.51
16_V	40_F	0.780	0.50
127_G	171_A	0.777	0.50
228_V	325_F	0.775	0.50
158_V	235_S	0.772	0.50
293_V	296_K	0.768	0.49
68_A	228_V	0.767	0.49
326_G	329_S	0.765	0.49
205_A	275_S	0.765	0.49
30_I	35_L	0.762	0.49
94_V	195_S	0.760	0.49
259_S	324_L	0.758	0.48
95_L	125_T	0.757	0.48
144_N	279_N	0.757	0.48
274_T	324_L	0.754	0.48
131_I	164_I	0.753	0.48
280_L	306_A	0.753	0.48
300_A	341_A	0.751	0.48
140_I	201_L	0.750	0.48
107_G	218_A	0.749	0.48
253_V	314_Y	0.749	0.48
212_K	220_I	0.747	0.47
223_T	300_A	0.746	0.47
192_L	232_S	0.745	0.47
35_L	151_L	0.744	0.47
206_N	218_A	0.738	0.47
101_V	269_F	0.737	0.47
186_A	260_V	0.735	0.46
269_F	318_I	0.735	0.46
330_L	334_G	0.732	0.46
47_V	208_M	0.731	0.46
64_K	210_S	0.729	0.46
139_G	225_L	0.727	0.46
100_S	126_I	0.724	0.45
71_Y	144_N	0.723	0.45
232_S	249_M	0.722	0.45
199_A	309_T	0.722	0.45
21_G	27_G	0.721	0.45
9_S	334_G	0.720	0.45
140_I	284_E	0.719	0.45
276_V	286_Q	0.719	0.45
130_L	300_A	0.718	0.45
133_M	154_F	0.715	0.45
84_G	277_I	0.713	0.44
115_G	247_I	0.712	0.44
88_N	275_S	0.712	0.44
101_V	318_I	0.711	0.44
108_A	223_T	0.710	0.44
104_S	243_F	0.709	0.44
134_T	296_K	0.707	0.44
188_S	247_I	0.707	0.44
184_L	327_Y	0.706	0.44
200_V	279_N	0.703	0.43
205_A	235_S	0.702	0.43
15_Y	34_F	0.701	0.43
24_F	189_Y	0.701	0.43
143_V	262_L	0.698	0.43
20_V	25_A	0.697	0.43
33_F	188_S	0.695	0.43
149_P	326_G	0.695	0.43
142_G	296_K	0.692	0.42
17_G	281_Y	0.690	0.42
46_L	89_V	0.690	0.42
156_M	231_A	0.690	0.42
323_P	326_G	0.689	0.42
188_S	253_V	0.688	0.42
98_V	268_I	0.687	0.42
171_A	252_V	0.687	0.42
22_A	314_Y	0.687	0.42
139_G	149_P	0.685	0.42
203_P	214_I	0.681	0.42
269_F	283_L	0.680	0.41
272_V	336_L	0.679	0.41
122_M	126_I	0.675	0.41
46_L	156_M	0.675	0.41
126_I	215_K	0.673	0.41
118_A	313_G	0.672	0.41
89_V	263_I	0.672	0.41
135_R	139_G	0.672	0.41
44_G	333_I	0.672	0.41
37_F	46_L	0.671	0.41
10_Q	151_L	0.669	0.40
7_S	90_F	0.665	0.40
93_F	180_W	0.663	0.40
22_A	323_P	0.662	0.40
54_L	183_L	0.660	0.40
160_A	331_A	0.658	0.39
219_L	254_Y	0.658	0.39
56_G	217_G	0.657	0.39
163_F	337_L	0.656	0.39
95_L	246_D	0.656	0.39
11_L	226_T	0.656	0.39
190_G	193_N	0.649	0.39
125_T	269_F	0.648	0.39
145_V	261_H	0.648	0.39
99_T	279_N	0.644	0.38
14_V	261_H	0.643	0.38
59_L	336_L	0.638	0.38
188_S	191_A	0.637	0.38
187_V	191_A	0.636	0.38
225_L	268_I	0.633	0.37
13_F	282_G	0.633	0.37
247_I	274_T	0.630	0.37
71_Y	325_F	0.630	0.37
216_K	301_A	0.630	0.37
127_G	305_T	0.629	0.37
52_F	268_I	0.628	0.37
246_D	323_P	0.628	0.37
18_T	25_A	0.627	0.37
8_A	229_L	0.626	0.37
108_A	208_M	0.625	0.37
50_G	127_G	0.624	0.37
71_Y	88_N	0.624	0.37
90_F	328_V	0.623	0.36
46_L	187_V	0.620	0.36
12_A	40_F	0.620	0.36
30_I	229_L	0.619	0.36
19_V	142_G	0.618	0.36
212_K	227_I	0.618	0.36
8_A	296_K	0.617	0.36
111_E	124_I	0.614	0.36
281_Y	329_S	0.613	0.36
191_A	236_L	0.611	0.35
48_S	223_T	0.611	0.35
8_A	67_N	0.608	0.35
202_V	271_E	0.607	0.35
26_T	339_K	0.606	0.35
141_F	152_I	0.606	0.35
48_S	182_W	0.606	0.35
104_S	228_V	0.604	0.35
12_A	44_G	0.603	0.35
58_K	202_V	0.602	0.35
145_V	200_V	0.601	0.35
317_L	323_P	0.601	0.35
96_L	307_Y	0.601	0.35
53_T	300_A	0.600	0.35
106_A	110_F	0.600	0.35
65_R	157_I	0.598	0.34
89_V	93_F	0.597	0.34
66_I	97_G	0.597	0.34
8_A	156_M	0.596	0.34
110_F	249_M	0.596	0.34
151_L	228_V	0.596	0.34
111_E	115_G	0.596	0.34
29_E	225_L	0.595	0.34
69_K	320_T	0.594	0.34
15_Y	102_M	0.594	0.34
82_T	85_R	0.592	0.34
55_L	59_L	0.592	0.34
43_F	301_A	0.590	0.34
117_S	163_F	0.589	0.34
40_F	223_T	0.588	0.34
20_V	29_E	0.586	0.33
67_N	212_K	0.585	0.33
132_V	231_A	0.584	0.33
182_W	186_A	0.582	0.33
87_I	109_L	0.582	0.33
59_L	163_F	0.582	0.33
52_F	185_S	0.582	0.33
23_G	317_L	0.580	0.33
19_V	229_L	0.580	0.33
166_S	244_L	0.580	0.33
47_V	156_M	0.580	0.33
171_A	297_Y	0.579	0.33
14_V	137_V	0.579	0.33
111_E	257_A	0.578	0.33
37_F	178_H	0.578	0.33
12_A	187_V	0.577	0.33
55_L	194_L	0.576	0.33
28_R	253_V	0.576	0.33
123_L	259_S	0.575	0.32
70_S	271_E	0.575	0.32
205_A	314_Y	0.575	0.32
72_Q	192_L	0.573	0.32
74_M	265_L	0.573	0.32
90_F	171_A	0.573	0.32
106_A	192_L	0.572	0.32
199_A	274_T	0.572	0.32
137_V	193_N	0.571	0.32
175_V	186_A	0.571	0.32
98_V	192_L	0.569	0.32
191_A	247_I	0.568	0.32
221_G	240_P	0.568	0.32
192_L	330_L	0.568	0.32
156_M	160_A	0.567	0.32
171_A	241_D	0.566	0.32
157_I	174_W	0.564	0.32
137_V	183_L	0.562	0.31
171_A	312_I	0.562	0.31
262_L	266_L	0.560	0.31
103_L	129_S	0.560	0.31
234_L	237_S	0.559	0.31
147_V	270_G	0.557	0.31
69_K	312_I	0.557	0.31
42_F	240_P	0.556	0.31
74_M	86_I	0.556	0.31
103_L	126_I	0.556	0.31
165_F	187_V	0.556	0.31
297_Y	301_A	0.555	0.31
209_S	266_L	0.554	0.31
109_L	240_P	0.553	0.31
64_K	130_L	0.551	0.31
157_I	312_I	0.551	0.31
151_L	277_I	0.551	0.31
234_L	289_S	0.550	0.31
156_M	162_S	0.550	0.31
18_T	71_Y	0.549	0.30
39_W	309_T	0.549	0.30
301_A	304_I	0.548	0.30
300_A	324_L	0.547	0.30
43_F	304_I	0.545	0.30
16_V	270_G	0.544	0.30
62_I	78_L	0.543	0.30
131_I	234_L	0.543	0.30
220_I	284_E	0.542	0.30
86_I	164_I	0.539	0.30
84_G	198_Q	0.539	0.30
18_T	282_G	0.538	0.30
41_G	182_W	0.537	0.30
42_F	234_L	0.536	0.29
137_V	264_Y	0.535	0.29
24_F	48_S	0.533	0.29
169_R	304_I	0.528	0.29
127_G	338_C	0.526	0.29
52_F	226_T	0.524	0.29
61_I	65_R	0.523	0.28
30_I	328_V	0.523	0.28
87_I	91_M	0.522	0.28
317_L	322_Y	0.522	0.28
139_G	203_P	0.522	0.28
26_T	57_A	0.522	0.28
71_Y	200_V	0.521	0.28
21_G	25_A	0.521	0.28
35_L	133_M	0.519	0.28
18_T	278_G	0.519	0.28
165_F	223_T	0.518	0.28
173_Q	304_I	0.518	0.28
25_A	193_N	0.518	0.28
88_N	314_Y	0.517	0.28
123_L	311_Q	0.516	0.28
113_Q	272_V	0.513	0.28
30_I	193_N	0.512	0.28
123_L	307_Y	0.512	0.28
79_F	82_T	0.511	0.28
145_V	292_P	0.510	0.28
35_L	299_F	0.510	0.28
103_L	311_Q	0.510	0.28
144_N	200_V	0.510	0.28
182_W	217_G	0.508	0.27
25_A	271_E	0.508	0.27
82_T	86_I	0.506	0.27
115_G	327_Y	0.504	0.27
320_T	336_L	0.503	0.27
127_G	297_Y	0.503	0.27
47_V	312_I	0.502	0.27
62_I	66_I	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3dh4A	3	0.9539	99.9	0.75	Contact Map
2xq2A	2	0.928	99.9	0.763	Contact Map
3l1lA	2	0.9452	99.8	0.791	Contact Map
3giaA	1	0.9741	99.6	0.812	Contact Map
4djkA	2	0.9193	99.3	0.849	Contact Map
2jlnA	1	0.9769	99	0.866	Contact Map
4wgvA	2	0.9308	98.5	0.886	Contact Map
2a65A	2	0.9798	98.4	0.89	Contact Map
4us3A	1	0.9741	98.4	0.891	Contact Map
4xp4A	1	0.9712	95.5	0.93	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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