GREMLIN Database
YKVI - Uncharacterized membrane protein YkvI
UniProt: O31674 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (336)
Sequences: 892 (730)
Seq/√Len: 39.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_V273_F8.0281.00
16_V224_M5.7121.00
101_V317_L5.3381.00
41_G233_F4.7591.00
35_L233_F4.5091.00
65_R211_E4.1071.00
246_D315_G4.0241.00
28_R32_E3.8931.00
88_N286_Q3.8571.00
41_G44_G3.7641.00
80_G84_G3.6391.00
49_G226_T3.5251.00
117_S120_I3.3831.00
15_Y56_G3.3361.00
218_A222_G3.2171.00
104_S313_G2.9261.00
12_A220_I2.6651.00
304_I308_I2.6281.00
217_G221_G2.3811.00
192_L196_L2.3581.00
193_N225_L2.3171.00
17_G22_A2.2961.00
42_F233_F2.2801.00
96_L100_S2.2651.00
53_T222_G2.2241.00
8_A216_K2.2050.99
40_F43_F2.0530.99
203_P271_E2.0140.99
15_Y221_G1.9310.99
28_R31_V1.9020.98
130_L303_M1.8950.98
55_L333_I1.8640.98
117_S138_K1.8510.98
26_T76_I1.8430.98
310_S313_G1.8030.98
92_L287_V1.7760.98
154_F267_I1.7430.97
81_A85_R1.7370.97
52_F193_N1.6970.97
108_A246_D1.6660.96
8_A220_I1.6600.96
83_A86_I1.6510.96
216_K220_I1.6270.96
257_A260_V1.6190.96
17_G148_V1.6120.96
26_T226_T1.6120.96
160_A164_I1.5950.95
232_S253_V1.5880.95
165_F168_S1.5820.95
57_A218_A1.5640.95
267_I294_K1.5630.95
127_G334_G1.5430.94
235_S252_V1.5260.94
81_A320_T1.5220.94
7_S10_Q1.5200.94
200_V203_P1.5190.94
57_A215_K1.5150.94
44_G182_W1.4880.93
15_Y19_V1.4800.93
33_F79_F1.4620.93
148_V271_E1.4560.92
56_G221_G1.4490.92
99_T280_L1.4320.92
148_V274_T1.4200.91
96_L306_A1.4000.91
307_Y311_Q1.3830.90
19_V225_L1.3810.90
157_I263_I1.3760.90
127_G131_I1.3670.90
70_S73_E1.3660.90
51_M190_G1.3650.90
22_A149_P1.3630.90
14_V135_R1.3540.89
129_S276_V1.3400.89
20_V271_E1.3380.89
102_M272_V1.3360.89
126_I303_M1.3350.89
54_L340_K1.3330.89
76_I85_R1.3220.88
144_N271_E1.3170.88
210_S213_V1.3050.87
249_M264_Y1.3000.87
271_E274_T1.2980.87
262_L304_I1.2950.87
26_T247_I1.2940.87
36_K177_P1.2930.87
215_K219_L1.2930.87
28_R105_G1.2860.87
107_G121_G1.2810.86
109_L265_L1.2750.86
131_I220_I1.2730.86
98_V106_A1.2720.86
89_V223_T1.2710.86
192_L281_Y1.2680.86
88_N148_V1.2610.86
226_T318_I1.2590.85
94_V192_L1.2500.85
17_G37_F1.2310.84
13_F18_T1.2300.84
149_P314_Y1.2240.84
104_S150_L1.2220.84
11_L158_V1.2210.84
224_M228_V1.2190.84
75_N151_L1.2160.83
30_I233_F1.2150.83
116_M124_I1.2050.83
18_T271_E1.2010.83
245_Y251_Q1.1990.83
106_A269_F1.1940.82
25_A277_I1.1870.82
158_V163_F1.1790.81
56_G222_G1.1780.81
14_V145_V1.1750.81
227_I255_L1.1730.81
55_L190_G1.1680.81
186_A190_G1.1680.81
182_W329_S1.1640.81
185_S299_F1.1610.80
13_F281_Y1.1600.80
270_G300_A1.1590.80
52_F190_G1.1580.80
106_A264_Y1.1530.80
229_L268_I1.1450.79
283_L302_I1.1430.79
157_I220_I1.1390.79
76_I187_V1.1320.79
26_T228_V1.1310.79
43_F47_V1.1220.78
110_F124_I1.1160.78
19_V193_N1.1100.77
159_V235_S1.1090.77
9_S50_G1.1020.77
191_A330_L1.0940.76
158_V324_L1.0930.76
27_G34_F1.0920.76
104_S302_I1.0900.76
294_K297_Y1.0820.75
105_G149_P1.0790.75
104_S112_E1.0740.75
102_M149_P1.0650.74
52_F225_L1.0590.74
45_I229_L1.0590.74
158_V253_V1.0580.74
93_F292_P1.0560.74
127_G169_R1.0520.73
68_A278_G1.0460.73
12_A221_G1.0430.73
33_F325_F1.0390.72
156_M163_F1.0330.72
17_G249_M1.0310.72
17_G228_V1.0300.72
169_R173_Q1.0300.72
63_S68_A1.0290.72
61_I64_K1.0280.72
18_T144_N1.0250.71
33_F323_P1.0250.71
93_F170_N1.0100.70
47_V112_E1.0080.70
143_V294_K1.0060.70
130_L134_T1.0010.70
50_G59_L0.9860.68
151_L182_W0.9780.68
148_V281_Y0.9780.68
270_G274_T0.9750.68
259_S266_L0.9740.67
22_A148_V0.9730.67
149_P323_P0.9700.67
29_E102_M0.9670.67
172_A240_P0.9610.66
284_E295_S0.9590.66
17_G144_N0.9590.66
196_L283_L0.9580.66
52_F235_S0.9500.66
61_I215_K0.9450.65
14_V18_T0.9380.65
50_G89_V0.9370.64
133_M299_F0.9350.64
63_S205_A0.9280.64
28_R314_Y0.9280.64
288_Q298_I0.9250.63
301_A305_T0.9230.63
71_Y286_Q0.9230.63
111_E118_A0.9220.63
86_I231_A0.9170.63
164_I304_I0.9140.62
24_F52_F0.9140.62
88_N285_K0.9120.62
145_V237_S0.9110.62
29_E193_N0.8990.61
77_F339_K0.8950.61
79_F192_L0.8940.61
56_G197_A0.8880.60
102_M276_V0.8870.60
149_P273_F0.8870.60
93_F334_G0.8820.60
119_Q311_Q0.8810.60
25_A275_S0.8800.60
45_I53_T0.8800.60
74_M280_L0.8750.59
171_A183_L0.8740.59
263_I293_V0.8740.59
288_Q294_K0.8720.59
53_T191_A0.8700.59
102_M222_G0.8700.59
314_Y323_P0.8690.59
102_M314_Y0.8540.57
160_A231_A0.8500.57
133_M277_I0.8490.57
150_L304_I0.8450.56
28_R315_G0.8450.56
151_L233_F0.8450.56
46_L334_G0.8440.56
137_V202_V0.8420.56
17_G271_E0.8400.56
287_V298_I0.8370.56
268_I276_V0.8360.56
63_S74_M0.8350.55
316_R320_T0.8340.55
24_F228_V0.8310.55
222_G323_P0.8250.55
157_I243_F0.8230.54
188_S197_A0.8230.54
24_F229_L0.8200.54
148_V200_V0.8160.54
268_I309_T0.8140.54
46_L50_G0.8120.53
165_F330_L0.8090.53
195_S332_F0.8080.53
187_V247_I0.8060.53
140_I143_V0.8050.53
15_Y125_T0.8030.53
274_T280_L0.8020.52
35_L98_V0.8020.52
254_Y261_H0.8010.52
143_V299_F0.7990.52
143_V146_F0.7990.52
236_L247_I0.7980.52
171_A175_V0.7950.52
45_I60_M0.7950.52
15_Y222_G0.7940.52
213_V216_K0.7940.52
47_V301_A0.7930.52
263_I320_T0.7890.51
35_L42_F0.7880.51
271_E279_N0.7850.51
8_A242_V0.7830.51
220_I224_M0.7820.51
214_I218_A0.7810.51
17_G278_G0.7810.51
16_V40_F0.7800.50
127_G171_A0.7770.50
228_V325_F0.7750.50
158_V235_S0.7720.50
293_V296_K0.7680.49
68_A228_V0.7670.49
326_G329_S0.7650.49
205_A275_S0.7650.49
30_I35_L0.7620.49
94_V195_S0.7600.49
259_S324_L0.7580.48
95_L125_T0.7570.48
144_N279_N0.7570.48
274_T324_L0.7540.48
131_I164_I0.7530.48
280_L306_A0.7530.48
300_A341_A0.7510.48
140_I201_L0.7500.48
107_G218_A0.7490.48
253_V314_Y0.7490.48
212_K220_I0.7470.47
223_T300_A0.7460.47
192_L232_S0.7450.47
35_L151_L0.7440.47
206_N218_A0.7380.47
101_V269_F0.7370.47
186_A260_V0.7350.46
269_F318_I0.7350.46
330_L334_G0.7320.46
47_V208_M0.7310.46
64_K210_S0.7290.46
139_G225_L0.7270.46
100_S126_I0.7240.45
71_Y144_N0.7230.45
232_S249_M0.7220.45
199_A309_T0.7220.45
21_G27_G0.7210.45
9_S334_G0.7200.45
140_I284_E0.7190.45
276_V286_Q0.7190.45
130_L300_A0.7180.45
133_M154_F0.7150.45
84_G277_I0.7130.44
115_G247_I0.7120.44
88_N275_S0.7120.44
101_V318_I0.7110.44
108_A223_T0.7100.44
104_S243_F0.7090.44
134_T296_K0.7070.44
188_S247_I0.7070.44
184_L327_Y0.7060.44
200_V279_N0.7030.43
205_A235_S0.7020.43
15_Y34_F0.7010.43
24_F189_Y0.7010.43
143_V262_L0.6980.43
20_V25_A0.6970.43
33_F188_S0.6950.43
149_P326_G0.6950.43
142_G296_K0.6920.42
17_G281_Y0.6900.42
46_L89_V0.6900.42
156_M231_A0.6900.42
323_P326_G0.6890.42
188_S253_V0.6880.42
98_V268_I0.6870.42
171_A252_V0.6870.42
22_A314_Y0.6870.42
139_G149_P0.6850.42
203_P214_I0.6810.42
269_F283_L0.6800.41
272_V336_L0.6790.41
122_M126_I0.6750.41
46_L156_M0.6750.41
126_I215_K0.6730.41
118_A313_G0.6720.41
89_V263_I0.6720.41
135_R139_G0.6720.41
44_G333_I0.6720.41
37_F46_L0.6710.41
10_Q151_L0.6690.40
7_S90_F0.6650.40
93_F180_W0.6630.40
22_A323_P0.6620.40
54_L183_L0.6600.40
160_A331_A0.6580.39
219_L254_Y0.6580.39
56_G217_G0.6570.39
163_F337_L0.6560.39
95_L246_D0.6560.39
11_L226_T0.6560.39
190_G193_N0.6490.39
125_T269_F0.6480.39
145_V261_H0.6480.39
99_T279_N0.6440.38
14_V261_H0.6430.38
59_L336_L0.6380.38
188_S191_A0.6370.38
187_V191_A0.6360.38
225_L268_I0.6330.37
13_F282_G0.6330.37
247_I274_T0.6300.37
71_Y325_F0.6300.37
216_K301_A0.6300.37
127_G305_T0.6290.37
52_F268_I0.6280.37
246_D323_P0.6280.37
18_T25_A0.6270.37
8_A229_L0.6260.37
108_A208_M0.6250.37
50_G127_G0.6240.37
71_Y88_N0.6240.37
90_F328_V0.6230.36
46_L187_V0.6200.36
12_A40_F0.6200.36
30_I229_L0.6190.36
19_V142_G0.6180.36
212_K227_I0.6180.36
8_A296_K0.6170.36
111_E124_I0.6140.36
281_Y329_S0.6130.36
191_A236_L0.6110.35
48_S223_T0.6110.35
8_A67_N0.6080.35
202_V271_E0.6070.35
26_T339_K0.6060.35
141_F152_I0.6060.35
48_S182_W0.6060.35
104_S228_V0.6040.35
12_A44_G0.6030.35
58_K202_V0.6020.35
145_V200_V0.6010.35
317_L323_P0.6010.35
96_L307_Y0.6010.35
53_T300_A0.6000.35
106_A110_F0.6000.35
65_R157_I0.5980.34
89_V93_F0.5970.34
66_I97_G0.5970.34
8_A156_M0.5960.34
110_F249_M0.5960.34
151_L228_V0.5960.34
111_E115_G0.5960.34
29_E225_L0.5950.34
69_K320_T0.5940.34
15_Y102_M0.5940.34
82_T85_R0.5920.34
55_L59_L0.5920.34
43_F301_A0.5900.34
117_S163_F0.5890.34
40_F223_T0.5880.34
20_V29_E0.5860.33
67_N212_K0.5850.33
132_V231_A0.5840.33
182_W186_A0.5820.33
87_I109_L0.5820.33
59_L163_F0.5820.33
52_F185_S0.5820.33
23_G317_L0.5800.33
19_V229_L0.5800.33
166_S244_L0.5800.33
47_V156_M0.5800.33
171_A297_Y0.5790.33
14_V137_V0.5790.33
111_E257_A0.5780.33
37_F178_H0.5780.33
12_A187_V0.5770.33
55_L194_L0.5760.33
28_R253_V0.5760.33
123_L259_S0.5750.32
70_S271_E0.5750.32
205_A314_Y0.5750.32
72_Q192_L0.5730.32
74_M265_L0.5730.32
90_F171_A0.5730.32
106_A192_L0.5720.32
199_A274_T0.5720.32
137_V193_N0.5710.32
175_V186_A0.5710.32
98_V192_L0.5690.32
191_A247_I0.5680.32
221_G240_P0.5680.32
192_L330_L0.5680.32
156_M160_A0.5670.32
171_A241_D0.5660.32
157_I174_W0.5640.32
137_V183_L0.5620.31
171_A312_I0.5620.31
262_L266_L0.5600.31
103_L129_S0.5600.31
234_L237_S0.5590.31
147_V270_G0.5570.31
69_K312_I0.5570.31
42_F240_P0.5560.31
74_M86_I0.5560.31
103_L126_I0.5560.31
165_F187_V0.5560.31
297_Y301_A0.5550.31
209_S266_L0.5540.31
109_L240_P0.5530.31
64_K130_L0.5510.31
157_I312_I0.5510.31
151_L277_I0.5510.31
234_L289_S0.5500.31
156_M162_S0.5500.31
18_T71_Y0.5490.30
39_W309_T0.5490.30
301_A304_I0.5480.30
300_A324_L0.5470.30
43_F304_I0.5450.30
16_V270_G0.5440.30
62_I78_L0.5430.30
131_I234_L0.5430.30
220_I284_E0.5420.30
86_I164_I0.5390.30
84_G198_Q0.5390.30
18_T282_G0.5380.30
41_G182_W0.5370.30
42_F234_L0.5360.29
137_V264_Y0.5350.29
24_F48_S0.5330.29
169_R304_I0.5280.29
127_G338_C0.5260.29
52_F226_T0.5240.29
61_I65_R0.5230.28
30_I328_V0.5230.28
87_I91_M0.5220.28
317_L322_Y0.5220.28
139_G203_P0.5220.28
26_T57_A0.5220.28
71_Y200_V0.5210.28
21_G25_A0.5210.28
35_L133_M0.5190.28
18_T278_G0.5190.28
165_F223_T0.5180.28
173_Q304_I0.5180.28
25_A193_N0.5180.28
88_N314_Y0.5170.28
123_L311_Q0.5160.28
113_Q272_V0.5130.28
30_I193_N0.5120.28
123_L307_Y0.5120.28
79_F82_T0.5110.28
145_V292_P0.5100.28
35_L299_F0.5100.28
103_L311_Q0.5100.28
144_N200_V0.5100.28
182_W217_G0.5080.27
25_A271_E0.5080.27
82_T86_I0.5060.27
115_G327_Y0.5040.27
320_T336_L0.5030.27
127_G297_Y0.5030.27
47_V312_I0.5020.27
62_I66_I0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dh4A 3 0.9539 99.9 0.75 Contact Map
2xq2A 2 0.928 99.9 0.763 Contact Map
3l1lA 2 0.9452 99.8 0.791 Contact Map
3giaA 1 0.9741 99.6 0.812 Contact Map
4djkA 2 0.9193 99.3 0.849 Contact Map
2jlnA 1 0.9769 99 0.866 Contact Map
4wgvA 2 0.9308 98.5 0.886 Contact Map
2a65A 2 0.9798 98.4 0.89 Contact Map
4us3A 1 0.9741 98.4 0.891 Contact Map
4xp4A 1 0.9712 95.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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