GREMLIN Database
MHQR - HTH-type transcriptional regulator MhqR
UniProt: O31672 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (131)
Sequences: 23912 (17427)
Seq/√Len: 1522.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_K93_Q3.1491.00
124_E134_R2.9431.00
50_P89_V2.6671.00
83_S91_F2.6451.00
79_I93_Q2.6331.00
48_D93_Q2.4001.00
121_S124_E2.3791.00
127_M131_M2.2811.00
127_M130_E2.2451.00
82_A90_T2.0761.00
44_Y102_L2.0611.00
50_P53_Q2.0171.00
119_V138_N1.8901.00
36_E75_K1.8901.00
120_L131_M1.8591.00
124_E127_M1.8551.00
83_S89_V1.8271.00
44_Y94_I1.7821.00
73_E80_R1.6801.00
97_K101_L1.6321.00
128_C131_M1.5961.00
76_E97_K1.5651.00
36_E71_K1.5561.00
51_L69_V1.5221.00
11_V133_K1.5101.00
124_E130_E1.4861.00
46_K57_K1.4621.00
69_V92_A1.4611.00
39_V68_V1.4551.00
33_N36_E1.4551.00
97_K100_G1.4531.00
101_L104_D1.4491.00
70_D74_Q1.4031.00
42_L57_K1.3721.00
44_Y99_I1.3661.00
131_M134_R1.3291.00
11_V129_T1.3121.00
30_H108_D1.2941.00
53_Q56_D1.2611.00
70_D87_R1.2611.00
11_V136_G1.2451.00
30_H104_D1.2131.00
26_H108_D1.2101.00
80_R90_T1.1951.00
61_A64_S1.1851.00
130_E134_R1.1821.00
39_V65_I1.1781.00
52_Q62_S1.1661.00
15_A136_G1.1631.00
51_L90_T1.1581.00
100_G104_D1.1541.00
52_Q56_D1.1411.00
48_D91_F1.1301.00
124_E131_M1.1111.00
60_L64_S1.1061.00
77_L101_L1.0781.00
125_V129_T1.0741.00
123_E127_M1.0721.00
129_T133_K1.0691.00
24_N28_H1.0671.00
51_L62_S1.0571.00
49_Q53_Q1.0481.00
51_L92_A1.0471.00
46_K49_Q1.0221.00
29_K108_D1.0211.00
14_R136_G1.0191.00
51_L65_I0.9931.00
13_S16_Y0.9891.00
53_Q57_K0.9821.00
63_G66_T0.9721.00
79_I95_T0.9651.00
66_T70_D0.9571.00
60_L65_I0.9521.00
108_D111_A0.9491.00
49_Q57_K0.9381.00
70_D73_E0.9381.00
94_I98_G0.9261.00
96_E99_I0.9161.00
47_G99_I0.9111.00
35_T68_V0.9101.00
99_I103_N0.9071.00
77_L97_K0.9051.00
18_S136_G0.9041.00
64_S67_Y0.9031.00
30_H105_I0.9021.00
75_K101_L0.8931.00
16_Y20_N0.8911.00
107_P111_A0.8821.00
109_H113_I0.8751.00
26_H115_E0.8741.00
75_K97_K0.8711.00
81_K91_F0.8661.00
43_L78_L0.8641.00
61_A67_Y0.8631.00
113_I116_M0.8621.00
15_A132_L0.8611.00
44_Y103_N0.8601.00
96_E100_G0.8591.00
82_A87_R0.8561.00
31_G75_K0.8461.00
26_H112_E0.8341.00
44_Y106_F0.8321.00
104_D108_D0.8201.00
37_F105_I0.8191.00
69_V78_L0.8181.00
39_V54_I0.8171.00
127_M134_R0.8121.00
122_E126_E0.8111.00
111_A114_D0.7821.00
67_Y71_K0.7811.00
73_E78_L0.7801.00
26_H111_A0.7781.00
84_P91_F0.7671.00
73_E79_I0.7661.00
71_K74_Q0.7631.00
115_E118_S0.7611.00
22_H112_E0.7561.00
86_D89_V0.7551.00
42_L46_K0.7551.00
48_D81_K0.7461.00
67_Y70_D0.7431.00
46_K53_Q0.7431.00
83_S86_D0.7401.00
24_N34_P0.7391.00
94_I99_I0.7381.00
40_L102_L0.7371.00
13_S17_R0.7371.00
120_L135_V0.7321.00
8_L129_T0.7271.00
69_V73_E0.7221.00
55_G65_I0.7211.00
35_T64_S0.7191.00
55_G62_S0.7191.00
112_E115_E0.7181.00
107_P110_A0.7181.00
12_L16_Y0.7141.00
121_S125_V0.7061.00
117_I125_V0.7021.00
42_L58_I0.7001.00
38_A58_I0.6991.00
111_A115_E0.6881.00
47_G93_Q0.6871.00
26_H29_K0.6861.00
126_E129_T0.6851.00
126_E130_E0.6801.00
65_I69_V0.6671.00
123_E126_E0.6661.00
100_G103_N0.6651.00
70_D80_R0.6581.00
51_L66_T0.6571.00
20_N23_M0.6541.00
17_R21_D0.6521.00
134_R138_N0.6511.00
133_K137_L0.6491.00
11_V14_R0.6481.00
37_F109_H0.6401.00
42_L49_Q0.6401.00
110_A114_D0.6381.00
43_L94_I0.6341.00
39_V58_I0.6321.00
20_N24_N0.6321.00
43_L49_Q0.6281.00
120_L125_V0.6241.00
104_D107_P0.6161.00
71_K75_K0.6131.00
23_M26_H0.6131.00
42_L54_I0.5981.00
41_E45_H0.5961.00
72_L77_L0.5931.00
15_A135_V0.5731.00
40_L44_Y0.5721.00
36_E68_V0.5721.00
12_L15_A0.5701.00
22_H115_E0.5701.00
41_E106_F0.5691.00
38_A42_L0.5641.00
14_R18_S0.5591.00
32_L105_I0.5581.00
12_L132_L0.5551.00
54_I92_A0.5501.00
131_M135_V0.5471.00
37_F102_L0.5451.00
76_E79_I0.5401.00
34_P38_A0.5361.00
41_E102_L0.5331.00
131_M138_N0.5331.00
80_R92_A0.5311.00
95_T98_G0.5291.00
130_E133_K0.5281.00
102_L106_F0.5271.00
22_H25_K0.5251.00
133_K136_G0.5221.00
52_Q55_G0.5211.00
120_L124_E0.5201.00
72_L78_L0.5031.00
109_H112_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yifA 2 0.9724 99.9 0.24 Contact Map
3u2rA 4 0.9103 99.9 0.251 Contact Map
3deuA 2 0.9034 99.9 0.251 Contact Map
3bj6A 2 1 99.9 0.252 Contact Map
3zplA 2 1 99.9 0.252 Contact Map
3cdhA 4 0.8966 99.9 0.255 Contact Map
3boqA 2 0.9172 99.9 0.255 Contact Map
3oopA 2 0.9379 99.9 0.259 Contact Map
2fbkA 2 0.9103 99.9 0.262 Contact Map
4rguA 4 0.9862 99.9 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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