GREMLIN Database
KIND - Sporulation kinase D
UniProt: O31671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 506 (439)
Sequences: 29410 (26643)
Seq/√Len: 1271.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
441_V496_E3.9651.00
361_N399_C3.8671.00
442_D446_G3.7931.00
486_H498_T3.7901.00
314_I333_I3.6521.00
475_K479_L3.5591.00
435_K500_T3.3021.00
439_K496_E3.2721.00
490_E493_R3.2541.00
452_L487_I3.2431.00
419_M443_N3.1821.00
448_S451_M3.1231.00
428_S439_K3.0281.00
437_I500_T2.9721.00
426_T441_V2.9641.00
386_E424_K2.9461.00
430_G437_I2.8951.00
437_I498_T2.8681.00
439_K498_T2.8371.00
386_E426_T2.7651.00
388_Q428_S2.7641.00
399_C481_Y2.7401.00
360_L398_K2.6981.00
318_Q334_E2.6761.00
487_I497_V2.5871.00
430_G439_K2.5781.00
428_S441_V2.5771.00
488_E496_E2.5651.00
388_Q426_T2.5571.00
474_C485_I2.4711.00
424_K443_N2.4481.00
318_Q331_S2.4271.00
311_S337_I2.4221.00
447_I451_M2.3731.00
359_E401_K2.3601.00
362_S365_D2.3551.00
451_M454_H2.2811.00
489_S495_T2.2781.00
478_V483_G2.2621.00
419_M423_G2.2461.00
478_V499_I2.2061.00
369_E405_K2.1991.00
384_E424_K2.1971.00
374_I409_L2.1771.00
407_V478_V2.1591.00
196_V271_Y2.1561.00
488_E498_T2.1521.00
323_G326_D2.1411.00
452_L489_S2.1201.00
407_V477_I2.0551.00
419_M425_L2.0451.00
448_S491_V2.0371.00
449_Q452_L2.0111.00
456_F485_I2.0001.00
447_I455_I2.0001.00
407_V474_C1.9991.00
484_S500_T1.9881.00
423_G443_N1.9711.00
479_L484_S1.8851.00
438_I499_I1.8801.00
322_K326_D1.8521.00
364_Q429_L1.8481.00
318_Q327_Q1.8371.00
202_N206_K1.8361.00
489_S493_R1.8151.00
375_Y379_N1.8141.00
408_I438_I1.8131.00
272_L275_R1.7531.00
403_H406_Q1.7501.00
400_T403_H1.7281.00
432_L437_I1.7221.00
244_E248_K1.7141.00
311_S338_K1.7081.00
290_E294_T1.7031.00
378_G416_L1.6991.00
107_Y177_V1.6981.00
418_S461_T1.6721.00
358_W398_K1.6651.00
276_Q280_E1.6641.00
272_L276_Q1.6551.00
454_H460_V1.6421.00
315_Q334_E1.6411.00
313_F329_Y1.6381.00
213_Q216_H1.6101.00
486_H500_T1.6061.00
317_L326_D1.5981.00
477_I481_Y1.5911.00
314_I334_E1.5841.00
341_N345_S1.5441.00
199_E268_V1.5311.00
186_K189_I1.5261.00
309_G313_F1.5241.00
454_H457_L1.4991.00
399_C404_I1.4891.00
451_M460_V1.4871.00
110_N114_D1.4761.00
185_L189_I1.4441.00
317_L330_F1.4401.00
276_Q279_L1.4341.00
303_I306_P1.4241.00
360_L396_L1.4221.00
489_S492_R1.4121.00
309_G336_E1.4041.00
197_Y270_Y1.3971.00
314_I318_Q1.3971.00
401_K405_K1.3861.00
377_E380_L1.3851.00
286_A289_L1.3741.00
310_I337_I1.3661.00
260_L263_I1.3611.00
160_T179_A1.3591.00
457_L460_V1.3481.00
105_G179_A1.3461.00
282_S285_E1.3431.00
278_Q282_S1.3331.00
447_I495_T1.3331.00
331_S335_Q1.3251.00
104_S180_I1.3171.00
277_T280_E1.3151.00
167_D171_N1.2991.00
280_E284_N1.2931.00
320_K326_D1.2911.00
362_S395_L1.2851.00
364_Q368_G1.2811.00
314_I337_I1.2801.00
369_E401_K1.2551.00
321_Y326_D1.2521.00
166_L172_V1.2501.00
389_Y429_L1.2431.00
411_V485_I1.2401.00
334_E338_K1.2391.00
403_H477_I1.2221.00
279_L283_E1.2141.00
313_F332_I1.2091.00
197_Y217_A1.2051.00
371_M387_L1.1961.00
478_V485_I1.1941.00
362_S396_L1.1921.00
241_V249_S1.1891.00
253_P276_Q1.1851.00
210_A215_S1.1781.00
405_K409_L1.1781.00
287_Q290_E1.1781.00
342_Q402_D1.1721.00
404_I481_Y1.1711.00
302_E306_P1.1621.00
90_Q94_E1.1611.00
407_V499_I1.1591.00
447_I487_I1.1581.00
254_L270_Y1.1531.00
447_I452_L1.1521.00
186_K190_N1.1511.00
368_G387_L1.1501.00
403_H480_M1.1491.00
292_I296_A1.1481.00
476_R479_L1.1461.00
413_K417_E1.1461.00
244_E250_L1.1401.00
310_I333_I1.1361.00
228_D232_W1.1291.00
336_E339_R1.1251.00
275_R278_Q1.1231.00
210_A214_A1.1201.00
328_L332_I1.1141.00
199_E207_M1.1101.00
390_L430_G1.1071.00
320_K323_G1.1061.00
212_G215_S1.1051.00
458_P476_R1.1031.00
292_I295_L1.1011.00
474_C478_V1.0991.00
412_A427_I1.0961.00
408_I440_V1.0951.00
164_P172_V1.0851.00
189_I192_L1.0831.00
408_I412_A1.0801.00
277_T281_R1.0781.00
200_V265_F1.0771.00
426_T443_N1.0751.00
253_P271_Y1.0731.00
367_I429_L1.0711.00
455_I487_I1.0691.00
451_M462_S1.0691.00
361_N366_I1.0661.00
303_I340_I1.0641.00
370_I412_A1.0631.00
406_Q477_I1.0621.00
348_L351_G1.0601.00
442_D494_G1.0551.00
374_I412_A1.0531.00
159_F180_I1.0451.00
358_W481_Y1.0441.00
322_K325_E1.0421.00
132_S136_K1.0421.00
452_L456_F1.0391.00
295_L299_T1.0381.00
366_I370_I1.0361.00
371_M375_Y1.0321.00
373_I409_L1.0271.00
329_Y333_I1.0271.00
258_I263_I1.0241.00
327_Q331_S1.0201.00
364_Q389_Y1.0171.00
136_K140_T1.0131.00
212_G216_H1.0121.00
311_S341_N1.0091.00
314_I330_F1.0091.00
412_A425_L1.0051.00
411_V497_V0.9961.00
371_M385_V0.9931.00
362_S394_P0.9921.00
107_Y115_V0.9831.00
324_E327_Q0.9831.00
435_K484_S0.9781.00
370_I405_K0.9761.00
410_N474_C0.9761.00
185_L188_L0.9721.00
368_G371_M0.9721.00
456_F487_I0.9721.00
442_D495_T0.9681.00
299_T347_F0.9641.00
302_E410_N0.9641.00
368_G372_P0.9631.00
85_D88_K0.9631.00
251_V254_L0.9621.00
429_L438_I0.9601.00
51_A55_L0.9601.00
109_L115_V0.9581.00
411_V474_C0.9551.00
199_E214_A0.9491.00
370_I409_L0.9491.00
110_N116_T0.9481.00
415_G425_L0.9441.00
63_N67_G0.9431.00
184_Y187_N0.9431.00
296_A299_T0.9411.00
345_S349_V0.9401.00
313_F333_I0.9391.00
476_R480_M0.9381.00
363_L436_A0.9371.00
89_M93_L0.9371.00
283_E286_A0.9361.00
432_L435_K0.9341.00
135_I139_E0.9331.00
121_E124_T0.9271.00
200_V209_F0.9261.00
312_G316_L0.9251.00
332_I335_Q0.9191.00
378_G385_V0.9191.00
240_P243_I0.9141.00
358_W399_C0.9121.00
302_E305_N0.9111.00
94_E98_D0.9091.00
243_I249_S0.9091.00
363_L438_I0.9051.00
55_L59_R0.8971.00
194_P198_I0.8961.00
231_S234_M0.8951.00
280_E283_E0.8951.00
200_V208_I0.8941.00
365_D369_E0.8891.00
240_P254_L0.8861.00
449_Q490_E0.8831.00
390_L393_Q0.8831.00
456_F497_V0.8821.00
187_N191_L0.8791.00
174_D177_V0.8781.00
366_I399_C0.8771.00
131_R135_I0.8751.00
86_I89_M0.8731.00
411_V499_I0.8721.00
105_G125_K0.8681.00
332_I336_E0.8651.00
367_I427_I0.8651.00
266_I270_Y0.8621.00
374_I416_L0.8591.00
183_D187_N0.8561.00
446_G495_T0.8561.00
65_L68_E0.8531.00
447_I489_S0.8501.00
59_R63_N0.8491.00
372_P375_Y0.8481.00
93_L97_F0.8481.00
157_P160_T0.8471.00
232_W239_N0.8421.00
201_V207_M0.8391.00
122_L125_K0.8381.00
432_L500_T0.8371.00
105_G118_S0.8361.00
281_R284_N0.8341.00
346_E403_H0.8331.00
122_L126_V0.8321.00
182_I185_L0.8311.00
418_S445_E0.8301.00
55_L58_H0.8281.00
281_R285_E0.8261.00
473_V477_I0.8251.00
394_P431_A0.8251.00
331_S334_E0.8251.00
419_M422_G0.8241.00
339_R405_K0.8221.00
49_Q52_S0.8221.00
311_S315_Q0.8221.00
288_K291_L0.8211.00
417_E461_T0.8201.00
109_L177_V0.8201.00
304_R341_N0.8201.00
145_I148_S0.8131.00
130_D133_F0.8111.00
370_I374_I0.8091.00
456_F459_F0.8091.00
128_L133_F0.8091.00
469_L473_V0.8061.00
449_Q453_D0.8061.00
315_Q318_Q0.8051.00
486_H499_I0.8041.00
367_I408_I0.8021.00
447_I453_D0.7991.00
109_L162_C0.7991.00
243_I246_L0.7961.00
65_L69_T0.7961.00
188_L191_L0.7961.00
52_S56_N0.7931.00
118_S123_K0.7931.00
390_L428_S0.7921.00
410_N413_K0.7921.00
342_Q346_E0.7911.00
309_G312_G0.7891.00
374_I413_K0.7881.00
132_S135_I0.7881.00
483_G502_P0.7851.00
487_I495_T0.7841.00
427_I440_V0.7821.00
383_V416_L0.7801.00
337_I341_N0.7801.00
377_E413_K0.7791.00
253_P257_I0.7771.00
197_Y211_S0.7751.00
378_G425_L0.7721.00
275_R279_L0.7721.00
67_G70_M0.7701.00
128_L131_R0.7691.00
311_S334_E0.7661.00
194_P197_Y0.7661.00
184_Y188_L0.7631.00
201_V205_G0.7601.00
472_V476_R0.7601.00
297_A300_A0.7591.00
128_L135_I0.7591.00
231_S235_K0.7581.00
437_I486_H0.7551.00
278_Q281_R0.7541.00
358_W482_G0.7531.00
273_L276_Q0.7511.00
478_V501_L0.7491.00
302_E406_Q0.7481.00
145_I149_Y0.7481.00
328_L331_S0.7441.00
162_C175_Y0.7421.00
158_I161_I0.7421.00
133_F137_A0.7411.00
86_I90_Q0.7391.00
376_S380_L0.7381.00
335_Q369_E0.7371.00
317_L329_Y0.7351.00
373_I405_K0.7351.00
152_R155_G0.7351.00
305_N309_G0.7331.00
350_L472_V0.7321.00
309_G332_I0.7291.00
325_E329_Y0.7251.00
91_S95_K0.7221.00
227_L230_I0.7221.00
255_S271_Y0.7171.00
182_I186_K0.7171.00
333_I337_I0.7161.00
483_G501_L0.7141.00
298_S458_P0.7131.00
202_N208_I0.7121.00
69_T72_R0.7121.00
352_K467_T0.7121.00
415_G440_V0.7111.00
92_I95_K0.7111.00
313_F336_E0.7101.00
306_P313_F0.7091.00
242_T245_E0.7071.00
417_E463_K0.7051.00
120_T124_T0.7011.00
53_V57_L0.6961.00
54_L57_L0.6951.00
297_A303_I0.6911.00
316_L329_Y0.6891.00
254_L257_I0.6881.00
214_A217_A0.6881.00
299_T303_I0.6871.00
439_K488_E0.6871.00
295_L306_P0.6861.00
323_G327_Q0.6861.00
377_E381_Y0.6851.00
305_N312_G0.6841.00
318_Q330_F0.6841.00
143_T148_S0.6831.00
243_I247_S0.6821.00
91_S94_E0.6811.00
318_Q321_Y0.6811.00
162_C177_V0.6811.00
424_K441_V0.6811.00
364_Q395_L0.6811.00
392_E431_A0.6791.00
279_L282_S0.6791.00
134_F138_K0.6781.00
308_T311_S0.6781.00
306_P310_I0.6771.00
197_Y210_A0.6771.00
300_A304_R0.6771.00
317_L333_I0.6771.00
348_L352_K0.6761.00
402_D405_K0.6731.00
297_A306_P0.6721.00
241_V251_V0.6711.00
293_G354_T0.6711.00
324_E328_L0.6701.00
110_N113_G0.6691.00
317_L320_K0.6691.00
336_E340_I0.6671.00
301_H410_N0.6661.00
351_G355_A0.6661.00
230_I234_M0.6651.00
378_G383_V0.6651.00
308_T312_G0.6651.00
256_C266_I0.6651.00
265_F269_L0.6631.00
88_K92_I0.6621.00
105_G119_T0.6621.00
211_S214_A0.6611.00
455_I497_V0.6611.00
316_L321_Y0.6611.00
251_V277_T0.6601.00
395_L436_A0.6591.00
294_T298_S0.6571.00
68_E71_A0.6571.00
200_V267_L0.6571.00
64_Y68_E0.6571.00
455_I472_V0.6561.00
203_Q263_I0.6541.00
108_F116_T0.6531.00
46_E49_Q0.6521.00
124_T127_N0.6501.00
299_T306_P0.6491.00
261_L264_L0.6481.00
411_V440_V0.6471.00
47_H51_A0.6471.00
92_I96_T0.6461.00
47_H50_E0.6461.00
406_Q473_V0.6461.00
383_V387_L0.6451.00
201_V256_C0.6451.00
383_V419_M0.6441.00
289_L292_I0.6441.00
147_D150_S0.6441.00
292_I303_I0.6431.00
326_D329_Y0.6391.00
304_R345_S0.6341.00
393_Q429_L0.6341.00
320_K329_Y0.6331.00
115_V118_S0.6321.00
445_E495_T0.6311.00
483_G499_I0.6311.00
315_Q319_K0.6301.00
49_Q53_V0.6281.00
130_D134_F0.6281.00
160_T177_V0.6271.00
60_N64_Y0.6271.00
240_P245_E0.6261.00
431_A436_A0.6251.00
256_C268_V0.6241.00
50_E54_L0.6241.00
229_D233_N0.6221.00
66_I69_T0.6191.00
338_K341_N0.6181.00
304_R348_L0.6181.00
339_R409_L0.6171.00
367_I387_L0.6161.00
87_K91_S0.6161.00
292_I297_A0.6151.00
269_L272_L0.6141.00
89_M92_I0.6131.00
458_P472_V0.6121.00
156_Q181_Q0.6121.00
167_D173_T0.6111.00
350_L353_P0.6111.00
145_I151_S0.6111.00
244_E247_S0.6091.00
229_D234_M0.6071.00
260_L264_L0.6051.00
414_N470_G0.6051.00
208_I265_F0.6051.00
403_H407_V0.6041.00
300_A306_P0.6041.00
340_I344_V0.6041.00
303_I307_L0.6031.00
237_Y253_P0.6031.00
246_L249_S0.6031.00
210_A217_A0.6021.00
406_Q409_L0.6011.00
293_G297_A0.5981.00
253_P256_C0.5981.00
373_I377_E0.5971.00
461_T466_G0.5951.00
296_A300_A0.5941.00
128_L132_S0.5941.00
378_G381_Y0.5941.00
50_E53_V0.5921.00
211_S217_A0.5921.00
250_L258_I0.5901.00
247_S251_V0.5891.00
196_V213_Q0.5891.00
193_S196_V0.5881.00
388_Q430_G0.5881.00
326_D330_F0.5881.00
294_T458_P0.5871.00
108_F174_D0.5871.00
376_S379_N0.5871.00
316_L320_K0.5861.00
308_T313_F0.5851.00
120_T123_K0.5851.00
87_K90_Q0.5841.00
452_L488_E0.5831.00
230_I233_N0.5811.00
187_N190_N0.5811.00
105_G109_L0.5811.00
201_V268_V0.5801.00
365_D368_G0.5791.00
108_F176_L0.5781.00
429_L436_A0.5771.00
261_L265_F0.5771.00
403_H481_Y0.5761.00
252_L256_C0.5751.00
157_P161_I0.5741.00
302_E336_E0.5721.00
366_I405_K0.5721.00
44_A47_H0.5711.00
111_A172_V0.5701.00
272_L279_L0.5691.00
61_K64_Y0.5691.00
259_V264_L0.5671.00
226_Y229_D0.5661.00
335_Q338_K0.5641.00
442_D445_E0.5641.00
107_Y118_S0.5641.00
160_T164_P0.5641.00
448_S462_S0.5641.00
384_E387_L0.5621.00
242_T250_L0.5611.00
172_V175_Y0.5611.00
303_I343_I0.5581.00
295_L300_A0.5571.00
150_S154_T0.5571.00
395_L431_A0.5571.00
147_D151_S0.5571.00
452_L497_V0.5571.00
426_T429_L0.5561.00
196_V199_E0.5561.00
301_H305_N0.5561.00
274_K278_Q0.5561.00
365_D401_K0.5551.00
136_K139_E0.5551.00
207_M210_A0.5511.00
118_S122_L0.5501.00
242_T246_L0.5501.00
349_V403_H0.5501.00
409_L413_K0.5491.00
350_L476_R0.5491.00
351_G354_T0.5481.00
159_F162_C0.5481.00
441_V490_E0.5471.00
310_I314_I0.5461.00
46_E50_E0.5451.00
329_Y336_E0.5431.00
289_L295_L0.5431.00
226_Y233_N0.5421.00
61_K65_L0.5421.00
137_A140_T0.5411.00
245_E248_K0.5401.00
58_H61_K0.5401.00
130_D135_I0.5401.00
272_L280_E0.5401.00
313_F316_L0.5401.00
383_V443_N0.5391.00
255_S260_L0.5391.00
361_N401_K0.5381.00
328_L372_P0.5381.00
164_P168_S0.5361.00
56_N60_N0.5361.00
310_I313_F0.5361.00
210_A213_Q0.5351.00
307_L311_S0.5351.00
382_N422_G0.5351.00
349_V353_P0.5341.00
107_Y179_A0.5341.00
485_I499_I0.5341.00
304_R313_F0.5341.00
259_V265_F0.5341.00
198_I211_S0.5341.00
108_F117_A0.5331.00
366_I401_K0.5331.00
188_L192_L0.5331.00
227_L231_S0.5311.00
250_L254_L0.5311.00
325_E328_L0.5301.00
474_C477_I0.5291.00
415_G419_M0.5281.00
477_I480_M0.5281.00
241_V244_E0.5271.00
379_N382_N0.5271.00
340_I347_F0.5271.00
338_K342_Q0.5271.00
302_E343_I0.5251.00
478_V484_S0.5251.00
60_N63_N0.5241.00
229_D232_W0.5231.00
407_V481_Y0.5231.00
289_L293_G0.5221.00
245_E249_S0.5221.00
146_S149_Y0.5211.00
119_T122_L0.5201.00
62_I66_I0.5191.00
347_F351_G0.5191.00
298_S305_N0.5181.00
449_Q489_S0.5181.00
158_I179_A0.5171.00
66_I70_M0.5171.00
295_L302_E0.5161.00
251_V274_K0.5161.00
252_L255_S0.5141.00
58_H65_L0.5141.00
329_Y332_I0.5121.00
402_D406_Q0.5111.00
88_K91_S0.5101.00
366_I404_I0.5101.00
300_A305_N0.5091.00
258_I264_L0.5091.00
95_K98_D0.5091.00
451_M455_I0.5091.00
151_S154_T0.5081.00
342_Q345_S0.5081.00
427_I438_I0.5071.00
165_V174_D0.5071.00
369_E372_P0.5071.00
57_L61_K0.5071.00
53_V56_N0.5061.00
382_N421_E0.5051.00
141_K145_I0.5041.00
183_D186_K0.5041.00
475_K484_S0.5031.00
105_G108_F0.5021.00
363_L397_V0.5021.00
394_P397_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gczA 2 0.6542 100 0.441 Contact Map
4i5sA 2 0.7431 100 0.445 Contact Map
3a0rA 2 0.6166 100 0.447 Contact Map
3d36A 2 0.4328 100 0.511 Contact Map
4q20A 2 0.4486 100 0.515 Contact Map
4bixA 2 0.419 100 0.516 Contact Map
2c2aA 2 0.4545 100 0.518 Contact Map
3jz3A 2 0.3103 100 0.522 Contact Map
4mpcA 2 0.5909 100 0.523 Contact Map
2q8gA 2 0.5889 100 0.531 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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