GREMLIN Database
MTND - Acireductone dioxygenase
UniProt: O31669 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (154)
Sequences: 911 (524)
Seq/√Len: 42.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E66_K3.9931.00
53_E56_Q3.7321.00
160_I169_P3.3211.00
112_S154_K2.5861.00
16_N19_E2.2871.00
112_S156_V2.2791.00
30_I71_R2.2791.00
114_H132_N2.2751.00
118_V128_D2.2681.00
88_K91_E2.2331.00
66_K69_S2.2101.00
66_K70_T2.1961.00
86_N89_L2.1550.99
78_D167_W2.1470.99
89_L92_L2.1120.99
14_I19_E2.0440.99
102_H167_W2.0030.99
103_T170_I1.9970.99
72_R105_D1.9780.99
114_H150_Q1.9690.99
81_S156_V1.8920.99
91_E94_E1.8260.98
112_S133_P1.8250.98
27_Q121_G1.7920.98
23_F26_S1.7620.98
81_S112_S1.7570.98
104_D163_T1.7170.97
51_E54_K1.7030.97
131_L155_V1.6710.97
68_I160_I1.6630.97
116_I130_R1.6350.97
96_F106_E1.6220.96
62_E69_S1.6010.96
114_H130_R1.5390.95
120_Q126_F1.5370.95
67_D71_R1.4760.94
55_Q59_D1.4640.94
49_L52_E1.4420.93
74_Y105_D1.4340.93
114_H152_D1.4240.93
15_E132_N1.4230.93
19_E22_S1.3970.92
90_D94_E1.3880.92
115_G147_F1.3840.92
111_V158_V1.3660.91
77_Q160_I1.3600.91
99_E136_L1.3550.91
74_Y162_V1.3290.90
78_D100_H1.3100.89
149_L155_V1.2990.89
102_H106_E1.2980.89
15_E19_E1.2970.89
36_I39_L1.2940.89
64_E67_D1.2860.88
80_I157_A1.2820.88
130_R150_Q1.2650.87
26_S142_N1.2550.87
93_L149_L1.2290.86
108_R147_F1.2280.86
159_R167_W1.2250.86
50_T53_E1.2110.85
96_F167_W1.2040.85
107_V139_V1.1970.84
77_Q109_F1.1710.83
110_I131_L1.1690.83
84_D153_R1.1300.81
13_T18_E1.1100.79
110_I153_R1.1000.79
75_K163_T1.0890.78
83_S86_N1.0790.77
133_P154_K1.0470.75
13_T26_S1.0120.73
117_F145_H1.0080.72
78_D117_F1.0030.72
87_P92_L1.0020.72
144_R171_Y0.9810.70
119_I139_V0.9630.69
76_A166_G0.9630.69
106_E167_W0.9610.69
17_Q33_Q0.9510.68
111_V168_V0.9440.67
150_Q153_R0.9410.67
19_E23_F0.9370.67
157_A169_P0.9290.66
77_Q166_G0.9260.66
108_R115_G0.9180.65
82_L155_V0.9120.65
40_P83_S0.9100.65
80_I92_L0.9050.64
66_K132_N0.8940.63
94_E152_D0.8930.63
61_F166_G0.8910.63
88_K92_L0.8880.63
82_L129_V0.8870.63
40_P165_E0.8770.62
116_I128_D0.8700.61
164_T169_P0.8650.61
124_G127_F0.8580.60
78_D96_F0.8560.60
161_F167_W0.8530.59
114_H151_E0.8510.59
126_F146_Y0.8490.59
82_L88_K0.8470.59
125_T151_E0.8370.58
13_T142_N0.8290.57
17_Q31_Y0.8290.57
97_K153_R0.8250.57
17_Q26_S0.8170.56
78_D159_R0.8110.56
76_A163_T0.8080.55
98_R171_Y0.8010.55
96_F102_H0.7930.54
93_L153_R0.7820.53
80_I107_V0.7810.53
19_E124_G0.7800.53
21_A26_S0.7780.53
90_D164_T0.7780.53
33_Q36_I0.7770.52
50_T54_K0.7740.52
139_V158_V0.7680.52
23_F127_F0.7630.51
68_I79_V0.7620.51
102_H147_F0.7610.51
14_I18_E0.7600.51
58_L62_E0.7600.51
19_E26_S0.7490.50
65_I168_V0.7440.49
33_Q141_E0.7410.49
93_L97_K0.7290.48
32_E67_D0.7250.48
109_F136_L0.7240.47
15_E21_A0.7090.46
78_D106_E0.7020.45
40_P112_S0.6990.45
64_E70_T0.6970.45
14_I23_F0.6950.45
18_E33_Q0.6910.44
79_V158_V0.6890.44
119_I122_Q0.6880.44
50_T63_T0.6840.44
13_T133_P0.6820.44
100_H167_W0.6780.43
131_L153_R0.6780.43
15_E56_Q0.6730.43
95_N139_V0.6730.43
63_T66_K0.6710.42
96_F147_F0.6700.42
103_T162_V0.6690.42
106_E147_F0.6670.42
103_T141_E0.6660.42
81_S131_L0.6630.42
82_L93_L0.6620.42
40_P52_E0.6620.42
121_G124_G0.6600.41
111_V134_G0.6590.41
119_I129_V0.6570.41
65_I69_S0.6560.41
139_V173_K0.6550.41
50_T73_G0.6550.41
118_V144_R0.6550.41
68_I73_G0.6530.41
65_I79_V0.6520.41
57_I114_H0.6440.40
96_F115_G0.6440.40
15_E25_D0.6430.40
23_F84_D0.6400.40
145_H167_W0.6380.39
99_E126_F0.6370.39
16_N23_F0.6350.39
58_L80_I0.6340.39
18_E22_S0.6330.39
93_L131_L0.6300.39
95_N168_V0.6290.39
103_T114_H0.6230.38
117_F161_F0.6190.38
117_F167_W0.6140.37
133_P157_A0.6130.37
82_L144_R0.6100.37
30_I72_R0.6030.36
18_E175_S0.5970.36
124_G144_R0.5950.36
96_F159_R0.5940.36
119_I127_F0.5940.36
99_E109_F0.5910.35
23_F80_I0.5880.35
15_E18_E0.5870.35
64_E139_V0.5860.35
109_F166_G0.5860.35
83_S154_K0.5810.34
22_S26_S0.5800.34
144_R172_E0.5790.34
126_F148_T0.5770.34
100_H159_R0.5750.34
19_E66_K0.5750.34
78_D161_F0.5740.34
35_D56_Q0.5730.34
110_I168_V0.5710.34
120_Q172_E0.5680.33
31_Y141_E0.5660.33
49_L158_V0.5660.33
72_R104_D0.5640.33
126_F160_I0.5600.33
57_I83_S0.5570.32
82_L169_P0.5560.32
69_S77_Q0.5510.32
13_T17_Q0.5480.32
163_T166_G0.5460.32
26_S63_T0.5460.32
69_S160_I0.5440.31
110_I148_T0.5430.31
99_E120_Q0.5430.31
24_L29_V0.5420.31
53_E80_I0.5420.31
74_Y128_D0.5410.31
17_Q21_A0.5370.31
22_S59_D0.5330.31
29_V119_I0.5310.30
74_Y163_T0.5300.30
65_I112_S0.5270.30
94_E154_K0.5250.30
120_Q146_Y0.5240.30
70_T75_K0.5190.29
14_I142_N0.5190.29
69_S166_G0.5140.29
146_Y172_E0.5110.29
93_L138_S0.5090.29
33_Q134_G0.5080.29
14_I22_S0.5070.28
110_I155_V0.5050.28
81_S86_N0.5020.28
40_P49_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qglA 1 0.9551 100 0.409 Contact Map
1zrrA 1 0.9438 100 0.442 Contact Map
1vr3A 1 0.8876 100 0.549 Contact Map
1uijA 3 0.764 98.4 0.849 Contact Map
3s7iA 3 0.7528 98.4 0.851 Contact Map
3d0jA 2 0.6685 98.4 0.851 Contact Map
2e9qA 6 0.6854 98.4 0.852 Contact Map
4lejA 3 0.6404 98.3 0.854 Contact Map
1fxzA 3 0.7416 98.3 0.854 Contact Map
3kscA 4 0.736 98.3 0.854 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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