GREMLIN Database
MTNB - Methylthioribulose-1-phosphate dehydratase
UniProt: O31668 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (184)
Sequences: 6219 (3742)
Seq/√Len: 275.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_D67_E4.9701.00
178_K182_E3.3031.00
103_N199_K3.1211.00
195_S199_K3.0511.00
112_G201_K2.7121.00
42_F85_T2.6141.00
43_L59_F2.5621.00
7_R33_I2.5401.00
10_E181_F2.3901.00
41_T61_L2.3351.00
93_A176_W2.2121.00
102_V195_S2.2121.00
149_P153_A2.1521.00
103_N195_S2.0601.00
106_V199_K2.0171.00
103_N198_L2.0061.00
86_H153_A1.9761.00
41_T69_A1.9571.00
12_A56_V1.9451.00
43_L61_L1.9431.00
165_A190_Y1.9331.00
86_H89_N1.9201.00
9_R13_E1.9011.00
97_L183_A1.8941.00
33_I180_A1.8831.00
55_T58_D1.8731.00
17_E21_R1.7871.00
94_G179_T1.7421.00
38_E41_T1.7341.00
199_K202_T1.7231.00
179_T182_E1.7011.00
35_V43_L1.6781.00
62_V81_T1.6541.00
14_V184_K1.6071.00
111_Y169_R1.6011.00
12_A16_R1.5911.00
9_R56_V1.5841.00
6_E10_E1.5771.00
95_C180_A1.5761.00
11_L31_L1.5721.00
21_R188_E1.5291.00
177_G182_E1.4801.00
65_N89_N1.4751.00
35_V38_E1.3971.00
102_V106_V1.3721.00
154_L157_E1.3721.00
173_I190_Y1.3701.00
11_L59_F1.3431.00
86_H90_K1.3421.00
90_K156_A1.3331.00
99_V187_L1.3231.00
90_K160_S1.3171.00
100_H171_H1.3111.00
33_I95_C1.2911.00
85_T89_N1.2811.00
16_R20_E1.2491.00
32_S96_C1.2451.00
17_E20_E1.2331.00
32_S88_Y1.2121.00
175_A187_L1.1961.00
153_A157_E1.1891.00
107_I201_K1.1871.00
68_P71_S1.1861.00
58_D75_L1.1811.00
18_L31_L1.1771.00
44_V78_S1.1651.00
98_H171_H1.1651.00
104_N173_I1.1561.00
168_I174_T1.1551.00
110_L203_L1.1381.00
198_L202_T1.1321.00
102_V192_F1.1261.00
12_A59_F1.1241.00
150_T153_A1.1231.00
143_E154_L1.1171.00
164_G186_V1.1121.00
34_K94_G1.1041.00
88_Y96_C1.0991.00
198_L203_L1.0981.00
197_H201_K1.0921.00
138_T163_S1.0871.00
35_V61_L1.0851.00
145_P154_L1.0831.00
61_L70_E1.0801.00
18_L97_L1.0791.00
191_E195_S1.0791.00
42_F81_T1.0631.00
36_T41_T1.0611.00
103_N191_E1.0601.00
192_F195_S1.0571.00
159_I176_W1.0551.00
19_A52_R1.0451.00
105_N108_S1.0391.00
46_A49_K1.0331.00
49_K58_D1.0211.00
14_V180_A1.0111.00
10_E33_I1.0011.00
99_V173_I0.9921.00
155_F168_I0.9921.00
104_N190_Y0.9911.00
165_A175_A0.9891.00
142_I145_P0.9791.00
143_E169_R0.9671.00
127_A130_L0.9491.00
12_A54_E0.9461.00
139_V144_N0.9461.00
21_R184_K0.9451.00
7_R35_V0.9431.00
177_G186_V0.9431.00
15_K31_L0.9431.00
71_S74_S0.9371.00
87_L93_A0.9321.00
10_E13_E0.9321.00
49_K75_L0.9281.00
63_D69_A0.9241.00
102_V199_K0.9191.00
150_T154_L0.9161.00
18_L184_K0.9151.00
101_T104_N0.9111.00
127_A189_A0.9071.00
34_K64_Q0.9051.00
8_W70_E0.8991.00
140_P143_E0.8951.00
113_D138_T0.8841.00
42_F62_V0.8781.00
173_I187_L0.8781.00
60_L76_K0.8661.00
14_V31_L0.8551.00
13_E53_K0.8501.00
83_L174_T0.8421.00
117_I197_H0.8281.00
6_E9_R0.8230.99
47_S76_K0.8170.99
83_L155_F0.8120.99
38_E61_L0.8110.99
101_T191_E0.8080.99
46_A59_F0.8080.99
154_L158_E0.8070.99
130_L163_S0.8060.99
54_E58_D0.8050.99
120_K197_H0.8010.99
182_E185_R0.7970.99
156_A159_I0.7900.99
101_T187_L0.7900.99
97_L187_L0.7860.99
182_E186_V0.7850.99
17_E184_K0.7840.99
53_K181_F0.7820.99
64_Q89_N0.7800.99
42_F64_Q0.7760.99
86_H156_A0.7670.99
159_I166_V0.7670.99
123_E126_K0.7640.99
119_F122_Q0.7630.99
106_V198_L0.7540.99
141_I144_N0.7530.99
118_T197_H0.7490.99
157_E160_S0.7460.99
32_S44_V0.7410.99
86_H149_P0.7380.99
45_T54_E0.7380.99
140_P163_S0.7360.99
44_V80_E0.7290.99
25_P192_F0.7290.99
107_I197_H0.7250.99
105_N172_G0.7250.99
158_E166_V0.7200.99
47_S78_S0.7150.99
148_I151_L0.7140.99
94_G178_K0.7120.98
147_H150_T0.7050.98
22_D195_S0.7030.98
89_N156_A0.7030.98
26_A185_R0.7020.98
139_V143_E0.6980.98
141_I169_R0.6970.98
7_R10_E0.6940.98
45_T88_Y0.6930.98
37_D41_T0.6920.98
90_K157_E0.6800.98
143_E157_E0.6780.98
8_W43_L0.6780.98
27_T47_S0.6670.98
87_L159_I0.6650.98
15_K51_K0.6640.98
121_G124_I0.6620.98
105_N196_Y0.6610.98
11_L43_L0.6610.98
18_L23_W0.6580.97
142_I146_A0.6560.97
66_G85_T0.6560.97
30_N78_S0.6530.97
117_I201_K0.6530.97
118_T121_G0.6520.97
64_Q67_E0.6500.97
81_T85_T0.6500.97
17_E26_A0.6450.97
29_G51_K0.6440.97
151_L154_L0.6410.97
19_A24_F0.6380.97
19_A25_P0.6360.97
50_D53_K0.6320.97
152_A155_F0.6240.97
34_K42_F0.6240.97
139_V142_I0.6230.97
175_A186_V0.6200.96
61_L69_A0.6170.96
149_P152_A0.6110.96
151_L155_F0.6090.96
144_N147_H0.6090.96
20_E52_R0.6060.96
124_I127_A0.6040.96
21_R26_A0.5990.96
156_A160_S0.5980.96
167_L173_I0.5970.96
110_L200_L0.5960.96
87_L174_T0.5870.95
24_F31_L0.5870.95
30_N80_E0.5870.95
147_H152_A0.5850.95
108_S167_L0.5840.95
110_L198_L0.5820.95
53_K58_D0.5820.95
58_D74_S0.5810.95
64_Q85_T0.5800.95
190_Y194_F0.5770.95
200_L203_L0.5760.95
117_I194_F0.5760.95
118_T122_Q0.5750.95
82_L149_P0.5740.95
155_F158_E0.5730.95
80_E151_L0.5720.94
7_R43_L0.5710.94
103_N106_V0.5640.94
25_P28_S0.5610.94
142_I154_L0.5610.94
19_A51_K0.5600.94
164_G176_W0.5560.94
8_W59_F0.5560.94
11_L15_K0.5560.94
113_D141_I0.5510.93
56_V59_F0.5510.93
10_E180_A0.5500.93
155_F159_I0.5500.93
164_G178_K0.5490.93
95_C183_A0.5480.93
68_P76_K0.5470.93
28_S192_F0.5440.93
33_I59_F0.5420.93
97_L175_A0.5410.93
104_N187_L0.5370.92
164_G182_E0.5360.92
8_W61_L0.5360.92
104_N194_F0.5340.92
101_T173_I0.5340.92
92_N178_K0.5310.92
185_R192_F0.5280.92
86_H152_A0.5270.92
107_I112_G0.5260.92
62_V85_T0.5250.92
54_E59_F0.5250.92
13_E16_R0.5240.91
166_V174_T0.5230.91
122_Q126_K0.5210.91
107_I194_F0.5210.91
104_N167_L0.5190.91
38_E64_Q0.5190.91
26_A188_E0.5180.91
155_F166_V0.5150.91
143_E147_H0.5120.91
11_L33_I0.5090.90
155_F174_T0.5090.90
30_N47_S0.5080.90
45_T59_F0.5030.90
82_L86_H0.5020.90
87_L96_C0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ocrA 4 0.9426 100 0.164 Contact Map
4c24A 3 0.9234 100 0.173 Contact Map
1e4cP 3 0.9139 100 0.178 Contact Map
2irpA 4 0.9474 100 0.18 Contact Map
4m6rA 3 0.9665 100 0.186 Contact Map
2fk5A 4 0.89 100 0.192 Contact Map
4xxfA 3 0.9043 100 0.194 Contact Map
1k0wA 3 0.9234 100 0.211 Contact Map
2z7bA 3 0.9187 100 0.219 Contact Map
1pvtA 3 0.9426 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.