GREMLIN Database
MTNX - 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
UniProt: O31667 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (209)
Sequences: 1003 (719)
Seq/√Len: 49.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G45_T7.7091.00
185_F210_I3.0581.00
85_V95_F3.0051.00
96_Y158_L2.9571.00
183_L202_L2.7501.00
69_S73_E2.7171.00
143_C150_C2.6811.00
185_F213_E2.6501.00
210_I213_E2.5591.00
80_G208_Y2.4261.00
18_M76_K2.2631.00
47_S146_Q2.2311.00
167_M177_A2.2001.00
78_R187_R2.1231.00
46_L54_R2.0671.00
188_D205_Q2.0571.00
41_V51_G2.0001.00
206_D209_E1.9871.00
186_A191_L1.9270.99
9_I165_I1.9230.99
84_F207_F1.8970.99
100_G150_C1.8950.99
149_C154_V1.8720.99
8_I168_I1.8530.99
41_V55_M1.8050.99
178_A184_C1.7820.99
194_C199_L1.7420.99
10_C16_I1.6910.98
16_I81_F1.6860.98
122_N148_G1.6440.98
122_N150_C1.6310.98
77_I109_L1.5940.98
82_R86_A1.5740.97
8_I88_I1.5640.97
147_C150_C1.5610.97
73_E108_P1.5360.97
186_A209_E1.5270.97
100_G176_E1.5270.97
103_D123_H1.5180.97
14_G101_G1.5100.97
12_F15_T1.4970.96
150_C176_E1.4910.96
184_C190_L1.4830.96
20_D23_I1.4670.96
89_N116_K1.4630.96
14_G190_L1.4350.95
6_P164_Y1.4260.95
125_S132_H1.4210.95
48_I52_V1.4170.95
30_A34_W1.4110.95
28_T74_D1.4100.95
191_L201_H1.4060.95
91_H215_E1.4030.95
40_G54_R1.3750.94
49_K146_Q1.3640.94
167_M181_S1.3610.94
102_M124_A1.3360.93
166_I185_F1.3320.93
87_F93_I1.3210.93
11_D15_T1.3200.93
65_E69_S1.3150.93
71_V109_L1.3120.93
84_F214_I1.2880.92
98_I120_Y1.2870.92
179_K197_Q1.2600.91
64_K68_T1.2570.91
36_A40_G1.2500.91
81_F207_F1.2500.91
97_V106_V1.2490.91
212_K215_E1.2450.91
191_L203_P1.2290.90
21_N101_G1.2100.89
22_I102_M1.2030.89
101_G178_A1.1960.89
14_G20_D1.1910.89
34_W58_L1.1900.89
83_E206_D1.1700.88
8_I84_F1.1610.87
155_I177_A1.1520.87
71_V74_D1.1450.87
36_A39_D1.1440.87
56_F133_I1.1360.86
24_N70_F1.1350.86
195_R203_P1.1270.86
64_K126_F1.1150.85
191_L195_R1.1130.85
188_D191_L1.1080.85
195_R201_H1.0870.84
209_E212_K1.0860.84
211_R215_E1.0790.83
168_I210_I1.0760.83
203_P210_I1.0670.82
21_N105_F1.0660.82
121_C179_K1.0660.82
149_C187_R1.0630.82
36_A45_T1.0610.82
37_L40_G1.0570.82
104_F108_P1.0550.82
50_E54_R1.0540.82
50_E87_F1.0500.81
100_G173_T1.0470.81
202_L210_I1.0420.81
17_T21_N1.0390.81
213_E216_N1.0310.80
58_L150_C1.0080.79
76_K112_G1.0070.79
156_H180_L0.9910.78
54_R57_G0.9900.77
125_S134_D0.9810.77
71_V88_I0.9730.76
66_E69_S0.9730.76
22_I52_V0.9730.76
80_G83_E0.9720.76
212_K216_N0.9690.76
153_S156_H0.9660.76
80_G84_F0.9620.75
25_I67_I0.9600.75
133_I137_H0.9570.75
29_F70_F0.9520.75
19_N27_K0.9510.75
102_M105_F0.9460.74
94_P162_N0.9390.74
81_F84_F0.9330.73
52_V102_M0.9310.73
86_A90_E0.9290.73
202_L213_E0.9280.73
9_I159_S0.9260.73
7_F159_S0.9240.72
36_A160_E0.9230.72
111_E116_K0.9190.72
204_Y210_I0.9170.72
101_G173_T0.9150.72
48_I100_G0.9140.72
178_A190_L0.9140.72
85_V114_V0.9080.71
78_R173_T0.9020.71
87_F211_R0.8990.70
96_Y166_I0.8900.70
102_M150_C0.8870.69
79_E82_R0.8860.69
21_N24_N0.8820.69
97_V110_L0.8720.68
172_V189_Y0.8660.67
21_N56_F0.8650.67
152_P155_I0.8640.67
169_G174_D0.8560.66
40_G43_S0.8520.66
88_I207_F0.8490.66
78_R148_G0.8430.65
22_I171_S0.8420.65
78_R100_G0.8390.65
143_C147_C0.8320.64
179_K199_L0.8300.64
69_S111_E0.8260.64
127_D132_H0.8220.63
103_D121_C0.8180.63
188_D209_E0.8160.63
27_K34_W0.8120.62
48_I173_T0.8110.62
16_I97_V0.8060.62
73_E112_G0.8050.62
52_V100_G0.8030.62
48_I102_M0.8030.62
167_M178_A0.7990.61
87_F91_H0.7990.61
90_E212_K0.7960.61
79_E195_R0.7900.60
102_M171_S0.7890.60
99_S106_V0.7860.60
83_E208_Y0.7770.59
69_S86_A0.7770.59
152_P177_A0.7760.59
16_I192_N0.7750.59
126_F129_D0.7740.59
17_T22_I0.7700.58
37_L56_F0.7660.58
17_T20_D0.7630.58
98_I154_V0.7620.57
100_G148_G0.7580.57
107_Y111_E0.7580.57
68_T104_F0.7550.57
80_G206_D0.7540.57
89_N92_E0.7530.57
22_I48_I0.7450.56
82_R90_E0.7410.55
29_F32_P0.7360.55
82_R203_P0.7350.55
100_G143_C0.7320.54
106_V199_L0.7320.54
83_E215_E0.7250.54
183_L201_H0.7240.54
22_I173_T0.7240.54
8_I206_D0.7200.53
7_F162_N0.7200.53
90_E215_E0.7200.53
158_L162_N0.7190.53
11_D170_D0.7190.53
168_I207_F0.7170.53
48_I176_E0.7130.53
8_I213_E0.7130.53
120_Y154_V0.7130.53
10_C95_F0.7100.52
148_G204_Y0.7080.52
33_E36_A0.7060.52
122_N143_C0.7060.52
135_W139_C0.7040.52
48_I106_V0.7030.51
90_E216_N0.7030.51
151_K174_D0.7010.51
6_P166_I0.7000.51
7_F165_I0.6890.50
78_R207_F0.6850.50
101_G186_A0.6850.50
5_K161_P0.6840.50
22_I149_C0.6830.49
38_K41_V0.6810.49
101_G184_C0.6810.49
37_L54_R0.6800.49
53_G135_W0.6800.49
152_P180_L0.6620.47
127_D168_I0.6620.47
158_L177_A0.6610.47
14_G29_F0.6600.47
20_D122_N0.6570.47
73_E86_A0.6560.47
36_A65_E0.6550.47
106_V167_M0.6540.46
92_E127_D0.6530.46
22_I150_C0.6470.46
16_I168_I0.6470.46
98_I149_C0.6460.46
29_F61_S0.6410.45
191_L199_L0.6410.45
156_H181_S0.6330.44
20_D34_W0.6290.44
56_F156_H0.6290.44
29_F51_G0.6280.44
131_I135_W0.6270.44
81_F194_C0.6240.43
91_H208_Y0.6210.43
65_E215_E0.6190.43
44_K171_S0.6160.43
102_M145_N0.6150.43
22_I105_F0.6150.43
83_E86_A0.6090.42
82_R216_N0.6040.41
40_G216_N0.6010.41
143_C176_E0.6000.41
125_S128_N0.5950.41
92_E118_R0.5940.40
121_C193_E0.5910.40
41_V172_V0.5910.40
5_K79_E0.5880.40
41_V48_I0.5870.40
75_A166_I0.5860.40
51_G100_G0.5860.40
29_F34_W0.5840.39
91_H160_E0.5830.39
167_M184_C0.5830.39
203_P214_I0.5830.39
59_L194_C0.5820.39
172_V176_E0.5800.39
104_F150_C0.5740.39
14_G186_A0.5730.38
155_I158_L0.5720.38
61_S89_N0.5710.38
17_T101_G0.5710.38
66_E70_F0.5700.38
95_F100_G0.5690.38
61_S70_F0.5670.38
209_E213_E0.5660.38
16_I77_I0.5650.38
21_N52_V0.5620.37
32_P35_M0.5620.37
159_S165_I0.5600.37
181_S207_F0.5590.37
23_I79_E0.5590.37
208_Y212_K0.5540.37
35_M39_D0.5510.36
6_P18_M0.5510.36
92_E212_K0.5490.36
44_K193_E0.5460.36
12_F214_I0.5460.36
92_E215_E0.5450.36
54_R160_E0.5420.35
10_C22_I0.5420.35
172_V175_V0.5420.35
84_F181_S0.5420.35
10_C100_G0.5390.35
23_I171_S0.5330.35
56_F107_Y0.5320.35
33_E113_I0.5320.35
164_Y167_M0.5270.34
103_D136_P0.5260.34
176_E187_R0.5220.34
192_N195_R0.5210.34
62_S129_D0.5200.33
59_L175_V0.5190.33
109_L190_L0.5190.33
13_D174_D0.5170.33
37_L51_G0.5150.33
102_M148_G0.5140.33
9_I201_H0.5120.33
119_I122_N0.5110.33
87_F215_E0.5090.32
36_A161_P0.5080.32
196_E208_Y0.5070.32
57_G200_N0.5070.32
118_R160_E0.5060.32
155_I187_R0.5050.32
60_P119_I0.5040.32
103_D107_Y0.5030.32
24_N77_I0.5020.32
32_P107_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2feaA 1 0.9574 100 0.591 Contact Map
3fvvA 2 0.8298 99.9 0.687 Contact Map
4ezeA 1 0.8851 99.8 0.701 Contact Map
4nv0A 1 0.9532 99.8 0.701 Contact Map
1rkuA 2 0.8638 99.8 0.705 Contact Map
1l7mA 1 0.8723 99.8 0.708 Contact Map
1nnlA 1 0.8255 99.8 0.72 Contact Map
3m1yA 2 0.8638 99.7 0.732 Contact Map
4fe3A 1 0.9149 99.7 0.733 Contact Map
1y8aA 1 0.9745 99.7 0.733 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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