MTNX - BACSU - GREMLIN Contacts

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MTNX - 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase

UniProt:	O31667	Sequences: MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSKTLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGMDFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSEPNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVKEVQEWLQNKNAGESSLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	235 (209)
Sequences:	1003 (719)
Seq/√Len:	49.8

BACSU - MTNX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
40_G	45_T	7.709	1.00
185_F	210_I	3.058	1.00
85_V	95_F	3.005	1.00
96_Y	158_L	2.957	1.00
183_L	202_L	2.750	1.00
69_S	73_E	2.717	1.00
143_C	150_C	2.681	1.00
185_F	213_E	2.650	1.00
210_I	213_E	2.559	1.00
80_G	208_Y	2.426	1.00
18_M	76_K	2.263	1.00
47_S	146_Q	2.231	1.00
167_M	177_A	2.200	1.00
78_R	187_R	2.123	1.00
46_L	54_R	2.067	1.00
188_D	205_Q	2.057	1.00
41_V	51_G	2.000	1.00
206_D	209_E	1.987	1.00
186_A	191_L	1.927	0.99
9_I	165_I	1.923	0.99
84_F	207_F	1.897	0.99
100_G	150_C	1.895	0.99
149_C	154_V	1.872	0.99
8_I	168_I	1.853	0.99
41_V	55_M	1.805	0.99
178_A	184_C	1.782	0.99
194_C	199_L	1.742	0.99
10_C	16_I	1.691	0.98
16_I	81_F	1.686	0.98
122_N	148_G	1.644	0.98
122_N	150_C	1.631	0.98
77_I	109_L	1.594	0.98
82_R	86_A	1.574	0.97
8_I	88_I	1.564	0.97
147_C	150_C	1.561	0.97
73_E	108_P	1.536	0.97
186_A	209_E	1.527	0.97
100_G	176_E	1.527	0.97
103_D	123_H	1.518	0.97
14_G	101_G	1.510	0.97
12_F	15_T	1.497	0.96
150_C	176_E	1.491	0.96
184_C	190_L	1.483	0.96
20_D	23_I	1.467	0.96
89_N	116_K	1.463	0.96
14_G	190_L	1.435	0.95
6_P	164_Y	1.426	0.95
125_S	132_H	1.421	0.95
48_I	52_V	1.417	0.95
30_A	34_W	1.411	0.95
28_T	74_D	1.410	0.95
191_L	201_H	1.406	0.95
91_H	215_E	1.403	0.95
40_G	54_R	1.375	0.94
49_K	146_Q	1.364	0.94
167_M	181_S	1.361	0.94
102_M	124_A	1.336	0.93
166_I	185_F	1.332	0.93
87_F	93_I	1.321	0.93
11_D	15_T	1.320	0.93
65_E	69_S	1.315	0.93
71_V	109_L	1.312	0.93
84_F	214_I	1.288	0.92
98_I	120_Y	1.287	0.92
179_K	197_Q	1.260	0.91
64_K	68_T	1.257	0.91
36_A	40_G	1.250	0.91
81_F	207_F	1.250	0.91
97_V	106_V	1.249	0.91
212_K	215_E	1.245	0.91
191_L	203_P	1.229	0.90
21_N	101_G	1.210	0.89
22_I	102_M	1.203	0.89
101_G	178_A	1.196	0.89
14_G	20_D	1.191	0.89
34_W	58_L	1.190	0.89
83_E	206_D	1.170	0.88
8_I	84_F	1.161	0.87
155_I	177_A	1.152	0.87
71_V	74_D	1.145	0.87
36_A	39_D	1.144	0.87
56_F	133_I	1.136	0.86
24_N	70_F	1.135	0.86
195_R	203_P	1.127	0.86
64_K	126_F	1.115	0.85
191_L	195_R	1.113	0.85
188_D	191_L	1.108	0.85
195_R	201_H	1.087	0.84
209_E	212_K	1.086	0.84
211_R	215_E	1.079	0.83
168_I	210_I	1.076	0.83
203_P	210_I	1.067	0.82
21_N	105_F	1.066	0.82
121_C	179_K	1.066	0.82
149_C	187_R	1.063	0.82
36_A	45_T	1.061	0.82
37_L	40_G	1.057	0.82
104_F	108_P	1.055	0.82
50_E	54_R	1.054	0.82
50_E	87_F	1.050	0.81
100_G	173_T	1.047	0.81
202_L	210_I	1.042	0.81
17_T	21_N	1.039	0.81
213_E	216_N	1.031	0.80
58_L	150_C	1.008	0.79
76_K	112_G	1.007	0.79
156_H	180_L	0.991	0.78
54_R	57_G	0.990	0.77
125_S	134_D	0.981	0.77
71_V	88_I	0.973	0.76
66_E	69_S	0.973	0.76
22_I	52_V	0.973	0.76
80_G	83_E	0.972	0.76
212_K	216_N	0.969	0.76
153_S	156_H	0.966	0.76
80_G	84_F	0.962	0.75
25_I	67_I	0.960	0.75
133_I	137_H	0.957	0.75
29_F	70_F	0.952	0.75
19_N	27_K	0.951	0.75
102_M	105_F	0.946	0.74
94_P	162_N	0.939	0.74
81_F	84_F	0.933	0.73
52_V	102_M	0.931	0.73
86_A	90_E	0.929	0.73
202_L	213_E	0.928	0.73
9_I	159_S	0.926	0.73
7_F	159_S	0.924	0.72
36_A	160_E	0.923	0.72
111_E	116_K	0.919	0.72
204_Y	210_I	0.917	0.72
101_G	173_T	0.915	0.72
48_I	100_G	0.914	0.72
178_A	190_L	0.914	0.72
85_V	114_V	0.908	0.71
78_R	173_T	0.902	0.71
87_F	211_R	0.899	0.70
96_Y	166_I	0.890	0.70
102_M	150_C	0.887	0.69
79_E	82_R	0.886	0.69
21_N	24_N	0.882	0.69
97_V	110_L	0.872	0.68
172_V	189_Y	0.866	0.67
21_N	56_F	0.865	0.67
152_P	155_I	0.864	0.67
169_G	174_D	0.856	0.66
40_G	43_S	0.852	0.66
88_I	207_F	0.849	0.66
78_R	148_G	0.843	0.65
22_I	171_S	0.842	0.65
78_R	100_G	0.839	0.65
143_C	147_C	0.832	0.64
179_K	199_L	0.830	0.64
69_S	111_E	0.826	0.64
127_D	132_H	0.822	0.63
103_D	121_C	0.818	0.63
188_D	209_E	0.816	0.63
27_K	34_W	0.812	0.62
48_I	173_T	0.811	0.62
16_I	97_V	0.806	0.62
73_E	112_G	0.805	0.62
52_V	100_G	0.803	0.62
48_I	102_M	0.803	0.62
167_M	178_A	0.799	0.61
87_F	91_H	0.799	0.61
90_E	212_K	0.796	0.61
79_E	195_R	0.790	0.60
102_M	171_S	0.789	0.60
99_S	106_V	0.786	0.60
83_E	208_Y	0.777	0.59
69_S	86_A	0.777	0.59
152_P	177_A	0.776	0.59
16_I	192_N	0.775	0.59
126_F	129_D	0.774	0.59
17_T	22_I	0.770	0.58
37_L	56_F	0.766	0.58
17_T	20_D	0.763	0.58
98_I	154_V	0.762	0.57
100_G	148_G	0.758	0.57
107_Y	111_E	0.758	0.57
68_T	104_F	0.755	0.57
80_G	206_D	0.754	0.57
89_N	92_E	0.753	0.57
22_I	48_I	0.745	0.56
82_R	90_E	0.741	0.55
29_F	32_P	0.736	0.55
82_R	203_P	0.735	0.55
100_G	143_C	0.732	0.54
106_V	199_L	0.732	0.54
83_E	215_E	0.725	0.54
183_L	201_H	0.724	0.54
22_I	173_T	0.724	0.54
8_I	206_D	0.720	0.53
7_F	162_N	0.720	0.53
90_E	215_E	0.720	0.53
158_L	162_N	0.719	0.53
11_D	170_D	0.719	0.53
168_I	207_F	0.717	0.53
48_I	176_E	0.713	0.53
8_I	213_E	0.713	0.53
120_Y	154_V	0.713	0.53
10_C	95_F	0.710	0.52
148_G	204_Y	0.708	0.52
33_E	36_A	0.706	0.52
122_N	143_C	0.706	0.52
135_W	139_C	0.704	0.52
48_I	106_V	0.703	0.51
90_E	216_N	0.703	0.51
151_K	174_D	0.701	0.51
6_P	166_I	0.700	0.51
7_F	165_I	0.689	0.50
78_R	207_F	0.685	0.50
101_G	186_A	0.685	0.50
5_K	161_P	0.684	0.50
22_I	149_C	0.683	0.49
38_K	41_V	0.681	0.49
101_G	184_C	0.681	0.49
37_L	54_R	0.680	0.49
53_G	135_W	0.680	0.49
152_P	180_L	0.662	0.47
127_D	168_I	0.662	0.47
158_L	177_A	0.661	0.47
14_G	29_F	0.660	0.47
20_D	122_N	0.657	0.47
73_E	86_A	0.656	0.47
36_A	65_E	0.655	0.47
106_V	167_M	0.654	0.46
92_E	127_D	0.653	0.46
22_I	150_C	0.647	0.46
16_I	168_I	0.647	0.46
98_I	149_C	0.646	0.46
29_F	61_S	0.641	0.45
191_L	199_L	0.641	0.45
156_H	181_S	0.633	0.44
20_D	34_W	0.629	0.44
56_F	156_H	0.629	0.44
29_F	51_G	0.628	0.44
131_I	135_W	0.627	0.44
81_F	194_C	0.624	0.43
91_H	208_Y	0.621	0.43
65_E	215_E	0.619	0.43
44_K	171_S	0.616	0.43
102_M	145_N	0.615	0.43
22_I	105_F	0.615	0.43
83_E	86_A	0.609	0.42
82_R	216_N	0.604	0.41
40_G	216_N	0.601	0.41
143_C	176_E	0.600	0.41
125_S	128_N	0.595	0.41
92_E	118_R	0.594	0.40
121_C	193_E	0.591	0.40
41_V	172_V	0.591	0.40
5_K	79_E	0.588	0.40
41_V	48_I	0.587	0.40
75_A	166_I	0.586	0.40
51_G	100_G	0.586	0.40
29_F	34_W	0.584	0.39
91_H	160_E	0.583	0.39
167_M	184_C	0.583	0.39
203_P	214_I	0.583	0.39
59_L	194_C	0.582	0.39
172_V	176_E	0.580	0.39
104_F	150_C	0.574	0.39
14_G	186_A	0.573	0.38
155_I	158_L	0.572	0.38
61_S	89_N	0.571	0.38
17_T	101_G	0.571	0.38
66_E	70_F	0.570	0.38
95_F	100_G	0.569	0.38
61_S	70_F	0.567	0.38
209_E	213_E	0.566	0.38
16_I	77_I	0.565	0.38
21_N	52_V	0.562	0.37
32_P	35_M	0.562	0.37
159_S	165_I	0.560	0.37
181_S	207_F	0.559	0.37
23_I	79_E	0.559	0.37
208_Y	212_K	0.554	0.37
35_M	39_D	0.551	0.36
6_P	18_M	0.551	0.36
92_E	212_K	0.549	0.36
44_K	193_E	0.546	0.36
12_F	214_I	0.546	0.36
92_E	215_E	0.545	0.36
54_R	160_E	0.542	0.35
10_C	22_I	0.542	0.35
172_V	175_V	0.542	0.35
84_F	181_S	0.542	0.35
10_C	100_G	0.539	0.35
23_I	171_S	0.533	0.35
56_F	107_Y	0.532	0.35
33_E	113_I	0.532	0.35
164_Y	167_M	0.527	0.34
103_D	136_P	0.526	0.34
176_E	187_R	0.522	0.34
192_N	195_R	0.521	0.34
62_S	129_D	0.520	0.33
59_L	175_V	0.519	0.33
109_L	190_L	0.519	0.33
13_D	174_D	0.517	0.33
37_L	51_G	0.515	0.33
102_M	148_G	0.514	0.33
9_I	201_H	0.512	0.33
119_I	122_N	0.511	0.33
87_F	215_E	0.509	0.32
36_A	161_P	0.508	0.32
196_E	208_Y	0.507	0.32
57_G	200_N	0.507	0.32
118_R	160_E	0.506	0.32
155_I	187_R	0.505	0.32
60_P	119_I	0.504	0.32
103_D	107_Y	0.503	0.32
24_N	77_I	0.502	0.32
32_P	107_Y	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2feaA	1	0.9574	100	0.591	Contact Map
3fvvA	2	0.8298	99.9	0.687	Contact Map
4ezeA	1	0.8851	99.8	0.701	Contact Map
4nv0A	1	0.9532	99.8	0.701	Contact Map
1rkuA	2	0.8638	99.8	0.705	Contact Map
1l7mA	1	0.8723	99.8	0.708	Contact Map
1nnlA	1	0.8255	99.8	0.72	Contact Map
3m1yA	2	0.8638	99.7	0.732	Contact Map
4fe3A	1	0.9149	99.7	0.733	Contact Map
1y8aA	1	0.9745	99.7	0.733	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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