GREMLIN Database
MTNW - 2,3-diketo-5-methylthiopentyl-1-phosphate enolase
UniProt: O31666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (388)
Sequences: 788 (443)
Seq/√Len: 22.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_A391_D7.0551.00
360_N394_L6.7091.00
371_A389_C5.2551.00
6_A101_L3.9301.00
103_D281_K3.7611.00
190_I194_T3.6761.00
153_E157_Q3.6731.00
223_A253_V3.6071.00
17_T67_A3.4641.00
385_K389_C3.4531.00
222_A230_L3.4191.00
384_E387_E3.2411.00
182_T185_A3.1241.00
156_R193_E3.0751.00
222_A227_A2.9981.00
52_I72_A2.8340.99
333_P368_A2.8230.99
156_R194_T2.7860.99
5_L70_T2.7540.99
149_S182_T2.7140.99
156_R160_L2.6810.99
5_L105_H2.6210.99
390_K393_K2.5990.99
393_K397_D2.5360.98
387_E393_K2.4920.98
261_V273_F2.4580.98
156_R190_I2.3670.97
232_F242_M2.3370.97
5_L72_A2.3340.97
380_Q385_K2.3170.97
193_E197_Q2.2980.97
205_A229_A2.2790.97
53_K70_T2.2770.97
375_A385_K2.1440.95
195_Y201_K2.1260.95
85_L106_F2.1190.95
324_F348_I2.0400.94
85_L110_F2.0190.93
118_K246_A2.0180.93
111_K285_Y1.9890.93
121_V315_V1.9820.93
159_A202_T1.9800.93
157_Q363_Q1.9560.92
193_E196_E1.9290.92
119_F254_P1.9180.92
367_R391_D1.9090.91
236_A261_V1.8960.91
334_G400_G1.8840.91
210_G214_D1.8820.91
70_T105_H1.8790.91
356_H362_A1.8720.91
29_T49_G1.8530.90
390_K394_L1.8380.90
191_L204_Y1.8260.89
55_E68_V1.8110.89
361_G365_G1.7850.88
160_L194_T1.7810.88
161_G366_G1.7780.88
394_L397_D1.7270.87
27_G92_K1.7250.87
185_A221_R1.7130.86
17_T69_I1.6690.85
122_Y322_Q1.6540.84
7_T105_H1.6510.84
136_L373_I1.6240.83
133_R345_I1.6230.83
221_R225_L1.6030.82
290_F348_I1.5730.81
179_P182_T1.5620.80
172_F175_T1.5550.80
189_Q193_E1.5540.80
122_Y126_K1.5510.80
242_M288_A1.5410.79
81_D84_A1.5390.79
292_L328_S1.5360.79
184_I206_V1.5120.78
9_L66_Q1.4910.77
371_A385_K1.4670.76
123_G289_D1.4580.75
375_A386_A1.4580.75
368_A399_W1.4410.75
227_A254_P1.4390.74
210_G218_K1.4370.74
382_I396_L1.4350.74
58_E341_R1.4350.74
42_E224_E1.4210.74
382_I392_L1.4200.73
174_E218_K1.4150.73
230_L254_P1.3980.72
219_A245_L1.3930.72
126_K129_G1.3840.72
139_I351_A1.3780.71
139_I205_A1.3580.70
214_D218_K1.3580.70
75_E107_S1.3560.70
326_V354_G1.3490.70
57_R66_Q1.3340.69
159_A191_L1.3290.68
212_T244_G1.3150.67
87_T233_N1.3140.67
155_L191_L1.3050.67
351_A369_F1.3050.67
108_E305_A1.2940.66
243_Q247_E1.2910.66
233_N260_A1.2900.66
21_A71_I1.2890.66
41_Q44_M1.2860.66
394_L398_K1.2840.66
370_R374_D1.2820.65
380_Q388_Q1.2730.65
27_G300_V1.2660.64
135_L324_F1.2660.64
118_K249_P1.2540.64
151_I187_G1.2490.63
133_R164_D1.2470.63
392_L395_A1.2440.63
56_E363_Q1.2390.63
259_P292_L1.2280.62
89_V104_L1.2240.62
290_F326_V1.2120.61
160_L197_Q1.2030.60
330_G353_G1.2000.60
143_V294_P1.1990.60
31_G74_P1.1970.60
200_H370_R1.1950.60
392_L396_L1.1920.60
28_L142_G1.1900.60
384_E389_C1.1880.59
384_E388_Q1.1870.59
257_A279_L1.1760.59
190_I193_E1.1700.58
56_E65_K1.1680.58
231_L294_P1.1470.57
358_H365_G1.1410.56
103_D116_G1.1200.55
124_I290_F1.1190.55
291_S323_T1.1060.54
256_M292_L1.1040.54
235_F239_L1.1020.54
174_E178_A1.0940.53
181_E221_R1.0890.53
172_F178_A1.0860.53
227_A230_L1.0830.52
126_K131_F1.0830.52
358_H361_G1.0810.52
230_L255_I1.0790.52
11_T66_Q1.0740.52
92_K292_L1.0730.52
137_M292_L1.0720.52
54_V69_I1.0720.52
10_L17_T1.0660.51
137_M259_P1.0650.51
168_D183_R1.0630.51
298_G330_G1.0620.51
382_I386_A1.0610.51
84_A87_T1.0510.50
383_D397_D1.0500.50
195_Y228_D1.0500.50
137_M256_M1.0490.50
353_G357_G1.0440.50
192_K196_E1.0430.50
148_L178_A1.0410.49
92_K299_S1.0390.49
210_G237_Y1.0370.49
345_I377_L1.0320.49
93_L328_S1.0300.49
138_S158_Q1.0280.49
214_D217_D1.0260.48
256_M259_P1.0220.48
128_L131_F1.0210.48
174_E179_P1.0200.48
156_R197_Q1.0160.48
55_E129_G1.0100.47
380_Q397_D1.0100.47
380_Q389_C1.0080.47
27_G292_L1.0020.47
185_A225_L0.9990.47
25_A29_T0.9980.46
291_S314_C0.9970.46
47_H210_G0.9930.46
31_G351_A0.9800.45
379_A388_Q0.9780.45
259_P299_S0.9780.45
277_L281_K0.9730.45
120_G183_R0.9720.45
48_K239_L0.9710.45
216_K220_R0.9670.44
184_I228_D0.9650.44
381_P384_E0.9640.44
53_K121_V0.9590.44
180_F218_K0.9580.44
223_A250_E0.9570.44
391_D397_D0.9560.44
75_E109_A0.9510.43
376_V380_Q0.9510.43
159_A194_T0.9500.43
388_Q397_D0.9450.43
34_T138_S0.9410.43
380_Q383_D0.9360.42
378_E397_D0.9350.42
209_T218_K0.9330.42
53_K82_I0.9320.42
203_L206_V0.9280.42
304_R308_L0.9280.42
155_L329_A0.9270.42
151_I178_A0.9260.42
111_K320_F0.9160.41
256_M290_F0.9160.41
55_E70_T0.9130.41
365_G368_A0.9080.40
117_P207_N0.9070.40
192_K195_Y0.9060.40
130_E217_D0.9050.40
378_E382_I0.9050.40
139_I328_S0.9040.40
79_S173_F0.9020.40
148_L152_K0.9010.40
294_P327_P0.8940.39
160_L224_E0.8940.39
152_K186_E0.8920.39
98_K253_V0.8900.39
200_H364_G0.8890.39
89_V101_L0.8850.39
92_K231_L0.8840.39
92_K300_V0.8810.39
84_A175_T0.8810.39
262_S266_T0.8780.38
9_L68_V0.8780.38
313_E316_R0.8770.38
292_L354_G0.8720.38
46_K126_K0.8690.38
170_E365_G0.8670.38
256_M328_S0.8670.38
188_K228_D0.8650.38
257_A288_A0.8640.38
297_Y338_L0.8620.37
73_Y298_G0.8600.37
386_A393_K0.8600.37
8_Y24_I0.8560.37
31_G170_E0.8550.37
185_A381_P0.8470.36
155_L187_G0.8450.36
284_R353_G0.8420.36
375_A382_I0.8400.36
389_C397_D0.8380.36
149_S186_E0.8370.36
27_G299_S0.8370.36
22_E362_A0.8360.36
5_L153_E0.8350.36
143_V171_I0.8350.36
25_A51_V0.8340.36
205_A209_T0.8330.36
213_A244_G0.8330.36
26_T29_T0.8310.35
107_S146_R0.8290.35
293_F327_P0.8260.35
94_S327_P0.8210.35
232_F315_V0.8210.35
45_Q108_E0.8190.35
108_E122_Y0.8170.35
6_A88_T0.8160.34
354_G358_H0.8150.34
109_A374_D0.8140.34
208_L368_A0.8120.34
292_L299_S0.8110.34
129_G201_K0.8110.34
186_E189_Q0.8080.34
12_E15_A0.8060.34
9_L57_R0.8060.34
53_K303_P0.8040.34
125_R346_D0.8030.34
321_N384_E0.8000.34
115_P247_E0.7970.33
22_E36_L0.7950.33
385_K388_Q0.7940.33
92_K171_I0.7890.33
35_D41_Q0.7880.33
248_D254_P0.7870.33
157_Q161_G0.7850.33
259_P327_P0.7800.32
194_T209_T0.7770.32
118_K253_V0.7770.32
276_A309_A0.7750.32
389_C394_L0.7740.32
99_I179_P0.7740.32
47_H144_I0.7730.32
380_Q392_L0.7700.32
133_R340_M0.7690.32
331_I339_L0.7690.32
18_E377_L0.7680.32
381_P387_E0.7670.32
206_V244_G0.7650.31
175_T178_A0.7630.31
378_E381_P0.7530.31
333_P399_W0.7530.31
50_R72_A0.7530.31
110_F224_E0.7520.31
142_G146_R0.7490.30
116_G281_K0.7470.30
130_E133_R0.7470.30
338_L396_L0.7460.30
383_D394_L0.7450.30
155_L275_H0.7440.30
157_Q189_Q0.7430.30
130_E134_P0.7430.30
116_G284_R0.7420.30
220_R224_E0.7410.30
205_A355_V0.7410.30
274_S348_I0.7390.30
137_M299_S0.7390.30
112_R149_S0.7390.30
214_D244_G0.7360.30
7_T70_T0.7350.30
192_K245_L0.7350.30
256_M299_S0.7340.30
84_A173_F0.7330.30
17_T54_V0.7300.29
149_S189_Q0.7290.29
262_S294_P0.7280.29
10_L24_I0.7270.29
85_L89_V0.7260.29
153_E269_P0.7250.29
375_A380_Q0.7250.29
219_A298_G0.7240.29
328_S354_G0.7230.29
147_D150_D0.7220.29
143_V175_T0.7210.29
157_Q160_L0.7190.29
92_K353_G0.7150.29
156_R383_D0.7130.28
51_V348_I0.7120.28
9_L102_I0.7110.28
317_E378_E0.7090.28
185_A201_K0.7090.28
337_P341_R0.7080.28
4_L68_V0.7060.28
338_L341_R0.7050.28
297_Y350_N0.7000.28
157_Q273_F0.7000.28
156_R182_T0.6960.27
142_G152_K0.6960.27
182_T224_E0.6960.27
81_D233_N0.6950.27
100_K276_A0.6950.27
5_L53_K0.6950.27
284_R287_G0.6950.27
85_L186_E0.6940.27
316_R319_A0.6940.27
83_P149_S0.6920.27
84_A172_F0.6910.27
49_G73_Y0.6900.27
197_Q387_E0.6890.27
382_I399_W0.6890.27
68_V239_L0.6880.27
35_D44_M0.6880.27
82_I286_C0.6860.27
112_R367_R0.6860.27
108_E112_R0.6850.27
118_K248_D0.6830.27
95_L155_L0.6790.27
126_K192_K0.6790.27
108_E341_R0.6770.26
96_D99_I0.6730.26
77_N88_T0.6730.26
90_F259_P0.6730.26
337_P382_I0.6720.26
166_I347_H0.6710.26
82_I239_L0.6690.26
33_W329_A0.6690.26
154_Q356_H0.6650.26
254_P357_G0.6650.26
142_G148_L0.6640.26
181_E225_L0.6640.26
7_T19_K0.6630.26
292_L327_P0.6630.26
336_V347_H0.6620.26
388_Q394_L0.6620.26
196_E245_L0.6620.26
381_P397_D0.6620.26
259_P293_F0.6610.26
305_A312_E0.6580.25
339_L347_H0.6550.25
84_A92_K0.6540.25
367_R371_A0.6530.25
312_E364_G0.6520.25
24_I96_D0.6510.25
118_K250_E0.6500.25
261_V327_P0.6480.25
71_I109_A0.6480.25
117_P168_D0.6460.25
397_D400_G0.6460.25
219_A249_P0.6430.25
375_A392_L0.6420.25
19_K22_E0.6410.25
10_L315_V0.6380.24
24_I69_I0.6360.24
10_L15_A0.6360.24
51_V282_L0.6360.24
241_V315_V0.6350.24
70_T374_D0.6340.24
177_L233_N0.6330.24
260_A348_I0.6310.24
133_R370_R0.6310.24
57_R68_V0.6310.24
95_L259_P0.6300.24
10_L69_I0.6300.24
110_F208_L0.6290.24
160_L190_I0.6290.24
261_V283_N0.6290.24
106_F391_D0.6270.24
288_A350_N0.6260.24
384_E393_K0.6250.24
136_L282_L0.6250.24
89_V273_F0.6240.24
134_P361_G0.6240.24
20_K27_G0.6230.24
43_Q188_K0.6200.24
203_L229_A0.6190.23
54_V312_E0.6180.23
108_E224_E0.6180.23
37_P300_V0.6170.23
246_A254_P0.6160.23
121_V324_F0.6160.23
195_Y200_H0.6160.23
134_P226_G0.6160.23
38_L41_Q0.6140.23
169_D183_R0.6140.23
122_Y265_F0.6120.23
258_H272_G0.6110.23
134_P359_P0.6100.23
88_T171_I0.6100.23
385_K391_D0.6100.23
257_A337_P0.6090.23
259_P294_P0.6090.23
24_I232_F0.6060.23
171_I350_N0.6050.23
25_A32_S0.6050.23
175_T298_G0.6030.23
256_M267_S0.6030.23
171_I294_P0.6030.23
256_M354_G0.6030.23
162_G198_T0.6030.23
113_A178_A0.6030.23
368_A372_I0.6020.23
122_Y378_E0.6020.23
20_K101_L0.6020.23
4_L78_F0.6020.23
81_D292_L0.6000.23
340_M377_L0.5980.22
93_L205_A0.5980.22
181_E185_A0.5970.22
90_F96_D0.5960.22
274_S314_C0.5950.22
224_E383_D0.5940.22
207_N231_L0.5930.22
138_S184_I0.5910.22
122_Y308_L0.5910.22
232_F245_L0.5900.22
142_G155_L0.5890.22
126_K247_E0.5880.22
388_Q393_K0.5870.22
129_G166_I0.5860.22
211_R240_D0.5850.22
42_E45_Q0.5850.22
340_M347_H0.5840.22
137_M328_S0.5840.22
163_V240_D0.5820.22
189_Q397_D0.5810.22
287_G330_G0.5810.22
102_I277_L0.5810.22
138_S163_V0.5790.22
18_E341_R0.5790.22
219_A248_D0.5780.21
71_I122_Y0.5780.21
125_R168_D0.5770.21
74_P365_G0.5770.21
242_M273_F0.5770.21
137_M296_P0.5770.21
136_L336_V0.5760.21
42_E367_R0.5760.21
311_H325_A0.5750.21
180_F190_I0.5750.21
51_V148_L0.5750.21
383_D396_L0.5740.21
18_E51_V0.5740.21
312_E316_R0.5720.21
154_Q362_A0.5710.21
198_T214_D0.5710.21
378_E393_K0.5710.21
29_T302_L0.5700.21
120_G125_R0.5700.21
27_G84_A0.5690.21
260_A332_H0.5690.21
312_E324_F0.5690.21
378_E389_C0.5690.21
259_P267_S0.5680.21
170_E361_G0.5660.21
172_F204_Y0.5660.21
100_K177_L0.5650.21
387_E390_K0.5640.21
222_A355_V0.5620.21
16_D19_K0.5620.21
246_A249_P0.5600.21
149_S340_M0.5590.21
189_Q269_P0.5580.21
111_K322_Q0.5580.21
129_G164_D0.5570.21
191_L254_P0.5560.20
161_G356_H0.5550.20
92_K207_N0.5550.20
92_K259_P0.5550.20
33_W331_I0.5550.20
20_K291_S0.5530.20
30_V293_F0.5530.20
158_Q166_I0.5520.20
235_F262_S0.5510.20
36_L357_G0.5510.20
139_I206_V0.5500.20
198_T341_R0.5500.20
343_F347_H0.5490.20
5_L322_Q0.5490.20
163_V244_G0.5490.20
227_A248_D0.5490.20
128_L193_E0.5480.20
47_H77_N0.5480.20
74_P77_N0.5470.20
51_V54_V0.5470.20
178_A350_N0.5460.20
78_F106_F0.5460.20
4_L323_T0.5460.20
50_R114_L0.5460.20
156_R161_G0.5420.20
104_L393_K0.5400.20
378_E385_K0.5400.20
220_R248_D0.5370.20
108_E383_D0.5360.20
103_D148_L0.5350.20
82_I277_L0.5320.19
139_I170_E0.5310.19
208_L245_L0.5310.19
122_Y316_R0.5310.19
330_G352_G0.5310.19
68_V149_S0.5310.19
232_F293_F0.5310.19
266_T275_H0.5310.19
93_L210_G0.5300.19
233_N277_L0.5290.19
341_R396_L0.5270.19
141_K258_H0.5250.19
89_V147_D0.5240.19
112_R153_E0.5230.19
128_L254_P0.5220.19
229_A290_F0.5200.19
13_P181_E0.5190.19
81_D94_S0.5180.19
131_F182_T0.5180.19
239_L370_R0.5170.19
260_A279_L0.5160.19
363_Q367_R0.5140.19
71_I172_F0.5140.19
166_I174_E0.5120.19
83_P282_L0.5110.19
39_V187_G0.5110.19
209_T348_I0.5100.19
116_G161_G0.5090.18
248_D327_P0.5080.18
54_V217_D0.5080.18
259_P262_S0.5070.18
298_G353_G0.5060.18
346_D375_A0.5060.18
330_G350_N0.5050.18
181_E397_D0.5050.18
157_Q390_K0.5040.18
120_G254_P0.5040.18
195_Y202_T0.5030.18
142_G329_A0.5030.18
311_H327_P0.5020.18
378_E383_D0.5020.18
50_R245_L0.5010.18
359_P392_L0.5010.18
296_P342_D0.5000.18
236_A260_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zviA 2 0.9901 100 0.076 Contact Map
2oemA 2 0.9926 100 0.087 Contact Map
4nasA 2 0.9877 100 0.09 Contact Map
3fk4A 2 0.9531 100 0.095 Contact Map
2d69A 4 0.9802 100 0.101 Contact Map
3kdnA 5 0.9852 100 0.101 Contact Map
3nwrA 2 0.9432 100 0.108 Contact Map
1ykwA 2 0.9432 100 0.11 Contact Map
2qygA 2 0.9728 100 0.11 Contact Map
4f0hA 4 0.9778 100 0.133 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.