GREMLIN Database
MTNE - Transaminase MtnE
UniProt: O31665 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (349)
Sequences: 43249 (29711)
Seq/√Len: 1590.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_K59_A3.3151.00
120_T141_K3.0541.00
78_A286_L2.8761.00
100_L106_G2.8741.00
305_A377_K2.8031.00
347_A385_K2.7081.00
115_L140_A2.6981.00
300_E304_N2.6861.00
84_K90_D2.6181.00
316_D329_P2.5861.00
186_S190_E2.5701.00
301_S373_E2.4721.00
119_D169_K2.4421.00
161_T198_E2.4201.00
74_R282_A2.3791.00
254_G259_I2.3281.00
378_E382_R2.2951.00
120_T143_E2.2261.00
48_E52_E2.1281.00
307_I311_R2.1051.00
185_T188_F2.0901.00
108_V112_Q2.0561.00
309_A312_E2.0301.00
125_D144_M1.9631.00
77_S93_P1.9501.00
309_A380_A1.9131.00
307_I319_A1.9081.00
78_A81_A1.8611.00
249_V281_A1.8391.00
190_E194_R1.8131.00
309_A384_G1.8081.00
159_S163_E1.7961.00
73_Y77_S1.7961.00
305_A309_A1.7771.00
342_L386_L1.7611.00
81_A286_L1.7501.00
309_A313_I1.7501.00
80_A93_P1.7401.00
204_V235_I1.7261.00
52_E56_R1.7071.00
161_T191_D1.7061.00
135_V140_A1.7041.00
378_E381_Y1.6851.00
156_D159_S1.6771.00
96_E256_A1.6731.00
132_W136_T1.6651.00
56_R283_E1.6451.00
159_S162_A1.6391.00
313_I384_G1.6341.00
347_A382_R1.6341.00
305_A373_E1.6281.00
51_V55_K1.6271.00
341_D345_E1.6261.00
77_S81_A1.6241.00
372_S375_R1.6211.00
274_F277_T1.6201.00
309_A381_Y1.6131.00
78_A282_A1.6071.00
308_T312_E1.6061.00
196_A203_V1.6041.00
110_L233_I1.6031.00
154_L188_F1.6031.00
120_T167_Q1.5961.00
311_R317_V1.5961.00
200_G231_I1.5881.00
121_I135_V1.5601.00
208_A237_T1.5551.00
335_T338_Q1.5451.00
304_N308_T1.5441.00
157_Y191_D1.5421.00
186_S220_L1.5421.00
132_W144_M1.5341.00
79_A251_F1.5201.00
125_D146_P1.5121.00
191_D194_R1.5101.00
111_P135_V1.5091.00
37_L379_A1.4941.00
110_L204_V1.4811.00
158_S191_D1.4701.00
72_S279_E1.4641.00
307_I317_V1.4581.00
52_E55_K1.4511.00
338_Q342_L1.4511.00
306_W326_A1.4511.00
252_A262_I1.4491.00
120_T165_R1.4471.00
91_L253_V1.4421.00
70_R263_N1.4331.00
53_E56_R1.4261.00
122_L168_A1.4241.00
312_E384_G1.4191.00
103_G235_I1.4081.00
351_V365_V1.3991.00
148_V188_F1.3951.00
188_F191_D1.3871.00
170_L204_V1.3791.00
123_V142_M1.3741.00
309_A377_K1.3681.00
73_Y93_P1.3671.00
238_L281_A1.3601.00
117_P139_K1.3591.00
336_S355_N1.3561.00
83_Y253_V1.3561.00
53_E283_E1.3521.00
337_E355_N1.3511.00
293_A297_A1.3481.00
298_R301_S1.3411.00
282_A286_L1.3381.00
307_I326_A1.3371.00
120_T168_A1.3261.00
306_W380_A1.3151.00
112_Q138_A1.3011.00
32_H348_N1.2981.00
298_R373_E1.2881.00
94_E256_A1.2861.00
92_D96_E1.2821.00
329_P363_G1.2801.00
194_R198_E1.2781.00
338_Q341_D1.2751.00
329_P364_Y1.2731.00
51_V59_A1.2731.00
54_M280_A1.2641.00
74_R286_L1.2601.00
327_W354_G1.2551.00
161_T165_R1.2481.00
261_A264_L1.2461.00
196_A201_I1.2451.00
161_T199_N1.2431.00
311_R319_A1.2421.00
164_I195_F1.2401.00
236_Y251_F1.2381.00
146_P159_S1.2281.00
148_V151_R1.2281.00
190_E225_T1.2231.00
157_Y195_F1.2231.00
195_F199_N1.2231.00
54_M58_V1.2181.00
187_E190_E1.2041.00
186_S224_Q1.1961.00
328_L367_V1.1921.00
373_E377_K1.1851.00
194_R197_A1.1841.00
377_K381_Y1.1821.00
187_E191_D1.1811.00
74_R279_E1.1791.00
111_P115_L1.1771.00
195_F201_I1.1761.00
70_R76_K1.1711.00
289_Q293_A1.1671.00
161_T195_F1.1661.00
106_G252_A1.1611.00
298_R302_R1.1601.00
303_R369_L1.1591.00
98_A259_I1.1561.00
111_P172_Y1.1551.00
122_L145_M1.1531.00
116_N119_D1.1531.00
375_R378_E1.1531.00
313_I381_Y1.1521.00
197_A229_K1.1461.00
260_E264_L1.1431.00
101_F105_A1.1411.00
56_R60_D1.1371.00
381_Y385_K1.1341.00
297_A300_E1.1311.00
283_E286_L1.1301.00
293_A296_N1.1291.00
82_F289_Q1.1251.00
76_K80_A1.1231.00
233_I254_G1.1121.00
193_V228_A1.1061.00
56_R59_A1.1021.00
303_R307_I1.0961.00
305_A308_T1.0961.00
230_D255_N1.0921.00
113_C265_Y1.0861.00
283_E287_A1.0841.00
186_S225_T1.0821.00
279_E282_A1.0801.00
171_M201_I1.0781.00
202_C233_I1.0761.00
215_D321_A1.0651.00
49_H52_E1.0591.00
79_A99_V1.0521.00
86_E289_Q1.0461.00
75_L99_V1.0441.00
162_A166_E1.0421.00
302_R305_A1.0391.00
297_A301_S1.0361.00
105_A266_Q1.0291.00
148_V156_D1.0291.00
49_H287_A1.0271.00
290_T294_E1.0251.00
340_S351_V1.0251.00
74_R77_S1.0251.00
165_R168_A1.0171.00
48_E51_V1.0171.00
83_Y251_F1.0141.00
148_V159_S1.0121.00
221_S224_Q0.9991.00
164_I201_I0.9981.00
33_D348_N0.9971.00
214_F300_E0.9901.00
115_L121_I0.9841.00
294_E298_R0.9811.00
291_C294_E0.9801.00
308_T311_R0.9771.00
316_D331_P0.9731.00
135_V142_M0.9731.00
79_A97_V0.9711.00
92_D256_A0.9701.00
197_A230_D0.9691.00
337_E341_D0.9681.00
266_Q270_F0.9671.00
304_N319_A0.9651.00
331_P363_G0.9641.00
336_S363_G0.9641.00
121_I170_L0.9641.00
202_C231_I0.9631.00
190_E228_A0.9621.00
233_I252_A0.9601.00
347_A386_L0.9501.00
80_A97_V0.9501.00
343_L351_V0.9481.00
157_Y161_T0.9481.00
193_V232_G0.9461.00
315_W330_V0.9431.00
52_E59_A0.9361.00
114_L170_L0.9311.00
197_A227_G0.9301.00
145_M163_E0.9291.00
342_L347_A0.9291.00
96_E259_I0.9281.00
115_L170_L0.9281.00
165_R199_N0.9271.00
382_R385_K0.9131.00
80_A92_D0.9121.00
158_S162_A0.9111.00
197_A231_I0.9081.00
256_A260_E0.9071.00
33_D378_E0.9031.00
335_T362_E0.8991.00
109_E266_Q0.8991.00
197_A228_A0.8971.00
202_C258_V0.8941.00
97_V253_V0.8921.00
136_T142_M0.8911.00
213_G219_P0.8861.00
124_P155_P0.8821.00
233_I258_V0.8791.00
114_L202_C0.8781.00
235_I252_A0.8771.00
294_E297_A0.8761.00
342_L345_E0.8741.00
72_S282_A0.8741.00
106_G235_I0.8731.00
259_I263_N0.8721.00
203_V222_F0.8681.00
103_G237_T0.8621.00
254_G262_I0.8561.00
122_L163_E0.8551.00
291_C295_Q0.8521.00
131_Y172_Y0.8511.00
45_P51_V0.8471.00
127_G174_N0.8421.00
31_G348_N0.8421.00
330_V365_V0.8421.00
133_S136_T0.8401.00
49_H283_E0.8391.00
290_T293_A0.8381.00
168_A201_I0.8371.00
98_A262_I0.8371.00
157_Y192_T0.8331.00
51_V58_V0.8321.00
302_R372_S0.8321.00
82_F86_E0.8301.00
158_S161_T0.8271.00
301_S305_A0.8271.00
337_E353_A0.8221.00
220_L224_Q0.8211.00
101_F274_F0.8181.00
343_L383_I0.8171.00
303_R320_P0.8091.00
82_F211_A0.8081.00
96_E229_K0.8071.00
44_Q298_R0.8071.00
86_E211_A0.8061.00
306_W309_A0.8061.00
339_F365_V0.8061.00
249_V273_L0.8051.00
113_C262_I0.8051.00
222_F225_T0.7991.00
73_Y76_K0.7991.00
72_S278_Q0.7981.00
124_P145_M0.7961.00
89_I223_L0.7921.00
249_V277_T0.7891.00
304_N307_I0.7831.00
53_E57_A0.7801.00
313_I380_A0.7801.00
157_Y188_F0.7791.00
336_S353_A0.7771.00
351_V367_V0.7771.00
81_A84_K0.7751.00
186_S218_K0.7711.00
367_V379_A0.7651.00
340_S353_A0.7651.00
222_F232_G0.7611.00
371_T375_R0.7601.00
213_G216_G0.7601.00
103_G208_A0.7561.00
122_L160_I0.7561.00
49_H291_C0.7551.00
105_A270_F0.7521.00
193_V203_V0.7521.00
147_L177_N0.7511.00
108_V138_A0.7501.00
98_A252_A0.7451.00
63_N279_E0.7441.00
306_W369_L0.7421.00
143_E163_E0.7391.00
355_N362_E0.7351.00
308_T377_K0.7301.00
327_W364_Y0.7281.00
104_K130_D0.7251.00
177_N180_T0.7221.00
145_M159_S0.7221.00
57_A60_D0.7211.00
76_K93_P0.7211.00
301_S304_N0.7191.00
223_L234_E0.7191.00
205_H222_F0.7171.00
349_V383_I0.7171.00
292_V296_N0.7161.00
112_Q265_Y0.7151.00
349_V382_R0.7141.00
125_D358_G0.7121.00
315_W328_L0.7111.00
151_R159_S0.7101.00
109_E262_I0.7071.00
228_A231_I0.7071.00
105_A109_E0.7061.00
154_L185_T0.7041.00
241_T292_V0.7011.00
164_I199_N0.7011.00
120_T169_K0.6961.00
211_A241_T0.6921.00
381_Y384_G0.6921.00
339_F343_L0.6921.00
275_R279_E0.6891.00
303_R319_A0.6831.00
164_I168_A0.6831.00
300_E303_R0.6831.00
123_V135_V0.6791.00
110_L262_I0.6791.00
80_A91_L0.6791.00
148_V154_L0.6781.00
183_V322_G0.6771.00
115_L119_D0.6761.00
46_T50_I0.6761.00
215_D300_E0.6751.00
78_A285_L0.6731.00
54_M276_A0.6731.00
82_F87_Y0.6731.00
336_S340_S0.6681.00
254_G258_V0.6621.00
42_P299_Y0.6571.00
302_R373_E0.6551.00
82_F242_Y0.6541.00
108_V269_M0.6531.00
122_L171_M0.6521.00
143_E168_A0.6521.00
328_L364_Y0.6521.00
33_D375_R0.6491.00
160_I195_F0.6491.00
184_A188_F0.6481.00
155_P188_F0.6461.00
279_E283_E0.6421.00
228_A232_G0.6401.00
257_S260_E0.6361.00
207_F234_E0.6351.00
296_N300_E0.6341.00
214_F322_G0.6341.00
68_S73_Y0.6331.00
87_Y210_G0.6321.00
124_P177_N0.6321.00
306_W376_L0.6321.00
374_E377_K0.6291.00
77_S80_A0.6281.00
160_I171_M0.6261.00
173_L189_F0.6261.00
305_A380_A0.6241.00
151_R154_L0.6231.00
121_I140_A0.6221.00
111_P170_L0.6201.00
295_Q299_Y0.6191.00
314_G331_P0.6151.00
336_S362_E0.6151.00
260_E263_N0.6131.00
334_Y339_F0.6131.00
123_V144_M0.6121.00
210_G236_Y0.6121.00
339_F386_L0.6111.00
100_L252_A0.6101.00
48_E59_A0.6091.00
238_L251_F0.6041.00
149_K329_P0.6031.00
349_V379_A0.6021.00
263_N266_Q0.6001.00
184_A189_F0.6001.00
310_C328_L0.5991.00
168_A171_M0.5991.00
91_L96_E0.5991.00
37_L376_L0.5991.00
332_E335_T0.5991.00
108_V134_G0.5971.00
131_Y135_V0.5961.00
162_A165_R0.5951.00
146_P163_E0.5891.00
75_L281_A0.5881.00
67_S72_S0.5881.00
118_G141_K0.5871.00
343_L386_L0.5851.00
57_A280_A0.5851.00
57_A279_E0.5841.00
49_H290_T0.5841.00
102_G248_R0.5831.00
227_G230_D0.5821.00
34_V350_A0.5801.00
312_E377_K0.5791.00
220_L225_T0.5781.00
238_L285_L0.5781.00
98_A263_N0.5771.00
372_S377_K0.5761.00
175_Y207_F0.5761.00
280_A283_E0.5751.00
165_R198_E0.5751.00
212_V299_Y0.5751.00
230_D257_S0.5741.00
154_L182_A0.5721.00
155_P160_I0.5701.00
76_K263_N0.5691.00
183_V213_G0.5671.00
182_A321_A0.5671.00
191_D195_F0.5661.00
150_D154_L0.5631.00
334_Y338_Q0.5631.00
207_F210_G0.5631.00
51_V54_M0.5621.00
214_F303_R0.5621.00
146_P156_D0.5621.00
36_N41_N0.5611.00
83_Y234_E0.5591.00
107_L134_G0.5581.00
317_V326_A0.5581.00
344_L350_A0.5581.00
215_D303_R0.5571.00
99_V249_V0.5571.00
74_R78_A0.5561.00
57_A283_E0.5551.00
278_Q282_A0.5551.00
143_E165_R0.5551.00
266_Q273_L0.5541.00
104_K128_Y0.5501.00
207_F221_S0.5501.00
219_P222_F0.5501.00
50_I284_A0.5491.00
98_A254_G0.5491.00
334_Y342_L0.5481.00
46_T51_V0.5481.00
161_T164_I0.5481.00
129_P356_G0.5461.00
46_T49_H0.5451.00
55_K58_V0.5441.00
113_C261_A0.5441.00
196_A200_G0.5441.00
60_D63_N0.5441.00
35_I378_E0.5431.00
163_E166_E0.5431.00
36_N39_Q0.5421.00
111_P138_A0.5421.00
359_E362_E0.5411.00
101_F273_L0.5411.00
171_M196_A0.5401.00
43_D302_R0.5401.00
318_T329_P0.5391.00
172_Y204_V0.5391.00
382_R386_L0.5381.00
116_N169_K0.5361.00
242_Y289_Q0.5361.00
123_V132_W0.5361.00
84_K89_I0.5341.00
289_Q292_V0.5311.00
112_Q269_M0.5301.00
220_L223_L0.5301.00
60_D283_E0.5291.00
47_P50_I0.5281.00
53_E280_A0.5281.00
255_N258_V0.5261.00
151_R156_D0.5261.00
47_P51_V0.5261.00
111_P134_G0.5231.00
257_S261_A0.5221.00
378_E385_K0.5201.00
229_K232_G0.5191.00
119_D167_Q0.5181.00
75_L282_A0.5171.00
110_L170_L0.5171.00
109_E265_Y0.5161.00
106_G250_G0.5151.00
175_Y183_V0.5141.00
295_Q298_R0.5141.00
38_G350_A0.5121.00
71_G76_K0.5111.00
170_L202_C0.5101.00
354_G364_Y0.5091.00
354_G357_F0.5061.00
72_S275_R0.5061.00
176_P322_G0.5051.00
221_S234_E0.5041.00
212_V296_N0.5031.00
75_L79_A0.5021.00
209_Y325_F0.5001.00
67_S275_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5dA 3 0.9472 100 0.284 Contact Map
3dydA 2 0.9296 100 0.285 Contact Map
3h14A 2 0.9221 100 0.289 Contact Map
1xi9A 4 0.9648 100 0.291 Contact Map
1j32A 2 0.9673 100 0.292 Contact Map
4my5A 2 0.9598 100 0.294 Contact Map
2o1bA 2 0.9422 100 0.295 Contact Map
1yizA 2 0.9623 100 0.295 Contact Map
1b5pA 2 0.9497 100 0.297 Contact Map
1gd9A 2 0.9673 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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