GREMLIN Database
MTNU - Hydrolase MtnU
UniProt: O31664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (245)
Sequences: 13935 (9787)
Seq/√Len: 625.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
134_E139_K3.2691.00
4_T235_E3.2501.00
16_K19_E2.7831.00
186_R189_E2.5261.00
216_D220_R2.4861.00
23_K229_E2.4821.00
214_I234_A2.4141.00
24_A44_W2.3791.00
83_S97_Y2.3531.00
226_G230_G2.2911.00
6_S233_R2.2751.00
180_K224_E2.2691.00
141_S157_H2.2651.00
143_L154_I2.1981.00
95_T110_R2.1571.00
6_S35_A2.1451.00
7_C195_A2.0801.00
29_E74_K2.0331.00
7_C197_C2.0041.00
39_V166_F2.0011.00
38_L77_V1.9821.00
78_H101_K1.9281.00
33_K233_R1.9221.00
29_E75_H1.9101.00
25_E71_T1.8991.00
25_E67_W1.8731.00
163_N242_A1.8711.00
5_I195_A1.8671.00
93_Y110_R1.8591.00
225_G230_G1.8561.00
36_D136_D1.8361.00
225_G232_V1.8041.00
25_E29_E1.7511.00
91_D125_S1.7051.00
193_F217_P1.7021.00
70_K74_K1.7011.00
135_L138_V1.6921.00
78_H98_I1.6771.00
35_A233_R1.6551.00
181_S184_I1.6401.00
100_D106_I1.6341.00
23_K26_F1.6251.00
80_V98_I1.5981.00
28_I38_L1.5931.00
139_K163_N1.5851.00
165_L192_C1.5691.00
68_L81_A1.5681.00
8_L38_L1.5661.00
26_F30_K1.5611.00
98_I142_G1.5561.00
30_K33_K1.5551.00
95_T108_E1.5511.00
96_M142_G1.5451.00
86_V110_R1.5401.00
101_K136_D1.5371.00
69_K99_A1.5271.00
71_T75_H1.5211.00
215_I221_V1.5171.00
140_S164_V1.5121.00
39_V197_C1.5081.00
195_A214_I1.4971.00
80_V166_F1.4971.00
223_A232_V1.4931.00
37_V166_F1.4921.00
78_H106_I1.4761.00
24_A40_L1.4671.00
72_A79_I1.4661.00
154_I165_L1.4661.00
100_D104_Q1.4581.00
240_E243_E1.4241.00
80_V96_M1.4211.00
78_H135_L1.4071.00
65_Q97_Y1.3941.00
180_K184_I1.3931.00
116_Q121_H1.3881.00
183_L196_A1.3871.00
61_G65_Q1.3831.00
22_K26_F1.3691.00
143_L167_I1.3671.00
28_I79_I1.3471.00
13_S19_E1.3371.00
99_A105_I1.3361.00
119_D122_L1.3301.00
181_S188_I1.3091.00
193_F222_L1.3041.00
8_L40_L1.2961.00
152_E155_R1.2961.00
143_L153_W1.2881.00
80_V142_G1.2871.00
25_E74_K1.2861.00
18_S22_K1.2821.00
96_M168_S1.2811.00
58_D62_R1.2641.00
8_L231_I1.2561.00
28_I71_T1.2491.00
27_F30_K1.2401.00
140_S166_F1.2311.00
19_E22_K1.2261.00
211_H224_E1.2221.00
146_Y150_F1.2201.00
83_S108_E1.2161.00
216_D222_L1.2041.00
36_D101_K1.1881.00
154_I167_I1.1781.00
21_I67_W1.1701.00
29_E71_T1.1671.00
216_D240_E1.1601.00
164_V195_A1.1521.00
66_S69_K1.1451.00
28_I77_V1.1261.00
109_Y131_G1.1221.00
107_K131_G1.1151.00
199_C203_N1.1051.00
187_A194_V1.1051.00
243_E247_S1.0961.00
21_I25_E1.0951.00
45_T64_A1.0911.00
10_F27_F1.0891.00
35_A38_L1.0831.00
66_S70_K1.0821.00
93_Y125_S1.0811.00
70_K73_K1.0751.00
67_W70_K1.0721.00
156_K160_K1.0631.00
19_E23_K1.0581.00
31_E77_V1.0551.00
25_E70_K1.0471.00
98_I133_F1.0441.00
162_A165_L1.0421.00
183_L194_V1.0371.00
109_Y147_D1.0261.00
97_Y108_E1.0241.00
180_K213_L1.0111.00
183_L215_I1.0091.00
58_D64_A1.0051.00
18_S63_S1.0041.00
202_S207_E1.0041.00
155_R190_N1.0041.00
61_G66_S1.0031.00
23_K27_F0.9961.00
27_F231_I0.9931.00
78_H136_D0.9861.00
22_K67_W0.9831.00
68_L79_I0.9761.00
62_R65_Q0.9741.00
78_H100_D0.9691.00
183_L213_L0.9591.00
10_F24_A0.9551.00
242_A246_E0.9551.00
132_Y139_K0.9471.00
43_L124_L0.9451.00
81_A99_A0.9421.00
4_T33_K0.9391.00
13_S16_K0.9381.00
76_G101_K0.9361.00
86_V95_T0.9361.00
65_Q99_A0.9301.00
134_E137_G0.9301.00
158_T192_C0.9291.00
141_S162_A0.9261.00
107_K133_F0.9261.00
179_W196_A0.9191.00
8_L27_F0.9111.00
9_Q212_S0.9111.00
177_D184_I0.9101.00
187_A215_I0.9071.00
135_L140_S0.8991.00
138_V163_N0.8881.00
4_T233_R0.8761.00
7_C214_I0.8751.00
111_K145_C0.8701.00
181_S185_A0.8691.00
222_L234_A0.8621.00
173_L207_E0.8611.00
67_W71_T0.8501.00
223_A234_A0.8471.00
112_A153_W0.8451.00
31_E34_H0.8441.00
237_D240_E0.8401.00
88_K91_D0.8391.00
239_Q242_A0.8341.00
18_S67_W0.8281.00
43_L48_Y0.8201.00
7_C232_V0.8191.00
29_E32_S0.8161.00
193_F236_I0.8141.00
132_Y162_A0.8131.00
177_D180_K0.8121.00
40_L44_W0.8121.00
60_D65_Q0.8111.00
138_V164_V0.8101.00
155_R159_T0.7981.00
65_Q69_K0.7921.00
49_D52_N0.7891.00
113_H147_D0.7851.00
94_N111_K0.7811.00
7_C212_S0.7691.00
22_K25_E0.7691.00
5_I236_I0.7661.00
163_N238_L0.7641.00
72_A75_H0.7631.00
31_E231_I0.7621.00
193_F241_S0.7581.00
193_F240_E0.7581.00
65_Q105_I0.7561.00
213_L221_V0.7531.00
17_P21_I0.7521.00
239_Q243_E0.7451.00
133_F140_S0.7431.00
221_V224_E0.7381.00
11_D200_T0.7371.00
170_E199_C0.7341.00
6_S231_I0.7321.00
9_Q210_G0.7301.00
24_A68_L0.7301.00
10_F44_W0.7281.00
24_A81_A0.7241.00
98_I140_S0.7231.00
116_Q119_D0.7231.00
170_E208_F0.7221.00
28_I75_H0.7171.00
37_V137_G0.7141.00
200_T228_E0.7101.00
240_E244_V0.7091.00
33_K231_I0.7081.00
26_F29_E0.7051.00
16_K20_N0.7041.00
148_I183_L0.7011.00
241_S245_R0.6981.00
31_E35_A0.6981.00
28_I40_L0.6971.00
6_S38_L0.6971.00
12_I199_C0.6961.00
167_I194_V0.6951.00
71_T74_K0.6941.00
39_V80_V0.6921.00
24_A28_I0.6881.00
11_D229_E0.6871.00
100_D136_D0.6861.00
157_H162_A0.6841.00
130_D153_W0.6841.00
94_N145_C0.6841.00
138_V238_L0.6821.00
115_F146_Y0.6811.00
37_V80_V0.6751.00
112_A130_D0.6721.00
87_R92_V0.6701.00
113_H150_F0.6701.00
17_P58_D0.6681.00
37_V78_H0.6661.00
143_L157_H0.6651.00
148_I167_I0.6641.00
21_I68_L0.6631.00
44_W81_A0.6631.00
176_L211_H0.6511.00
59_E87_R0.6511.00
199_C208_F0.6501.00
78_H137_G0.6491.00
69_K105_I0.6491.00
52_N55_E0.6481.00
69_K104_Q0.6461.00
39_V195_A0.6421.00
220_R240_E0.6401.00
3_W137_G0.6371.00
165_L194_V0.6361.00
62_R66_S0.6351.00
13_S20_N0.6321.00
115_F149_R0.6291.00
218_W244_V0.6281.00
97_Y105_I0.6271.00
30_K231_I0.6271.00
69_K72_A0.6241.00
10_F23_K0.6231.00
43_L84_V0.6231.00
3_W138_V0.6231.00
171_W175_R0.6211.00
3_W236_I0.6201.00
158_T190_N0.6171.00
120_E124_L0.6161.00
146_Y149_R0.6151.00
158_T251_F0.6131.00
153_W157_H0.6101.00
54_D57_A0.6071.00
88_K110_R0.6071.00
149_R171_W0.6061.00
213_L224_E0.6041.00
48_Y145_C0.6021.00
172_P175_R0.6011.00
35_A77_V0.5981.00
149_R182_L0.5951.00
3_W37_V0.5951.00
200_T229_E0.5951.00
202_S205_D0.5941.00
105_I108_E0.5941.00
238_L242_A0.5931.00
198_N212_S0.5921.00
46_T56_L0.5861.00
21_I71_T0.5851.00
177_D181_S0.5831.00
115_F171_W0.5791.00
86_V108_E0.5791.00
32_S75_H0.5761.00
63_S66_S0.5741.00
36_D137_G0.5731.00
186_R190_N0.5721.00
45_T68_L0.5691.00
54_D58_D0.5681.00
64_A67_W0.5671.00
78_H140_S0.5631.00
94_N144_I0.5621.00
11_D199_C0.5621.00
24_A71_T0.5611.00
86_V93_Y0.5611.00
30_K233_R0.5601.00
53_L56_L0.5591.00
131_G160_K0.5591.00
198_N209_A0.5591.00
130_D157_H0.5541.00
83_S95_T0.5541.00
30_K230_G0.5531.00
184_I221_V0.5511.00
171_W179_W0.5481.00
25_E75_H0.5471.00
115_F172_P0.5471.00
173_L176_L0.5451.00
173_L209_A0.5440.99
148_I182_L0.5430.99
169_A179_W0.5410.99
211_H227_R0.5390.99
13_S23_K0.5380.99
182_L185_A0.5370.99
48_Y124_L0.5370.99
84_V124_L0.5360.99
98_I135_L0.5340.99
131_G142_G0.5330.99
207_E227_R0.5310.99
144_I147_D0.5300.99
69_K73_K0.5300.99
139_K160_K0.5280.99
88_K93_Y0.5270.99
42_E145_C0.5250.99
46_T64_A0.5210.99
151_P189_E0.5210.99
59_E62_R0.5210.99
87_R90_S0.5200.99
155_R251_F0.5200.99
154_I186_R0.5180.99
45_T81_A0.5170.99
157_H165_L0.5160.99
36_D76_G0.5150.99
82_G94_N0.5130.99
18_S21_I0.5120.99
21_I45_T0.5120.99
176_L209_A0.5110.99
178_H218_W0.5110.99
43_L94_N0.5100.99
149_R179_W0.5100.99
130_D156_K0.5100.99
71_T79_I0.5100.99
141_S165_L0.5100.99
197_C214_I0.5090.99
40_L81_A0.5060.99
180_K221_V0.5030.99
146_Y171_W0.5030.99
163_N241_S0.5020.99
171_W196_A0.5010.99
107_K142_G0.5010.99
112_A147_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3p8kA 2 1 100 0.121 Contact Map
4izuA 2 0.9537 100 0.131 Contact Map
2w1vA 2 0.9961 100 0.139 Contact Map
2vhhA 5 1 100 0.153 Contact Map
3ivzA 2 0.9653 100 0.156 Contact Map
1uf5A 4 1 100 0.162 Contact Map
1f89A 2 0.9768 100 0.163 Contact Map
1emsA 3 0.9961 100 0.165 Contact Map
2e11A 2 0.9807 100 0.168 Contact Map
2dyuA 5 0.9846 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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