GREMLIN Database
MTNK - Methylthioribose kinase
UniProt: O31663 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (383)
Sequences: 517 (366)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_Q337_E5.2101.00
126_G133_Y4.4981.00
123_A136_L4.4751.00
91_Q143_F3.6531.00
208_N372_T3.5491.00
141_G299_T3.5371.00
17_A21_A3.4521.00
164_L256_Y3.2520.99
194_F199_R3.2460.99
221_S225_S3.2430.99
77_T172_E3.2050.99
139_H246_T3.0980.99
135_H139_H3.0130.99
27_F33_L2.8600.99
123_A241_A2.7740.98
140_I239_I2.7670.98
142_E299_T2.7490.98
120_L245_E2.6710.98
49_I60_I2.6630.98
301_S320_T2.5900.97
175_D179_R2.5450.97
347_H352_D2.5360.97
165_V226_A2.4700.96
79_D82_R2.4250.96
151_S228_T2.4120.96
153_D161_K2.3820.96
87_A254_A2.3710.95
305_Q319_L2.3340.95
214_E378_R2.3160.95
208_N376_E2.3030.95
290_N385_T2.2790.94
141_G295_T2.2550.94
119_H245_E2.2540.94
372_T376_E2.1500.92
211_V375_I2.1450.92
13_N16_S2.1430.92
145_G303_A2.1330.92
259_I326_I2.0810.91
31_S51_D2.0690.91
136_L241_A2.0510.90
131_E243_E2.0420.90
43_L117_L2.0270.90
120_L242_S2.0040.89
335_G371_G1.9920.89
199_R206_W1.9830.89
140_I266_F1.9540.88
176_I345_L1.9330.88
24_L104_Y1.9250.87
70_V345_L1.8820.86
17_A35_C1.8730.86
115_E247_K1.8590.85
284_P364_K1.7860.83
38_I59_I1.7700.82
97_H142_E1.7680.82
260_G329_E1.7540.82
154_Y322_T1.7510.82
42_N238_S1.7370.81
381_F390_L1.7110.80
21_A60_I1.7020.80
218_L332_G1.6890.79
217_K321_D1.6770.79
144_L263_V1.6750.79
136_L140_I1.6550.78
148_L263_V1.6280.77
301_S319_L1.6080.76
36_Q48_H1.6020.75
373_A377_K1.5920.75
177_T222_F1.5830.74
45_Y70_V1.5820.74
132_N280_A1.5800.74
160_V163_Q1.5710.74
188_D206_W1.5670.74
183_T219_K1.5550.73
266_F292_V1.5540.73
242_S245_E1.5480.73
267_I289_V1.5480.73
17_A60_I1.5300.72
176_I180_L1.5290.72
150_Y307_D1.5260.72
37_E40_D1.5260.72
122_I249_I1.5150.71
197_E361_I1.4980.70
180_L345_L1.4960.70
195_E364_K1.4790.69
100_P114_M1.4650.68
205_L343_I1.4630.68
12_L16_S1.4580.68
117_L122_I1.4360.67
90_R151_S1.4340.67
9_Y43_L1.4310.67
327_F331_I1.4280.66
296_F300_F1.4250.66
238_S340_R1.4250.66
48_H116_D1.3980.65
221_S329_E1.3870.64
103_F114_M1.3740.63
146_K303_A1.3700.63
366_L370_T1.3700.63
78_I110_A1.3640.63
323_L326_I1.3610.63
86_S107_T1.3580.62
195_E361_I1.3550.62
272_L367_A1.3540.62
342_T371_G1.3540.62
337_E342_T1.3530.62
186_F215_A1.3470.62
174_C255_F1.3260.60
197_E357_F1.3160.60
199_R203_E1.3050.59
221_S333_F1.2950.59
57_A116_D1.2930.58
201_F365_R1.2920.58
200_P203_E1.2900.58
297_E301_S1.2880.58
384_I387_V1.2670.57
275_L370_T1.2540.56
66_Y71_G1.2350.55
64_V74_W1.2350.55
186_F336_C1.2300.55
274_A286_Y1.2290.55
102_V122_I1.2260.54
290_N388_I1.2170.54
79_D107_T1.2100.53
361_I364_K1.2090.53
76_L122_I1.2090.53
90_R168_F1.2080.53
121_K131_E1.2080.53
215_A336_C1.2010.53
119_H242_S1.1880.52
260_G332_G1.1840.52
185_P192_N1.1780.51
36_Q50_Y1.1770.51
109_M184_D1.1720.51
154_Y220_K1.1610.50
42_N340_R1.1600.50
202_V343_I1.1590.50
48_H57_A1.1590.50
165_V169_T1.1580.50
67_A345_L1.1550.50
43_L122_I1.1530.50
354_I360_R1.1500.50
51_D56_R1.1500.50
194_F206_W1.1450.49
26_L58_L1.1430.49
48_H59_I1.1250.48
210_S376_E1.1220.48
228_T365_R1.1170.48
144_L259_I1.1150.47
153_D162_K1.1120.47
260_G326_I1.1100.47
271_F391_F1.1090.47
327_F384_I1.1090.47
225_S325_H1.1090.47
138_Q295_T1.1030.47
162_K176_I1.1010.47
335_G375_I1.0970.46
382_K386_D1.0960.46
141_G279_G1.0950.46
116_D171_P1.0910.46
82_R86_S1.0910.46
148_L259_I1.0810.45
227_E364_K1.0800.45
37_E42_N1.0770.45
162_K178_E1.0770.45
100_P234_L1.0750.45
43_L46_V1.0550.44
177_T182_F1.0520.43
200_P365_R1.0520.43
90_R93_E1.0490.43
266_F270_L1.0440.43
129_E268_A1.0430.43
39_G255_F1.0380.43
237_G340_R1.0350.42
295_T299_T1.0250.42
45_Y64_V1.0240.42
188_D199_R1.0230.42
238_S346_A1.0180.41
176_I179_R1.0120.41
97_H146_K1.0110.41
95_V146_K1.0090.41
122_I182_F1.0080.41
340_R344_G1.0060.41
286_Y391_F1.0050.41
214_E218_L1.0030.40
45_Y67_A1.0000.40
287_E291_Q1.0000.40
328_E379_S0.9990.40
181_V230_I0.9950.40
128_I349_A0.9900.40
42_N237_G0.9850.39
100_P103_F0.9850.39
26_L31_S0.9810.39
10_E16_S0.9740.39
337_E340_R0.9700.39
17_A49_I0.9690.38
281_D284_P0.9680.38
95_V98_L0.9660.38
219_K344_G0.9650.38
273_N364_K0.9600.38
70_V180_L0.9560.38
126_G131_E0.9500.37
42_N253_F0.9480.37
178_E219_K0.9450.37
302_E306_K0.9440.37
238_S344_G0.9430.37
214_E217_K0.9400.37
283_E392_K0.9380.37
71_G75_P0.9370.37
144_L148_L0.9350.36
123_A236_T0.9350.36
166_K169_T0.9290.36
120_L304_W0.9280.36
132_N284_P0.9270.36
38_I48_H0.9270.36
331_I374_F0.9210.36
149_F152_S0.9200.36
265_Q342_T0.9160.35
94_H256_Y0.9140.35
184_D345_L0.9140.35
156_L164_L0.9080.35
155_A309_L0.9070.35
253_F337_E0.9040.35
304_W319_L0.9010.34
255_F360_R0.9000.34
331_I387_V0.8960.34
134_P246_T0.8920.34
74_W184_D0.8910.34
340_R346_A0.8900.34
198_L347_H0.8880.34
322_T326_I0.8860.34
125_K349_A0.8860.34
81_A112_T0.8840.34
9_Y117_L0.8830.33
69_V77_T0.8800.33
212_K352_D0.8790.33
185_P340_R0.8760.33
260_G323_L0.8730.33
177_T185_P0.8720.33
162_K180_L0.8700.33
148_L296_F0.8680.33
75_P81_A0.8640.32
162_K165_V0.8600.32
137_S288_H0.8600.32
42_N185_P0.8550.32
234_L265_Q0.8540.32
335_G374_F0.8510.32
157_E160_V0.8500.32
20_L104_Y0.8490.32
193_D347_H0.8450.31
66_Y70_V0.8420.31
39_G178_E0.8390.31
233_D250_D0.8380.31
271_F374_F0.8360.31
43_L261_F0.8350.31
238_S253_F0.8290.31
46_V177_T0.8280.30
383_T386_D0.8260.30
275_L363_R0.8210.30
275_L391_F0.8200.30
184_D371_G0.8130.30
146_K299_T0.8130.30
70_V75_P0.8070.29
271_F370_T0.8060.29
273_N276_S0.8040.29
42_N344_G0.8020.29
214_E320_T0.8000.29
74_W261_F0.7990.29
94_H151_S0.7990.29
162_K226_A0.7990.29
102_V127_L0.7960.29
178_E255_F0.7930.29
177_T238_S0.7920.29
237_G346_A0.7910.29
272_L276_S0.7900.29
172_E378_R0.7900.29
228_T259_I0.7880.28
192_N340_R0.7870.28
338_L367_A0.7840.28
65_P261_F0.7810.28
211_V335_G0.7780.28
174_C219_K0.7760.28
83_I116_D0.7750.28
325_H382_K0.7700.27
21_A35_C0.7670.27
94_H150_Y0.7670.27
351_L363_R0.7670.27
273_N285_L0.7650.27
12_L312_Y0.7610.27
194_F240_F0.7610.27
161_K165_V0.7610.27
116_D240_F0.7580.27
119_H363_R0.7550.27
227_E319_L0.7530.27
15_S31_S0.7520.27
70_V261_F0.7520.27
91_Q259_I0.7500.27
222_F232_G0.7500.27
272_L348_V0.7480.26
193_D244_H0.7460.26
377_K380_E0.7460.26
138_Q141_G0.7450.26
32_T52_Q0.7440.26
168_F256_Y0.7440.26
136_L381_F0.7430.26
272_L338_L0.7420.26
9_Y98_L0.7420.26
288_H291_Q0.7410.26
122_I251_P0.7400.26
303_A307_D0.7400.26
19_A325_H0.7370.26
120_L361_I0.7370.26
45_Y66_Y0.7360.26
123_A292_V0.7350.26
92_G101_R0.7350.26
248_V356_P0.7350.26
65_P152_S0.7350.26
31_S358_D0.7340.26
164_L167_Q0.7330.26
88_L249_I0.7320.26
33_L56_R0.7280.25
291_Q295_T0.7270.25
289_V313_A0.7260.25
64_V78_I0.7230.25
237_G253_F0.7220.25
149_F304_W0.7210.25
227_E333_F0.7190.25
192_N237_G0.7170.25
221_S227_E0.7160.25
72_E76_L0.7160.25
191_T343_I0.7150.25
356_P359_K0.7140.25
143_F248_V0.7140.25
215_A375_I0.7100.25
106_D377_K0.7100.25
155_A175_D0.7070.24
63_A251_P0.7070.24
124_R341_R0.7060.24
181_V234_L0.7050.24
177_T269_N0.7050.24
142_E316_D0.7050.24
127_L285_L0.7050.24
85_S143_F0.7040.24
184_D223_L0.7020.24
208_N370_T0.7020.24
253_F340_R0.7010.24
41_G235_H0.7010.24
239_I243_E0.7000.24
235_H258_P0.6990.24
294_E385_T0.6990.24
148_L153_D0.6980.24
133_Y239_I0.6980.24
43_L185_P0.6970.24
136_L266_F0.6960.24
33_L55_D0.6940.24
237_G337_E0.6920.24
381_F387_V0.6910.24
360_R377_K0.6880.24
111_V214_E0.6880.24
141_G145_G0.6880.24
63_A70_V0.6860.24
67_A70_V0.6850.23
84_E233_D0.6850.23
141_G292_V0.6840.23
202_V205_L0.6830.23
192_N238_S0.6810.23
13_N243_E0.6810.23
42_N177_T0.6800.23
346_A368_L0.6780.23
243_E379_S0.6770.23
123_A288_H0.6740.23
47_F176_I0.6700.23
182_F333_F0.6700.23
377_K381_F0.6700.23
332_G378_R0.6700.23
170_N183_T0.6680.23
287_E392_K0.6670.23
197_E358_D0.6650.23
161_K180_L0.6650.23
43_L177_T0.6630.22
274_A391_F0.6620.22
122_I245_E0.6620.22
324_S382_K0.6600.22
305_Q316_D0.6570.22
71_G87_A0.6560.22
43_L81_A0.6550.22
146_K302_E0.6550.22
151_S208_N0.6530.22
146_K150_Y0.6520.22
204_K377_K0.6510.22
100_P304_W0.6500.22
84_E250_D0.6490.22
68_K364_K0.6490.22
21_A30_K0.6470.22
65_P75_P0.6460.22
202_V357_F0.6440.22
253_F346_A0.6440.22
19_A290_N0.6430.22
252_E262_D0.6410.22
196_E199_R0.6410.22
16_S322_T0.6390.21
122_I350_D0.6390.21
48_H67_A0.6390.21
219_K346_A0.6380.21
342_T375_I0.6340.21
79_D86_S0.6320.21
45_Y78_I0.6320.21
42_N192_N0.6300.21
370_T388_I0.6290.21
88_L251_P0.6290.21
23_K358_D0.6280.21
269_N350_D0.6270.21
45_Y180_L0.6250.21
349_A367_A0.6250.21
38_I98_L0.6230.21
59_I116_D0.6230.21
386_D389_E0.6220.21
104_Y111_V0.6220.21
377_K383_T0.6210.21
20_L279_G0.6210.21
174_C178_E0.6200.21
50_Y97_H0.6190.21
77_T169_T0.6180.21
103_F263_V0.6180.21
132_N281_D0.6170.21
287_E302_E0.6160.20
280_A388_I0.6160.20
126_G139_H0.6160.20
238_S337_E0.6160.20
219_K296_F0.6140.20
173_L237_G0.6130.20
228_T356_P0.6110.20
185_P238_S0.6100.20
234_L304_W0.6100.20
120_L154_Y0.6090.20
280_A382_K0.6060.20
203_E207_N0.6050.20
177_T346_A0.6040.20
26_L35_C0.6020.20
213_I317_G0.6020.20
63_A81_A0.6010.20
123_A277_R0.5990.20
147_T263_V0.5990.20
57_A139_H0.5970.20
91_Q227_E0.5960.20
359_K387_V0.5950.20
213_I217_K0.5940.20
244_H298_E0.5930.20
344_G348_V0.5920.20
34_T52_Q0.5900.19
243_E298_E0.5900.19
92_G387_V0.5900.19
99_V188_D0.5900.19
271_F289_V0.5880.19
108_E280_A0.5880.19
302_E385_T0.5860.19
123_A143_F0.5860.19
40_D170_N0.5850.19
77_T143_F0.5840.19
339_I371_G0.5830.19
377_K388_I0.5830.19
174_C344_G0.5830.19
246_T266_F0.5830.19
190_D215_A0.5820.19
233_D252_E0.5800.19
61_K252_E0.5790.19
185_P222_F0.5780.19
174_C251_P0.5780.19
230_I368_L0.5760.19
239_I363_R0.5760.19
22_V128_I0.5760.19
113_V377_K0.5760.19
33_L51_D0.5740.19
67_A73_S0.5740.19
8_L108_E0.5730.19
87_A268_A0.5690.19
177_T253_F0.5680.19
230_I291_Q0.5670.19
203_E298_E0.5650.18
243_E287_E0.5650.18
362_G365_R0.5630.18
160_V230_I0.5620.18
138_Q299_T0.5620.18
181_V219_K0.5620.18
14_E301_S0.5620.18
177_T232_G0.5590.18
234_L268_A0.5590.18
179_R223_L0.5590.18
66_Y75_P0.5590.18
333_F336_C0.5590.18
153_D174_C0.5580.18
55_D205_L0.5570.18
358_D379_S0.5570.18
196_E361_I0.5560.18
370_T374_F0.5560.18
121_K129_E0.5550.18
137_S141_G0.5550.18
52_Q200_P0.5550.18
64_V184_D0.5540.18
73_S345_L0.5530.18
253_F258_P0.5530.18
273_N277_R0.5520.18
64_V261_F0.5510.18
22_V25_G0.5510.18
69_V254_A0.5470.18
109_M223_L0.5460.18
114_M148_L0.5460.18
27_F38_I0.5460.18
278_D292_V0.5450.18
13_N68_K0.5450.18
109_M273_N0.5450.18
9_Y45_Y0.5440.18
17_A38_I0.5440.18
137_S208_N0.5430.18
159_K175_D0.5420.18
213_I321_D0.5420.18
40_D76_L0.5410.18
224_T268_A0.5410.18
101_R338_L0.5400.18
279_G363_R0.5400.18
179_R248_V0.5400.18
289_V292_V0.5390.18
173_L255_F0.5390.18
67_A74_W0.5390.18
34_T267_I0.5380.17
8_L321_D0.5360.17
152_S300_F0.5360.17
243_E382_K0.5350.17
186_F323_L0.5340.17
69_V176_I0.5320.17
65_P71_G0.5320.17
66_Y110_A0.5320.17
139_H142_E0.5320.17
83_I240_F0.5310.17
61_K262_D0.5310.17
58_L147_T0.5300.17
198_L365_R0.5300.17
67_A184_D0.5290.17
182_F300_F0.5290.17
76_L161_K0.5280.17
233_D262_D0.5280.17
281_D285_L0.5260.17
40_D46_V0.5260.17
201_F372_T0.5250.17
31_S113_V0.5250.17
82_R167_Q0.5250.17
280_A284_P0.5240.17
220_K227_E0.5240.17
81_A110_A0.5220.17
203_E206_W0.5210.17
289_V295_T0.5200.17
181_V268_A0.5190.17
21_A113_V0.5180.17
358_D362_G0.5180.17
180_L240_F0.5170.17
47_F256_Y0.5170.17
207_N355_V0.5160.17
35_C38_I0.5160.17
323_L381_F0.5160.17
70_V74_W0.5160.17
67_A83_I0.5140.17
192_N202_V0.5130.17
205_L361_I0.5120.17
90_R164_L0.5120.17
67_A112_T0.5110.17
91_Q100_P0.5110.17
60_I290_N0.5080.16
140_I320_T0.5070.16
199_R240_F0.5070.16
27_F56_R0.5070.16
246_T251_P0.5050.16
152_S236_T0.5030.16
48_H118_S0.5030.16
23_K34_T0.5010.16
90_R94_H0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pywA 2 0.9773 100 0.5 Contact Map
2olcA 3 0.9572 100 0.505 Contact Map
3f7wA 1 0.6952 99.9 0.836 Contact Map
2qg7A 2 0.7985 99.9 0.836 Contact Map
3fegA 2 0.7733 99.9 0.838 Contact Map
3csvA 2 0.7557 99.9 0.84 Contact Map
3atsA 1 0.7884 99.9 0.842 Contact Map
3g15A 2 0.801 99.9 0.842 Contact Map
4da5A 2 0.8212 99.9 0.843 Contact Map
4ocvA 1 0.8539 99.9 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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